Clinical trials: Sepsis, completed
Disability, Physical Activity
Actigraphy to MEasuRe Intensive Care Unit Activity
This study is to determine whether accelerometry can be used to measure physical activity occurring during routine clinical care in a diverse population of patients with medical or surgical critical illness.
- Conditions
- Disability, Physical Activity, Aging, Critical Illness
- Trial name
- AMERICA (NCT02263716)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Vanderbilt University
Staphylococcus Haemolyticus, Staphylococcal Infections
Staphylococcus Haemolyticus in the Neonatal Intensive Care Unit of CHSD in 2023: Analysis and Trends
This study looks at cases of Staphylococcus haemolyticus infections in newborns hospitalized in the Neonatal Intensive Care Unit (NICU) at the Saint-Denis Hospital in 2023.
- Conditions
- Staphylococcus Haemolyticus, Staphylococcal Infections, Sepsis, Catheter-Related Infections
- Trial name
- NCT07013864
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Centre Hospitalier de Saint-Denis
S. Aureus Bloodstream Infection
Collect Clinical Data in Chinese Patients Received CUBICIN Treatment for Actual Usage in Clinical Practice
This is a Multicenter, observational, non-interventional registry designed to collect clinical data in Chinese patients who have received CUBICIN treatment under condition of actual usage in clinical practice.
- Trial name
- NCT01212601
- Where
- 18 sites in China
- Volunteers
- 203 people
- Sponsor
- AstraZeneca
Sepsis, Thiamine Deficiency
Effect of Thiamine on Serum Glucagon And Reactive Oxygen Species (ROS)
This research is a clinical trial with a Randomized Controlled Trial (RCT) design. The purpose is to identify the effect of intravenous thiamine administration compared to normal saline placebo on glucagon levels and ROS levels…
- Trial name
- NCT05663164
- Testing
- Vitamin B
- Where
- Indonesia
- Volunteers
- 30 people
- Sponsor
- Universitas Sumatera Utara
Sepsis, Respiratory Failure
Study of Sedative Medications in Patients With Severe Infection and Respiratory Failure
Patients with infections in their blood often become very sick. These patients are usually put in an intensive care unit for careful observation and treatment.
- Conditions
- Sepsis, Respiratory Failure, Agitation
- Trial name
- PRO-DEFENSE (NCT02203019)
- Testing
- Propofol, Dexmedetomidine, Fentanyl
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Texas Tech University Health Sciences Center
Septic Shock
ALBumin Italian Outcome Septic Shock-BALANCED Trial (ALBIOSS-BALANCED)
Septic shock is a devastating condition often observed in ICU. It is characterized by pro-inflammatory and immune responses, organ failures, high incidence of AKI and lethality.
- Trial name
- ALBIOSS-BAL (NCT03654001)
- Testing
- Albumin, Balanced
- Where
- 37 sites in Italy
- Volunteers
- 1,319 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Septic Shock
Hypotension in the Weaning From Vasopressor Drugs
Although there is consensus in the literature on hemodynamic management of septic shock in the resuscitation phase, the best way to conduct the weaning of vasopressor drugs in the stabilization phase remains open.
- Trial name
- RENOVA (NCT05506319)
- Testing
- Norepinephrine, Vasopressin
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- Hospital Nossa Senhora da Conceicao
Sepsis and Septic Shock
The Prognostic Impact of Right Ventricular Systolic Dysfunction on the Survival of Patients With Sepsis and Septic Shock
This study sought to evaluate the association of right ventricular systolic dysfunction and 28-day in-hospital mortality in patients with sepsis and septic shock.
- Trial name
- NCT06193109
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Burapha University
Sepsis at Intensive Care Unit
Validation of a Urinary Biomarker as Diagnostic Tool for AKI in Sepsis
BACKGROUND: Early diagnosis and prognostication of acute kidney injury in patients with sepsis is key to further our understanding this disease and in the evaluation of new interventions for this condition.
- Trial name
- NCT01981993
- Testing
- Urinary proteomic analysis
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- University Hospital, Ghent
Coronavirus Infection, Sepsis
Annexin A5 in Patients With Severe COVID-19 Disease
Randomized, double-blind, placebo-controlled trial comparing 2 doses of SY-005 (recombinant human Annexin A5) to placebo in patients with severe coronavirus 2019 disease in a single hospital centre with 2 intensive care units
- Trial name
- AX-COVID (NCT04748757)
- Testing
- recombinant human annexin A5
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Fluid and Electrolyte Imbalance
Volume Kinetics of Fluid Resuscitation in Early Sepsis
The recommended volume resuscitation for patients with early sepsis-induced hypoperfusion is at least 30 ml/kg of crystalloid administered within the first three hours.
- Trial name
- NCT06499701
- Testing
- Ringer's Lactate
- Where
- 2 sites in Romania
- Volunteers
- 13 people
- Sponsor
- Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu
Sepsis, Severe Infection
Evaluation of Monocyte Volume Distribution Width (MDW) for Early Detection of Sepsis
The measurement of monocyte volume width distribution (MDW) is intended for use with adult patients presenting to the emergency department (ED), where a CBC with Differential has been ordered, as an aid in the early detection of…
- Trial name
- MDW (NCT03145428)
- Testing
- CBC-Diff Monocyte volume width distribution (MDW)
- Where
- 3 sites in United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Beckman Coulter, Inc.
Severe Septic Syndrome (Severe Sepsis and Septic Shock) Diagnosed and Treated by Mobile Intensive Care Unit
Samu Save Sepsis: Early Goal Directed Therapy in Pre Hospital Care of Patients With Severe Sepsis and/or Septic Shock
The purpose of this study is to determine whether an aggressive strategy of severe sepsis patients since pre hospital care, including early antibiotics administration, hemodynamic optimization, and opotherapy when indicated…
- Trial name
- SSS (NCT02473263)
- Testing
- Ceftriaxone, Piperacillin tazobactam, Norepinephrine
- Where
- France
- Volunteers
- 398 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis, Endotoxemia, Immunosuppression
The Effects of Human Endotoxemia on Functional Capacity of Hematopoietic Stem and Progenitor Cells
We will investigate whether human endotoxemia induces changes in human bone marrow cells and their downstream effector cells. To comprehensively investigate underlying mechanisms behind functional and transcriptional changes in…
- Trial name
- LPS-BM (NCT05570643)
- Testing
- LPS
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Septic Shock
Methylene Blue in Early Septic Shock
Septic shock is a subset of sepsis characterized by a decrease in vascular tone, which contributes to impaired regional blood flow distribution, and leads to organic failure.
- Trial name
- SHOCKEM-Blue (NCT04446871)
- Testing
- 0.9% sodium chloride, Methylene Blue
- Where
- Mexico
- Volunteers
- 91 people
- Sponsor
- Hospital Civil de Guadalajara
Hemodialysis
HeRO Vascular Access Device Bacteremia Study
The purpose of this study is to compare the safety and effectiveness of the HeRO Vascular Access Device in access challenged (e.g., catheter-dependent) hemodialysis patients.
- Trial name
- NCT00889564
- Testing
- HeRO Vascular Access Device
- Where
- 7 sites in United States
- Volunteers
- 38 people
- Sponsor
- Merit Medical Systems, Inc.
Bacteremia, Gram-Negative Bacterial Infections
Impact of Continuous Venovenous Haemofiltration on Organ Failure During the Early Phase of Severe Sepsis
The impact of continuous veno-venous haemofiltration (CVVH) on sepsis-induced multiple organ failure severity is controversial. We thus sought to assess the effect of early application of haemofiltration on the degree of organ…
- Conditions
- Bacteremia, Gram-Negative Bacterial Infections, Gram-Positive Bacterial Infections, Pneumonia, Bacterial
- Trial name
- NCT00406198
- Testing
- venovenous hemofiltration
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Hopital Lariboisière
Critical Illness, Acute Respiratory Distress Syndrome
TelePORT Pilot Study
Although more than 50% of survivors of critical illness experience one or more post-intensive care syndrome (PICS) problems, there are still no validated interventions for the management of PICS.
- Conditions
- Critical Illness, Acute Respiratory Distress Syndrome, Septic Shock
- Trial name
- TelePORT (NCT03926533)
- Testing
- Telehealth
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Vanderbilt University
Sepsis
Antimicrobial Stewardship Reduces MDRO Isolates in Critically Ill Patients
Antimicrobial exposure is known to reduce the selection for various drug-resistant organisms. Numerous studies have demonstrated the association between antimicrobial use and MDR bacteria detection.
- Trial name
- NCT02128399
- Volunteers
- 978 people
- Sponsor
- Jianfeng Xie
Sepsis
SHOCK US STUDY: Fluid Responsiveness in Sepsis Measured by Ultrasonography
The study aim is to examine point-of-care ultrasound findings, reliability, and ease of performance in association with fluid responsiveness for patients with severe sepsis and septic shock.
- Trial name
- NCT02170233
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Yale University
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