Clinical trials: Sentinel Node
Ductal Carcinoma In Situ
Comparative Effectiveness of Sentinel Lymph Node Biopsy for Ductal Carcinoma In Situ
Patients with ductal carcinoma in situ (DCIS) treated with available therapies have experienced excellent outcomes and very low mortality rates due to the disease's non-invasive nature.
- Trial name
- NCT02908178
- Testing
- Sentinel lymph node biopsy (SLNB)
- Where
- United States
- Volunteers
- 28,291 people
- Sponsor
- Yale University
Breast Cancer
Feasibility of One-Step Sentinel Lymph Node (SLN) Biopsy With Radiolabeled Methylene Blue (IND 70,627)
The purpose of this study is to develope a one-step procedure to perform a biopsy of axillary lymph nodes on the same side as the breast tumor in women diagnosed with breast cancer.
- Trial name
- NCT00784849
- Testing
- Methylene blue
- Where
- 2 sites in United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Breast Cancer Lymphedemas
Bioelectrical Impedance Utilization and Dietary Intake Relation in the Breast Cancer Related Lymphedema
The purpose of this study was to investigate the clinical role of bioelectrical impedance analysis (BIA) and the relationship between the occurrence of breast cancer related lymphedema (BCRL) and dietary factors in breast cancer…
- Trial name
- NCT03391206
- Testing
- Inbody 720
- Where
- South Korea
- Volunteers
- 228 people
- Sponsor
- Severance Hospital
Thyroid Neoplasm
Lateral Neck Sentinel Lymph Node Biopsy(LSLNB)in PTC
Objective: To investigate the incidence of lateral neck node occult metastasis and to show the usefulness of sentinel lymph node biopsy (SLNB) in the detection of lateral neck node metastasis in thyroid carcinoma, the…
- Trial name
- LSLNB (NCT01137097)
- Testing
- Lateral sentinel lymph node biopsy
- Where
- South Korea
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Node-positive Breast Cancer
MUltimodal Targeted Axillary Surgery
The present trial will prospectively evaluate the accuracy of both a systematic predefined axillary ultrasound imaging together with tumor load quantification of suspicious and sentinel axillary lymph nodes to predict overall…
- Trial name
- MUTAS (NCT04039893)
- Testing
- Systematic axillary ultrasound imaging, Sentinel node, Excision of suspicious lymph nodes
- Where
- Spain
- Volunteers
- 160 people
- Sponsor
- Parc de Salut Mar
Breast Cancer
VST-1001 (Dilute Fluorescein) for Lymphatic Mapping & Localization of Lymph Nodes in Patients With Breast Cancer
The purpose of this Phase 1 portion of this clinical research study is to find out what dose of dilute fluorescein is needed for a surgeon to best see important lymph nodes that need to be removed during surgery (a standard of…
- Trial name
- NCT02294565
- Testing
- VST-1001, 99mTc-labeled sulfur colloid
- Where
- 2 sites in United States
- Volunteers
- 147 people
- Sponsor
- Vestan, Inc.
Breast Neoplasms
ICG and Blue Dye Guided Sentinel Lymph Node Biopsy in Patients Underwent Neoadjuvant Therapy
The value of sentinel lymph node biopsy (SLNB) in patients underwent neoadjuvant chemotherapy is controversial. Lower detection rate and higher false negative rate are the main problem.
- Trial name
- NCT02869815
- Testing
- ICG+Methylene Blue
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking University People's Hospital
Rectal Cancer
Feasibility Study to Develop Sentinel Lymph Node Mapping in Rectal Cancer Patients
The purpose of this study is to see if investigators can develop a technique to identify sentinel lymph nodes in the rectum for rectal cancer patients with the use of a radiotracer (Tc-sulfur colloid), a dye (Spot), and imaging…
- Trial name
- NCT02112240
- Testing
- Intraoperative Mobile Gamma Camera imaging, Endoscopic injection of 99mTc-sulfur colloid, Endoscopic injections of Spot
- Where
- United States
- Sponsor
- University of Virginia
Endometrial Neoplasms
Indocyanine Green Versus Blue Dye for Detection of Sentinel Lymph Node In Endometrial Cancer
To determine the difference in the proportion of hemipelves with successful detection of Sentinel Lymph Node according to the dye used (indocyanine green with near-infrared imaging vs blue dye) in women with endometrial cancer.
- Trial name
- NCT02564276
- Testing
- Sentinel lymph node biopsy
- Where
- Canada
- Volunteers
- 132 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Vulval Cancer, Sentinel Lymph Node Detection
Charcoal Carbon Black Dye Use in Sentinel Lymph Node Mapping in Early Stage Vulvar Cancer
The aim of this study is to investigate the detection rate, sensitivity and specifity of charcoal carbon black dye as a sentinel lymph node tracer in inguinofemoral lymph node(s) in early stage vulvar cancer
- Trial name
- IFLND (NCT06694116)
- Testing
- sentinel lymph node biopsy using carbon dye
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul University
Breast Cancer
Current Value of Axillary Ultrasound in the Staging of Breast Cancer. Is BSGC Still Necessary?
AUS/FNAC allows the identification of tumors without axillary tumor involvement, or with low axillary tumor burden, many of which do not benefit from SLNB, in the staging of early breast cancer.
- Trial name
- NCT03193008
- Where
- Spain
- Volunteers
- 1,400 people
- Sponsor
- Corporacion Parc Tauli
Endometrial Cancer
Predictors of Node Positivity in Endometrial Cancer
To investigate the role of histological and moleculr profile of endometrial cancer patietns in predicting the risk of nodal metastases in endometrila cancer patients.
- Trial name
- NCT05793333
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Early Stage Breast Cancer
Registry Trial to Evaluate the Clinical Utilization of Targeted Axillary Dissection (TAD)
A downstaging of axillary tumor-spread can be achieved in about 40% of the patients receiving neoadjuvant chemotherapy (NACT). The impact of NACT on loco-regional tumor control has not yet been sufficiently investigated.
- Trial name
- NCT03102307
- Testing
- Not suitable for TAD, Suitable for TAD
- Where
- 3 sites in Germany
- Volunteers
- 548 people
- Sponsor
- Kliniken Essen-Mitte
Cervical Cancer, Vulvar Cancer
Survey on Lymphedema After Sentinel Lymph Node Biopsy in People With Cervical or Vulvar Cancer
The purpose of this study is to collect information that may identify people who are at risk of developing lower extremity lymphedema (LEL) after sentinel lymph node biopsy (SLN) during surgery for early-stage vulvar or cervical…
- Trial name
- NCT05255393
- Testing
- Questionnaires
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer
Sentinel Lymph Node Mapping Post-Injection Site Pain
This is a pain survey study that will compare the level of discomfort experienced by breast cancer patients after injection of either technetium-labeled sulfur colloid or technetium-labeled tilmanocept, both FDA-approved agents…
- Trial name
- NCT02065232
- Testing
- Tilmanocept, Sulfur Colloid
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of California, San Diego
Endometrial Neoplasms
Sentinel Lymph Node Mapping In Endometrial Cancer
Lymph node assessment provides the crucial information about the prognosis of endometrial cancer. Sentinel lymph node stands in the first station on the lymph node metastasis pathways.
- Trial name
- SLNMIEC (NCT03778255)
- Testing
- Sentinel Lymph Node Biopsy
- Where
- China
- Volunteers
- 635 people
- Sponsor
- Peking University People's Hospital
Sentinel Lymph Node, Breast Cancer
A Clinical Feasibility Study of a Photoacoustic Finder
Determining the prognosis of breast cancer relies significantly on axillary staging by sentinel lymph node biopsy (SLNb). The SLNb is generally performed using radioisotopes, blue dyes, or both to improve the false negative rate.
- Trial name
- NCT06412211
- Testing
- Photoacoustic finder
- Where
- South Korea
- Volunteers
- 129 people
- Sponsor
- Seoul St. Mary's Hospital
Sentinel Lymph Node, Melanoma (Skin)
SPY-X: A Study to Assess the Feasibility of Using SPY Alone for Sentinel Node Localization for Melanoma or Breast Cancer
The objective of this study is to determine if fluorescence lymphangiography can be used alone to localize sentinel nodes in patients with melanoma or breast cancer.
- Conditions
- Sentinel Lymph Node, Melanoma (Skin), Breast Cancer
- Trial name
- SPYX (NCT03294330)
- Testing
- IC-Green KIT
- Where
- 3 sites in United States
- Volunteers
- 35 people
- Sponsor
- Milton S. Hershey Medical Center
Squamous Cell Carcinoma of the Anus
Study to Determine the Feasibility of Sentinel Node Biopsy in Patients With Anal Cancer
The purpose of this study is assess the technical and operational feasibility of a specialised biopsy technique, sentinel lymph node biopsy (SLNB), in patients with anal cancer.
- Trial name
- R-SeNSAR (NCT02162641)
- Testing
- Sentinel lymph node biopsy
- Sponsor
- The Christie NHS Foundation Trust
Breast Cancer
Locoregional Control With Radiotherapy of Breast Cancer Patients With MACrometastases Treated With MAstectomy (MACMA)
Sentinel lymph node biopsy (SLNB) is the standard procedure to stage the axilla in clinically node-negative invasive breast cancer (IBC) patients undergoing upfront surgery.
- Trial name
- MACMA (NCT06378294)
- Testing
- Mastectomy
- Where
- 7 sites in Spain
- Volunteers
- 82 people
- Sponsor
- University Hospital A Coruña