Clinical trials: Sentinel Nodes
Head and Neck Cancer
Multicenter Phase II Study of Sentinel Node Detection in Squamous Cell Carcinoma T1-T2N0 of the Oropharynx Treated With Radiotherapy and Larynx Treated by Surgery, Laser or Robot
Fifty patients with squamous cell carcinoma of the larynx T1 or T2N0 will therefore have a 99mTc lymphoscintigraphy per operative.
- Trial name
- GS-OROPHARYNX (NCT03010553)
- Testing
- Detection and resection of sentinel lymph node
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Solid Tumor
Indocyanine Green (ICG) Guided Sentinel Lymph Node Mapping for Pediatric Visceral Solid Tumors
The purpose of the study is to find out the usefulness and safety of a dye called Indocyanine Green (ICG for short). This dye will be used to help the surgeon find lymph nodes draining solid tumors inside the abdomen that need to…
- Trial name
- NCT05645523
- Testing
- Indocyanine Green
- Where
- 3 sites in United States
- Volunteers
- 35 people
- Sponsor
- St. Jude Children's Research Hospital
Melanoma (Skin Cancer)
Superparamagnetic Iron Oxide for Sentinel Lymph Node Localization in Patients With Cutaneous Melanoma: MagMen-II
A randomized, international, phase III, multi-center, non- inferiority trial assessing the safety and efficacy of Magtrace® (superparamagnetic iron oxide, SPIO) in identification of lymph nodes in patients with cutaneous melanoma…
- Trial name
- MagMen-II (NCT07552597)
- Testing
- Superparamagnetic Iron Oxide, Technetium (99mTc)
- Volunteers
- 254 people
- Sponsor
- Vastra Gotaland Region
Breast Cancer
Impact of Osteopathic Manipulative Medicine on Sentinal Lymph Node Biopsy Dye and Tracer Uptake
The goal of this clinical trial is to learn if osteopathic manipulative medicine (OMM) will allow for more uptake of isosulfan blue dye and radiotracers used in sentinal lymph node biopsy (SLNB) compared to massage alone.
- Trial name
- OMM on SLNB (NCT07269860)
- Testing
- OMM prior to SLNB
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Arizona
Breast Cancer
GeneSearch Breast Lymph Node (BLN) Assay Timing Study
This study is designed to collect data about the amount of time required to use the assay in clinical-use conditions.
- Trial name
- NCT00595023
- Testing
- GeneSearch™ Breast Lymph Node (BLN) Assay
- Where
- 6 sites in United States
- Volunteers
- 233 people
- Sponsor
- Janssen Diagnostics, LLC
Head and Neck Tumors
Randomized, Open-label Economic and Medical Study on the Lymph Node Management of Squamous Cell Carcinoma of the Oral Cavity and Oropharynx Tumor Stage 1 or 2, Nodes 0 (T1-T2 N0) Operable
Currently, patients with cancer of oral cavity or oropharynx T1-T2N0 classified, are treated surgically with systematic lymph node dissection while in 70%, there is no lymph node metastasis.
- Trial name
- SentiMERORL (NCT02855723)
- Testing
- Surgery: GS strategy, Surgery: Classic strategy
- Where
- France
- Volunteers
- 307 people
- Sponsor
- University Hospital, Montpellier
Head and Neck Squamous Cell Carcinoma
SPIO-enhanced MRI in Oral Cancer for Sentinel Lymph Node Identification
To explore the feasibility of sentinel lymph node identification by SPIO injection followed by MRI in head-and-neck cancer patients.
- Trial name
- MAG-NODE (NCT04803331)
- Testing
- SPIO-enhanced MRI
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Radboud University Medical Center
Breast Carcinoma, Breast Cancer
Omission of Axillary Lymph Node Dissection in Case of Tumor Spread to Lymph Nodes in the Armpit in Breast Cancer
SENOMAC-ULTRA enrols patients who are planned for upfront surgery for a breast cancer that has spread to lymph nodes in the armpit, and that have been detected already prior to surgery by imaging, e.g. ultrasonography.
- Conditions
- Breast Carcinoma, Breast Cancer, Breast Surgery
- Trial name
- SENOMAC-ULTRA (NCT06869629)
- Testing
- Targeted axillary dissection, Axillary lymph node dissection
- Where
- 4 sites in Finland, South Korea and 1 more
- Volunteers
- 1,380 people
- Sponsor
- Karolinska Institutet
Breast Cancer With Low to Intermediate HER2 Expression, Breast Cancer (Triple Negative Breast Cancer (TNBC))
Use of Magtrace Bracketing for Excision of Lesion and Sentinel Lymph Node Localization in Breast Conserving Surgery for Breast Cancer
Breast cancer is the commonest cancer affecting women worldwide. Early breast cancer is treated surgically with wide local excision of tumor with axillary staging operations like sentinel node biopsy.
- Conditions
- Breast Cancer With Low to Intermediate HER2 Expression, Breast Cancer (Triple Negative Breast Cancer (TNBC)), Breast Cancer (Triple Negative Type), Breast Cancer - Infiltrating Ductal Carcinoma
- Trial name
- MagBracket (NCT07844473)
- Testing
- Super paramagnetic iron oxide bracketing injection
- Where
- Saudi Arabia
- Volunteers
- 35 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Breast Cancer
Near-Infrared Fluorescent Sentinel Lymph Node Mapping for Breast Cancer
Sentinel lymph node (SLN) mapping is the standard of care for the surgical staging of breast cancer. We propose a method of SLN mapping based on the use of invisible near-infrared fluorescent light that has significant advantages…
- Trial name
- NCT00721370
- Testing
- NIR imaging system
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Beth Israel Deaconess Medical Center
Melanoma
Melanoma Molecular Profiling Analysis
There is a significant need to develop new and more effective ways to treat melanoma that will decrease patient morbidity and mortality.
- Trial name
- NCT00889980
- Testing
- Biospecimen banking
- Where
- United States
- Volunteers
- 237 people
- Sponsor
- University of Pittsburgh
Head and Neck Cancer
Lymph Drainage Mapping for Tailoring Elective Nodal Irradiation in Head and Neck Cancer
This study aims to explore the safety and outcome of lymph drainage mapping(LDM) to individually tailor the elective nodal irradiation (ENI) to the ipsilateral neck only.
- Trial name
- SUSPECT-2 (NCT03968679)
- Testing
- Unilateral elective nodal irradiation
- Where
- Netherlands
- Volunteers
- 90 people
- Sponsor
- The Netherlands Cancer Institute
Breast Cancer
Clinical Application of Dual Sentinel Lymph Node Staining Method in Breast Cancer
This study aimed to evaluate the feasibility of dual sentinel node staining method using mixture of indocyanine green(ICG) and radioisotope (RI) in breast cancer patients who receive neoadjuvant chemotherapy.
- Trial name
- NCT02168452
- Testing
- sentinel lymph node biopsy(SLNB)
- Where
- South Korea
- Volunteers
- 5 people
- Sponsor
- National Cancer Center, Korea
Sentinel Lymph Node, Breast Cancer
A Clinical Feasibility Study of a Photoacoustic Finder
Determining the prognosis of breast cancer relies significantly on axillary staging by sentinel lymph node biopsy (SLNb). The SLNb is generally performed using radioisotopes, blue dyes, or both to improve the false negative rate.
- Trial name
- NCT06412211
- Testing
- Photoacoustic finder
- Where
- South Korea
- Volunteers
- 129 people
- Sponsor
- Seoul St. Mary's Hospital
Breast Cancer
Axillary Nodal Burden in HER2+ and TNBC
This study aimed to evaluated rates of pathologic axillary nodal metastasis in patients with with early-stage HER2-positive BC or TNBC who had clinically node-negative status on preoperative ultrasonography and underwent upfront…
- Trial name
- NCT07211451
- Testing
- Breast conserving surgery with axillary surgery
- Where
- South Korea
- Volunteers
- 1,571 people
- Sponsor
- Gangnam Severance Hospital
Breast Cancer
Sentinel Lymph Node Total Tumoral Load as a Predictor of Non Sentinel Node Involvement in Early Breast Cancer
This is a retrospective, multicentric cohort study of patient cases with cT1-3, N0 early breast cancer, who previously had intraoperative sentinel lymph node (SLN) evaluation by one-step nucleic acid amplification (OSNA) assay…
- Trial name
- SOLO-1 (NCT01669265)
- Where
- 9 sites in Spain
- Volunteers
- 701 people
- Sponsor
- SOLTI Breast Cancer Research Group
Vulva Cancer
SLN Mapping and ICG Dye for Vulvar Cancer
Doctors typically use blue dye to assist in locating and extracting lymph nodes for biopsy. However, this process can prove somewhat challenging for both patients and medical teams due to its need for extensive coordination and…
- Trial name
- NCT06035068
- Testing
- Indocyanine green
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Tufts Medical Center
Colorectal Cancer
Lymphatic Mapping and Sentinel Lymph Node Biopsy in the Treatment of Colorectal Cancer
RATIONALE: Diagnostic procedures, such as lymph node mapping and biopsy, may improve the ability to detect the extent of colorectal cancer.
- Trial name
- NCT00005640
- Testing
- Preoperative Endoscopy, Technetium Tc 99m Sulfur Colloid, Gamma Probe
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Sentinel Lymph Node Biopsy, Colon Cancer
Comparison Between ex Vivo and in Vivo Injection of Blue Dye in Sentinel Lymph Node Mapping for Colon Cancer
The technique of sentinel lymph node mapping in patients with colon cancer varies among reports, and the optimal method remain to be established.
- Trial name
- NCT00654342
- Testing
- Intraoperative injection (in vivo), Postoperative injection (ex vivo)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Chung-Ang University
Breast Carcinoma
Axillary Dissection Based on the Histological Result of the Sentinel Node, in Patients With Breast Carcinoma
The purpose of this study is to evaluate the disease free and overall survival of patients with breast carcinomas of small size, i.e., not greater than 2.0 cm and with clinically non palpable axillary lymph nodes, undergoing…
- Trial name
- NCT00970983
- Testing
- quadrantectomy and axillary dissection, quadrantectomy + sentinel node biopsy
- Where
- Italy
- Volunteers
- 532 people
- Sponsor
- European Institute of Oncology