Clinical trials: Sensitization, Central
Chronic Pain, Fibromyalgia
Mindfulness to Improve Functional Outcomes in Patients With Fibromyalgia or Central Sensitization
The primary aim of the study will be to determine the feasibility of utilizing a web-based mindfulness program in adult patients with chronic pain with a diagnosis of fibromyalgia or central sensitization.
- Conditions
- Chronic Pain, Fibromyalgia, Central Sensitisation
- Trial name
- NCT03693274
- Testing
- BreathAware for Pain Management
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Vanderbilt University Medical Center
Fibrous Dysplasia of Bone, McCune Albright Syndrome
PAINDYS_Characterizing Pain in Fibrous Dysplasia of Bone/McCune-Albright Syndrome: an Exploratory Pilot Study
Fibrous dysplasia of bone (FD) / McCune-Albright syndrome (MAS) is a rare congenital bone disorder affecting one or multiple bones, caused by a mosaic somatic mutation of the GNAS gene.
- Trial name
- PAINDYS (NCT07476768)
- Testing
- Visit 1 at the center
- Where
- France
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Chronic Pain, Back Pain
Sensorial Discrimination in Chronic Low Back Pain
In this study, the effect of sensory discrimination training on cortical reorganization, pain and functionality in chronic nonspecific low back pain in which central sensitization is dominant will be investigated.
- Conditions
- Chronic Pain, Back Pain, Central Sensitisation
- Trial name
- NCT05169918
- Testing
- Core stabilization, Sensorial Discrimination Training
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Istanbul University - Cerrahpasa
Cystitis, Interstitial, Dysmenorrhea
Chronic Pain Risk Associated With Menstrual Period Pain
The purpose of this study is to determine if some women with dysmenorrhea (painful periods) are at higher future risk of developing chronic pelvic pain (CPP) and if oral contraceptives (OC) can be used to reverse this chronic…
- Conditions
- Cystitis, Interstitial, Dysmenorrhea, Migraine Disorders, Pelvic Pain
- Trial name
- CRAMPP (NCT02214550)
- Testing
- cyclic microgestin 1/20, continuous microgestin 1/20
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Healthy Participants
Association Between Central Sensitization and the Root Mean Square of Successive Differences
The aim of this study was to examine the relationship between central sensitization and resting RMSSD (Root Mean Square of Successive Differences) in individuals exhibiting prolonged sitting behavior, controlling for potential…
- Trial name
- NCT07755332
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Istanbul Demiroglu Bilim University
Neuropathic Pain
Exploring the Role of the GABAergic Modulation in Pain Transmission in Human
Neuropathic pain affects about 7% of the general population in European countries. Meta-analyses indicate that only a minority of neuropathic pain patients has adequate response to drug therapy and management of neuropathic pain…
- Trial name
- NDMC-101 (NCT03375034)
- Testing
- NDMC 20mg, NDMC60mg, Clonazepam 1.5mg
- Where
- Switzerland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Jules Desmeules
Fibromyalgia
Generalized Hypersensitivity in Patients With Fibromyalgia Syndrome
Fibromyalgia (FM) is a chronic musculoskeletal pain disorder with unknown causes. Our previous studies showed abnormal sensations of second pain (wind-up), indicating central hypersensitivity as an important mechanism of FM.
- Trial name
- NCT04415866
- Testing
- Paced Auditory Serial Addition task (PASAT)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Knee Osteoarthritis
Pain Sensitization and Outcome Following Physiotherapy in Patients With Knee Osteoarthritis
Pain is the dominant symptom of knee osteoarthritis and recent evidence suggests factors outside of local joint pathology, such as pain sensitization, can contribute significantly to the pain experience.
- Trial name
- NCT02310945
- Testing
- Physiotherapy
- Where
- 3 sites in Ireland
- Volunteers
- 140 people
- Sponsor
- University College Dublin
Chronic Pain, Central Sensitisation
Mechanisms Of Change in Adolescent Pain Self-management
The MOCAS Study aims to describe the mechanisms through which sleep deficiency affects youth responses to an online pain self-management intervention over a 6-month period.
- Conditions
- Chronic Pain, Central Sensitisation, Headache
- Trial name
- MOCAS (NCT04043962)
- Testing
- Web-based CBT (Web-MAP)
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Seattle Children's Hospital
Shoulder Pain
Central and Peripheral Sensitization, and Pain Contributing Factors in Shoulder Pain Patients and Healthy People
Compared to healthy subjects, central and peripheral sensitization will be investigated in patients with non-specific shoulder pain, since no data is available at the moment.
- Trial name
- NCT05360589
- Where
- Italy
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Back Pain Lower Back Chronic
Effectiveness of a Psychoeducative Intervention on Patients With Cronic Low Back Pain
One of the treatment modalities currently available in this hospital to treat this type of patients with low back pain who present with chronic pain are the group sessions that are carried out to provide information to the…
- Trial name
- PNE (NCT03964389)
- Testing
- Pain Neuroscience Education" (PNE)
- Where
- Spain
- Volunteers
- 179 people
- Sponsor
- Universidad Miguel Hernandez de Elche
Chronic Pain Syndrome, Sensitization, Central
Management of Chronic Non-Cancer Pain With Non-Pharmacological Therapies
A randomized controlled clinical trial will be conducted, involving a psychoeducational activity as the intervention. There will be a control group of patients with non-cancer chronic pain who will continue their usual treatment.
- Conditions
- Chronic Pain Syndrome, Sensitization, Central, Quality of Life, Patient Empowerment
- Trial name
- NCT06440668
- Testing
- Chronic Pain Management Workshop with Non-Pharmacological Therapies
- Where
- Spain
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Hospital San Juan de Dios del Aljarafe de Sevilla
Impingement Syndrome
Evaluation of Inadequate Response to Ultrasound-Guided Subacromial Corticosteroid Injection in Shoulder Impingement Syndrome
The aim of this study is to investigate the impact of central sensitization in patients with shoulder impingement syndrome who have shown an inadequate response to ultrasound-guided subacromial corticosteroid injection.
- Trial name
- NCT06655714
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Beylikduzu State Hospital
Fibromyalgia
Clinical Effects of Radiofrequency in Fibromyalgia
The aim of this study is to analyze the effects of a single-session of Radiofrequency in patients with Fibromyalgia in comparison to a placebo group.
- Trial name
- NCT05641740
- Testing
- Single-session of Radiofrequency
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Universidad de Granada
Neck Pain, Central Nervous System Sensitization
Central Sensitization and Clinical Parameters in Chronic Neck Pain
This study is a retrospective, cross-sectional observational study that assesses the correlations among central sensitization, pain, psychosocial factors, and temporomandibular function in patients with chronic neck pain.
- Conditions
- Neck Pain, Central Nervous System Sensitization, Temporomandibular Joint Dysfunction Syndrome, Chronic Pain
- Trial name
- NCT07462416
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Turkoglu Dr. Kemal Beyazit State Hospital
Lateral Epicondylitis, Central Sensitization
Central Sensitization and Ultrasound in Lateral Epicondylitis
Lateral epicondylitis (LE) is a common musculoskeletal disorder characterized by pain and tenderness over the lateral elbow and may become chronic despite conservative treatment.
- Trial name
- NCT07827898
- Testing
- Pressure pain threshold, Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Bariatric Surgery, Central Sensitization
The Effect of Bariatric Surgery to Central Sensitization
Nowadays obesity is emerging as a very common health problem. It has been shown in various studies that obesity may be an important risk factor for the onset and progression of knee osteoarthritis (OA).
- Trial name
- NCT03460691
- Testing
- Bariatric surgery
- Volunteers
- 50 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Chronic Pain, Central Sensitisation
Brain MRI for Knee OA
It has been estimated that 300 million people worldwide have osteoarthritis (OA), and this has increased by 97% over the past 25 years.
- Conditions
- Chronic Pain, Central Sensitisation, Knee Osteoarthritis
- Trial name
- NCT05986513
- Testing
- Cold Pressor Gel Test
- Where
- 2 sites in Canada
- Volunteers
- 66 people
- Sponsor
- Toronto Rehabilitation Institute
Carpal Tunnel Syndrome
Mechanisms of Neural Mobilization in the Treatment of Chronic Pain
The purpose of this study was to determine the effect of a manual therapy technique (neural mobilization) on measures of clinical pain and function, experimental pain sensitivity, and on the function of the median nerve in…
- Trial name
- NCT00929123
- Testing
- neural mobilization, healthy controls
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Florida
Rheumatoid Arthritis (RA), Transcutaneous Vagus Nerve Stimulation
the Effect and Mechanism of Percutaneous Auricular Electrical Stimulation in Preventing Central Sensitization Pain in Patients With Rheumatoid Arthritis
This multicenter, randomized, double-blind, sham-controlled trial aimed to evaluate the preventive efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) against central-sensitization-related pain in high-risk…
- Trial name
- taVNS for Pain (NCT07870564)
- Testing
- taVNS
- Volunteers
- 124 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences