Clinical trials: Sepsis, Severe
Community-acquired Pneumonia, Severe Pneumonia
Fulminant Severe CAP - an Observational Study
Severe community-acquired pneumonia (CAP) represents a major cause of hospital mortality. Among severe CAP cases, some exhibit a rapidly progressive evolution, leading to severe ARDS/acute respiratory failure and septic shock…
- Conditions
- Community-acquired Pneumonia, Severe Pneumonia, ARDS, Human, Sepsis
- Trial name
- FULMISCAP (NCT06516601)
- Testing
- no intervention
- Where
- 2 sites in Italy
- Volunteers
- 1,460 people
- Sponsor
- University of Trieste
Severe Sepsis, Severe Sepsis Without Septic Shock
Sepsis Clinical Decision Support [CDS] Master Enrollment Study Protocol
This protocol will collect real-world data retrospectively from the electronic health record (EHR) as data obtained from the delivery of routine medical care to develop a machine learning (ML)-based Clinical Decision Support…
- Trial name
- NCT05304728
- Where
- 10 sites in United States
- Volunteers
- 40,000 people
- Sponsor
- Beckman Coulter, Inc.
Sepsis, Severe Community-acquired Pneumonia (sCAP)
Molecular Biomarkers for Sepsis
This multi-center observational case-control study in Intensive Care Unit (ICU) patients is to identify novel biomarkers allowing to recognize severe community acquired pneumonia (sCAP) -associated sepsis at an earlier stage and…
- Conditions
- Sepsis, Severe Community-acquired Pneumonia (sCAP), Infection, Bacterial
- Trial name
- NCT04280354
- Testing
- compare data patterns by data-driven algorithms to determine sepsis, compare data patterns by data-driven algorithms to predict sepsis-related mortality
- Where
- 15 sites in Switzerland
- Volunteers
- 3 people
- Sponsor
- University Hospital, Basel, Switzerland
Sepsis, Septic Shock
Health Related Quality of Life After Intensive Care for Sepsis, a National Cohort Study.
The study aims to map the health-related quality of life (HRQoL) after intensive care for Sepsis with the hypothesis that it will be lower than that in the general population.
- Conditions
- Sepsis, Septic Shock, Sepsis, Severe
- Trial name
- NCT06368336
- Volunteers
- 210,484 people
- Sponsor
- Uppsala University Hospital
ARDS, Human, Sepsis, Severe
The Effect pf Goal-directed De-escalation in ARDS on Organ Function and Mortality
Objective: To compare two de-escalation strategies guided by either extravascular lung water or global end-diastolic volume-oriented algorithms in patients with sepsis and ARDS. Design: A prospective randomized study.
- Trial name
- NCT04508296
- Testing
- Goal directed de-escalation therapy
- Where
- Russia
- Volunteers
- 46 people
- Sponsor
- Northern State Medical University
Carbapenem-Resistant Enterobacteriaceae Infection, Bloodstream Infection
Seven Versus 14 Days of Antibiotic Therapy for Multidrug-resistant Gram-negative Bacilli Infections
Antimicrobial resistance is a major global problem, particularly in hospital-acquired infections (HAIs). Gram-negative bacilli (GNB), including Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii, are among the…
- Conditions
- Carbapenem-Resistant Enterobacteriaceae Infection, Bloodstream Infection, Severe Infection, Pseudomonas Aeruginosa
- Trial name
- OPTIMISE (NCT05210387)
- Testing
- Duration of therapy
- Where
- 29 sites in Brazil
- Volunteers
- 107 people
- Sponsor
- Hospital Moinhos de Vento
Sepsis Due to Streptococcus, Group A, Risk Factors
Invasive Group A Streptococcal Infection
This study is observational, retrospective and prospective study in pediatric patients hospitalized with invasive streptococcal A infection
- Conditions
- Sepsis Due to Streptococcus, Group A, Risk Factors, Severe Infection, Medical Care
- Trial name
- ISAI (NCT05788861)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Association Clinique Thérapeutique Infantile du val de Marne
Sepsis, Septic Shock
Early Administration of Vitamin C in Patients With Sepsis or Septic Shock in Emergency Departments
In this clinical trial the effect of early administration of Vitamin C is investigated in patients admitted at the emergency department with sepsis or septic shock.
- Conditions
- Sepsis, Septic Shock, Sepsis, Severe
- Trial name
- c-easie (NCT04747795)
- Testing
- Vitamin C, Normal saline
- Where
- 8 sites in Belgium
- Volunteers
- 301 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pseudomonas Infections, Pseudomonas Septicemia
Monocyte Profiles in Critically Ill Patients With Pseudomonas Aeruginosa Sepsis
The present study focuses on patients with Pseudomonas aeruginosa (PSA) sepsis. The aim of the present study is to find out whether the M1 (pro-inflammatory) or M2 (anti-inflammatory) phenotype predominates in blood monocytes in…
- Conditions
- Pseudomonas Infections, Pseudomonas Septicemia, Pseudomonas; Pneumonia, Pseudomonal Bacteraemia
- Trial name
- MIPSA (NCT03044223)
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Sepsis, Severe Sepsis
Plasma Inducible Nitric Oxide Synthase (iNOS) Assay and Sepsis Study
The primary objective is to demonstrate that the plasma inducible nitric oxide synthase (iNOS) assay (PliNOSa® test) has an acceptable relative risk ratio for predicting the onset of sepsis within 72 hours of testing when…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- PliNOSa® Test (NCT01371929)
- Volunteers
- 166 people
- Sponsor
- Research & Diagnostic Antibodies
Severe Sepsis
The Efficacy of Si-Ni-Tang (a Chinese Herbal Formula) for Severe Sepsis
The purpose of this study is to evaluate the efficacy of Si-Ni-Tang (a Chinese Herbal Formula documented in Shang Han Lun) in treating severe sepsis.
- Trial name
- NCT02777606
- Testing
- Si-Ni-Tang
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Severe Sepsis
Symphony IL-6 Study in Patients at Risk of Severe Sepsis
Symphony IL-6 is a device that quantitates human IL-6 by fluorescence enzyme immunoassay (FEIA) from whole-blood specimens. Use of Symphony IL- 6 removes the need for plasma separation before testing.
- Trial name
- NCT05665153
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Bluejay Diagnostics, Inc.
Meningococcal Infections, Septic Shock
Septic cArdiac Deficiency and MenIngococcal seveRe Sepsis
Use of brain natriuretic peptide to evaluate the cardiac function in the course of meningococcal septic shock or severe sepsis.
- Conditions
- Meningococcal Infections, Septic Shock, Severe Sepsis
- Trial name
- SAMIRA (NCT02041663)
- Testing
- BNP
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Severe Sepsis
Symphony IL-6 Cutoff Establishment Study for Patients at Risk of Severe Sepsis Due to COVID-19
Symphony IL-6 is a device that quantitates human IL-6 by fluorescence enzyme immunoassay (FEIA) from whole-blood specimens. Use of Symphony IL- 6 removes the need for plasma separation before testing.
- Trial name
- NCT05060250
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Bluejay Diagnostics, Inc.
Severe Sepsis
Symphony IL-6 Cutoff Validation Study for Patients at Risk of Severe Sepsis
Symphony IL-6 is a device that quantitates human IL-6 by fluorescence enzyme immunoassay (FEIA) from whole-blood specimens. Use of Symphony IL- 6 removes the need for plasma separation before testing.
- Trial name
- NCT05048927
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Bluejay Diagnostics, Inc.
Severe Sepsis, Septic Shock
Role of Ulinastatin in Preventing Severe Sepsis and Consequent Morbidities and Mortality
The study will enhance the theory in the frame of reference on the efficacy of Ulinastatin while managing sepsis and subsequent morbidity and mortality.
- Conditions
- Severe Sepsis, Septic Shock, MODS
- Trial name
- MUNI-SEP (NCT05895240)
- Testing
- Ulinastatin
- Where
- Pakistan
- Volunteers
- 175 people
- Sponsor
- Jinnah Postgraduate Medical Centre
Sepsis, Severe Sepsis
ED Tracking Sheet Implementation
The purpose of this study is to assess whether implementation of an ED Sepsis Tracking Sheet effects the percentage of goal-directed sepsis criteria met in a tertiary care academic Emergency Department.
- Conditions
- Sepsis, Severe Sepsis, Systemic Inflammatory Response Syndrome
- Trial name
- NCT05213923
- Testing
- ED Sepsis Tracking Sheet
- Where
- United States
- Volunteers
- 194 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Severe Sepsis
Lotta Alla Sepsi Ospedaliera - Fighting Hospital Sepsis
Sepsis is widespread (1.8 million cases annually worldwide) and accounts for a very high mortality: 20-25% of all severe sepsis, 40-70% of all septic shock.
- Trial name
- NCT01804764
- Where
- Italy
- Volunteers
- 1,123 people
- Sponsor
- University of Milano Bicocca
Sepsis Syndrome, Sepsis
Mitochondrial DNA as a Biomarker of Sepsis Severity
Mitochondria are organelles (a specialized subunit of a cell) responsible for providing cells with energy. For reasons not yet understood, mitochondria will release their DNA into blood in response to cellular injury or cell…
- Conditions
- Sepsis Syndrome, Sepsis, Severe Sepsis, Septic Shock
- Trial name
- MBOSS (NCT03077672)
- Where
- 2 sites in United States
- Volunteers
- 1,304 people
- Sponsor
- Weill Medical College of Cornell University
Sepsis, Severe
Effect of Probiotics on Cytokines in Sepsis in Children
To assess the effect of probiotics on cytokine's level(interleukin 6 and Transforming growth factor-β1)in children admitted to PICU with sepsis.
- Trial name
- NCT05467605
- Testing
- probiotics( Lactobacillus acidophilus, lactobacillus delbruekii and lactobacillus fermentum 10 billions),, maltose dissolved in distilled water
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University