Clinical trials: Sentinel Node
Breast Cancer Metastatic, Sentinel Lymph Node
Rapid Assessment of Sentinel Lymph Node Metastasis Status Using a Pan-CK-targeting NIR-II Fluorescent Probe in Breast Cancer
Breast malignant tumors are a serious threat to women's health, and the current treatment for breast malignant tumors is still dominated by surgery, but the problems faced by patients after surgery such as edema and tumor…
- Conditions
- Breast Cancer Metastatic, Sentinel Lymph Node, Sentinel Lymph Node Biopsy (SLNB), Metastasis
- Trial name
- NIR-II (NCT07154563)
- Testing
- NIR-II probe (i.e ICG-CK) incubation solution
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Yunnan Cancer Hospital
Arm Lymphedema, Breast Cancer
Lymphedema Evaluation After Adjuvant Hypofractionated Radiotherapy for 1-2 Macrometastatic Sentinel Lymph Nodes
In this observational prospective studi patients with invasive breast cancer no more than 5 cm and clinically node negative, scheduled for conservative surgery and Sentinel Node Biopsy (SNB), are enrolled in the protocol if they…
- Conditions
- Arm Lymphedema, Breast Cancer, Radiotherapy Side Effect
- Trial name
- AXILL-ART (NCT06321653)
- Testing
- Hypofractionated radiotherapy scheme
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- European Institute of Oncology
Breast Cancer, Sentinel Lymph Node
A Study for Optimization of 6% Hydroxyethyl Starch Based Indocyanine Green Near-infrared Fluorescence Navigated Sentinel Lymph Node Biopsy for Breast Cancer Patients
A study for dosage-image optimization of 6% hydroxyethyl starch diluted indocyanine green for near-infrared fluorescence navigated sentinel lymph node mapping for breast cancer patient.
- Trial name
- NCT05365204
- Testing
- Near infrared fluorescence navigated sentinel lymph node mapping
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch
Breast Cancer
Fluorescein for Sentinel Lymph Node Biopsy (SLNB) in Breast Cancer
The study goal is to develop a new method of intraoperative lymphatic mapping with fluorescent contrast agents to improve the outcome of therapeutic breast cancer surgery.
- Trial name
- NCT01614184
- Testing
- Fluorescein
- Sponsor
- University of Utah
Colon Cancer, Colon Surgery
Indocyanine Green (ICG) in the ex Vivo Detection of Sentinel Lymph Node (SLN)in Colon Cancer
Evaluation of the possibility to detect sentinel lymph node(s) after ex vivo Indocyanine Green injections around the tumour in pieces of colectomy from patients with colon cancer.
- Trial name
- 2068 (NCT01995591)
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Jules Bordet Institute
Sentinel Lymph Node
Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in Initially Node Positive Breast Cancer Patients, Could it Omit Axillary Dissection ?
The aim of this study is to determine the accuracy and safety of SLNB after neoadjuvant chemotherapy.
- Trial name
- NCT06130241
- Testing
- sentinle lymphnode biopsy
- Volunteers
- 30 people
- Sponsor
- Assiut University
Porocarcinoma, Sentinel Lymph Node
Sentinel Lymph Node Biopsy in Porocarcinoma
Eccrine porocarcinoma (EPC) is a slow-growing carcinoma arising from the eccrine sweat glands. Based on its clinical presentation it can be confused with malignant and benign skin lesions, both.
- Trial name
- NCT03647631
- Testing
- sentinel lymph node biopsy
- Where
- Italy
- Volunteers
- 2 people
- Sponsor
- Ospedale Policlinico San Martino
Sentinel Lymph Node, Superficial Uterine Vein
Correlation of Pelvic Sentinel Lymph Node With Superficial Vein
Pelvic Sentinel Lymph Node (SLN) biopsy is an important integral part of endometrial surgery. Although SLN is usually found on internal iliac artery, location is variable.
- Conditions
- Sentinel Lymph Node, Superficial Uterine Vein, Deep Uterine Vein
- Trial name
- NCT06741007
- Testing
- Retroperitoneal pelvic lymphatic and uterine vessel dissection
- Volunteers
- 100 people
- Sponsor
- Istanbul University
Breast Cancer, Sentinel Lymph Node
Sentinel Node Localization and Staging with Low Dose Superparamagnetic Iron Oxide
Sentinel lymph node (SLN) status is pivotal for treatment decisions in breast cancer patients. The dual technique with Technetium99m (Tc99) and blue dye (BD) is yet the current routine for SLN detection.
- Trial name
- MAGSNOW (NCT05359783)
- Testing
- Superparamagnetic Iron Oxide
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Vastra Gotaland Region
Sentinel Lymph Node, Ovarian Cancer Stage I
SEntine Lymph Node in earLY Ovarian Cancer (SELLY)
The present study aims at investigating the feasibility, the detection rate and the negative predictive value of sentinel node in predicting the presence or absence of lymph node metastasis in ovarian cancer patients
- Trial name
- SELLY (NCT03563781)
- Testing
- Sentinel node detection
- Where
- Italy
- Volunteers
- 176 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Melanoma (Skin)
Studying Tumor Tissue Samples From Patients With Melanoma Who Have Undergone Sentinel Lymph Node Biopsy
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00897481
- Testing
- gene expression analysis, mutation analysis, diagnostic laboratory biomarker analysis
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Leeds Cancer Centre at St. James's University Hospital
Breast Cancer
Axillary Radiotherapy for Early Stage Breast Cancer With Limited Positive Sentinel Lymph Nodes
This study is designed to evaluate the feasibility and safety of axillary radiotherapy for early stage breast cancer with limited positive sentinel lymph nodes.
- Trial name
- NCT02612012
- Testing
- axillary radiotherapy
- Where
- China
- Volunteers
- 475 people
- Sponsor
- Fudan University
Cancer
Fluorescein for Lymphatic Mapping and Sentinel Lymph Node (SLN) Biopsy in Patients With Stage I and II Malignant Melanoma
The purpose of this research study is to use two different drugs to find where melanoma might spread and to remove these tissues.
- Trial name
- NCT00847522
- Testing
- Fluorescein
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Utah
Endometrial Carcinoma
Improved Method of Detecting Cancer Metastases
The purpose of this study is to compare the Instillation Technique Using The Modified Intra- Uterine Manipulator Catheter With Methylene Blue, Isosulfan Blue or Indocyanine Green Dyes, Compared to Cervical Injection, For Sentinel…
- Trial name
- SITs (NCT02368067)
- Testing
- Standard of Care Sentinal Node Dye, Study Sentinal Node Dye
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Southeastern Regional Medical Center
Breast Cancer
Axillary Lymph Node Dissection Versus no Dissection in Breast Cancer With Positive Sentinel Lymph Node
The recently randomized trial (ASCOG Z0011) support that among patients with limited sentinel lymph node (SLN) metastatic breast cancer treated with breast conservation and systemic therapy, the use of sentinel lymph node biopsy…
- Trial name
- Z0011-China (NCT01796444)
- Testing
- Sentinel Lymph Node Biopsy, Intraoperative Pathological Examination, Axillary Lymph Node Dissection
- Where
- China
- Sponsor
- Shandong Cancer Hospital and Institute
Omitting Sentinel Lymph Node Biopsy in Early-stage Breast Cancer
De-escalation in Axillary Surgery for Early-stage Breast Cancer
The goal of this clinical trial is to determine if the omission of sentinel lymph node biopsy is safe for early-stage breast cancer patients in our institution (Clinical Hospital Centre Rijeka).
- Trial name
- RIDES (NCT07098507)
- Testing
- sentinel lymph node biopsy, omission of sentinel lymph node biopsy
- Where
- Croatia
- Volunteers
- 620 people
- Sponsor
- Clinical Hospital Center Rijeka
Breast Cancer, Sentinel Lymph Node Biopsy (SLNB)
Implementation of Indocyanine Green to Identify Sentinel Lymph Nodes During Surgery for Breast Cancer
The goal of this clinical trial is to learn how to successfully introduce a new method for finding the sentinel lymph node during breast cancer surgery into routine hospital care.
- Conditions
- Breast Cancer, Sentinel Lymph Node Biopsy (SLNB), Sentinel Lymph Node Detection, Sentinel Lymph Node
- Trial name
- INFINITE (NCT07146295)
- Testing
- Technetium (99mTc), Indocyanine Green, Sentinel lymph node biopsy
- Where
- 7 sites in Netherlands
- Volunteers
- 1,760 people
- Sponsor
- Isabelle Henskens
Sentinel Lymph Node, Breast Cancer
Carbon Dye Tattooing of Biopsied Axillary Node in Breast Cancer
The primary aim of this prospective, multicentre study is to determine whether the involved node can be marked using black carbon dye and successfully identified at the time of surgery.
- Conditions
- Sentinel Lymph Node, Breast Cancer, Tattoo; Pigmentation, Axilla; Breast
- Trial name
- pre-ATNEC (NCT03640819)
- Testing
- Tattooing of biopsied node
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Breast Cancer
VST-1001 (Dilute Fluorescein) for Lymphatic Mapping & Localization of Lymph Nodes in Patients With Breast Cancer
The purpose of this Phase 1 portion of this clinical research study is to find out what dose of dilute fluorescein is needed for a surgeon to best see important lymph nodes that need to be removed during surgery (a standard of…
- Trial name
- NCT02294565
- Testing
- VST-1001, 99mTc-labeled sulfur colloid
- Where
- 2 sites in United States
- Volunteers
- 147 people
- Sponsor
- Vestan, Inc.
Head and Neck Cancer
Diagnostic Trial in Patients Who Are Undergoing Surgery for Early Stage Mouth Cancer
RATIONALE: Diagnostic procedures to detect cancer cells in sentinel lymph nodes may help plan effective cancer treatment. PURPOSE: Diagnostic trial to study the effectiveness of lymph node mapping and sentinel lymph node…
- Trial name
- NCT00042926
- Testing
- immunohistochemistry staining method, conventional surgery, lymphangiography
- Volunteers
- 161 people
- Sponsor
- Alliance for Clinical Trials in Oncology