Clinical trials: Sensitization, Central
Sensory Profiles, Nociplastic Pain, Low Back Pain
Type 3 Predictive Observational Study for Sensory Profiles in Central Sensitization in Low Back Pain Population.
This study conducts prognostic research to develop, validate, and evaluate the predictive role of sensory profiles in the development of sensory profiles over time.
- Trial name
- T3PredCohSt (NCT05097235)
- Where
- Netherlands
- Volunteers
- 114 people
- Sponsor
- Vrije Universiteit Brussel
Myofacial Pain, Central Sensitization
Comparison of Treatment Alternatives for Myofascial Pain Causing Central Sensitization
Myofascial pain is a regional muscle pain condition characterized by hard local areas and tender bands, known for the presence of trigger points in muscle tissue. The treatment is to eliminate the etiologic factor.
- Trial name
- Myofascialpain (NCT06869161)
- Testing
- Stabilization splint, Muscle exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Cukurova University
Diabetes Mellitus (DM)
Central Sensitization in Painful and Painless Diabetic Peripheral Neuropathy
This research is structured as a cross-sectional observational study. The primary objective is to compare central sensitization across painful and painless phenotypes of diabetic peripheral neuropathy.
- Trial name
- NCT07316322
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Inonu University
Pain, Hyperalgesia
Analgesic Effect of Oxytocin Receptor Modulation
Carbetocin is a synthetic analogue of the hormone Oxytocin and is routinely used in obstetric anesthesiology to control uterine bleeding after cesarean section.
- Conditions
- Pain, Hyperalgesia, Central Sensitization
- Trial name
- NCT01918475
- Testing
- Carbetocin
- Where
- Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Rotator Cuff Tears
Effect of Central Sensitization on Response to Physical Therapy in Patients With Partial Supraspinatus Tear
This prospective observational study aims to investigate whether central sensitization influences the response to physical therapy in patients with partial supraspinatus tendon tears.
- Trial name
- NCT07664137
- Testing
- Standard Physical Therapy and Rehabilitation
- Volunteers
- 60 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Autonomic Nervous System Modulation, Pain Perception
Pain Perception and the Autonomic Nervous System
In this study, we want to investigate how pain processing and sensation are related to a certain part of the nervous system, the so-called autonomic nervous system.
- Conditions
- Autonomic Nervous System Modulation, Pain Perception, Pain Sensitivity, Central Sensitization
- Trial name
- NCT06667895
- Testing
- respiratory gated taVNS, random burst stimulation, continuous stimulation
- Where
- Switzerland
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Schweinhardt Petra
Endometriosis, Postoperative Pain
Postoperative Pain Trajectories After Endometriosis Surgery
The pain associated with endometriosis reflects a multifactorial pathophysiology combining peripheral nociception, central sensitisation and psychosocial factors.
- Conditions
- Endometriosis, Postoperative Pain, Pain Trajectories, Chronic Postsurgical Pain
- Trial name
- TRACK-ENDO (NCT07882498)
- Testing
- Perioperative quantitative sensory testing, questionnaire
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Virtual Reality, Kinesiophobia
Can Virtual Reality Exercise Help Restore Both Body and Mind in Chronic Low Back Pain
The goal of this clinical trial is to learn if an immersive virtual reality (VR) exercise program can help reduce back pain and improve physical function and psychological well-being in adults with chronic low back pain.
- Conditions
- Virtual Reality, Kinesiophobia, Chronic Low Back Pain (CLBP), Central Sensitization
- Trial name
- NCT07207083
- Testing
- Immersive Virtual Reality-based Exercise (FitXR, Meta Quest 3s), Conventional Exercise Program (Matched Exercise, without VR)
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- dongmin kang
Fibromyalgia
The Relationship Between Serum S100B and Brain-Derived Neurotrophic Factor
Fibromyalgia is a chronic pain syndrome characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and cognitive symptoms.
- Trial name
- S100B-BDNF (NCT07358754)
- Testing
- No Intervention (Observational Study)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Cough, Healthy Controls
Neurophysiology of Cough Reflex Hypersensitivity
Central sensitisation is an increase in the excitability of nerves within the central nervous system, which can lead to heightened sensitivity to certain stimuli. This process is involved in some chronic pain conditions e.g.
- Trial name
- NOTCH (NCT00977366)
- Testing
- Hydrochloric acid (0.15 molar), Saline
- Where
- United Kingdom
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Knee Osteoarthritis
Influence of Central Sensitization on Efficacy of Patient-controlled Epidural Analgesia in Osteoarthritis Patients Undergoing Total Knee Replacement
Nociceptor inputs can trigger a prolonged but reversible increase in the excitability and synaptic efficacy of neurons in central nociceptive pathways, the phenomenon of central sensitization.
- Trial name
- NCT01863342
- Testing
- CSI score < 40, CSI score ≥ 40
- Where
- South Korea
- Volunteers
- 98 people
- Sponsor
- Yonsei University
Fibromyalgia, Primary, Fibromyalgia
Pain Phenotypes in Patients With Fibromyalgia Syndrome
Fibromyalgia Syndrome (FMS); is a complex syndrome characterized by many symptoms such as chronic widespread pain, fatigue and sleep disorders, cognitive dysfunctions and psychiatric disorders.
- Conditions
- Fibromyalgia, Primary, Fibromyalgia, Chronic Pain Syndrome, Pain, Neuropathic
- Trial name
- NCT05941780
- Testing
- Pain classification method
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Kutahya Health Sciences University
Osteoarthritis
A Single Center 2-way Crossover Study to Investigate the Mechanism of Action of Etoricoxib in Subjects With Osteoarthritis Knee Pain
The purpose of this study is to investigate which pain mechanisms that can be affected by etoricoxib compared to placebo (inactive medication)in subjects with painful knee osteoarthritis af 4 weeks of treatment.
- Trial name
- NCT01619150
- Where
- Denmark
- Volunteers
- 39 people
- Sponsor
- C4Pain
Chronic Pain, Nociceptive Pain
Central Sensitisation in Nociceptive and Neuropathic Pain
This study aims to investigate differences in central sensitization among patients with chronic nociceptive pain, neuropathic pain, and mixed pain conditions.
- Conditions
- Chronic Pain, Nociceptive Pain, Neuropathic Pain, Mixed Pain (Nociceptive and Neuropathic)
- Trial name
- ALGOS (NCT07321080)
- Testing
- Neuropsychological assessment, Laser evoked potentials
- Where
- Italy
- Volunteers
- 185 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Hyperalgesia, Secondary
Reliability of Measuring the Area and Intensity of Secondary Hyperalgesia Induced by High Frequency Stimulation
This study is designed to evaluate the method of assessing the and intensity areas of secondary hyperalgesia induced by High Frequency Stimulation (HFS).
- Trial name
- NCT03966508
- Testing
- High-frequency electrical stimulation
- Where
- Belgium
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Headache Disorder
Headaches: Effects on Sleep, Sensitization, and Psychological Factors
Headache is one of the most common health problems in the society and negatively affects the quality of life of individuals. Increasing complaints of headache in recent years can be associated with many physiological and…
- Trial name
- NCT06603493
- Testing
- Assessment of sleep disorders, Assessment of Central Sensitization, Assessment of depression, anxiety and stress levels
- Where
- Turkey (Türkiye)
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Nagihan Acet
Rotator Cuff Lesion, Subacromial Impingement Syndrome
Investigation of the Effect of Central Sensitization Symptom Severity on Steroid Injection Results in Shoulder Pain
The aim of this study was to investigate the effect of the presence and severity of pre-treatment central sensitization on the results of subacromial/ intra-articular shoulder injection in patients with rotator cuff…
- Conditions
- Rotator Cuff Lesion, Subacromial Impingement Syndrome, Shoulder Pain, Chronic Pain
- Trial name
- NCT06404125
- Testing
- Range of Motion of Shoulde Joint, Hand Grip Test, Numeric Rating Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Temporomandibular Disorder (TMD)
Marine Lipids Ease Painful TMD
The ADAPT study is a single-site, Phase 2b, randomized, quadruple-masked, placebo-controlled trial evaluating an omega-3 dietary supplement enriched with specialized pro-resolving mediator (SPM) precursors in adults with chronic…
- Trial name
- ADAPT (NCT07437313)
- Testing
- SPM Precursor-Enriched Marine Lipid Supplement, Medium-Chain Triglyceride Supplement
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Carolina, Chapel Hill
Chronic Low Back Pain
Intra-operative Ketamine Infusions in Opioid-dependent Patients With Chronic Lower Back Pain
Noxious stimuli occurring intraoperatively and postoperatively generate central sensitization, decreasing pain thresholds and ultimately increasing analgesic requirements.
- Trial name
- NCT00899600
- Testing
- Ketamine, Normal saline
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Chronic Pain
QST and Neuropathic Pain
To establish the sensory profile of patients using quantitative sensory testing (QST) and questionnaires as well as the level of sensitisation using temporal summation and diffuse noxious inhibitory control paradigms in all…
- Trial name
- NCT03806010
- Testing
- Quantitative sensory testing
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Barts & The London NHS Trust