Clinical trials: Sepsis, completed
Septic Shock
Impact of Midodrine Administration on the Clinical Outcome of Septic Shock Patients
1. Assess the impact of midodrine administration on weaning of IV vasopressors 2. Assess the cost effectiveness of using midodrine in critically ill patients
- Trial name
- NCT03911817
- Testing
- Midodrine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Septic Shock
Adjunctive Methylene Blue in Septic Shock
Adjunctive Methylene BLUe in Septic SHock (BLUSH) is a single centre concealed-allocation parallel-group open-label randomized controlled pilot trial to ascertain the feasibility of a trial evaluating the efficacy and safety of…
- Trial name
- BLUSH (NCT06900140)
- Testing
- Methylene Blue, Usual Care
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Dr. Shannon M. Fernando
Candidemia, Invasive Candidiasis
Non-Conventional Microbiological Methods in the Diagnosis of Candidemia
This study evaluates the diagnostic value of non-conventional microbiological methods for early detection of candidemia and invasive candidiasis in adult hospitalized patients with suspected invasive fungal infection.
- Trial name
- NCT07422155
- Testing
- Candida Diagnostic Testing Panel
- Where
- Slovenia
- Volunteers
- 2 people
- Sponsor
- Institute of Oncology Ljubljana
Septic Shock
Hydrocortisone 50 mg Every 6 Hours Compared to Hydrocortisone 300 mg Per Day in Treatment of Septic Shock.
We performed a multicenter, prospective, randomized, double-blind, pilot study in four adult medical intensive care units. Patients presenting septic shock were rapidly administered one of two regimens of hydrocortisone, either a…
- Trial name
- HSHC00582434 (NCT02768740)
- Testing
- Hydrocortisone hemisuccinate
- Volunteers
- 120 people
- Sponsor
- Association Niçoise de Réanimation Médicale
HIV Infections
The Anti-HIV Effects of Saquinavir Soft Gelatin Capsules Versus Indinavir in Patients Who Have Used Saquinavir Hard Gelatin Capsules for One Year
To determine, in HIV-infected patients, whether switching to a new soft gelatin capsule formulation of saquinavir or to indinavir following prolonged use of the original hard capsule formulation of saquinavir results in an acute…
- Trial name
- NCT00000848
- Testing
- Indinavir sulfate, Saquinavir
- Where
- 16 sites in United States
- Volunteers
- 144 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Abdominal Sepsis
Assessment of Peritoneal Immune Response in Patients With Severe Intra-abdominal Sepsis Managed With Laparostomy and Vacuum Assisted Closure (VAC)
Protocol Synopsis Protocol title: Assessment of peritoneal immune response in patients with severe intra-abdominal sepsis managed by laparostomy and VAC Purpose: Assessment of peritoneal immune response in patients with severe…
- Trial name
- NCT01410526
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aristotle University Of Thessaloniki
Neonatal Sepsis
Distribution of Haptoglobin Phenotype in Septic and Non Septic Pre-term Neonates (PTSH)
The Haptoglobin (Hp) gene locus at chromosome 16q22 is polymorphic with two alleles denoted 1 and 2 .The gene product exists in three phenotypes: 1-1, 2-1, and 2-2.
- Trial name
- NCT00800449
- Where
- Israel
- Volunteers
- 133 people
- Sponsor
- Irina Kessel
Sepsis
Adjunctive Granisetron Therapy in Patients With Sepsis or Septic Shock
In this prospective, single-center,randomized,controlled,single-blind clinical trial,Patients will be randomly assigned to receive granisetron or placebo for 4 days or until leaving the ICU(death or transfer from ICU to general…
- Trial name
- GRANTISS (NCT03924518)
- Testing
- Granisetron Hydrochloride
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Zhujiang Hospital
Sepsis
Neutropenic Fever, Inflammatory Markers and Sepsis in Haematological Patients
The aim of this study is to find out whether inflammation markers including cardiac markers have predictive value in evaluation of pathogenesis of sepsis in neutropenic haematological patients.
- Trial name
- NCT00781040
- Testing
- Severe sepsis vs. non-severe sepsis
- Where
- 2 sites in Finland
- Volunteers
- 273 people
- Sponsor
- Kuopio University Hospital
Bacteremia, Septicemia
Diagnosis of Bacteremia/Septicemia and Culture Negative Endocarditis by the Karius Sequencing-Based Infectious Disease Diagnostic Assay
Prospective study at Duke University Hospital comparing the Karius Infectious Disease Diagnostic Sequencing Assay to blood culture results in admitted patients with bacteremia/septicemia.
- Trial name
- NCT02988414
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Karius, Inc.
Catheter-Related Infections, Central Venous Catheters
Advanced Dressings for CVC Infection Prevention in PICU
Randomised, single-blind clinical trial comparing chlorhexidine gluconate-impregnated transparent dressings versus conventional transparent dressings in the prevention of central venous catheter-related bloodstream infections…
- Conditions
- Catheter-Related Infections, Central Venous Catheters, Bloodstream Infection, Pediatric Intensive Care Units
- Trial name
- NCT07175116
- Testing
- 3M™ Tegaderm™ Antimicrobial Transparent Dressing (chlorhexidine gluconate-impregnated), Conventional transparent polyurethane dressing
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- University of Seville
Sepsis
Dynamic Arterial Elastance as a Predictor of Arterial Blood Pressure Response to Fluid Administration in Septic Patients
Correction of arterial hypotension is essential for adequate cellular metabolism. maintaining MAP above a minimum level has been recommended in order to prevent further tissue hypoperfusion and organ dysfunction.Functional…
- Trial name
- NCT03179215
- Testing
- fluid challange
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Cairo University
Septic Shock, Peritonitis
Pharmacokinetic Study on Echinocandins for Patients With Septic Shock Following Secondary Peritonitis (EPI Study)
The main objective of this study is to describe the pharmacokinetics of the prescribed echinocandins for septic shock with secondary peritonitis for which intra-abdominal fungal infection is suspected or proven.
- Trial name
- NCT02805049
- Testing
- Echinocandins
- Where
- 2 sites in Australia, France
- Volunteers
- 24 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Sepsis at Intensive Care Unit
Validation of a Urinary Biomarker as Diagnostic Tool for AKI in Sepsis
BACKGROUND: Early diagnosis and prognostication of acute kidney injury in patients with sepsis is key to further our understanding this disease and in the evaluation of new interventions for this condition.
- Trial name
- NCT01981993
- Testing
- Urinary proteomic analysis
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- University Hospital, Ghent
Sepsis, Immunosuppression
Expression and the Clinical Significance of Neutrophil PD-L1 During Sepsis
Immunosuppression is the leading cause of death in septic patients. Neutrophils are classical components of innate immunology, but recent studies showed that neutrophils might display antigen presenting function and inhibit…
- Trial name
- NCT01976884
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Sepsis
Sepsis Alert Routine Implementation in the Emergency Department
This study evaluates the impact of a structured sepsis alert routine, that has been implemented in the Emergency Department (ED) of Karolinska University Hospital Huddinge, Sweden.
- Trial name
- SARIED (NCT07020598)
- Volunteers
- 3,389 people
- Sponsor
- Region Stockholm
Sepsis, Severe Sepsis
Implementation and Evaluations of Sepsis Watch
The purpose of this study is to study the implementation and impact of an early warning system to detect and treat sepsis in the emergency room.
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT03655626
- Testing
- Sepsis Watch
- Where
- United States
- Volunteers
- 32,003 people
- Sponsor
- Duke University
COPD, Congestive Heart Failure
Use of Non Invasive Hemodynamic Cardiovascular Monitoring to Evaluate Emergency Department Patients
This study is an observational prospective pilot trial that utilizes finger cuff non invasive hemodynamic monitoring (NexfinHD Monitor) to assess 4 different groups (CHF/COPD, Trauma, Sepsis, Stroke) of patients on arrival to the…
- Conditions
- COPD, Congestive Heart Failure, Trauma, Sepsis
- Trial name
- NCT00851214
- Testing
- NexfinHD Monitor
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Henry Ford Health System
Sepsis, Severe Sepsis
Prehospital Antibiotics Against Sepsis Trial
Sepsis is one of the most frequent reasons for referral to emergency departments (EDs) worldwide. The incidence of sepsis is likely to rise in the upcoming years.
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- PHANTASi (NCT01988428)
- Testing
- Ceftriaxone 2000 mg
- Where
- 34 sites in Netherlands
- Volunteers
- 2,672 people
- Sponsor
- Amsterdam UMC, location VUmc
Acinetobacter Infections
Clinical Outcomes and Global Epidemiology -Data Coordinating Center
The primary objective is to assess for independent predictors of in-hospital mortality (up to 28 days) in patients with Acinetobacter bloodstream infection.
- Trial name
- NCT00524563
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Pittsburgh
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