Clinical trials: Sentinel Nodes
Sentinel Lymph Node Biopsy (SLNB), Early Stage Ovarian Tumors
Patent Blue SLN in Early Ovarian Cancer Prospective Study (FIGO I-II) Evaluating Patent Blue SLN Mapping. Injection Into IP/UO Ligaments in Situ. Goals: Assess Feasibility and Accuracy vs Standard Lymphadenectomy to Minimize Surgical Morbidity
the standard of care in case of early ovarian cancer (stage I or II) is a complete surgery. This surgery includes : hysterectomy (remove of the uterus), bilateral salpingo-oophorectomy (remove of the adnexa), omentectomy (remove…
- Trial name
- NCT07508306
- Testing
- Sentinel node biopsy with patent blue dye
- Where
- Tunisia
- Volunteers
- 30 people
- Sponsor
- Faculty of Medicine of Tunis
Breast Cancer, Locally Advanced Breast Cancer
Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy For Locally Advanced Breast Cancer
This study is being done to help the investigators determine how accurate the sentinel lymph node biopsy (SLNB) procedure is in identifying residual cancer cells after neoadjuvant chemotherapy in patients presenting with locally…
- Trial name
- NCT03255577
- Testing
- Sentinel Lymph Node Biopsy (SLNB)
- Where
- 8 sites in United States
- Volunteers
- 162 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Early-stage Lung Cancer
Injection of 99mTc-nanocolloid and ICG to Identify, Retrieve and Qualify TDLN in Early-stage NSCLC
The patient wil receive intra- or peritumoral injections of 99mTc-nanocolloid if malignancy is found during a navigation bronchoscopy. A SPECT/CT-scan will be made to image injections sites and sentinel lymph nodes (SLN).
- Trial name
- INITIATE (NCT05555199)
- Testing
- 99mTc-nanocolloid, ICG
- Where
- Netherlands
- Volunteers
- 72 people
- Sponsor
- Radboud University Medical Center
Lymph Node Metastases, Breast Cancer
A Prospective Validation Cohort Study of a Prediction System on nSLN Metastasis in Early Breast Cancer
In the previous study, the investigator established a predictive model for non-sentinel lymph node involvement in early breast cancer (cT1-2cN0, 1-2 SLNs involvement).
- Conditions
- Lymph Node Metastases, Breast Cancer, Predictive Cancer Model
- Trial name
- NCT03280134
- Testing
- axillary lymph node dissection (ALND)
- Where
- China
- Volunteers
- 388 people
- Sponsor
- Zhejiang Cancer Hospital
Early Breast Cancer
Refusal of Sentinel Lymph Node Biopsy in Patients With Luminal A Subtype Early Breast Cancer
Sentinel lymph node biopsy (SLNB) is the standard of axillary lymph node surgical staging in patients with early breast cancer. The main goal of the study is to abandon axillary surgery in patients over 59 years old with early…
- Trial name
- LumiNOde (NCT07579286)
- Testing
- breast resection, Breast resection with sentinel lymph node biopsy
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- N.N. Petrov National Medical Research Center of Oncology
Breast Cancer
GeneSearch™ Breast Lymph Node (BLN) Assay China Registration Study
The primary objective of this trial is to compare GeneSearch™ Breast Lymph Node (BLN) Test Kit to permanent pathological section, so as to evaluate the clinical sensitivity and specificity of GeneSearch™ Breast Lymph Node (BLN)…
- Trial name
- NCT00869674
- Testing
- GeneSearch™ Breast Lymph Node (BLN) Assay
- Where
- 6 sites in China
- Volunteers
- 540 people
- Sponsor
- Johnson & Johnson Medical, China
Ovarian Epithelial Cancer
Sentinel Node Detection With Technetium-99m Albumin Nanocolloid and ICG in Patients With Epithelial Ovarian Cancer
Study to evaluate the diagnostic precision of ICG and 99mTc nanocolloid albumin in sentinel lymph node detection in early ovarian epithelial cancer.
- Trial name
- Melisa-II (NCT05937620)
- Testing
- 99mTC nanocolloid albumin injection, ICG injection
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Breast Cancer
Role of Indocyanine Green (ICG) for Detection of Sentinel Nodes in Breast Cancer
This is a single-center prospective study evaluating the diagnostic performance and safety of Infracyanine in women with early breast cancer whose the research of sentinel node(s) combines isotopes and Infracyanine.
- Trial name
- NCT02875626
- Testing
- Infracyanine
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Association Pour La Recherche des Thérapeutiques Innovantes en Cancérologie
ALND, Sentinel Lymph Node Biopsy (SLNB)
Upfront Targeted Axillary Dissection for Luminal Breast Cancer With Limited Axillary Involvement
The present study aims to avoid axillary lymph node dissection (ALND) in patients with an Ultrasound (US) detected positive preoperative lymph node involvement (1 or 2 suspicious lymph-nodes) and a needle histology/cytology…
- Conditions
- ALND, Sentinel Lymph Node Biopsy (SLNB), Targeted Axillary Dissection (TAD)
- Trial name
- UTAD (NCT07278726)
- Testing
- Upfront Targeted Axillary Dissection (UTAD)
- Where
- 14 sites in Italy, Switzerland
- Volunteers
- 150 people
- Sponsor
- European Institute of Oncology
Breast Cancer
Internal Mammary Sentinel Lymph Node Biopsy With Modified Injection Technique
Internal Mammary Lymph Node (IMLN) and Axillary Lymph Node (ALN) are regarded as "the first station" of lymphatic drainage in breast cancer, serving as an important reference for lymph staging and decision-making.
- Trial name
- NCT03541278
- Testing
- MIT, IM-SLNB
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Shandong Cancer Hospital and Institute
Breast Cancer
Breast Cancer: Axillary Conservation After Neoadjuvant Chemotherapy in Micro Metastatic Sentinel Lymph Nodes.
Italian multicentric non inferiority clinical study to verify whether the omission of axillary lymph node intervention in patients with SLN (Sentinel Lymph Nodes) ypN1mi after NAC (Neo Adiuvant Chemotherapy) does not lead to a…
- Trial name
- NEONOD2 (NCT04019678)
- Testing
- Omission of Axillary dissection
- Where
- Italy
- Volunteers
- 850 people
- Sponsor
- Istituto Clinico Humanitas
Lymph Node Metastasis, Breast Cancer
Sensitivity and Predictive Value of Frozen Section of Sentinel Lymph Node Biopsy in Post Neoadjuvant Setting
Axillary lymph node status is one of the most important prognostic factors in primary breast carcinomas. Sentinel lymph node biopsy has been increasing in post neoadjuvant setting when axillary nodes show good clinical and…
- Trial name
- NCT06401590
- Testing
- FROZEN SENTINEL LYMPH NODE BIOPSY
- Where
- Pakistan
- Volunteers
- 286 people
- Sponsor
- Aga Khan University
Uterine Cervical Neoplasms
Sentinel Lymph Node Mapping In Cervical Cancer
Lymph node assessment provides the crucial information about the prognosis of cervical cancer. Sentinel lymph node stands in the first station on the lymph node metastasis pathways.
- Trial name
- SLNMICC (NCT03778268)
- Testing
- sentinel lymph node biopsy
- Where
- 2 sites in China
- Volunteers
- 1,143 people
- Sponsor
- Peking University People's Hospital
Breast Cancer
AXillary Surgery After NeoAdjuvant Treatment
The optimal surgical axillary staging technique in patients who convert from the clinically positive to clinically negative lymph node status under neoadjuvant therapy (cN+ → ycN0) remains to be clarified.
- Trial name
- AXSANA (NCT04373655)
- Where
- Germany
- Volunteers
- 3,000 people
- Sponsor
- European Breast Cancer Research Association of Surgical Trialists