Clinical trials: Sepsis Biomarker
Sepsis, Septic Shock
We Collected Blood Samples From Septic Shock Patients and Measured ELABELA, Creatinine, and NGAL Levels. Survival After 7 Days Was Recorded and Analyzed to Evaluate the Potential of Serum ELABELA as an Early Diagnostic Marker for Sepsis-associated Acute Kidney Injury.
The investigators selected patients diagnosed with sepsis who were admitted to the Intensive Care Unit (ICU) of Huai'an First People's Hospital between June 2022 and December 2023, as well as healthy individuals with normal…
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- ELABELA（ELA） (NCT06001294)
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Xiangcheng Zhang
Sepsis
Procalcitonin-Guided Antimicrobial Discontinuation
The current study aims to validate the diagnostic use of PCT assessing its capability to individualize and shorten the duration of antibiotic therapy in critically ill patients with suspected or confirmed sepsis.
- Trial name
- NCT00250666
- Testing
- PCT measurement
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- University Hospital, Geneva
Sepsis, Septic Shock
Evaluation of Candidate Biomarkers to Predict Disease Severity and Acute Kidney Injury in Sepsis Patients
Investigators predict that the information that can be obtained in terms of renal functions before clinical development in sepsis patients can be valuable in terms of guiding treatment algorithms, planning renal replacement…
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- NCT05310812
- Testing
- Biochemical evaluation.
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Istanbul University
AKI - Acute Kidney Injury
Renal Cell Arrest and Damage Biomarkers in Progression and Outcome of Septic AKI
The aim of the current study is to assess the predictive value of renal cell arrest biomarkers (urinary TIMP2 and IGFBP7), renal damage biomarkers (urinary KIM-1) and microscopic examination of urinary sediment in progression and…
- Trial name
- NCT06064487
- Testing
- renal cell arrest and damage biomarkers assessment
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Alexandria University
Sepsis
Evaluation of biomArkers for Quick SEpsis Diagnosis - ErASED Study
Since the "Sepsis-3" consensus statement in 2016, sepsis has been defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Recognition of sepsis is mostly based on clinical criteria.
- Trial name
- NCT07655154
- Where
- Italy
- Volunteers
- 2 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Sepsis
Monocyte Distribution Width (MDW): An Early Marker of Sepsis in Patients With Comorbidities
In patients with the aforementioned comorbidities, septic conditions are common and associated with high mortality rates. Early diagnosis, along with prompt and appropriate management, has become a major challenge for emergency…
- Trial name
- MDW (NCT06953154)
- Testing
- monocyte distribution width
- Where
- Tunisia
- Volunteers
- 325 people
- Sponsor
- Hôpital Universitaire Sahloul
Sepsis
Identification and Clinical Efficacy Analysis of Biomarkers in Sepsis Patients
Sepsis, a severe response to bacterial infection, lacks understanding of immunometabolic features that can identify high-risk patients.
- Trial name
- NCT05911711
- Testing
- Prognostic factor
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Kangdong Sacred Heart Hospital
Sepsis, Burn Injury
Surgical Critical Care Initiative (SC2i) Tissue and Data Acquisition Protocol (TDAP) in Burn Patients Improving the Robustness and Generalizability of Post-burn Sepsis Prediction With the Post-Burn Sepsis Digital Twin. Group 1
This study is following adult patients with serious burn injuries to better understand how their bodies respond to treatment and recovery.
- Conditions
- Sepsis, Burn Injury, Wound Healing, Critical Illness
- Trial name
- NCT07249762
- Testing
- Observational Cohort (No Intervention)
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Severe Sepsis, Sepsis
Early Identification and Effective Management of Pediatric Sepsis
In patients diagnosed as sepsis on PICU admission, early and accurate identification of patients who will develop organ dysfunction (severe sepsis) is critical for effective management and positive outcome.
- Conditions
- Severe Sepsis, Sepsis, Septic Shock
- Trial name
- NCT03996720
- Where
- 4 sites in China
- Volunteers
- 175 people
- Sponsor
- Children's Hospital of Fudan University
Sepsis
Biomarkers to Predict Acute Respiratory Distress Syndrome(ARDS) in Patients With Sepsis
Sepsis-induced acute respiratory distress syndrome (ARDS) is a life-threatening acute inflammatory lung injury, associated with increased pulmonary microvascular permeability, increased lung weight, and loss of aerated lung…
- Trial name
- NCT05914428
- Testing
- ALDH2 rs671 mutation
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Qilu Hospital of Shandong University
Sepsis, Severe
Procalcitonin in Diagnosis of Sepsis in Critically Ill Patient
correlation between procalcitonin levels and the severity of sepsis and it's possibility to be used as a prognostic marker in patients with sepsis and severe sepsis
- Trial name
- NCT04105400
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Sepsis, Acute Lung Injury
Biological Markers to Identify Early Sepsis and Acute Lung Injury
There are no clear markers to identify sepsis and acute lung injury at early stage in clinical settings which would result in improved survival of the patients. In collaboration with the research team led by Dr. Zhang at St.
- Trial name
- NCT00825357
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chimei Medical Center
Sepsis
HSPA12B as a Potential Biomarker for Sepsis and Severe Sepsis
Molecules indicating endothelial injury may serve as biomarkers for severe sepsis because of the critical role of endothelial injury in organ dysfunction during severe sepsis.
- Trial name
- NCT01847248
- Where
- China
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Sepsis, Early Diagnosis
The Biomarker Prediction Model of Septic Risk in Infected Patients
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to an infection. Sepsis is associated with high mortality because of the complex mechanisms.
- Conditions
- Sepsis, Early Diagnosis, Biomarkers
- Trial name
- NCT05095324
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Sepsis, Septic Shock
Renal Arterial Resistive Index Versus Novel Biomarkers for Early Prediction of Sepsis Associated-acute Kidney Injury
Populations at high risk of Sepsis-Associated Acute Kidney Injury (SA-AKI) have been identified. Sources of sepsis, in particular, bloodstream infection, abdominal and genitourinary sepsis, and infective endocarditis, are…
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- RRIBIOSAKI (NCT03799159)
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Islam Elsayed Mohamed Ahmed
Sepsis, Severe Sepsis
Safety and Efficacy of Procalcitonin Guided Antibiotic Therapy in Adult Intensive Care Units (ICU's)
This is a randomized controlled trial comparing standard-of-care therapy of infections in critically ill patients with a procalcitonin-guided approach evaluating efficacy (antibiotics consumption) and safety (mortality).
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- SAPS (NCT01139489)
- Testing
- procalcitonin-guidance
- Where
- Netherlands
- Volunteers
- 1,575 people
- Sponsor
- Amsterdam UMC, location VUmc
Vasorin, Septic Shock
Diagnostic and Prognostic Evaluation of Vasorin During Septic Shock
Septic shock is the most severe form of infection. Currently, an early specific biomarker for septic shock is needed. Remember that shock situations are numerous, not only septic (eg hemorrhagic, cardiogenic...), and also…
- Conditions
- Vasorin, Septic Shock, Shock, Biomarker
- Trial name
- VASO-DIAG (NCT07203833)
- Testing
- blood sample
- Where
- France
- Volunteers
- 144 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Sepsis
Diagnostic and Prognostic Biomarkers of Sepsis
This study aims to evaluate sepsis biomarkers as soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) and soluble urokinase plasminogen activator receptor (sUPAR) in diagnosis of sepsis in comparison to the…
- Trial name
- NCT04767893
- Where
- Egypt
- Volunteers
- 67 people
- Sponsor
- Sohag University
Neonatal Sepsis, Sepsis
CBC Indices and Serum Lactate in Neonatal Sepsis
Neonatal sepsis is a leading cause of illness and death in Neonatal Intensive Care Units (NICUs). Diagnosing it quickly is challenging because the early signs often overlap with other common newborn health issues.
- Trial name
- NCT07663084
- Volunteers
- 80 people
- Sponsor
- Assiut University
Infections, Sepsis
Can Measurement of Neutrophil-derived ROS Production be a Novel Biomarker of Sepsis?
Neutrophils are indispensable for host defense and have an important roles in modulating the immune system in both the innate and adaptive immune response.
- Conditions
- Infections, Sepsis, Septic Shock
- Trial name
- LIT-sepsis (NCT05968287)
- Testing
- The Leukocyte ImmunoTest™ (LIT™)
- Where
- Turkey (Türkiye)
- Volunteers
- 276 people
- Sponsor
- Gazi University