Clinical trials: Sepsis Syndromes
Shock, Sepsis
The Effects of Sedative on the Fluid Responsiveness in Critically Ill Patients
Hypotension and bradycardia are often observed following induction of dexmedetomidine or propofol sedation.Cardiac preload decrease by sedative agents was often considered as one of main causes for this hypotension.The…
- Trial name
- NCT01447875
- Testing
- Passive Leg Raising, propofol or mexmedetomidine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Southeast University, China
Supraventricular Arrhythmia, Septic Shock
Rate, Rhythm or Risk Control for New-onset Supraventricular Arrhythmia During Septic Shock: a Randomized Controlled Trial
New-onset supraventricular arrhythmia (NOSVA) is reported in 40 % of patients with septic shock and is associated with hemodynamic alterations and mortality.
- Trial name
- CAFS (NCT04844801)
- Testing
- Risk control strategy, Heart-Rate control strategy:, Rhythm control strategy:
- Where
- France
- Volunteers
- 240 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
SIRS, Sepsis
The Application of Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Sepsis & Relevant Acute Kidney Injuries
Triggering receptor expressed on myeloid cells-1 is a member of the immunoglobulin superfamily of receptors that is specifically expressed on the surfaces of monocytes and neutrophils.TREM-1 expression is increased in infectious…
- Trial name
- NCT01333657
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Chinese PLA General Hospital
COVID-19, SARS-CoV2 Infection
Effect of IMMUNEPOTENT-CRP on Serum Pro-Inflammatory Cytokines in Mild to Moderate COVID-19
In this study, the effects of IMMUNEPOTENT-CRP (I-CRP), a dialyzable leukocyte extract (DLE) derived from bovine spleen cells, on the levels of key inflammatory cytokines in outpatients with COVID-19 were examined.
- Trial name
- ICRPDLECOVID (NCT06676709)
- Testing
- IMMUNEPOTENT-CRP (I-CRP)
- Where
- 2 sites in Mexico
- Volunteers
- 80 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Bloodstream Infections
RCT Meropenem vs Piperacillin-Tazobactam for Definitive Treatment of BSI's Due to Ceftriaxone Non-susceptible Escherichia Coli and Klebsiella Spp.
No randomized controlled trials (RCTs) have yet been performed comparing different treatment options for AmpC or ESBL-producing Enterobacteriaceae.
- Trial name
- MERINO (NCT02176122)
- Testing
- Meropenem, Piperacillin-tazobactam combination product
- Where
- 31 sites in Australia, Canada and 7 more
- Volunteers
- 391 people
- Sponsor
- The University of Queensland
Sepsis, Sepsis and Septic Shock
Study on the Construction and Application of Early Warning Model of Sepsis in Critically Ill Patients
The condition of sepsis patients changes rapidly, whom are often accompanied by impaired respiratory, circulatory, renal, and coagulation functions. So far, the prognosis of sepsis at home and abroad is not ideal.
- Conditions
- Sepsis, Sepsis and Septic Shock, Infection
- Trial name
- sepsis model (NCT06904001)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Sepsis, Septic Shock
Predictive algoRithm for EValuation and Intervention in SEpsis
In this prospective study, the ability of a machine learning algorithm to predict sepsis and influence clinical outcomes, will be investigated at Cabell Huntington Hospital (CHH).
- Conditions
- Sepsis, Septic Shock, Severe Sepsis
- Trial name
- PREVISE (NCT03235193)
- Testing
- Severe Sepsis Prediction, Severe Sepsis Detection
- Where
- United States
- Volunteers
- 2,296 people
- Sponsor
- Dascena
Sepsis
HFIP Ex-vivo Study
Sepsis, a multi organ failure caused by infectious diseases, is a major health burden with an average mortality rate of 26%. Cells of the innate immune system of hosts recognize specific patterns of pathogenic bacteria and…
- Trial name
- NCT04059263
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- University of Zurich
Heart Failure, Sepsis
Skeletal Muscle Oxygenation in Critically Ill
It is possible to measure skeletal muscle tissue oxygenation (StO2) using near infrared spectroscopy(NIRS). It is performed non invasively.
- Conditions
- Heart Failure, Sepsis, Septic Shock, Cardiogenic Shock
- Trial name
- NCT00384644
- Testing
- NiRS measurment of tissue oxygenation
- Where
- Slovenia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Sepsis, Acute Renal Failure
Super High-Flux - High Volume Dialysis in Sepsis-Induced Acute Renal Failure
Patients within the intensive care unit who have severe infections causing shock and kidney failure have almost a 60% risk of dying despite antibiotic therapy, surgical drainage of the site of infection and intensive care support…
- Trial name
- NCT00333593
- Testing
- Large pore dialyser, Standard dialyser
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Austin Health
Mesenchymal Stromal Cells, Remestemcel-L
MSCs in COVID-19 ARDS
The mortality rate in SARS-CoV-2-related severe ARDS is high despite treatment with antivirals, glucocorticoids, immunoglobulins, and ventilation.
- Conditions
- Mesenchymal Stromal Cells, Remestemcel-L, Acute Respiratory Distress Syndrome, COVID
- Trial name
- NCT04371393
- Testing
- Remestemcel-L
- Where
- 21 sites in United States
- Volunteers
- 223 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Severe Sepsis
Australasian Resuscitation In Sepsis Evaluation Randomised Controlled Trial
The ARISE RCT is a multi-centre, randomised, controlled trial of EGDT compared to standard care in patients with severe sepsis presenting to the ED.
- Trial name
- ARISE (NCT00975793)
- Testing
- Early Goal Directed Therapy (EGDT)
- Where
- 51 sites in Australia, Finland and 3 more
- Volunteers
- 1,600 people
- Sponsor
- Belinda Howe
Septic Shock
Cerebral Oxygenation in Septic Patients Using Vasopressors - the Conscious Study
The purpose of this study is to reveal if higher doses of vasopressors in septic shock patients correlates with cerebral vasoconstriction and lower cerebral oximetry.
- Trial name
- CONSCIOUS (NCT02237833)
- Where
- Norway
- Volunteers
- 15 people
- Sponsor
- Karl-Andre Wian
Sepsis
Evaluation of Serum Procalcitonin in Critically Ill Patients With Suspected Sepsis
Procalcitonin is a promising marker of sepsis in critically ill patients. Procalcitonin have better diagnostic accuracy compared to White blood cell count and C - reactive protein.
- Trial name
- NCT03506152
- Testing
- Serum Procalcitonin
- Where
- Pakistan
- Volunteers
- 103 people
- Sponsor
- Aga Khan University
Sepsis, Septic Shock
Effectiveness of Non-invasive Vagus Nerve Stimulation as an Adjuvant Treatment in Patients With Sepsis in Intensive Care.
Sepsis is one of the leading causes of death in intensive care. About 50% of patients with septic shock die after 1 year; and 50% of survivors suffer from cognitive decline.
- Trial name
- SNV-Sepsis (NCT04774705)
- Testing
- SNV activ group (Non-invasive transcutaneous stimulation of the vagus nerve )
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Critical Illness, Complication of Ventilation Therapy
Cerebral Autoregulation in Non Neurological Critical Patients.
Brief Summary Cerebral Autoregulation is a well known physiological response to blood pressure changes to maintain the cerebral perfusion.
- Conditions
- Critical Illness, Complication of Ventilation Therapy, Systemic Inflammatory Response Syndrome, Failed Moderate Sedation During Procedure, Sequela
- Trial name
- NCT01731106
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
PPROM, Early-Onset Neonatal Sepsis
Predicting EONS in PPROM Patients
An EONS occurred in nearly 14-22 % of the preterm infant of pregnant women with PPROM. To this day no risk prediction is established.
- Trial name
- PEONS (NCT03819192)
- Testing
- microbiome analysis, Conventional cultures, CAAP48 measurement
- Where
- 2 sites in Germany
- Volunteers
- 150 people
- Sponsor
- Jena University Hospital
Sepsis, Inflammation
Investigation of Plasma Mitochondrial DNA Level in Septic Patients
To determine the plasma levels of mtDNA in ICU department patients with and without sepsis and evaluate their association with severity, systemic inflammation and outcomes.
- Trial name
- NCT02019992
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Central South University
Septic Shock, Critically Ill
Resuscitation Strategies in Septic Shock
The purpose of this study, in mechanically ventilated septic shock patients, is to determine whether a fluid loading strategy based on parameters derived from the transpulmonary thermodilution technique may lead to more…
- Trial name
- ReSSeS (NCT02150512)
- Testing
- Transpulmonary Thermodilution, Surviving Sepsis Guidelines (SSG)
- Where
- Netherlands
- Volunteers
- 170 people
- Sponsor
- Medisch Spectrum Twente
Community-Acquired Infections, Respiratory Tract Infections
Validation of Vital Signs and Symptoms for the Diagnosis of Serious Infections in Children in the Paediatric A&E.
Validation of Vital Signs and Symptoms for the Diagnosis of Serious Infections in Acutely Ill Children in a High Prevalent Setting: The Paediatric Accidents \& Emergencies through prospective observational data collection…
- Conditions
- Community-Acquired Infections, Respiratory Tract Infections, Sepsis, Urinary Tract Infections
- Trial name
- ERNIE3 (NCT01396798)
- Where
- Belgium
- Volunteers
- 1,500 people
- Sponsor
- KU Leuven
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