Clinical trials: Sentinel Nodes
Breast Neoplasms
Comparison Study of Sentinel Lymph Node Biopsy by Multimodal Method in Breast Cancer
Sentinel lymph node biopsy (SLNB) has become a mainstay surgery method in breast cancer. It provides the surgeon the evidence of axillary lymph node metastasis, which determines the extent of surgery.
- Trial name
- NCT01856452
- Testing
- the mixture including indocyanine green, radioisotope
- Where
- South Korea
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Sentinel Lymph Node, Endometrial Cancer
Sentinel Node Detection in Endometrial Cancer: A Consolidation Study on Detection Rates of Metastatic Disease
Evaluation of removal of Sentinel lymph nodes only for detection of pelvic lymph node metastases in high risk and low risk endometrial cancer.
- Conditions
- Sentinel Lymph Node, Endometrial Cancer, Lymphedema
- Trial name
- NCT03838055
- Testing
- Injection of tracer ( ICG) and detection of sentinel lymph nodes
- Where
- Sweden
- Volunteers
- 362 people
- Sponsor
- Region Skane
Sentinel Lymph Node, Breast Cancer
Is Breast Massage Necessary to Find Sentinel Lymph Node?
Sentinel lymph node biopsy is important for staging in patients with breast cancer and changes the way of surgery. One of the most commonly used methods to find the sentinel lymph node during surgery is to apply blue dye around…
- Trial name
- NCT05663112
- Testing
- Sentinel lymph node biopsy, Breast massage, Blue dye injection
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people
- Sponsor
- Manisa Celal Bayar University
Early-stage Lung Cancer
Injection of 99mTc-nanocolloid and ICG to Identify, Retrieve and Qualify TDLN in Early-stage NSCLC
The patient wil receive intra- or peritumoral injections of 99mTc-nanocolloid if malignancy is found during a navigation bronchoscopy. A SPECT/CT-scan will be made to image injections sites and sentinel lymph nodes (SLN).
- Trial name
- INITIATE (NCT05555199)
- Testing
- 99mTc-nanocolloid, ICG
- Where
- Netherlands
- Volunteers
- 72 people
- Sponsor
- Radboud University Medical Center
Gastric Cancer, Molecular Imaging
Novel Humanized Ferritin-Based NIR Fluorescent Probe for Identifying Sentinel Lymph Node Metastasis in Early Gastric Cancer
With the widespread adoption of early cancer screening, the proportion of early gastric cancer (EGC) in China has been gradually increasing. The primary treatments for EGC are endoscopic and surgical interventions.
- Trial name
- NCT07294638
- Testing
- VE/CX-FTn-ICG injection solution
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Breast Cancer
Fluorescein for Sentinel Lymph Node Biopsy (SLNB) in Breast Cancer
The study goal is to develop a new method of intraoperative lymphatic mapping with fluorescent contrast agents to improve the outcome of therapeutic breast cancer surgery.
- Trial name
- NCT01614184
- Testing
- Fluorescein
- Sponsor
- University of Utah
Breast Cancer
Axillary Sentinel Lymph Node Detection in Breast Cancers > 2 cm
The purpose of this study is to evaluate the quality criteria of the SLN detection technique in breast cancer patients with a tumor size (clinical measurement) greater than 2 centimeters (rate of false negatives, rate of…
- Trial name
- GAS2PLUS (NCT00636467)
- Testing
- No name
- Where
- 22 sites in France
- Volunteers
- 249 people
- Sponsor
- Centre Leon Berard
Carcinoma
Extent of Central Lymph Node Dissection in Papillary Thyroid Microcarcinoma
Occult lymph node metastasis is common in micro papillary thyroid cancer. However, the role of lymph node dissection in the treatment of microPTC remains controversial.
- Trial name
- NCT01149161
- Testing
- Routine central neck dissection
- Where
- South Korea
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Esophagus
Contrast-Enhanced Ultrasound Identification of Sentinel Nodes in Esophageal Cancer
This pilot trial studies how well an ultrasound with a contrast agent (perflubutane microbubble [Sonazoid]) works in identifying sentinel lymph nodes in participants with esophageal cancer.
- Trial name
- NCT03578224
- Testing
- Endoscopic Ultrasound-Guided Fine-Needle Aspiration (EUS-FNA), Contrast-Enhanced Ultrasound, Fine-Needle Aspiration
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Sentinel Lymph Node Biopsy, Mastectomy, Subcutaneous
SLNB After Nipple Sparing Mastectomy
Sentinel Lymph Node Biopsy (SLNB) after nipple sparing mastectomy (NSM) is controversial. This study aims to investigate feasibility of SLNB with radioisotope method.
- Trial name
- NCT04140188
- Testing
- Senti-Scint (99mTc- pertechnetate combined with human albumin)
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Endometrial Neoplasms
Sentinel Lymph Node Detection in Endometrial Cancer
In endometrial cancer (EC) pelvic and paraaortic lymphadenectomy is performed only in high risk groups (with approximately 20% of patients having lymph node metastases (LNM)) whereas no lymphadenectomy is recommended in low risk…
- Trial name
- NCT02690259
- Testing
- Sentinel node procedure
- Where
- Sweden
- Volunteers
- 257 people
- Sponsor
- Region Skane
Breast Cancer
Locoregional Control With Radiotherapy of Breast Cancer Patients With MACrometastases Treated With MAstectomy (MACMA)
Sentinel lymph node biopsy (SLNB) is the standard procedure to stage the axilla in clinically node-negative invasive breast cancer (IBC) patients undergoing upfront surgery.
- Trial name
- MACMA (NCT06378294)
- Testing
- Mastectomy
- Where
- 7 sites in Spain
- Volunteers
- 82 people
- Sponsor
- University Hospital A Coruña
Endometrial Cancer
Feasibility of Gallium-68-tilmanocept PET/CT for Sentinel Lymph Node Detection in Endometrial Cancer
This pilot study evaluates the feasibility of 68Ga-tilmanocept PET/CT for SLN mapping in patients with endometrial cancer.
- Trial name
- SENGA (NCT05446324)
- Testing
- Gallium-68-tilmanocept
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- UMC Utrecht
Endometrial Cancer, Lymphadenectomy
Comparison of Transvaginal Paracervical and Transperitoneal Approaches in Lymphadenectomy During v-NOTES Surgery for Patients Diagnosed With Endometrial Cancer
The aim of this study is to compare two types of lymphadenectomy (transperitoneal vs. paracervical) during the lymphadenectomy phase of endometrial cancer staging surgery performed using V-NOTES, a new and advanced technique.
- Conditions
- Endometrial Cancer, Lymphadenectomy, Sentinel Lymph Node Biopsy, Minimally Invasive Surgical Procedures
- Trial name
- ENDONOTE (NCT06870903)
- Testing
- Extraperitoneal(transvaginal paracervical sentinel lymphadenectomy) group lymphadenectomy, Transperitoneal lymphadenectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
DCIS
Delayed Selective Sentinel Node Biopsy for Patients Undergoing Mastectomy for DCIS
In the case of a patient undergoing total mastectomy for intraductal carcinoma (DCIS), the sentinel lymph node is not excised during the primary surgery but only marked for identification.
- Trial name
- NCT05912569
- Testing
- Delay sentinel node biopsy
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Seoul National University Hospital
Parathyroid Adenoma, Thyroid Adenoma
Evaluation of a New CZT System
The purpose of the study is to check if the new CZT system has an advantage in detection of small osseous processes, thyroid adenomas, parathyroid adenomas and detection of sentinel node, in comparison with the techniques in use.
- Trial name
- NCT01084356
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Breast Cancer
Sienna and Sentimag in Sentinel Lymph Node Biopsy
The aim of this study is to evaluate a new method for the localization of breast cancer sentinel lymph node using Sienna+® and Sentimag® detection in comparison to our standard techniques with radio-isotopes.
- Trial name
- Sienna (NCT03036475)
- Testing
- Sienna+ injection
- Volunteers
- 52 people
- Sponsor
- Yolanda Chan
Sentinel Lymph Node, Ovarian Cancer Stage I
SEntine Lymph Node in earLY Ovarian Cancer (SELLY)
The present study aims at investigating the feasibility, the detection rate and the negative predictive value of sentinel node in predicting the presence or absence of lymph node metastasis in ovarian cancer patients
- Trial name
- SELLY (NCT03563781)
- Testing
- Sentinel node detection
- Where
- Italy
- Volunteers
- 176 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Breast Cancer
Sentinel Node Biopsy in Breast Cancer: Omission of Axillary Clearance After Macrometastases. A Randomized Trial.
Since the introduction of sentinel node biopsy in breast cancer, it has become clear that its use is reliable and reproducible. Today, it is clinical routine to not remove further lymph nodes from the axilla (arm pit) in case the…
- Trial name
- NCT02240472
- Testing
- Omission of axillary clearance
- Where
- 33 sites in Denmark, Greece and 1 more
- Volunteers
- 2,766 people
- Sponsor
- Karolinska Institutet
Breast Cancer, Sentinel Lymph Node Biopsy (SLNB)
Finding Sentinel Lymph Nodes During Mastectomy Using Indocyanine Green (INIGMA Study)
This pilot study evaluates the diagnostic value of indocyanine green (ICG) fluorescence for sentinel lymph node biopsy (SLNB) performed through the mastectomy incision in breast cancer patients.
- Conditions
- Breast Cancer, Sentinel Lymph Node Biopsy (SLNB), Sentinel Lymph Node Detection, Sentinel Lymph Node
- Trial name
- INIGMA (NCT07362485)
- Testing
- Indocyanine green (ICG)-fluorescence guided sentinel lymph node biopsy
- Where
- 2 sites in Netherlands
- Volunteers
- 90 people
- Sponsor
- Isabelle Henskens