Clinical trials: Sepsis Syndromes
Sepsis
Electroencephalographic Patterns of Septic Patients and Its Correlation With Cognitive Outcomes
The investigators evaluated the electroencephalographic pattern by the Sinek and Young scales during ICU stay and its correlation with cognitive impairment determined by the Montreal Cognitive Assessment (MOCA) in septic patients…
- Trial name
- NCT05448534
- Testing
- Eletroencephalography
- Where
- Brazil
- Volunteers
- 160 people
- Sponsor
- Hospital Sao Domingos
Cytokine Release Syndrome in COVID-19-induced Pneumonia
Canakinumab MAP in COVID-19 Pneumonia With CRS
This is a global Managed Access Program (MAP) to provide access to canakinumab to patients with cytokine release syndrome resulting from COVID-19 pneumonia
- Trial name
- NCT04476706
- Testing
- canakinumab
- Sponsor
- Novartis Pharmaceuticals
Sepsis
Bioimpedance Analysis in Septic Intensive Care Unit (ICU) Patients
Patients with severe infections initially require large amounts of fluid as part of resuscitation. Later on however, problems may arise from excess fluid such as increased time on a ventilator and kidney damage.
- Trial name
- BIOVISION (NCT01379404)
- Testing
- Bioelectric Impedance Analysis
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Neonatal Sepsis, Sepsis
Probiotics for Prevention Neonatal Infection
Neonatal sepsis (serious infection) continues to be one of the major causes of morbidity and mortality in the newborn period around the world.
- Conditions
- Neonatal Sepsis, Sepsis, Neonatal Infections
- Trial name
- NCT01214473
- Testing
- Synbiotics, Maltodextrin
- Where
- 2 sites in India
- Volunteers
- 4,556 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Sepsis
Impact of 30 mg/kg Amikacin and 8 mg/kg Gentamicin on Serum Concentrations in Critically Ill Patients With Severe Sepsis
Low first-dose peak serum concentrations of amikacin and gentamicin are commonly reported in ICU patients. The present study aimed to assess whether 30 mg/kg amikacin or 8 mg/kg gentamicin achieved target concentrations in ICU…
- Trial name
- Aminoside_II (NCT02898961)
- Testing
- 30 mg/kg amikacin or 8 mg/kg gentamicin
- Where
- France
- Volunteers
- 63 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Kidney Stone, Kidney Calculi
Evaluation of Infection in Obstructing Urolithiasis
Obstructing urolithiasis can be life-threatening in the setting of urinary tract infection. The purpose of this study is to identify and validate risk factors and markers for the presence of infection and development of sepsis…
- Conditions
- Kidney Stone, Kidney Calculi, Urinary Tract Obstruction, Infection
- Trial name
- eIOU (NCT04332861)
- Testing
- Initial clinical and laboratory evaluation
- Where
- 2 sites in United States
- Volunteers
- 477 people
- Sponsor
- University of Texas Southwestern Medical Center
Acute Lung Injury (ALI), Acure Respiratory Distress Syndrome (ARDS)
Effect of Intraoperative Fluid Restriction on Postoperative Outcomes in Video-assisted Thoracic Surgery (VATS)
The objective of this study is to compare the effects of two intraoperative fluid regimens - restrictive versus liberal (standard)- on postoperative outcomes (e.g.
- Conditions
- Acute Lung Injury (ALI), Acure Respiratory Distress Syndrome (ARDS), Sepsis
- Trial name
- NCT00854386
- Testing
- liberal fluid administration, restrictive fluid administration
- Where
- 2 sites in Israel
- Volunteers
- 200 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Neonatal SEPSIS, Perinatal Mortality
Outcomes in Spontaneous and ART Twin Pregnancies
During the last decades, assisted reproductive technique has been transformed from a miracle to real and has become widely used for treatment human infertility. this was associated with increased the rate of twin pregnancies
- Conditions
- Neonatal SEPSIS, Perinatal Mortality, Maternal Morbidity
- Trial name
- NCT03590483
- Where
- Iraq
- Volunteers
- 200 people
- Sponsor
- Hawler Medical University
Allogeneic Stem Cell Transplantation
Xylitol BSI Multisite - Reduction of Bloodstream Infections From Oral Organisms in Pediatric Stem Cell Transplant
Bloodstream infections (BSI) caused by bacteria translocating across injured oral mucosa are a significant cause of morbidity and mortality in patients undergoing stem cell transplantation (SCT).
- Trial name
- NCT05579639
- Testing
- Xylitol
- Where
- 3 sites in United States
- Volunteers
- 256 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cardiovascular Diseases
Reexamining Her Cardiovascular Risk - Ottawa WomeN's Longitudinal Cohort Study
The full HER CROWN will be a prospective cohort study to propose a novel, women-specific cardiovascular risk score/ algorithm in the prediction of hard cardiovascular outcomes (myocardial infarction, unstable angina, coronary…
- Trial name
- HER-CROWN (NCT05632601)
- Testing
- PET scan
- Where
- Canada
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Systemic Inflammatory Response Syndrome
Perioperative Sitagliptin Medication for Reduction of the Inflammatory Response Associated With Cardiopulmonary Bypass
Sitagliptin is an inhibitor of the enzyme dipeptidylpeptidase-4 (DPP-4) and represents an established drug in type 2 diabetes mellitus treatment. However, Sitagliptin may also have several antiinflammatory properties.
- Trial name
- SiCa-Flam (NCT05725798)
- Testing
- Sitagliptin
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Muenster
Bacteremia
A Phase 3 Telavancin Staphylococcus Aureus (S. Aureus) Bacteremia Trial
This is a multicenter, randomized, open-label, noninferiority trial of telavancin versus standard IV therapy control (e.g., vancomycin, daptomycin, anti-staphylococcal penicillin (PCN), or cefazolin) in the treatment of subjects…
- Trial name
- NCT02208063
- Testing
- Telavancin, Vancomycin, Daptomycin
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Cumberland Pharmaceuticals
Sepsis-related Myocarditis
Sepsis and Myocarditis
This prospective cohort study aims to investigate the cardiac manifestations of sepsis and their influence on disease outcomes among adult patients at Jimma University Medical Center, Ethiopia, from May 2025 to May 2026.
- Trial name
- NCT07079605
- Testing
- Standard treatment for sepsis of any focus, Treatment for the sepsis with standard management of cardiac failure
- Where
- Ethiopia
- Volunteers
- 226 people
- Sponsor
- Jimma University
Severe Sepsis
Extravascular Lung Water Index in Severe Sepsis
To investigate whether extravascular lung water index (EVLI) is an independent predictor for multiorgan dysfunction syndrome (MODS) in patients with severe sepsis and to determine if increased EVLI may serve as an predictor for…
- Trial name
- EVLI in sepsis (NCT00986271)
- Testing
- EVLI was determinated by PiCCO plus system.
- Volunteers
- 67 people
- Sponsor
- Chang Gung Memorial Hospital
Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)
Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS
The TRIPS study is a prospective, multi-center, double-blind, adaptively randomized, placebo-controlled clinical trial of the drug anakinra for reversal of moderate to severe hyperinflammation in children with sepsis-induced…
- Trial name
- TRIPS (NCT05267821)
- Testing
- Anakinra
- Where
- 32 sites in United States
- Volunteers
- 500 people
- Sponsor
- Nationwide Children's Hospital
Malaria,Falciparum, Malaria
Pyronaridine in Healthy Adult Participants Infected With Blood Stage Malaria
This is an open-label, adaptive study that will utilise the P. falciparum induced blood stage malaria (IBSM) model to characterise the pharmacokinetic/pharmacodynamic (PK/PD) profile of pyronaridine.
- Conditions
- Malaria,Falciparum, Malaria, Malaria Recrudescence, Parasitemia
- Trial name
- NCT05287893
- Testing
- Pyronaridine, P. falciparum IBSM infection
- Where
- 2 sites in Australia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Catheter-Related Infections, Central Venous Catheters
Advanced Dressings for CVC Infection Prevention in PICU
Randomised, single-blind clinical trial comparing chlorhexidine gluconate-impregnated transparent dressings versus conventional transparent dressings in the prevention of central venous catheter-related bloodstream infections…
- Conditions
- Catheter-Related Infections, Central Venous Catheters, Bloodstream Infection, Pediatric Intensive Care Units
- Trial name
- NCT07175116
- Testing
- 3M™ Tegaderm™ Antimicrobial Transparent Dressing (chlorhexidine gluconate-impregnated), Conventional transparent polyurethane dressing
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- University of Seville
Selective Plasma Filtration
Selective Plasmofiltration for Abdominal Septic Shock: a Clinical Ctudy
Group 1: 34 patients received prolonged hemodiafiltration (CVVHDF) on an emergency basis. Group 2: 35 patients received early isolated CVVHDF.
- Trial name
- SPASS (NCT07121647)
- Testing
- renal replacement therapy., early isolated CVVHDF., combined extracorporeal blood purification therapy
- Where
- Russia
- Volunteers
- 101 people
- Sponsor
- Pirogov Russian National Research Medical University
Covid19
Vitamin D, Omega-3, and Combination Vitamins B, C and Zinc Supplementation for the Treatment and Prevention of COVID-19
The NUTROVID Factorial Trials The purpose of the NUTROVID-Prevent and NUTROVID-Treat Factorial Trials is to determine whether Vitamin B Complex, Vitamin C, and Zinc; Vitamin D; and Omega3, taken at dosages approximating…
- Trial name
- NUTROVID (NCT04828538)
- Testing
- Vitamin D, Omega DHA / EPA, Vitamin C, Vitamin B complex and Zinc Acetate
- Where
- Mexico
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hospital de la Soledad
Breast Neoplasms, Fever
A Prospective, Randomized, Phase III Trial of FLAC (5-Fluorouracil, Leucovorin, Adriamycin, Cytoxan) Chemotherapy With GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor) Versus PIXY 321 in Advanced Breast Cancer
This is a prospective, randomized Phase III trial of FLAC chemotherapy with GM-CSF versus PIXY321 in advanced breast cancer. The primary endpoints of this study will be the duration of thrombocytopenia and the time to recovery of…
- Conditions
- Breast Neoplasms, Fever, Hematologic Diseases, Neutropenia
- Trial name
- NCT00001338
- Testing
- FLAC chemotherapy with GM-CSF
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- National Cancer Institute (NCI)
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