Clinical trials: Sentinel Nodes
Breast Cancer
Feasibility and Effectiveness of Sentinel Lymph Node Biopsy in Inflammatory Breast Cancer
This study is for participants with inflammatory breast cancer (IBC). The purpose of this study is to find out whether it is possible to take a sample of underarm lymph nodes for participants with IBC.
- Trial name
- NCT07876986
- Testing
- Sentinel node biopsy with blue dye and radioisotope
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Case Comprehensive Cancer Center
Melanoma
Evaluation of the Effects of Local Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) in Adjuvant Administration on Dendritic Cells in Skin of Melanoma Patients and in Sentinel Lymph Nodes: MEL38
Goal: To characterize the cellular events that occur in vivo after vaccination with an emulsion of GMCSF-in-adjuvant. Design: Open-label, single dose study in two stages.
- Trial name
- MEL38 (NCT00912574)
- Testing
- GM-CSF-in-adjuvant, Montanide ISA-51, GM-CSF and Montanide ISA-51
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Virginia
Lymph Node Metastasis, Breast Cancer
Sensitivity and Predictive Value of Frozen Section of Sentinel Lymph Node Biopsy in Post Neoadjuvant Setting
Axillary lymph node status is one of the most important prognostic factors in primary breast carcinomas. Sentinel lymph node biopsy has been increasing in post neoadjuvant setting when axillary nodes show good clinical and…
- Trial name
- NCT06401590
- Testing
- FROZEN SENTINEL LYMPH NODE BIOPSY
- Where
- Pakistan
- Volunteers
- 286 people
- Sponsor
- Aga Khan University
Ductal Carcinoma In Situ
Comparative Effectiveness of Sentinel Lymph Node Biopsy for Ductal Carcinoma In Situ
Patients with ductal carcinoma in situ (DCIS) treated with available therapies have experienced excellent outcomes and very low mortality rates due to the disease's non-invasive nature.
- Trial name
- NCT02908178
- Testing
- Sentinel lymph node biopsy (SLNB)
- Where
- United States
- Volunteers
- 28,291 people
- Sponsor
- Yale University
Sentinel Lymph Node
Cost of Using FLUOrescence to Green of Indocyanine for the Detection of Breast Cancer.
The purpose of this study is to analyze the average direct costs of each of these techniques, represented by the costs directly linked to the management of breast cancer, to the surgical intervention and to the techniques…
- Trial name
- FLUOBREAST-2 (NCT05699291)
- Testing
- Sentinel node detection technique
- Where
- France
- Volunteers
- 163 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Rectal Cancer Stage III, Rectal Cancer Stage IV
Sentinel Lymph Node Biopsy in Rectal Cancer
Rectal cancer is one of the most common malignant tumors, with 9% to 23% of patients experiencing pelvic sidewall lymph node metastasis.
- Trial name
- NCT05830890
- Testing
- Sentinel lymph node biopsy, Indocyanine green solution, fluorescence laparoscope
- Where
- China
- Volunteers
- 87 people
- Sponsor
- National Cancer Center, China
Sentinel Lymph Node, Breast Cancer
TAD After Chemotherapy in Locally Advanced Breast Cancer
This is an observational study to validate target axillary dissection (TAD) in locally advanced tumors (cN2 and/or cT4).
- Conditions
- Sentinel Lymph Node, Breast Cancer, Locally Advanced
- Trial name
- NCT05763641
- Testing
- Target Axillary Dissection
- Where
- 2 sites in Spain
- Volunteers
- 162 people
- Sponsor
- Hospital Universitari de Bellvitge
Testicular Germ Cell Tumor
Sentinel Lymph Node Procedure in Testicular Germ Cell Tumour
Assessment of accuracy of sentinel node biopsy, defined as the false negative rate.
- Trial name
- SENATOR (NCT03448822)
- Testing
- sentinel node procedure
- Volunteers
- 76 people
- Sponsor
- The Netherlands Cancer Institute
Ovarian Neoplasms, Sentinel Node
Sentinel Node Detection in Ovarian Cancer
Recently the investigators have shown that the SN procedure performed through the injection of tracers into the ovarian ligaments is feasible and promising in patients with clinical early stage ovarian cancer (OC).
- Trial name
- SONAR-2 (NCT02540551)
- Testing
- Injection of radioactive tracer combined with Patent Blue
- Where
- Netherlands
- Volunteers
- 11 people
- Sponsor
- Maastricht University Medical Center
Endometrial Cancer, Cervical Cancer
Determining the Sensitivity of Sentinel Lymph Nodes Identified With Robotic Fluorescence Imaging
Description: This is a multi-institutional study investigating the sensitivity and negative predictive value of sentinel lymph nodes mapped with robotic assisted near infrared imaging after cervical injection of indocyanine green…
- Trial name
- FIRES (NCT01673022)
- Testing
- IC Green
- Where
- 7 sites in United States
- Volunteers
- 430 people
- Sponsor
- Indiana University
Breast Neoplasms
Study of Fluorodeoxyglucose (FluGlucoScan) in Patients With Breast Cancer: Correlation With Histologic Findings of Sentinel Node Biopsies and Axillary Dissection
Breast cancer affects many women. One of the places to which it can spread is the lymph glands under the arm. The type of treatment offered to patients often will depend on whether those lymph glands have cancer in them or not.
- Trial name
- NCT00123799
- Testing
- Positron Emission Tomography Imaging
- Where
- Canada
- Volunteers
- 199 people
- Sponsor
- AHS Cancer Control Alberta
Sentinel Lymph Node, Breast Cancer
Carbon Dye Tattooing of Biopsied Axillary Node in Breast Cancer
The primary aim of this prospective, multicentre study is to determine whether the involved node can be marked using black carbon dye and successfully identified at the time of surgery.
- Conditions
- Sentinel Lymph Node, Breast Cancer, Tattoo; Pigmentation, Axilla; Breast
- Trial name
- pre-ATNEC (NCT03640819)
- Testing
- Tattooing of biopsied node
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Ocular Sebaceous Carcinoma, Ocular Basal Cell Carcinoma
Sentinel Lymph Node Biopsy in Ocular Surface and Adnexal Cancers
The study involves enrollment of patients with sebaceous carcinoma, Merkel's carcinoma, Porocarcinoma, Melanoma, and squamous cell Ca of the ocular surface and adnexa both primary and relapsed after surgical and/or…
- Conditions
- Ocular Sebaceous Carcinoma, Ocular Basal Cell Carcinoma, Ocular Surface Squamous Neoplasia, Merkel Cell Carcinoma, Unspecified
- Trial name
- BLS (NCT05797415)
- Testing
- Sentinel Lymph Node Biopsy
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sentinel Lymph Node Biopsy
Axillary Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in Patients With Initial cN1 Breast Cancer
SLNB has been recommended by domestic and foreign guidelines for patients with initial cN1 and NAC descending to ycN0. However, the best technical path is still not very clear at present, and the long-term tumor safety data is…
- Trial name
- NCT06518135
- Testing
- SLNB group
- Where
- China
- Volunteers
- 508 people
- Sponsor
- Henan Cancer Hospital
Lung Cancer
Pilot Study of Novel Fluorescence Endoscopic Device for Sentinel Lymph Node Mapping in Lung Cancer
This research study is studying a new imaging method that will show lymph nodes in the lung during lung cancer surgery. The name of the study intervention involved in this study is: -- The combination of the FluoSCOPE device and…
- Trial name
- NCT02423148
- Testing
- Indocyanine green (ICG), FluoSCOPE
- Sponsor
- Dana-Farber Cancer Institute
Breast Cancer
Ultrasound-assisted CNSs Mapping Versus Dual-tracer-guided Sentinel Lymph Node Biopsy
The investigators suggested ultrasound-assisted Carbon nanoparticle suspensions (CNSs) mapping had great clinical value in clinical application and might serve as a useful alternative to the dual-tracer-guided SLNB.
- Trial name
- UltraCars (NCT04951245)
- Testing
- UC group: ultrasound-assisted CNSs guided, GC group: CNSs plus ICG dual-tracer-guided
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Guangdong Provincial People's Hospital
Breast Cancer
Pilot Indocyanine Green Imaging for Mapping of Arm Draining Lymphatics & Nodes in Breast Cancer
The purpose of this study is to determine if Indocyanine Green (IC-GREEN) is comparable to isosulfan blue (IS-BLUE) in the identification of arm lymphatics and arm-draining nodes during nodal staging procedures in breast cancer.
- Trial name
- NCT01771666
- Testing
- SPY Elite Imaging, Indocyanine Green, Isosulfan blue
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Stanford University
Colon Cancer
Sentinel Lymph Node Mapping and Analysis in Colon Cancer Using Indocyanine Green Dye
Approximately 20-30 % of colon cancer patients who have no metastasis in lymph nodes after definitive colectomy have recurrence with distant metastasis.
- Trial name
- NCT04351009
- Testing
- sentinel lymph node mapping
- Where
- India
- Volunteers
- 48 people
- Sponsor
- Asian Institute of Gastroenterology, India
Endometrial Cancer
Investigating the Use of Fluorescence Imaging in Endometrial Cancer Surgery
The main purpose of the study is to evaluate the detection rate and accuracy of fluorescence imaging in endometrial cancer staging by sentinel node assessment.
- Trial name
- NCT01562106
- Testing
- Fluorescence-guided sentinel lymph node detection
- Where
- 3 sites in United States
- Volunteers
- 123 people
- Sponsor
- Swedish Medical Center
Sentinel Lymph Node, Endometrial Cancer
Sentinel Lymph Node in Early-Stage Endometrium Cancer
The aim of this prospective study is to investigate whether the detection rate of sentinel lymph node (SLN) with double tracer injected at two different sites may be increased compared to the standard use of a single tracer with…
- Trial name
- NCT06163963
- Testing
- Sentinel Lymph Node Mapping With Double Tracer and Double Injection Sites in Early-Stage Endometrium Cancer, charcoal injection to uterus to map sentinel lymph nodes
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul University