Clinical trials: Sepsis Syndromes
Sepsis Syndrome, Emergency Department
Can we Improve Mortality Prediction in Patients With Sepsis in the Emergency Department
This study aims to identify the prognostic role of procalcitonin (PCT), soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1), the soluble form of the urokinase plasminogen activator receptor (suPAR), highly…
- Conditions
- Sepsis Syndrome, Emergency Department, Biomarker
- Trial name
- NCT06338111
- Testing
- ELISA Sepsis Biomarkers dosage
- Where
- Romania
- Volunteers
- 67 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Sepsis, Lymphocyte Disorder T
Esmolol in Sepsis Management:Evaluating Immunomodulatory Effects and Impact on Patient Outcomes
Evaluate the effectiveness of esmolol, a selective β1-adrenergic receptor blocker, in modulating immune responses and improving patient outcomes in sepsis.
- Conditions
- Sepsis, Lymphocyte Disorder T, Immunologic Paralysis, Catecholamine; Overproduction
- Trial name
- NCT06390748
- Testing
- esmolol
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Lin Chen
Septic Shock, Shock
Hemodynamic Response to Angiotensin-II When Used as the Second Vasopressor Agent for Septic Shock
Norepinephrine is a catecholamine that is the first-line vasopressor for septic shock. The addition of non-catecholamine vasopressors, including vasopressin and angiotensin-II may be used in adults with septic shock that have…
- Conditions
- Septic Shock, Shock, Sepsis, Systemic Inflammatory Response Syndrome
- Trial name
- NCT06122987
- Testing
- Angiotensin II and hydrocortisone sodium succinate
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Kingman Regional Medical Center
Acute Respiratory Distress Syndrome, Sepsis
Multiple Study of Electroaccpuncture in ARDS
In order to clarify the clinical efficacy of electroacupuncture on inhibiting systemic inflammatory response, improving respiratory mechanics parameters and prognosis in patients with sepsis-related ARDS.
- Trial name
- NCT06278675
- Testing
- Acupuncture needles
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Nanjing University of Traditional Chinese Medicine
Sepsis, Acute Respiratory Distress Syndrome
Electroacupuncture Modulates SPMs Metabolism and Respiratory Symptoms in Patients With Sepsis Complicating ARDS
In this interventional clinical trial, researchers will administer electroacupuncture versus sham electroacupuncture to sepsis patients with ARDS and collect objective outcome measures. The study will be divided into 2 groups.
- Trial name
- NCT06006325
- Testing
- electroacupuncture treatment
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Tianjin Nankai Hospital
ARDS, Human, Sepsis, Severe
The Effect pf Goal-directed De-escalation in ARDS on Organ Function and Mortality
Objective: To compare two de-escalation strategies guided by either extravascular lung water or global end-diastolic volume-oriented algorithms in patients with sepsis and ARDS. Design: A prospective randomized study.
- Trial name
- NCT04508296
- Testing
- Goal directed de-escalation therapy
- Where
- Russia
- Volunteers
- 46 people
- Sponsor
- Northern State Medical University
Fluid Overload, Critical Illness
Role of Active Deresuscitation After Resuscitation:
The RADAR-Canada trial is a pilot RCT undertaken to assess the acceptability of, compliance with, and biologic consequences of a deresuscitation protocol designed to expedite the removal of excess interstitial fluid in patients…
- Conditions
- Fluid Overload, Critical Illness, Sepsis, ARDS
- Trial name
- RADAR-Canada (NCT06326112)
- Testing
- Furosemide Injection, Metolazone Tablets
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Unity Health Toronto
Premature Birth, Respiratory Distress Syndrome in Premature Infant
Physiologically Based Cord Clamping To Improve Neonatal Outcomes In Moderate And Late Preterm Newborns
Before birth, the baby's lungs are filled with fluid and babies do not use the lungs to breathe, as the oxygen comes from the placenta. As delivery approaches, the lungs begin to absorb the fluid.
- Conditions
- Premature Birth, Respiratory Distress Syndrome in Premature Infant, Sepsis, Intraventricular Hemorrhage of Prematurity
- Trial name
- PhyCordPrem (NCT06280872)
- Testing
- Physiological Based Cord Clamping, Differed Cord Clamping
- Where
- 2 sites in Belgium
- Volunteers
- 180 people
- Sponsor
- Queen Fabiola Children's University Hospital
Cardiovascular Diseases, Acute Coronary Syndrome
The IndONEsia ICCU Registry: a Multicenter Cohort of Intensive Cardiovascular Care Units Patients in Indonesia
Patients in the Intensive Cardiovascular Care Unit (ICCU) often present with cardiovascular disease (CVD) issues accompanied by various non-cardiovascular conditions.
- Conditions
- Cardiovascular Diseases, Acute Coronary Syndrome, Heart Failure, Heart Disease, Coronary
- Trial name
- NCT06265714
- Where
- 9 sites in Indonesia
- Volunteers
- 12,950 people
- Sponsor
- Universitas Indonesia
Sepsis, Non-Infectious Systemic Inflammatory Response Syndrome
Gene Expression Objective Definition of Early Sepsis In Children
GEODESIC is a prospective descriptive cohort investigation that will examine the generalizability of the novel host gene expression biomarkers, SeptiCyteTM LAB, SeptiCyteTM VIRUS, SeptiCyteTM BACT, and SeptiCyteTM TRIAGE…
- Trial name
- GEODESIC (NCT06231862)
- Testing
- SeptiCyte (various)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Seattle Children's Hospital
Sepsis, Trauma
BIA Assessment of Polymyoneuropathy in Critically Ill Patients
The aim of the study is to monitor and evaluate changes in body composition, with a special emphasis on muscle mass, in the context of polyneuromyopathy of critically-ill patients at ICU, on artificial ventilation (duration of…
- Conditions
- Sepsis, Trauma, Respiratory Insufficiency, Surgery
- Trial name
- NCT04758676
- Testing
- Nutritional and physiotherapy protocol, BIA, Standard of care
- Where
- 2 sites in Czechia
- Volunteers
- 60 people
- Sponsor
- University Hospital Ostrava
COVID-19, Critical Illness
Immune Modulation by Exosomes in COVID-19
Following whole blood stimulation with mesenchymal stem cell derived exosomes, immune phenotype, cytokine release and mRNA expression patterns from critically ill patients with COVID-19 will be determined.
- Conditions
- COVID-19, Critical Illness, Hypercytokinemia, Lung Fibrosis
- Trial name
- IMECOV19 (NCT05191381)
- Testing
- Application of exosomes in a whole blood assay
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Sepsis
Using Biomarkers to Optimize Antibiotic Strategies in Sepsis
The proposed work will provide critical insights into the potential impact of a biomarker-based algorithm on reducing unnecessary antibiotic use in different adult and pediatric/neonatal ICU's.
- Trial name
- NCT02207114
- Testing
- Biomarker Algorithm Intervention
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- University of Pennsylvania
Hypoxemia, Pulmonary Sepsis
Effect of Lung Protective One-lung Ventilation With Fix and Variable PEEP on Oxygenation and Outcome
During One-lung ventilation, the use of lower tidal volumes (VT) is helpful to avoid over-distension, provide sufficient oxygenation, but can result in increased atelectasis.
- Conditions
- Hypoxemia, Pulmonary Sepsis, ARDS, Human, Pneumonia
- Trial name
- NCT03968120
- Testing
- Change of ventilatory settings
- Where
- Hungary
- Volunteers
- 140 people
- Sponsor
- University of Debrecen
Sepsis, AKI
Effect of Antibiotic Choice On ReNal Outcomes (ACORN)
Sepsis is one of the most common causes of acute illness and death in the United States. Early, empiric broad-spectrum antibiotics are a mainstay of sepsis treatment.
- Conditions
- Sepsis, AKI, Neurotoxicity
- Trial name
- ACORN (NCT05094154)
- Testing
- anti-pseudomonal cephalosporin, anti-pseudomonal penicillin
- Where
- United States
- Volunteers
- 2,634 people
- Sponsor
- Vanderbilt University Medical Center
Skin and Soft Tissue Infections, Hiv
ASAP: Access to Syringes at Pharmacies for the Prevention of Bloodborne Infections Among People Who Inject Drugs
Access to Syringes at Pharmacies (ASAP) is a refinement of an evidence-based, pharmacy intervention to increase pharmacy-based sales of syringes to PWID in order to reduce bloodborne illnesses among them.
- Conditions
- Skin and Soft Tissue Infections, Hiv, Hepatitis C, Bloodstream Infection
- Trial name
- ASAP (NCT05270135)
- Testing
- ASAP
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Arizona
AIDS, Pneumonia
Metagenomic Next-Generation Sequencing Guides Anti-Infection Strategies
This study aims to observe the effectiveness of clinical application in guiding anti-infection treatments in AIDS patients with severe pneumonia and/or sepsis using Metagenomic Next-Generation Sequencing-based technology in the…
- Conditions
- AIDS, Pneumonia, Sepsis, Neonatal
- Trial name
- NCT06145841
- Testing
- Pathogen metagenomic next-generation sequencing
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Guangzhou 8th People's Hospital
Streptococcal Sepsis, Invasive Group A Beta-Haemolytic Streptococcal Disease
Adjunctive Clindamycin Versus Linezolid for β-lactam Treated Patients With Invasive Group A Streptococcal Infections
This study aims to emulate a hypothetical target pragmatic multi-center, non-blinded trial of adult inpatients in the PINC AITM dataset with B-lactam treated culture confirmed monomicrobial invasive Group A streptococcus (GAS)…
- Conditions
- Streptococcal Sepsis, Invasive Group A Beta-Haemolytic Streptococcal Disease, Necrotizing Soft Tissue Infection, Infection, Bloodstream
- Trial name
- iGASAntitox (NCT06126263)
- Testing
- Linezolid, Clindamycin
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Trauma Injury, Brain Injuries
The Effect of Supraglottic and Oropharyngeal Decontamination on the Incidence of Ventilator-associated Pneumonia
Oropharynx is the main source of pathogen microorganisms for the ventilator - associated pneumoniae. As known bacteriophages can eliminate different pathogen microorganisms or reduce a degree of a pathogen's colonization.
- Conditions
- Trauma Injury, Brain Injuries, Abdominal Sepsis, Pancreatitis
- Trial name
- SGDC-VAP (NCT04325685)
- Testing
- Control, Antiseptic Solution, Bacteriophage
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Northern State Medical University
Covid19, Acute Respiratory Distress Syndrome
Blood Volume Assessment in COVID-19 and Bacterial Sepsis
In patients with SARS-CoV-2 or bacterial infection admitted to the intensive care unit (ICU), the state of the intravascular volume, the characteristics of the blood volume components, and the development of a vascular leak is…
- Conditions
- Covid19, Acute Respiratory Distress Syndrome, Bacterial Sepsis, Bacterial Infections
- Trial name
- BVAC19 (NCT04517695)
- Testing
- BVA-100, Transpulmonary Thermodilution (TPTD), Sublingual Microcirculation
- Where
- 3 sites in United States
- Volunteers
- 39 people
- Sponsor
- NYU Langone Health