Clinical trials: Sepsis, Severe
Sepsis, Severe Sepsis
Inferior Vena Cava Collapsibility Index in Severe Sepsis
There is debate regarding the use of non invasive (ultrasound assessed) parameters of fluid volume status in patients with sepsis.
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT02195830
- Testing
- Ultrasound of the inferior vena cava
- Where
- United Kingdom
- Volunteers
- 112 people
- Sponsor
- Teesside University
Sepsis, Severe Sepsis and Septic Shock
Evaluation of CPD MNV as an Aid in the Diagnosis and Risk Assessment of Sepsis (Protocol # Sepsis 1-14)
The investigators hypothesize that CPD parameters will provide improved prediction of sepsis compared to currently employed laboratory parameters.
- Trial name
- Beckman (NCT02232750)
- Where
- United States
- Volunteers
- 1,320 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Septic Shock, Vasodilatory Shock
Vasopressin Use in Septic Shock From Türkiye
The goal of this observational study is to examine the early hemodynamic effects and clinical outcomes of vasopressin use in patients with septic shock.
- Conditions
- Septic Shock, Vasodilatory Shock, Critical Illness Sepsis, Severe, Critical Illness
- Trial name
- (VASCO-TURK) (NCT06953297)
- Where
- Turkey (Türkiye)
- Volunteers
- 146 people
- Sponsor
- Karadeniz Technical University
Puerperal: [Major Infection] or [Sepsis]
Diagnostic Breath Analysis Study to Detect Sepsis
Analysis of exhaled breath samples using a high-speed gas chromatography medical device will identify Volatile Organic Compounds (VOC) that are specifically associated with SIRS and Sepsis.
- Trial name
- NCT02532959
- Testing
- Diagnostic Breath Analysis
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Landon Pediatric Foundation
Sepsis
Efficacy and Pharmacokinetics of Meropenem in Severe Septic Patients
The experimental and control group were used different administration of Meropenem through monitoring the Meropenem plasma concentration and clinical data
- Trial name
- NCT03645668
- Testing
- Meropenem Injection
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Severe Sepsis, Microcirculation
Microcirculation Guided Therapy Versus "Standard Treatment" of Severe Sepsis
The purpose of this study is to asses the recovery of organ failure between two resuscitation protocols in severe sepsis: standard, pressure guided therapy versus a microcirculation guided therapy
- Trial name
- NCT00484133
- Testing
- Dopamine, dobutamine, enoximone
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Onze Lieve Vrouwe Gasthuis
Acute Renal Failure, SIRS
BK Virus and Renal Dysfunction in Postoperative/Posttraumatic Critically Ill Patients
The purpose of this study is to find out whether acute renal failure is associated with BK virus reactivation in postoperative/posttraumatic critically ill patients with severe SIRS/sepsis and shock.
- Conditions
- Acute Renal Failure, SIRS, Sepsis, Critically Ill
- Trial name
- BICUK (NCT00736827)
- Where
- Germany
- Volunteers
- 51 people
- Sponsor
- University of Ulm
Sepsis, Severe
Accuracy of Venous Excess Ultrasound (VEXUS) Score Versus Central Venous Pressure in Patients With Severe Sepsis
assessing septic patients with a noninvasive ultrasound protocol, and earlier identification of fluid overload to help clinicians decide whether to administer supplemental fluid therapy or suspend its administration and to…
- Trial name
- NCT06586931
- Volunteers
- 60 people
- Sponsor
- Minia University
Severe Sepsis, Septic Shock
Antibiotic Administration and Blood Culture Positivity in Severe Sepsis and Septic Shock
Sepsis is a significant cause health care expenditure and carries an extremely high rate of morbidity and mortality if not treated appropriately.
- Conditions
- Severe Sepsis, Septic Shock, Bacteremia
- Trial name
- NCT01867905
- Where
- 7 sites in United States, Canada
- Volunteers
- 330 people
- Sponsor
- University of British Columbia
Septic Shock
Therapeutic Plasma Exchange in Adult Patients With Severe Sepsis
The incidence of sepsis (severe infection) has increased over the last four decades. Severe sepsis and septic shock are among the leading causes of death for patients admitted to critical care units with mortality ranging from…
- Trial name
- NCT04057872
- Testing
- Therapeutic plasma exchange
- Where
- 2 sites in Canada
- Volunteers
- 17 people
- Sponsor
- Alberta Health Services, Calgary
Severe Sepsis, Septic Shock
Outcomes of Severe Sepsis Patients in Surgical Intensive Care Units
Retrospective review of the outcomes of severe sepsis patients in Surgical Intensive Care Unit of National Taiwan University Hospital from January 1, 2009 to December 31, 2011.
- Trial name
- NCT01919138
- Where
- Taiwan
- Volunteers
- 762 people
- Sponsor
- National Taiwan University Hospital
New Onset Atrial Fibrillation, Severe Sepsis
Use of Amiodarone in Atrial Fibrillation Associated With Severe Sepsis or Septic Shock
Purpose/Objectives: Severe sepsis and septic shock are a common cause of new onset atrial fibrillation (NOAF) in the intensive care unit. Development of NOAF in this setting can prolong length of stay and increase mortality.
- Conditions
- New Onset Atrial Fibrillation, Severe Sepsis, Septic Shock
- Trial name
- NCT02668432
- Testing
- Amiodarone
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Septic Shock, Sepsis, Severe
As an Early Indicator Biomarker of Prognosis and Mortality in Children With Sepsis and Septic Shock: suPAR
The sepsis and septic shock remain major causes of child morbidity and mortality, despite the use of modern antibiotics and resuscitation therapies.
- Trial name
- suPAR (NCT04459572)
- Testing
- suPAR
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Ege University
Shock, Surgical, Systemic Inflammatory Response Syndrome
Thromboelastography in in Patients With Sepsis
Methods: The study is an observational prospective trial that includes 150 patients 18 or older admitted to our icu because of severe sepsis or septic shock as defined by the American College of Chest Physicians/ Society of…
- Trial name
- NCT00994877
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Severe Sepsis
The Pilot Study of the Efficacy of Polymyxin-B Hemoperfusion in Critically Ill Patients With Severe Sepsis
This research project is a study to immunology changes in critically ill patients with severe sepsis by using Endotoxin Activity Assay (EAA) combined with Polymyxin-B Hemoperfusion.
- Trial name
- NCT02413541
- Testing
- Polymyxin-B Hemoperfusion, Standard treatment
- Where
- Thailand
- Volunteers
- 90 people
- Sponsor
- Chulalongkorn University
Major Trauma, Sepsis
Effect of Anti-inflammatory and Anti-microbial Co-supplementations in Traumatic ICU Patients at High Risk of Sepsis
The occurrence of sepsis in trauma patients is a very serious complication. Identifying trauma patients at high risk of sepsis was not revealed in the latest surviving sepsis campaign in 2016.
- Trial name
- DrNoha-ICU (NCT04216459)
- Testing
- oral lactobacillus probiotics plus intramuscular cholecalciferol, intravenous vitamin C plus thiamine
- Where
- Egypt
- Volunteers
- 112 people
- Sponsor
- Mansoura University
Sepsis, Septic Shock
Predictive algoRithm for EValuation and Intervention in SEpsis
In this prospective study, the ability of a machine learning algorithm to predict sepsis and influence clinical outcomes, will be investigated at Cabell Huntington Hospital (CHH).
- Conditions
- Sepsis, Septic Shock, Severe Sepsis
- Trial name
- PREVISE (NCT03235193)
- Testing
- Severe Sepsis Prediction, Severe Sepsis Detection
- Where
- United States
- Volunteers
- 2,296 people
- Sponsor
- Dascena
Severe Sepsis
Australasian Resuscitation In Sepsis Evaluation Randomised Controlled Trial
The ARISE RCT is a multi-centre, randomised, controlled trial of EGDT compared to standard care in patients with severe sepsis presenting to the ED.
- Trial name
- ARISE (NCT00975793)
- Testing
- Early Goal Directed Therapy (EGDT)
- Where
- 51 sites in Australia, Finland and 3 more
- Volunteers
- 1,600 people
- Sponsor
- Belinda Howe
Sepsis, Adrenal Insufficiency
Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsis
The purpose of this study is to determine if the combination of hydrocortisone plus fludrocortisone is more efficacious than hydrocortisone alone in treating adrenal insufficiency in severe sepsis.
- Trial name
- NCT00368381
- Testing
- Hydrocortisone, Fludrocortisone
- Sponsor
- CAMC Health System
Infection, Bacterial, Infection Prevention
Optimising Kangaroo Care to Reduce Neonatal Severe Infection/Sepsis and Resistant Bacterial Colonisation Among High-risk Infants in NICU.
NeoDeco is a pragmatic, multicenter, parallel-group, cluster-randomised hybrid effectiveness-implementation trial designed to evaluate the impact of implementing optimised Kangaroo Care (KC) at the unit level compared to standard…
- Trial name
- NeoDeco (NCT05993442)
- Testing
- Optimised kangaroo care
- Where
- 24 sites in Greece, Italy and 3 more
- Volunteers
- 3,080 people
- Sponsor
- PENTA Foundation