Clinical trials: Sepsis Associated Encephalopathy
Sepsis-Associated Encephalopathy
Role of MSCT Volumetry in Assessment of Brain Atrophy in Septic Patients
assessment of brain atrophy associated with septic ICU patients by using MSCT Volumetry
- Trial name
- NCT06112119
- Testing
- MSCT
- Volunteers
- 55 people
- Sponsor
- Assiut University
Sepsis, Sepsis Associated Encephalopathy
EEG Changes and Cognitive Profiles in Sepsis Patients With Different Inflammatory Phenotypes
To characterize the electroencephalogram (EEG) features of sepsis patients with distinct inflammatory response phenotypes, dynamically track their evolutionary trajectories, and analyze their associations with long-term changes…
- Conditions
- Sepsis, Sepsis Associated Encephalopathy, Sepsis and Septic Shock, Sepsis at Intensive Care Unit
- Trial name
- NCT07760415
- Testing
- EEG monitoring
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Xiangya Hospital of Central South University
Encephalopathy, Organ Dysfunction Syndrome
Prospective Analysis of Septic Associated Encephalopathy Using the Non-invasive Acoustocerebrography-ACG
The patients of the group "sepsis" are measured several times with the non-invasive multi-spectral sonography (Sonovum "ACG-Diagnosesystem") (days 1, 3, 7 and 14).
- Trial name
- SAEACG (NCT03173196)
- Testing
- Non-invasive Multispectral Sonography
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Rostock
Sepsis, Severe Sepsis
Septic Encephalopathy and Late Cognitive Dysfunction
Delirium and long-term cognitive dysfunction are important problems in intensive care patients. Patients with sepsis are at a high risk of developing delirium (septic encephalopathy), which may be an important risk factor for the…
- Trial name
- NCT00772096
- Testing
- n-3 fatty acids
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University Hospital, Basel, Switzerland
Sepsis, Altered Mental Status
Sepsis Associated Encephalopathy (SAE) Biomarkers
Sepsis associated encephalopathy (SAE) is a poorly understood acute cerebral dysfunction that frequently appears in the setting of sepsis induced systemic inflammation.
- Conditions
- Sepsis, Altered Mental Status, Sepsis-Associated Delirium, Sepsis Associated Encephalopathy
- Trial name
- NCT03133208
- Testing
- Blood draws
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Florida
Sepsis-Associated Encephalopathy
Establishment of a Cohort of Patients With Sepsis-associated Encephalopathy (SAE)
In this study, the researcher involved the sepsis patients(defined by sepsis 3.0) in Peking Union Medical College Hospital. The SAE was defined as the Glasgow Coma Scale (GCS) score of less than 15 and the Non-SAE group GCS = 15.
- Trial name
- SAE (NCT04230447)
- Testing
- No intervention
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Yi Li, MD
Sepsis-Associated Encephalopathy, Mismatch Negativity
The Dynamic Change of MMN in Patients With Sepsis Associated Encephalopathy
Sepsis-associated encephalopathy (SAE), is one of the most common organ dysfunction during the acute phase in sepsis and septic shock.
- Trial name
- NCT04870983
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Chinese Medical Association
Septic Encephalopathy, Delirium
Cognitive Processing in Patients Surviving Delirium. Neuropsychological, EEG and Structural Brain Correlates.
The research program explores how delirium influenced brain function in patients surviving delirium and septic encephalopathy from a non neurological specialized ICU cohort from 2013 to 2015 in Rigshospitalet (Glostrup).
- Conditions
- Septic Encephalopathy, Delirium, Sepsis
- Trial name
- NCT03562689
- Testing
- Delirium and with septic encephalopathy.
- Where
- Denmark
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Trans Cranial Doppler Ultrasonography in Heamodynamic Optimisation in Septic Shock
Hemodynamic Optimisation Guided With Transcranial Doppler in Septic Shock
Randomized, controlled, prospective trial, including ICU patients with Sepsis or septic Shock, at the early phase. patients will be randomized in 2 groups regarding the hemodynamic management and catecholamin doses: Group 1…
- Trial name
- NCT04398069
- Testing
- hemodynamic optimisation aiming to achieve normal cerebral perfusion
- Where
- Tunisia
- Volunteers
- 24 people
- Sponsor
- Mongi Slim Hospital
Sepsis
Pathogenesis and Cerebrovascular Manifestations of Septic Encephalopathy
Septic encephalopathy is an important complication of sepsis. Why some patients with sepsis develop septic encephalopathy is unknown.
- Trial name
- NCT00410111
- Where
- Switzerland
- Volunteers
- 23 people
- Sponsor
- University Hospital, Basel, Switzerland
Sepsis
Optic Nerve Sheath Diameter for Prediction of Sepsis Associated Encephalopathy
Sepsis-associated brain dysfunction (SABD)with increased intracranial pressure is a complex pathology that can lead to unfavourable outcome.
- Trial name
- NCT05849831
- Testing
- Ultrasound measurement of Optic nerve sheath diameter
- Where
- 2 sites in Egypt
- Volunteers
- 89 people
- Sponsor
- Zagazig University
Delirium, Delirium of Mixed Origin
Trazodone vs. Quetiapine for the Treatment of ICU Delirium
This is a single-center, prospective observational pilot study. The objective of this study is to evaluate the effectiveness of trazodone as compared to quetiapine, in the management of ICU delirium in adult (>=18 years old)…
- Conditions
- Delirium, Delirium of Mixed Origin, Delirium, Sepsis Associated, Delirium in Old Age
- Trial name
- TQDelirium (NCT05307003)
- Testing
- Trazodone, Quetiapine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Southern California
Sepsis
Relationship of Cerebral Perfusion Pressure Variability to Sepsis-associated Encephalopathy
The purpose of the study is to evaluate whether variability of CPP (cerebral perfusion pressure) is related to sepsis-associated encephalopathy and outcomes of patients with sepsis.
- Trial name
- NCT02288715
- Testing
- no interventions
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Kang Yan
Sepsis-Associated Encephalopathy
Adjunctive Sedation With Dexmedetomidine for the Prevention of Severe Inflammation and Septic Encephalopathy
Septic encephalopathy (SE) is defined as acute cerebral dysfunction in patients with sepsis or septic shock. SE occurs in up to 50% of critically ill patients with sepsis and is associated with a high mortality and morbidity.
- Trial name
- ADVISE (NCT04076826)
- Testing
- Dexmedetomidine, Propofol or Midazolam, Blood sampling
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Sepsis-associated Encephalopathy
Optic Nerve Sheath Diameter / Eyeball Transverse Diameter Ratio and Prognosis of Sepsis Associated Encephalopathy
Sepsis is associated with a mortality rate of 20-25%, with significant increase in case of associated comorbidities or shock. SAE is one of the most common forms of encephalopathy encountered in critically ill patients, with…
- Trial name
- NCT05918705
- Testing
- Ultrasound optic nerve sheath diameter / eyeball transverse diameter ratio
- Where
- Egypt
- Volunteers
- 89 people
- Sponsor
- Zagazig University
Critical Illness, Sepsis
Cerebral Oxygen Challenge of Passive Leg Raising Test in Sepsis
Sepsis related cerebral dysfunction was underestimated in critical illness setting, and inflammatory response of brain could not be monitored directly and cerebral oximetry offered information of cerebral dysfunction.
- Conditions
- Critical Illness, Sepsis, Cerebral Injury
- Trial name
- NCT03523169
- Volunteers
- 120 people
- Sponsor
- Peking Union Medical College Hospital
Critical Illness, Brain Injuries
Neurocognitive Impairment in Pediatric Patients With Meningoencephalitis and Sepsis-associated Encephalopathy
Neurocognitive impairment is frequently observed in pediatric patients with meningoencephalitis (ME) and sepsis-associated encephalopathy (SAE) which represent two relevant central nervous system (CNS) diseases in pediatric…
- Conditions
- Critical Illness, Brain Injuries, Encephalopathy, Delirium
- Trial name
- NCIPED (NCT04467762)
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- University of Rostock
Sepsis-Associated Encephalopathy
Correlation of Formyl Peptide Receptor 1 With Sepsis-related Encephalopathy
The pathogenesis of sepsis-associated encephalopathy (SAE) is unclear, Formylpeptide receptor 1 (FPR1) is a cell membrane receptor that recruits leukocytes and mediates inflammatory responses after activation, but its role and…
- Trial name
- NCT05451537
- Where
- China
- Volunteers
- 100 people
- Sponsor
- General Hospital of Ningxia Medical University
Sepsis-Associated Encephalopathy
Ulinastatin Treatment Reduces the Incidence of Sepsis-associated Encephalopathy
This study was conducted to explore the association between ulinastatin treatment and the incidence of sepsis-associated encephalopathy (SAE) in patients with sepsis.
- Trial name
- NCT07090278
- Testing
- ulinastatin
- Where
- China
- Volunteers
- 2,734 people
- Sponsor
- Shusheng Li
Critical-Illness, Polyneuropathy
Neurological Outcome in Surgical and Non-surgical Septic Patients
Systemic inflammation and sepsis cause multi organ failure including severe neurologic impairment in the course of disease. Neurologic failure typically presents as critical-illness-polyneuropathy/-myopathy and septic…
- Conditions
- Critical-Illness, Polyneuropathy, Myopathy, Septic Encephalopathy
- Trial name
- NOSEPP (NCT02442986)
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- University of Rostock