Clinical trials: Sepsis, completed
Norepinephrine, Sepsis
The Impact of Early Norepinephrine Administration on Outcomes of Patients With Sepsis-induced Hypotension
Septic shock is defined as sepsis with persistent hypotension requiring vasopressors to maintain mean arterial pressure (MAP)≥ 65 mmHg and a serum lactate level of > 2 mmol/L (18 mg/dL) despite sufficient volume resuscitation .
- Conditions
- Norepinephrine, Sepsis, Hypotension
- Trial name
- NCT05774054
- Testing
- Crystalloid, noradrenaline
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Tanta University
Trauma Injury, Major Abdominal Surgery
Bolus Versus Continuous Enteral Tube Feeding
Stress metabolisms induced by severe trauma, large abdominal surgery procedures, sepsis, etc. leads to metabolic changes, which increase energy expenditure, enhanced protein catabolism, insulin resistance.
- Conditions
- Trauma Injury, Major Abdominal Surgery, Sepsis
- Trial name
- NCT04080479
- Testing
- Quadriceps Muscle Layer Fitness, Muscle Strength, Acute Physiology and Chronic Health Evaluation
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- University Hospital Ostrava
Kidney Calculi, Urinary Tract Infections
Do Dynamic Urinary Leukocyte and Nitrite Changes Improve Risk Prediction for Infectious Complications Following PCNL?
Background Percutaneous nephrolithotomy (PCNL) is widely recognized as the primary surgical approach for managing sizable and anatomically complex kidney stones., yet postoperative infection-related complications remain common…
- Conditions
- Kidney Calculi, Urinary Tract Infections, Sepsis
- Trial name
- NCT07238673
- Where
- China
- Volunteers
- 346 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Endotoxemia
The Effects of Acetylsalicylic Acid on Immunoparalysis Following Human Endotoxemia
Rationale: The last years, research focus has moved to immunostimulatory agents in order to restore or increase the functionality of the immune system during sepsis-induced immunoparalysis.
- Trial name
- SALYCENDO (NCT02922673)
- Testing
- Aspirin
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Magnesium Sulfate, Pregnancy; Pre-Eclampsia
The Effect of Magnesium Use in Reversal of Neuromuscular Block With Sugammadex
Magnesium therapy used for seizure prophylaxis in patients with preeclampsia. Magnesium has been shown to prolong the effect of nondepolarizing neuromuscular blocking agents (NMBA) and neostigmine used to reverse the effect of…
- Conditions
- Magnesium Sulfate, Pregnancy; Pre-Eclampsia, Neuromuscular Blockade
- Trial name
- NCT05558969
- Testing
- pregnant women taking magnesium
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Eskisehir Osmangazi University
Sepsis, Septic
Evaluation of the Clinical Relationship Between Procalcitonin Level and Bacteremia Agent in Intensive Care Unit Patients
In intensive care units, sepsis, which can be defined as bacteremia and the irregular and uncontrolled inflammatory response to it, is one of the most important causes of mortality.
- Conditions
- Sepsis, Septic, Bacteremia and Sepsis, Intensive Care Medicine
- Trial name
- NCT06958354
- Where
- Turkey (Türkiye)
- Volunteers
- 1,529 people
- Sponsor
- Gulhane Training and Research Hospital
Critical-Illness, Polyneuropathy
Neurological Outcome in Surgical and Non-surgical Septic Patients
Systemic inflammation and sepsis cause multi organ failure including severe neurologic impairment in the course of disease. Neurologic failure typically presents as critical-illness-polyneuropathy/-myopathy and septic…
- Conditions
- Critical-Illness, Polyneuropathy, Myopathy, Septic Encephalopathy
- Trial name
- NOSEPP (NCT02442986)
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- University of Rostock
Candidemia, Invasive Candidiasis
CRITIC - Treatment of Candidemia and Invasive Candidiasis
Patients will receive 2mg/kg/day IV daily administration of AmBisome® over 30-60 minutes as a reaction to signs/symptoms and positive Candida culture
- Trial name
- CRITIC (NCT00670657)
- Testing
- AmBisome
- Where
- Italy
- Volunteers
- 39 people
- Sponsor
- Gilead Sciences
Invasive Fungal Infections
Non-interventional Study for Prevention and Treatment of Fungal Infections in Paediatric Patients in Asia/Oceania - ERADICATE Study
The aim of the study is to prospectively evaluate the safety and efficacy of micafungin when prescribed for prophylaxis or treatment of fungal infections in different real-world clinical conditions and centers, in pediatric…
- Trial name
- NCT03174457
- Testing
- Micafungin
- Where
- 16 sites in Hong Kong, Singapore and 3 more
- Volunteers
- 120 people
- Sponsor
- Astellas Pharma Singapore Pte. Ltd.
Critical Illness, Sepsis
Does GM-CSF Restore Neutrophil Phagocytosis in Critical Illness?
Despite the introduction of multiple preventative measures rates of hospital acquired infection in the intensive care unit remain high. New approaches to tackling this problem are required.
- Conditions
- Critical Illness, Sepsis, Immuno-suppression
- Trial name
- GMCSF (NCT01653665)
- Testing
- Leukine, Normal Saline
- Where
- 4 sites in United Kingdom
- Volunteers
- 64 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Platelet Abnormality, Renal Failure
Hemogram Parameter Changes With Sepsis Filter
Hemodiafiltration is initiated in hemodynamically unstable patients in intensive care units. In some patients, additional devices called cytokine filters or sepsis filters are added to remove inflammatory cytokines.
- Conditions
- Platelet Abnormality, Renal Failure, Immune System Disorder
- Trial name
- NCT06948630
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people
- Sponsor
- Samsun University
Antibiotic Stewardship
The DETOURS Trial: De-escalating Empiric Treatment: Opting Out of Rx for Selected Patients With Suspected Sepsis - Opt-Out Protocol Trial
The objective of this study is to implement an opt-out protocol to guide appropriate de-escalation of antibiotics in qualifying patients.
- Trial name
- NCT03517007
- Testing
- Opt-Out Protocol
- Where
- 10 sites in United States
- Volunteers
- 762 people
- Sponsor
- Duke University
Obstruction, Cancer
Intravenous Nutrition in Hospitalized Patients: Comparison of Two Oils
Intravenous nutrition is an important therapy for the recovery of many patients. It is indicated when the patients cannot take food by mouth or use their intestines for feeding.
- Conditions
- Obstruction, Cancer, Ileus, Malnutrition
- Trial name
- NCT01943409
- Testing
- Intralipid, ClinOleic
- Where
- Canada
- Volunteers
- 303 people
- Sponsor
- Johane Allard
Septic Shock, Resuscitation
The Effect Of Resuscitation Guided By Two Different Dynamic Parameters On Time To Normalization Of The Capillary Refill Time In Adult Patients With Septic Shock
The aim of this study is to compare the effect of resuscitation guided by Left ventricular outflow tract-velocity time integral (LVOT-VTI) variation versus the effect of resuscitation guided by inferior vena cava (IVC) variation…
- Trial name
- NCT06122909
- Testing
- Group VTI, Group IVC
- Where
- 2 sites in Egypt
- Volunteers
- 90 people
- Sponsor
- Kasr El Aini Hospital
Late Onset Neonatal Sepsis, Necrotising Enterocolitis
Lactoferrin Prophylaxis in VLBW and Regulator T-cells
The aim of the study is to evaluate whether oral administration of 200 mg/day lactoferrin (LF) to very low birth weight infants reduces late onset sepsis and necrotising enterocolitis and the effect of LF on regulatory T cells.
- Conditions
- Late Onset Neonatal Sepsis, Necrotising Enterocolitis, Very Low Birth Weight Infants
- Trial name
- NCT01287507
- Testing
- Lactoferrin (bovine origin)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara University
Systemic Inflammatory Response Syndrome
Endothelial Microparticles as a Biomarker for Diagnosis and Prognosis in Early Sepsis
Sepsis is a major global health problem, leading to substantial morbidity and mortality despite medical care. The initial diagnosis of sepsis is a clinical challenge, as it is based on nonspecific systemic criteria.
- Trial name
- NCT01998139
- Where
- 2 sites in United States, Qatar
- Volunteers
- 137 people
- Sponsor
- Weill Medical College of Cornell University
Sepsis
TELEmedicine as an Intervention for Sepsis in Emergency Departments
Sepsis is a life-threatening condition that has doubled in incidence over the past decade, and timely aggressive medical intervention has been shown to save lives.
- Trial name
- TELEvISED (NCT04441944)
- Testing
- Telemedicine
- Where
- United States
- Volunteers
- 1,191 people
- Sponsor
- University of Iowa
Candida Sepsis, Candidiasis, Invasive
Early Identification of Candida in Intra-abdominal Candidiasis
Intra-abdominal candidiasis remains the first origin of invasive candidiasis in critically ill patients with a mortality up to 60%. This high mortality is partly related to delay of anti-fungal treatment administration.
- Conditions
- Candida Sepsis, Candidiasis, Invasive, Peritonitis Infectious, Critically Ill
- Trial name
- ICCA (NCT05264571)
- Testing
- calscreener, Metabolic profile, optical microscopy
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Central Hospital, Nancy, France
Meningitis, Septicemia
Understanding the Immune Response to Meningitis Vaccines
The purpose of the study is to evaluate and compare the immune response to two vaccines against 4 related bacteria: meningococcal serogroups A, C, W-135 and Y.
- Trial name
- NCT00901940
- Testing
- Meningococcal (Groups A, C, Y and W-135) Conjugate, Meningococcal polysaccharide A, C, Y and W135 and Menveo
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Preterm Birth, Low Birth Weight
Perinatal Conditions Influencing Morbidity, Mortality, and Medical Care in Newborns
This study focuses on understanding the conditions that affect newborn health and survival from pregnancy to the first weeks of life at the Isidro Ayora Hospital.
- Conditions
- Preterm Birth, Low Birth Weight, Intrauterine Growth Restriction (IUGR), Perinatal Asphyxia
- Trial name
- UCE (NCT06653374)
- Testing
- Infant, Premature
- Where
- Ecuador
- Volunteers
- 26,000 people
- Sponsor
- HOSPITAL GINECO OBSTETRICO ISIDRO AYORA
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.