Clinical trials: Sentinel Nodes
N1/N2b Oral Cavity Cancer, Head and Neck Skin Cancer
Prospective Clinical Study to Identify Secondary Sentinel Lymph Nodes in Patients With N1/N2b Oral Cavity or H&N Skin Cancers Using Patent Blue V and Indocyanine Green Dyes
Head and neck (H\&N) cancer has a poor prognosis and high morbidity with ~50% survival and frequent treatment resistance. Most deaths result from local or loco-regional progression rather than distant metastasis.
- Trial name
- preReDSeL (NCT07518485)
- Testing
- Patent blue V dye injection, Indocyanine green dye injection
- Where
- 2 sites in Switzerland
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Laryngeal Squamous Cell Carcinoma, Hypopharynx Squamous Cell Carcinoma
Personalized Elective Neck Irradiation Guided by Sentinel Lymph Node Biopsy in Larynx and Pharynx Cancer. The PRIMO Study.
Rationale | Elective neck irradiation is performed in head and neck cancer patients treated with definitive (chemo)radiotherapy. The aim is to eradicate nodal metastases that are not detectable by pretreatment imaging techniques.
- Conditions
- Laryngeal Squamous Cell Carcinoma, Hypopharynx Squamous Cell Carcinoma, Oropharyngeal Squamous Cell Carcinoma
- Trial name
- PRIMO (NCT05333523)
- Testing
- Sentinel lymph node biopsy guided selective elective neck irradiation, Standard elective neck irradiation
- Where
- 9 sites in Netherlands
- Volunteers
- 242 people
- Sponsor
- Radboud University Medical Center
Breast Cancer
Computed Tomography (CT) Based Lymphatic Mapping and Localization of Sentinel Lymph Node in Breast Cancer Patients
Breast cancer patients who diagnosed by core needle biopsy or excisional biopsy underwent CT scan to locate the sentinel lymph node (SLN) before SLN biopsy (SLNB) at the same day of surgery.
- Trial name
- NCT00952679
- Testing
- Breast Lesion Localization Needles (interv)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Fudan University
Cervical Cancer
Robot-assisted Approach to Cervical Cancer
The purpose of the RACC trial is to compare the oncologic outcome defined as recurrence-free survival (RFS) between robot-assisted and open radical hysterectomy for the treatment of early stage cervical cancer.
- Trial name
- RACC (NCT03719547)
- Testing
- Abdominal radical hysterectomy, Robot-assisted radical hysterectomy, Sentinel lymph node biopsy
- Where
- Sweden
- Volunteers
- 800 people
- Sponsor
- Karolinska Institutet
Melanoma, Breast Cancer
Contrast-enhanced Ultrasound for Sentinel Node Detection
This is a prospective single-center interventional non-inferiority study where subjects are participating for one day for patients 18 years or older with melanoma, breast cancer or head \& neck cancer (including melanoma of head…
- Conditions
- Melanoma, Breast Cancer, Head & Neck Cancer
- Trial name
- NCT07310758
- Testing
- Sonazoid
- Where
- Netherlands
- Volunteers
- 91 people
- Sponsor
- The Netherlands Cancer Institute
Ovarian Cancer, Lymph Node Metastasis
Magtrial: Magtrace® as Tracer for Sentinel Lymph Node Detection in Early Stage Epithelial Ovarian Cancer
Epithelial ovarian cancer (EOC) remains the tumour with the most unfavourable prognosis within the field of gynaecological oncology.
- Trial name
- NCT05375526
- Testing
- Magtrace
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Maastricht University Medical Center
Breast Cancer, Sentinel Lymph Node Biopsy
The Validation of Sentinel Lymph Node Biopsy After Neo-adjuvant Chemotherapy in Breast Cancer Patients
Neoadjuvant or primary systemic treatment is increasingly applied in the treatment of operable breast cancer. Down staging of the primary tumor is one of the important goals of neoadjuvant chemotherapy treatment (NCT), thereby…
- Conditions
- Breast Cancer, Sentinel Lymph Node Biopsy, Neoadjuvant Therapy
- Trial name
- NCT04986306
- Testing
- SLNB + ALND
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Cheng-Kung University Hospital
Testicular Cancer, Testicular Germ Cell Tumor
Minimally-invasive ICG-guided Retroperitoneal Sentinel Lymph Node Dissection in the Primary Staging of Testicular Cancer Versus Standard of Care
Testicular cancer is highly curable, but approximately 20-30% of patients with clinical stage I disease harbor occult retroperitoneal lymph node metastases that are not detected by conventional imaging.
- Trial name
- RAISN 2 (NCT07699640)
- Testing
- ICG-Guided Retroperitoneal Sentinel Lymph Node Biopsy, Radical Inguinal Orchiectomy
- Where
- 10 sites in Finland, Germany
- Volunteers
- 171 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Breast Cancer, Sentinel Lymph Node
Prospective Feasibility Study Applying the ACOSOG Z0011 Criteria to Chinese Patients
In patients undergoing breast-conserving surgery and having positive sentinel lymph nodes (SLNs), the ACOSOG Z0011 trial showed equivalent overall survival(OS) and disease-free survival(DFS) outcomes for patients receiving SLN…
- Conditions
- Breast Cancer, Sentinel Lymph Node, Local Recurrence of Malignant Tumor of Breast
- Trial name
- NCT03606616
- Testing
- no further ALND arm
- Where
- China
- Volunteers
- 142 people
- Sponsor
- Peking University People's Hospital
Breast Cancer
Internal Mammary Sentinel Lymph Node Biopsy With Modified Injection Technique
Internal Mammary Lymph Node (IMLN) and Axillary Lymph Node (ALN) are regarded as "the first station" of lymphatic drainage in breast cancer, serving as an important reference for lymph staging and decision-making.
- Trial name
- NCT03541278
- Testing
- MIT, IM-SLNB
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Shandong Cancer Hospital and Institute
Eye Disease, Melanoma
Sentinel Lymph Node (SLN) Biopsy for Conjunctival/Eyelid Melanoma
The goal of this clinical research study is to find the sentinel lymph node (SLN) (s) and biopsy it (them) to see if the patient has small or low volume metastatic disease that would otherwise have been missed.
- Trial name
- NCT00386906
- Testing
- Sentinel Lymph Node Mapping and Biopsy
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- M.D. Anderson Cancer Center
Vulvar Cancer, Sentinel Lymph Node
Optical Guided Sentinel Node Biopsy for Staging of Vulvar Cancer (I)
The aim of this study is to investigate whether Sentinel Node biopsy can be performed without the use of lymphoscintigraphy and with ICG as a mono-tracer in women with vulvar cancer, unifocal tumor < 4 cm (clinical stage IB and…
- Trial name
- SENTIVUC (NCT06029504)
- Where
- Denmark
- Volunteers
- 115 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Melanoma, Skin, Adjuvant Treatment
One-year Recurrence-free Survival of Melanoma Patients Eligible for a Sentinel Lymph Node Biopsy
Melanoma is one of the most aggressive solid cancers, although mortality can be reduced with early treatment. Immunotherapy has transformed the prognosis of this pathology.
- Trial name
- MELASENTI (NCT06809491)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Central Hospital, Nancy, France
Early Gastric Cancer
Quality Control Study of Laparoscopic Sentinel Node Biopsy in Early Gastric Cancer
Laparoscopic sentinel lymph node biopsy and stomach preserving surgery in ealry gastric cancer is less invasive method which can increase quality of life. Multicenter phase III trial is requred to validate this method.
- Trial name
- NCT01544413
- Testing
- Laparoscopic sentinel lymph node biopsy
- Where
- 15 sites in South Korea
- Volunteers
- 112 people
- Sponsor
- National Cancer Center, Korea
Cutaneous Melanoma
Minimal SN Tumor Burden
The purpose of this registry is to collect data in order to discover whether melanoma patients with minimal SN tumor burden should undergo a complete lymph node dissection (CLND) or not.
- Trial name
- Minitub (NCT01942603)
- Where
- 22 sites in Belgium, France and 8 more
- Volunteers
- 296 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Sentinel Lymph Node
SLN in Colon Cancer Using a Multimodal Tracer
Rationale: Lymph node status is the most important factor in the selection of patients for adjuvant chemotherapy after surgical treatment of primary colorectal carcinoma.
- Trial name
- NCT02850783
- Testing
- 89Zr-nanocoll and Indocyanine Green
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- VU University of Amsterdam
Non Endometrioid Carcinoma, Endometrioid Carcinoma
Evaluation of Sentinel Node Policy in Early Stage Endometrial Carcinomas at Intermediate and High Risk of Recurrence.
The aim of this trial is to evaluate the sentinel node policy in early stage endometrial carcinomas at intermediate and high risk of recurrence (by comparing the sentinel node policy to current initial staging protocols).
- Trial name
- SENTIRAD (NCT02598219)
- Testing
- Pre-operative SN mapping with radionucleide, Intra-operative SN mapping with patent V blue dye, Intra-operative SN mapping with indocyanin green
- Where
- 16 sites in France
- Volunteers
- 262 people
- Sponsor
- Centre Oscar Lambret
Breast Cancer, Pectoral Nerves Block
Comparing the QoR of PECS Block and GA in Breast-conserving Surgery With Sentinel Lymph Node Biopsy
The aim of this randomized controlled trial (RCT) is to assess the Quality of Recovery (QoR) in Breast-conserving Surgery (BCS) with Sentinel Lymph Node Biopsy (SLNB) using Pectoral Nerves (PECS) Block and General Anesthesia…
- Conditions
- Breast Cancer, Pectoral Nerves Block, Breast-Conserving Surgery, Sentinel Lymph Node Biopsy
- Trial name
- NCT06120439
- Testing
- PECS II combined with intercostal nerve blockade;, General anesthesia with laryngeal mask
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Jun Zhang
Stage I Breast Cancer, Stage II Breast Cancer
Comparison of Use of Indocyanine Green and 99mTc-labeled Radiotracer for Axillary Lymphatic Mapping in Patients With Breast Cancer
This clinical trial will enroll up to 130 adult women with a confirmed diagnosis of clinical stage 1 or 2 breast cancer who are undergoing breast cancer surgery with lumpectomy or mastectomy and planned axillary sentinel node…
- Trial name
- NCT02419807
- Testing
- Indocyanine Green Solution, Technetium Tc-99m Sulfur Colloid, Lymphoscintigraphy
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Case Comprehensive Cancer Center
Early Stage Endometrial Cancer, Sentinel Lymph Nodes
Sentinel Lymph Node Biopsy Versus Lymphadenectomy in Endometrial Cancer
To compare sentinel lymph nodes biopsy versus comprehensive lymphadenectomy in patients with early stage endometrial cancer.
- Conditions
- Early Stage Endometrial Cancer, Sentinel Lymph Nodes, Lymphadenectomy
- Trial name
- NCT05048173
- Testing
- Sentinel lymph node mapping and biopsy, Lymphadenectomy
- Where
- Taiwan
- Volunteers
- 334 people
- Sponsor
- Far Eastern Memorial Hospital