Clinical trials: Sepsis, completed
Sepsis, Bacterial Infections
Unfractioned Heparin for Treatment of Sepsis
The purpose of this study is to determine whether low dose continuous infusion of unfractioned heparin (500 units/hour), in addition to the standard treatment, is efficacious as complementary therapy for sepsis patients.
- Trial name
- NCT00100308
- Testing
- Unfractioned heparin, saline
- Where
- Colombia
- Volunteers
- 319 people
- Sponsor
- Universidad de Antioquia
Systemic Inflammatory Response Syndrome
Effects of Free Fatty Acids and 3-hydroxybutyrate on Protein, Glucose, Lipid Metabolism and Intracellular Signals.
The investigators hypothesize that the investigators can detect protein-sparing effects of administration of the ketone 3-hydroxybutyrate and free fatty acids during simulation of an acute inflammatory disease.
- Trial name
- NCT01752348
- Testing
- Endotoxin, US standard reference E.coli
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Sepsis, Septic Shock
Comparing Blood-Based Ratios for Predicting Outcomes in Sepsis and Septic Shock
Sepsis and septic shock are serious conditions associated with a high risk of organ dysfunction and death. Simple laboratory-based markers may help identify critically ill patients who are at greater risk of poor outcomes.
- Trial name
- NCT07819708
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Benha University
Septic Shock
Proadrenomedullin and Copeptin in Patients With Septic Shock
This study evaluates the usefulness of pro-adrenomedullin (precursor of a vasodilatory peptide involved in septic shock pathogenesis) and copeptin (a stable peptide of the arginine vasopressin precursor) to predict, at the moment…
- Trial name
- proADM (NCT03104933)
- Where
- Spain
- Volunteers
- 103 people
- Sponsor
- Spanish Network for Research in Infectious Diseases
Tuberculosis, HIV I Infection
Early Empiric Anti-Mycobacterium Tuberculosis Therapy for Sepsis in Sub-Saharan Africa
In sub-Saharan Africa, tuberculosis (TB) is the etiology of 25-50% of bloodstream infections (BSIs) and the leading cause of sepsis among people living with HIV.
- Conditions
- Tuberculosis, HIV I Infection, Sepsis
- Trial name
- ATLAS (NCT04618198)
- Testing
- Immediate anti-TB therapy, Sepsis-specific dose anti-TB therapy
- Where
- 2 sites in Tanzania, Uganda
- Volunteers
- 437 people
- Sponsor
- University of Virginia
Sepsis, Infection
Evaluation of the Heparin Binding Protein Levels in Sepsis
Present criteria used to define sepsis are non-specific, making it difficult to both distinguish sepsis from other diseases and to predict which patients are likely to become more severely ill.
- Conditions
- Sepsis, Infection, Septic Shock
- Trial name
- HBP (NCT02533011)
- Testing
- HBP lab test
- Where
- United States
- Volunteers
- 1,055 people
- Sponsor
- Christiana Care Health Services
Peritonitis, Sepsis
The Value of PSP in Predicting Outcome in ICU Surgical Peritonitis Patients
The purpose of this study is to determine the diagnostic accuracy of Pancreatic Stone Protein (PSP) in predicting patient outcomes with suspected peritonitis in the Intensive Care Unit after abdominal surgery and compare PPS with…
- Conditions
- Peritonitis, Sepsis, Multiple Organ Failure, Death
- Trial name
- NCT01465711
- Testing
- All abdominal surgical procedures, Intubation, Imaging
- Where
- Germany
- Volunteers
- 137 people
- Sponsor
- University of Magdeburg
Obstetric Labor Complications, Post-partum Hemorrhage
Improving Maternal and Child Health in India: Evaluating Demand and Supply Side Strategies (IMATCHINE)
The study evaluates the impact of a new conditional cash transfer (CCT) program (Thayi Bhagya Yojana) to promote child birth in obstetric facilities in the state of Karnataka, India in order to determine its policy value and to…
- Conditions
- Obstetric Labor Complications, Post-partum Hemorrhage, Sepsis, Pre-eclampsia
- Trial name
- IMATCHINE (NCT01480544)
- Testing
- Experimental: Treatment 1, Experimental: Treatment 2
- Where
- India
- Volunteers
- 14,990 people
- Sponsor
- Duke University
Sepsis
Pulse Photoplethysmography as an Early Tool for the Diagnosis of Sepsis
Early management of sepsis is associated with better outcome. However, this requires early recognition of the sepsis host. One recently developed customized pulse photoplethysmography (PPG) device manages to measure nitric oxide…
- Trial name
- PROUD-1 (NCT04149132)
- Testing
- pulse photoplethysmography (PPG), Measurements of nitric oxide (NO) and malondialdehyde (MDA)
- Where
- 4 sites in Greece
- Volunteers
- 200 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Septic Shock
Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis
Multicenter, prospective, phase 3 randomized non-blinded interventional trial of fluid treatment strategies in the first 24 hours for patients with sepsis-induced hypotension.
- Trial name
- CLOVERS (NCT03434028)
- Testing
- Early Vasopressors, Early Fluids
- Where
- 50 sites in United States
- Volunteers
- 1,563 people
- Sponsor
- Massachusetts General Hospital
Sepsis
Changes in Exhaled 13CO2/12CO2 Breath Delta Value as an Early Indicator of Infection in ICU Patients
Carbon-12 and carbon-13 are naturally-abundant isotopes in exhaled breath carbon dioxide. The ratio of carbon-13 to carbon-12 in exhaled breath is known as the breath delta value (BDV).
- Trial name
- NCT02327130
- Testing
- Isomark Canary™
- Where
- 6 sites in United States
- Volunteers
- 32 people
- Sponsor
- Isomark, LLC
Sepsis
Evaluation of Serum Procalcitonin in Critically Ill Patients With Suspected Sepsis
Procalcitonin is a promising marker of sepsis in critically ill patients. Procalcitonin have better diagnostic accuracy compared to White blood cell count and C - reactive protein.
- Trial name
- NCT03506152
- Testing
- Serum Procalcitonin
- Where
- Pakistan
- Volunteers
- 103 people
- Sponsor
- Aga Khan University
Birth Asphyxia, Very Low Birth Weight Baby
Naushero Feroze Neonatal Survival Project
The present study will be carried out in close collaboration with the National Program for Lady Health Workers, a Ministry of Health program with 100,000 Lady Health Workers covering 60% of the rural population of Pakistan.
- Conditions
- Birth Asphyxia, Very Low Birth Weight Baby, Neonatal Sepsis
- Trial name
- AKU (NCT01350765)
- Testing
- Intervention, Control
- Where
- Pakistan
- Volunteers
- 37,201 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Sepsis, Septic Shock
Intravenously Administered M6229 in Critically Ill Sepsis Patients
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Mortality is high and survivors frequently suffer from long-term sequelae.
- Conditions
- Sepsis, Septic Shock, Critical Illness
- Trial name
- HistoSeps (NCT05208112)
- Testing
- M6229
- Where
- 2 sites in Netherlands
- Volunteers
- 10 people
- Sponsor
- A.P.J. Vlaar
Catheter-related Bloodstream Infection
Reducing Catheter-Related Bloodstream Infections in the ICU With a Chlorhexidine-Impregnated Sponge (BIOPATCH)
We proposed to perform a prospective randomized controlled trial to study the effect of the use of a commercially-available chlorhexidine-impregnated sponge (Biopatch) as part of central venous catheter care on catheter-related…
- Trial name
- NCT00548132
- Testing
- Chlorhexidine-impregnated foam dressing
- Where
- United States
- Volunteers
- 1,088 people
- Sponsor
- Washington University School of Medicine
Septic Shock, Acute Kidney Injury
Norepinephrine / Vasopressin Combination for Resuscitation in Septic Shock
Although norepinephrine is commonly used and is the recommended agent for the treatment of hypotension in volume-resuscitated hyperdynamic septic shock, Low doses of vasopressin may be added to norepinephrine to maintain arterial…
- Trial name
- NCT04302584
- Testing
- norepinephrine / Vasopressin
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Bacteremia, Catheter-Related Infections
Evaluation of Bacteremia Epidemiology During the COVID Period in One French University Hospital
The main objective of this retrospective cohort is to evaluate the impact of the first epidemic wave during lockdown on bacteremia epidemiology in one French University Hospital.
- Trial name
- NCT05640349
- Testing
- Positive blood culture
- Where
- France
- Volunteers
- 4,200 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Sepsis, Necrotizing Enterocolitis
Effect of Vitamin A in the Treatment of Neonatal Sepsis and Necrotizing Enterocolitis
The purpose of the study is to determine whether vitamin A can improve survival and facilitate recovery from sepsis and necrotizing enterocolitis in hospitalized neonates.
- Conditions
- Sepsis, Necrotizing Enterocolitis, Meningitis, Pneumonia
- Trial name
- NCT00707785
- Testing
- Vitamin A
- Where
- Bangladesh
- Volunteers
- 424 people
- Sponsor
- Johns Hopkins University
Infection, Sepsis
Proadrenomedullin and Microcirculation in Monitoring Organ Dysfunction in Patient With Infection
This study evaluates the association between plasmatic levels of Mid Regional Proadrenomedullin (MR-proADM) and the sublingual microcirculation in critical care patients admitted with infection, sepsis or septic shock.
- Conditions
- Infection, Sepsis, Septic Shock
- Trial name
- NCT03931967
- Testing
- MR-proADM
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Università Politecnica delle Marche
Septic Shock
Comparison of Radial and Femoral Artery Site Invasive Blood Pressure Measurement in Septic Shock Patients
Inaccurate monitoring of mean arterial pressure (MAP) could lead to improper treatment in the form of excessive fluid infusion or unnecessary vasopressor therapy; therefore, accurate hemodynamic monitoring is crucial in treatment…
- Trial name
- NCT03475667
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
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