Clinical trials: Sepsis Septic Shock
Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome, Septic Shock
Early Continuous Renal Replacement Therapy for Pediatric Septic Shock
Septic shock is a major cause of morbidity and mortality in critically ill children. Continuous renal replacement therapy (CRRT) is increasingly used as adjunctive support in pediatric septic shock to improve hemodynamic…
- Trial name
- NCT07370753
- Where
- Vietnam
- Volunteers
- 50 people
- Sponsor
- National Children's Hospital, Vietnam
Septic Shock
Comparison of Extubation Delay After Prolonged Sedation
This monocentric, prospective, controlled, randomized, single-blind study will be conducted in surgical resuscitation at the Rouen University Hospital.
- Trial name
- ISOREA (NCT04710914)
- Testing
- Prolonged sedation with isoflurane, Prolonged sedation with midazolam
- Where
- France
- Volunteers
- 1 people
- Sponsor
- University Hospital, Rouen
Sepsis, Volume Assessment
Evaluation of Fluid Infusion With LifeFlow for Patients With Suspected Septic Shock
The LifeFlow rapid infusion device is a handheld manually-operated device that has been shown in early trials to increase the rate of bolus fluid infusion up to 3 times the rate of delivery attributed to conventional rapid…
- Trial name
- NCT03673891
- Testing
- Life Flow
- Sponsor
- University of Arizona
Sepsis, Septic Shock
Central Venous Catheter Colonisation Among Critically Ill Patients in Intensive Care Units
Background: Central Venous catheter insertion technique and indwelling time are major risk factors for CVC colonisation. Colonisation occurs through microbial migration and biofilm formation along the catheter insertion tract.
- Conditions
- Sepsis, Septic Shock, Post-cardiac Surgery, Post-Cardiorespiratory Arrest Coma
- Trial name
- NCT03270774
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Makerere University
Septic Shock
Blessing or Curse? Combined Vitamin Therapy in Non Viral Septic Shock.
Introduction: Septic shock leads to high morbidity and mortality in critically ill patients. Several lower-case scientific studies have supported the synergistic positive effect of vitamin C, thiamine, and hydrocortisone on…
- Trial name
- NCT06152458
- Testing
- Vitamin C
- Where
- Hungary
- Volunteers
- 43 people
- Sponsor
- University of Pecs
Septic Shock, Adverse Event
Early Versus Conventional Cessation of Hydrocortisone in Septic Shock
Septic shock is one of the causes of death in ICU and hospital. Refractory shock is the problem which healthcare providers should recognize though it is difficult to handle with.
- Conditions
- Septic Shock, Adverse Event, Hydrocortisone, Hyperglycemia
- Trial name
- CESSHYDRO (NCT05818826)
- Testing
- normal saline solution, Hydrocortisone and normal saline solution
- Where
- Thailand
- Volunteers
- 160 people
- Sponsor
- Mahidol University
Septic Shock
LANdiolol MIcrocirculatory Effects During Septic chOc (MILANOS)
The objectives of this study are to evaluate the effect of continuous intravenous Landiolol injection (from 0.5 to 10 µg/kg/min during 12 hours ) up to a 15% decrease in Heart Rate (HR) on microcirculatory vascular reactivity vs.
- Trial name
- MILANOS (NCT04931225)
- Testing
- Landiolol
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bacteremia, Bacteremia Sepsis
Monocyte Distribution Width (MDW) in the General Population of Emergency Department Patients With and Without Bacteremia
This project will evaluate the usefulness of Monocyte Distribution Width (MDW) for the diagnosis of blood culture positivity (BSI) in patients in the Emergency Department (ED) and reevaluate the usefulness of MDW in patients with…
- Conditions
- Bacteremia, Bacteremia Sepsis, Sepsis, Septic Shock
- Trial name
- NCT05296590
- Testing
- Monocyte Distribution Width (MDW) , observation
- Where
- United States
- Volunteers
- 50,000 people
- Sponsor
- Henry Ford Health System
Septic Shock, Vasopressor Resistance, Multiple Organ Dysfunction
Biological Effects of Hemoadsorption in Septic Shock
Septic shock is the most severe form of sepsis and continues to carry an in-hospital mortality of between 30% and 50% despite advances in compliance with the Surviving Sepsis Campaign care bundles.
- Conditions
- Septic Shock, Vasopressor Resistance, Multiple Organ Dysfunction, Sepsis, Hemoperfusion
- Trial name
- Bio-HA380 (NCT07715110)
- Testing
- Hemoadsorption cartridge
- Where
- 2 sites in Spain
- Volunteers
- 16 people
- Sponsor
- Miguel Sanchez Garcia
Septic Shock
Evaluating Dynamic Arterial Elastance in Septic Shock Patients.
Assess the effectiveness and safety of using dynamic arterial elastance as a tool for weaning vasopressor support in patients with septic shock, compared to a control group
- Trial name
- EaDyn (NCT06118775)
- Testing
- EaDyn Weaning Arm:, PAM Weaning Arm:
- Where
- Colombia
- Volunteers
- 114 people
- Sponsor
- Fundación Santa Fe de Bogota
Sepsis, Sepsis and Septic Shock
Study on the Construction and Application of Early Warning Model of Sepsis in Critically Ill Patients
The condition of sepsis patients changes rapidly, whom are often accompanied by impaired respiratory, circulatory, renal, and coagulation functions. So far, the prognosis of sepsis at home and abroad is not ideal.
- Conditions
- Sepsis, Sepsis and Septic Shock, Infection
- Trial name
- sepsis model (NCT06904001)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Shock, Septic
Efficacy, Safety and Tolerability of Nangibotide in Patients With Septic Shock
This is a randomized, double-blind, placebo-controlled dose-selection study in which two doses of nangibotide are tested versus placebo.
- Trial name
- ASTONISH (NCT04055909)
- Testing
- nangibotide low dose, nangibotide high dose
- Where
- 43 sites in Belgium, Denmark and 4 more
- Volunteers
- 355 people
- Sponsor
- Inotrem
Septic Shock, Hemodynamic Instability
Whether a Minimal Volume Could Predict Fluid Responsiveness Using Thermodilution by PAC in Septic Shock Patients
Assessment of fluid responsiveness (FR) is to detect whether patient could benefit from fluid therapy. Mini fluid challenge has been widely used in clinical practice to prevent patients from volume overload.
- Conditions
- Septic Shock, Hemodynamic Instability, Fluid Therapy
- Trial name
- NCT04515511
- Testing
- 4% gelatin
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College Hospital
Septic Shock, Acute Kidney Injury
Safety and Efficacy of HA380 Hemoadsorption in Patients With Septic Shock
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Intensive care unit (ICU) mortality in patients with septic shock and acute kidney injury (AKI) requiring continuous…
- Trial name
- HEMOX-HDF (NCT04997421)
- Testing
- Combined HA380 hemoadsorption and continuous veno-venous hemodiafiltration (CVVHDF) with Oxiris®-AN69 membranes, Continuous veno-venous hemodiafiltration (CVVHDF) with Oxiris®-AN69 membranes
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Turku University Hospital
Septic Shock
Comparison of ECMO Use and Conventional Treatment in Adults With Septic Shock
Although few cases reported successful treatment of septic shock using extracorporeal membrane oxygenation (ECMO) in adults, no studies compared ECMO to conventional treatment (without ECMO) as treatment for adults with septic…
- Trial name
- NCT01685112
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Severe Sepsis, Septic Shock
Minimally-Invasive Cardiovascular Hemodynamic Optimization (MiCHO) Versus Early Goal-Directed Therapy (EGDT) in the Management of Septic Shock
Early intervention in the treatment of septic shock, including early goal-directed therapy (EGDT) in the first 6 hours of disease presentation, has been shown to significantly decrease mortality.
- Trial name
- MiCHO (NCT00535821)
- Testing
- Esophageal Doppler monitoring - CardioQ, Deltex Inc, Central line with CVP and continuous ScvO2 monitoring
- Where
- 4 sites in United States
- Volunteers
- 5 people
- Sponsor
- Loma Linda University
Sepsis, Acute Kidney Injury
Comparison of Balanced Crystalloids and Normal Saline in Septic Patients
In this prospective randomized controlled trial, investigators attempt to study the effects of acetated Ringer's solution on the prognosis and renal function of patients with sepsis in intensive care unit compared with normal…
- Conditions
- Sepsis, Acute Kidney Injury, Septic Shock, Sepsis, Severe
- Trial name
- NCT03685214
- Testing
- 0.9% saline, lactated Ringer's solution
- Where
- China
- Volunteers
- 500 people
- Sponsor
- ZhiYong Peng
Septic Shock
Association Between Muscle L3 CT Scan Muscle Derived Parameters of Muscle Function Upon Intensive Care Unit Admission and 3 Months Mortality After ICU Discharge for Patients Admitted for Septic Shock. The SIMS Study
Muscle dysfunction in intensive care units is associated with significant morbidity and mortality. During septic shock, there is an increased catabolism and systemic inflammation resulting in quantitative and qualitative muscle…
- Trial name
- SIMS (NCT07483710)
- Testing
- Evaluation of muscle dysfunction in intensive care units for septic schock patients
- Where
- 4 sites in France
- Volunteers
- 196 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Septic Shock, Sepsis
Heamodynamic Effects of Paracetamol in Septic Shock Patients
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Septic shock is defined as sepsis that has circulatory, cellular, and metabolic abnormalities that are associated with a greater…
- Trial name
- NCT06076980
- Testing
- Paracetamol, Normal saline
- Where
- Egypt
- Volunteers
- 61 people
- Sponsor
- Ayah Mohammed Khalil
Sepsis, Septic Shock
Vitamin C, Thiamine, Cyanocobalamine, Pyridoxine and Hydrocortisone in Sepsis
Prospective, experimental, longitudinal cohort study in septic patients treated at ER and ICU at General Hospital Zone 11 IMSS Piedras Negras Coahuila.
- Trial name
- NCT04197115
- Testing
- Vitamin C, Hydrocortisone, Complex B
- Where
- Mexico
- Volunteers
- 19 people
- Sponsor
- IMSS Hospital General de Zona 11, Piedras Negras
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