Clinical trials: Sepsis Syndromes
COVID-19
Assessment of Efficacy and Safety of Ruxolitinib in Participants With COVID-19-Associated ARDS Who Require Mechanical Ventilation (RUXCOVID-DEVENT)
The purpose of this study is to evaluate the efficacy and safety of ruxolitinib in the treatment of participants with COVID-19-associated Acute Respiratory Distress Syndrome (ARDS) who require mechanical ventilation.
- Trial name
- NCT04377620
- Testing
- Ruxolitinib
- Where
- 36 sites in United States, Russia
- Volunteers
- 211 people
- Sponsor
- Incyte Corporation
Sepsis
Study of Multiple-dose Kukoamine B Mesilate in Sepsis Patients
Phase I study of multiple-dose Kukoamine B Mesilate in Sepsis Patients
- Trial name
- NCT03237728
- Testing
- 0.06mg/kg,KB, 0.12mg/kg,KB, 0.24mg/,KB
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Tianjin Chasesun Pharmaceutical Co., LTD
Sepsis, Intestinal Mucosal Barrier
The Roles of IL-9/E-cadherin and Ferroptosis in Intestinal Mucosal Barrier Injury in Sepsis
The investigators aim to evaluate the roles of IL-9/E-cadheirin and ferroptosis in the intestinal mucosal barrier injury of sepsis.
- Conditions
- Sepsis, Intestinal Mucosal Barrier, Ferroptosis
- Trial name
- NCT05410665
- Testing
- Standard treatments for sepsis
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Sepsis, Bacterial Infections
Integrated Clinical Decision Support for Empiric Antibiotic Selection in Sepsis
As antibiotic resistance increases globally, it becomes more difficult to select empiric antibiotic therapy, particularly in patients with sepsis who stand to benefit from early adequate treatment.
- Conditions
- Sepsis, Bacterial Infections, Community-Acquired Infections, Hospital Infection
- Trial name
- IDEAS-CRXO (NCT06103500)
- Testing
- Clinical Decision Support Algorithm for Empiric Antibiotics in Sepsis
- Where
- 3 sites in Canada
- Volunteers
- 1,478 people
- Sponsor
- Ottawa Hospital Research Institute
Gastric Residuals Assessment, Prematurity
Does Routine Assessment of Gastric Residuals in Preterm Neonates Influence Time Taken to Reach Full Enteral Feeding?
The study aims to compare routine assessment of gastric residuals versus no assessment of residuals in preterm neonates with respect to time taken for achieving full enteral feeding and the incidence of possible complications…
- Conditions
- Gastric Residuals Assessment, Prematurity, Sepsis Newborn, Necrotizing Enterocolitis of Newborn
- Trial name
- GRASS (NCT03111329)
- Testing
- No aspiration of gastric residuals
- Where
- 2 sites in Czechia, Ireland
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Institute for the Care of Mother and Child, Prague, Czech Republic
Sepsis
Sepsis Pre-Alert Monitoring Intervention: Study to Investigate Targeted Enhanced Monitoring for Sepsis
Sepsis is a leading cause of death worldwide, and contributes to approximately 750,000 hospitalizations per year, a third of which may die.
- Trial name
- NCT03473769
- Testing
- Vital Signs at 2 Hours, Confusion Assessment method for the ICU (CAM-ICU)
- Where
- United States
- Sponsor
- NYU Langone Health
Subarachnoid Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal
Detecting Sepsis in Patients With Severe Subarachnoideal Hemorrhage
The study aims to evaluate the suitability of the SOFA score implemented by the Sepsis 3 guideline to detect sepsis in patients suffering from subrarachnoid hemorrhage.
- Conditions
- Subarachnoid Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal, Sepsis Syndrome, Sepsis
- Trial name
- NCT05246969
- Testing
- Sepsis detection
- Where
- Germany
- Volunteers
- 58 people
- Sponsor
- Goethe University
Sepsis, Severe Community-acquired Pneumonia (sCAP)
Molecular Biomarkers for Sepsis
This multi-center observational case-control study in Intensive Care Unit (ICU) patients is to identify novel biomarkers allowing to recognize severe community acquired pneumonia (sCAP) -associated sepsis at an earlier stage and…
- Conditions
- Sepsis, Severe Community-acquired Pneumonia (sCAP), Infection, Bacterial
- Trial name
- NCT04280354
- Testing
- compare data patterns by data-driven algorithms to determine sepsis, compare data patterns by data-driven algorithms to predict sepsis-related mortality
- Where
- 15 sites in Switzerland
- Volunteers
- 3 people
- Sponsor
- University Hospital, Basel, Switzerland
Sepsis
Assessment of Disease Severity, Progression and Treatment in Infected Patients Presenting to the Emergency Department
The results of the SIDED study (doi: 10.1186 / s13054-019-2329-5) showed that MR-proADM can be a good biomarker to establish the prognosis of patients attended in the emergency department (ED) due to suspected infection.
- Trial name
- ADAPTED (NCT03992794)
- Testing
- Measurement of MR-proADM
- Where
- 3 sites in Spain
- Volunteers
- 684 people
- Sponsor
- Juan González-del Castillo
Sepsis, Post Cardiac Surgery Low Output Syndrome Requiring Inotropic/Vasopressor Therapy
Comparison of Central Venous Oxygen Saturation Measurements by Non-invasive Mespere Venous Oximeter and Central Venous Catheter
The intent of this study is to validate the venous blood oxygenation measurements of the Mespere VA Oximeter compared to the saturations measured by venous blood sampling through an inserted central vein catheter, which is…
- Conditions
- Sepsis, Post Cardiac Surgery Low Output Syndrome Requiring Inotropic/Vasopressor Therapy, Cardiogenic Shock Post Myocardial Infarction, Hypoxemic Respiratory Failure.
- Trial name
- NCT01788956
- Testing
- Mespere Venous Oximeter, Co-Oximeter
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Mespere Lifesciences Inc.
Brain Injuries, Dementia
ACT-ICU Study: Activity and Cognitive Therapy in the Intensive Care Unit
Intensive care unit (ICU) hospitalization saves lives but often does so at a high personal cost to ICU survivors who frequently experience significant cognitive impairment and an array of physical and functional disabilities that…
- Conditions
- Brain Injuries, Dementia, Myopathies, Muscle Disorders
- Trial name
- ACT-ICU (NCT01270269)
- Testing
- Behavioral: Physical and functional rehabilitation, Behavioral: Cognitive, physical, & functional rehabilitation
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Vanderbilt University
Sepsis
Indicators of Inflammation and Coagulation in Sepsis
We will collect blood samples from patients with the diagnosis of sepsis and other ICU patients. We will describe the course of different mediator levels and organ injury markers and follow their progression throughout the course…
- Trial name
- NCT01128283
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Oklahoma
Neonatal Sepsis
White Blood Cells and Platelets Indices as a Prognostic Factor in Neonatal Sepsis
Sepsis is a complex condition initiated by a pathogen and mediated by cytokines followed by immune, inflammatory, and coagulation homeostasis disturbances, its evolution being dictated by a complicated balance between pro…
- Trial name
- NCT03880305
- Testing
- complete blood count
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Respiratory Distress Syndrome, Adult
Evaluation of Safety & Efficacy of BIO-11006 Inhalation Solution in Patients With ARDS
This Phase IIa pilot study is a placebo controlled, multicenter study to evaluate safety and efficacy of aerosolized BIO-11006 Inhalation Solution in ARDS patients.
- Trial name
- NCT03202394
- Testing
- BIO-11006
- Where
- 5 sites in United States
- Volunteers
- 38 people
- Sponsor
- BioMarck Pharmaceuticals, Ltd.
Sepsis
Electronic Early Notification of Sepsis in Hospitalized Ward Patients
Screening for sepsis has been recommended by the Surviving Sepsis Campaign Clinical Practice Guidelines to facilitate early identification and early management of sepsis.
- Trial name
- SCREEN (NCT04078594)
- Testing
- sepsis e-alert
- Where
- Saudi Arabia
- Volunteers
- 65,250 people
- Sponsor
- King Abdullah International Medical Research Center
Sepsis, Septic Shock
Mitochondrial Function in Septic Patients
Aim #1 To investigate the prevalence, risk and correlation of the level of sepsis with mitochondrial dysfunction in sepsis patients Aim 1.1 To investigate the prevalence of mitochondria dysfunction among sepsis patients Aim 1.2…
- Trial name
- MtiSS (NCT03748537)
- Testing
- Hydrocortisone
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Chiang Mai University
Critically Ill, Acute Kidney Injury
Renal Resistive Index and Cardiac Output Changes During Resuscitation Predict the Occurrence of Acute Kidney Injury in Septic Shock Patients
Record the renal resistive index and hemodynamic parameters ( record the cardiac output and stroke volume if the patient's next to kin agree to undertake a PiCCO monitoring ) before and after resuscitation for severe sepsis or…
- Conditions
- Critically Ill, Acute Kidney Injury, Septic Shock
- Trial name
- CORRI (NCT01862588)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhongda Hospital
Sepsis
Beta-lactam Intermittent Versus Continuous Infusion and Combination Antibiotic Therapy in Sepsis
Patients hospitalized in ICU with sepsis (infection with life-threatening organ dysfunction according to sepsis 3.0 definitions) or septic shock presumably due to MDR-GNB (multidrug resistant Gram-negative bacteria).
- Trial name
- BICCS (NCT05681442)
- Testing
- continuous pivotal βL-AB, intermittent pivotal βL-AB, AG infusion most 1 dose
- Where
- 26 sites in France
- Volunteers
- 600 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis (SMQ), Opportunistic Infections
Evaluation of Reporting of Antibody-Drug Conjugate Associated Sepsis-related Toxicities
Although antibody-drug conjugate(ADC) has proved effective in treating many cancers, few patients receiving ADC may experience rare but life-threatening sepsis-related toxicities such as sepsis and septic shock.
- Conditions
- Sepsis (SMQ), Opportunistic Infections, Agranulocytosis
- Trial name
- NCT05349383
- Testing
- Antibody-Drug Conjugate, Antineoplastic and immunomodulating agents other than Antibody-Drug Conjugate
- Where
- China
- Volunteers
- 24,618 people
- Sponsor
- Central South University
Bloodstream Infection
European Prospective Bloodstream Infection Cohort
Background: Bloodstream infections (BSIs) and sepsis continue to pose significant public health challenges, contributing to high morbidity and mortality worldwide.
- Trial name
- EPIC-BSI (NCT07082322)
- Where
- Germany
- Volunteers
- 40,000 people
- Sponsor
- University Hospital Freiburg
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