Clinical trials: Sentinel Lymph Node Biopsy (SLNB)
Invasive Breast Carcinoma, Sentinel Lymph Node Biopsy (SLNB)
Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in IBC
This study will prospectively determine the feasibility and oncological safety of sentinel lymph node biopsy (SLNB) after neoadjuvant chemotherapy (NACT) in inflammatory breast cancer patients traditionally considered ineligible…
- Conditions
- Invasive Breast Carcinoma, Sentinel Lymph Node Biopsy (SLNB), Neoadjuvant Chemotherapy
- Trial name
- SYMPHONY (NCT07080944)
- Testing
- SLN identification using technetium-99m, SLN intra-operatory identification with radioguided surgery, Axillary Limph Node Dissection (ALND)
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- European Institute of Oncology
Breast Cancer, Sentinel Lymph Node Biopsy (SLNB)
Finding Sentinel Lymph Nodes During Mastectomy Using Indocyanine Green (INIGMA Study)
This pilot study evaluates the diagnostic value of indocyanine green (ICG) fluorescence for sentinel lymph node biopsy (SLNB) performed through the mastectomy incision in breast cancer patients.
- Conditions
- Breast Cancer, Sentinel Lymph Node Biopsy (SLNB), Sentinel Lymph Node Detection, Sentinel Lymph Node
- Trial name
- INIGMA (NCT07362485)
- Testing
- Indocyanine green (ICG)-fluorescence guided sentinel lymph node biopsy
- Where
- 2 sites in Netherlands
- Volunteers
- 90 people
- Sponsor
- Isabelle Henskens
Invasive Breast Cancer, Ductal Carcinoma in Situ of the Breast
Axillary Reverse Mapping (ARM) Technique
The purpose of this pilot study is to compare a new surgical technique (axillary reverse mapping) to standard axillary surgery in patients diagnosed with invasive or in situ breast cancer.
- Trial name
- ARM (NCT03109522)
- Testing
- axillary reverse mapping (ARM), Standard axillary surgery (SLNB or ALND)
- Where
- 2 sites in Canada
- Volunteers
- 130 people
- Sponsor
- McMaster University
Breast Cancer (Triple Negative Breast Cancer (TNBC)), Breast Cancer
Exemption of SLNB After Neoadjuvant Therapy for Triple-negative and Her2-positive Breast Cancer
The neoadjuvant system therapy (NAST) can significantly increase the pathological complete response (pCR) rate for patients with triple-negative (TNBC) and HER2-positive breast cancer.
- Trial name
- NCT07498400
- Testing
- Exemption of SLNB
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Xijing Hospital
Breast Cancer, Locally Recurrent Breast Cancer
Photo-medicine-Guided Dual Approach for Reoperation of Sentinel Lymph Nodes in Locally Recurrent Breast Cancer Patients
Sentinel lymph node biopsy (SLNB) is essential for staging and treatment planning in early breast cancer patients. As a less invasive procedure, it has replaced axillary lymph node dissection (ALND) by reducing complications and…
- Conditions
- Breast Cancer, Locally Recurrent Breast Cancer, Sentinel Lymph Node Biopsy (SLNB), Reoperation
- Trial name
- NCT06780748
- Testing
- Identification rate of sentinel lymph node
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Breast Cancer, Early-Stage Invasive Breast Carcinoma
Radiotherapy and Long-term Outcomes in Early Breast Cancer With SLNB Omission
This prospective, multicenter observational cohort study evaluates long-term outcomes in patients with early-stage invasive breast cancer who undergo breast-conserving surgery without sentinel lymph node biopsy or other axillary…
- Trial name
- APROOB Cohort (NCT07803081)
- Testing
- Adjuvant Breast Radiotherapy
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Samsung Medical Center
Sentinel Lymph Node Biopsy, Locoregional Neoplasm Recurrence
SLNB After Neoadjuvant Treatment in Node Positive Patients
From May 2016 till May 2018 all breast cancer patients with operable disease submitted to surgery after neoadjuvant treatment would be divided in four groups considering initially clinical axillary stage, axillary procedure that…
- Conditions
- Sentinel Lymph Node Biopsy, Locoregional Neoplasm Recurrence, Progression, Disease
- Trial name
- NCT03833960
- Volunteers
- 65 people
- Sponsor
- Clinical Hospital Center Rijeka
Breast Cancer Surgery, Neoadjuvant Therapy
Application of Targeted Axillary Lymph Node Resection in Axillary Surgery After Neoadjuvant Chemotherapy for Breast Cancer: an Open-label, Multicenter Study
In this study, following the full informed consent of patients regarding the safety and potential benefits of the new intervention regimen, pathologically confirmed lymph nodes were pre-labeled with carbon nanoparticles prior to…
- Conditions
- Breast Cancer Surgery, Neoadjuvant Therapy, Sentinel Lymph Node Biopsy (SLNB)
- Trial name
- NCT07032220
- Testing
- carbon suspension
- Where
- China
- Volunteers
- 175 people
- Sponsor
- Fujian Medical University Union Hospital
Breast Cancer Female, Breast Cancer
Omission of SLNB in Triple-negative and HER2-positive Breast Cancer Patients With rCR and pCR in the Breast After NAST
Currently, axillary surgery for breast cancer is considered as staging procedure that does not seem to influence breast cancer mortality, since the risk of developing metastasis depends mainly on the biological behaviour of the…
- Trial name
- NCT04101851
- Testing
- omission of SLNB
- Where
- 40 sites in Austria, Germany and 2 more
- Volunteers
- 350 people
- Sponsor
- Toralf Reimer, MD PhD
Breast Cancer, Pectoral Nerves Block
Comparing the QoR of PECS Block and GA in Breast-conserving Surgery With Sentinel Lymph Node Biopsy
The aim of this randomized controlled trial (RCT) is to assess the Quality of Recovery (QoR) in Breast-conserving Surgery (BCS) with Sentinel Lymph Node Biopsy (SLNB) using Pectoral Nerves (PECS) Block and General Anesthesia…
- Conditions
- Breast Cancer, Pectoral Nerves Block, Breast-Conserving Surgery, Sentinel Lymph Node Biopsy
- Trial name
- NCT06120439
- Testing
- PECS II combined with intercostal nerve blockade;, General anesthesia with laryngeal mask
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Jun Zhang
Breast Cancer, Sentinel Node
The Efficacy of Sentimag in Detection of Sentinel Node Biopsy
The aim of this study is to evaluate the Sentimag/Sienna+ System (Sentimag®) in clinical routine practice. On the one hand this allows evaluation of the equivalence of the two techniques.
- Trial name
- SMART (NCT02739425)
- Testing
- Sentimag Device
- Where
- United Kingdom
- Volunteers
- 104 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Sentinel Lymph Node Biopsy, Mastectomy, Subcutaneous
SLNB After Nipple Sparing Mastectomy
Sentinel Lymph Node Biopsy (SLNB) after nipple sparing mastectomy (NSM) is controversial. This study aims to investigate feasibility of SLNB with radioisotope method.
- Trial name
- NCT04140188
- Testing
- Senti-Scint (99mTc- pertechnetate combined with human albumin)
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Testicular Germ Cell Tumor
Sentinel Lymph Node Biopsy in Stage AI-IIA Germ Cell Tumors
The goal of this clinical trial is to evaluate the efficacy of sentinel lymph node biopsy in stage AI-IIA germ cell tumors (seminoma/nonseminoma).
- Trial name
- PITERLAND (NCT06133699)
- Testing
- Orchofuniculectomy with simultaneous laparoscopic biopsy of the sentinel lymph node using indocyanine green dye with/without methylene blue dye., Radiopharmaceutical administration (Technetium/methylene blue)
- Where
- Russia
- Volunteers
- 44 people
- Sponsor
- N.N. Petrov National Medical Research Center of Oncology
Breast Cancer
Axillary Radiotherapy or Axillary Lymph Node Dissection in Patients With Clinically Node- Positive Breast Cancer Undergoing Upfront Tailored Axillary Surgery
This trial is to investigate if in patients with clinically node positive breast cancer undergoing upfront surgery, treatment with TAS and ART is superior to ALND in terms of arm-related Quality of Life (QoL) and occurrence of…
- Trial name
- OPBC-10/ NOAX (NCT07140172)
- Testing
- Axillary lymph node dissection (ALND), Axillary radiotherapy (ART)
- Where
- 55 sites in United States, Austria and 9 more
- Volunteers
- 1,060 people
- Sponsor
- University Hospital, Basel, Switzerland
Breast Cancer, Clinically Assessed Negative Axillary Lymph Nodes
Omission of SLNB in CN0 Early Breast Cancer
The OMSLNB trial adopts a prospective, single-arm, non-inferiority, phase-II, open-label study design. Patients with unilateral invasive breast cancer （tumor ≤3cm） and assessed as cN0 will be eligible for inclusion, enrolled…
- Conditions
- Breast Cancer, Clinically Assessed Negative Axillary Lymph Nodes, Sentinel Lymph Node
- Trial name
- NCT05935150
- Testing
- Omit SLNB
- Where
- China
- Volunteers
- 311 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Sentinel Lymph Node Biopsy (SLNB), Early Stage Ovarian Tumors
Patent Blue SLN in Early Ovarian Cancer Prospective Study (FIGO I-II) Evaluating Patent Blue SLN Mapping. Injection Into IP/UO Ligaments in Situ. Goals: Assess Feasibility and Accuracy vs Standard Lymphadenectomy to Minimize Surgical Morbidity
the standard of care in case of early ovarian cancer (stage I or II) is a complete surgery. This surgery includes : hysterectomy (remove of the uterus), bilateral salpingo-oophorectomy (remove of the adnexa), omentectomy (remove…
- Trial name
- NCT07508306
- Testing
- Sentinel node biopsy with patent blue dye
- Where
- Tunisia
- Volunteers
- 30 people
- Sponsor
- Faculty of Medicine of Tunis
Thyroid Cancer, Lymph Node Metastasis
The Usefulness of Staining Lymph Nodes During Operations for Cancer Thyroid in Detecting the Nodes That Have Cancer
Detection of lymph nodes starting to be involved by cancer spreading from the thyroid gland during operation is useful. It saves the patient from having a second operation to remove these nodes later on when they become obvious.
- Trial name
- NCT00794053
- Testing
- detecting lymph node metastasis by staining
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- University of Alexandria
Breast Cancer
Bupivacaine vs Placebo for Unilateral Mastectomy Surgical Site Post-operative Pain Control
The purpose of this study is to compare using FDA-approved bupivacaine (a numbing medicine), along with the usual medications for post-operative pain control to using the usual medications for postoperative pain control alone.
- Trial name
- NCT03351348
- Testing
- Bupivacaine, patient-reported pain scores, saline
- Where
- 7 sites in United States
- Volunteers
- 165 people
- Sponsor
- Memorial Sloan Kettering Cancer Center