Clinical trials: Septic
Sepsis, Septic Shock
Thoracic Fluid Content During Stabilization and Therapeutic De-escalation in Septic Shock
In ICU, fluid challenge represents one of the cornerstones of hemodynamic care. However, fluid overload due to an excessive and/or inappropriate fluid administration could be associated with morbidity or mortality.
- Conditions
- Sepsis, Septic Shock, Hemodynamic Instability, Fluid Overload
- Trial name
- TFC-SEPSIS (NCT06572995)
- Where
- 2 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Brest
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Sepsis, Septic Shock
Can Gdf-15 Level Predict Progression to Multiple Organ Failure in Patients With Septic Shock
The aim of this observational study is to investigate whether GDF-15 levels can predict clinical outcome in patients admitted to the intensive care unit with a diagnosis of septic shock.
- Conditions
- Sepsis, Septic Shock, Multi Organ Failure
- Trial name
- NCT06808100
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Ankara City Hospital Bilkent
Shock, Septic
Sevoflurane Sedation in Patients With Septic Shock
Recent in vivo studies from others as well as the investigators group demonstrated that volatile anesthetics immunomodulate sepsis and improve outcome.
- Trial name
- SSiS (NCT03643367)
- Testing
- Sevoflurane, Control Group
- Where
- 4 sites in Switzerland
- Volunteers
- 153 people
- Sponsor
- University of Zurich
Cardiogenic Shock, Septic Shock
Levosimendan Versus Dobutamine in Shock Patients
The purpose of the study is to compare the efficacy of levosimendan with that of dobutamine in patients with unstable hemodynamics (shock).
- Trial name
- NCT00093301
- Testing
- Levosimendan, Dobutamine
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Wentworth Area Health Services
Septic Shock
Hemodynamic Effects of Vasopressin in Early Septic Shock Stage
Vasopressin is a vasopressor used in patients with septic shock. However, its systemic hemodynamic effects and its microcirculation effects are not completely known and understood.
- Trial name
- NCT02053675
- Testing
- Vasopressin infusion
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- Federal University of São Paulo
Secondary Peritonitis After Intestinal Perforation
Procalcitonin Ratio's Impact on the Decision Upon On-demand Relaparotomy in Septic Peritonitis
Procalcitonin (PCT) serum levels are monitored in patients with secondary peritonitis after initial operative focus elimination to investigate the PCT ratio's impact on decision-making for or against early relaparotomy in the…
- Trial name
- NCT01768936
- Where
- Germany
- Volunteers
- 234 people
- Sponsor
- CHIR-Net
Sepsis
Efficacy & Safety of Resatorvid in Adults With Severe Sepsis
The purpose of this study is to determine the optimal dose of Resatorvid for reducing 28-day all-cause mortality in subjects with severe sepsis.
- Trial name
- NCT00143611
- Testing
- Resatorvid
- Where
- 144 sites in United States, Australia and 15 more
- Volunteers
- 277 people
- Sponsor
- Takeda
Septic Shock, Vascular Dysfunction
Shenfu Injection Modulates Carotid Elasticity in Septic Shock
What is this study about? We are studying whether Shenfu Injection (a traditional Chinese herbal medicine) can help improve blood vessel health in patients with septic shock-a severe complication of infections that can damage…
- Conditions
- Septic Shock, Vascular Dysfunction, Arterial Stiffness, Carotid Artery Elasticity Alterations
- Trial name
- NCT06915506
- Testing
- Shenfu Injection
- Where
- China
- Volunteers
- 48 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Sepsis, Septic Shock
Validation of SOFA-2 for Mortality and Sepsis-3 Prevalence in Turkey
The goal of this observational study is to validate the effectiveness of the new SOFA-2 score in predicting mortality and to determine the current frequency of sepsis in adult patients admitted to Intensive Care Units (ICUs) in…
- Conditions
- Sepsis, Septic Shock, Critical Illness, Organ Dysfunction
- Trial name
- TURK-SOFA2 (NCT07300306)
- Where
- Turkey (Türkiye)
- Volunteers
- 3,379 people
- Sponsor
- Marmara University
HAP - Hospital Acquired Pneumonia, VAP - Ventilator Associated Pneumonia
HAP/VAP Diagnosis in Critically Ill Septic Patients Using a Multiplex PCR Array
Multicenter, randomized, controlled, open-label trial to assess if semiquantitative multiplex PCR assay, as compared to conventional microbiology, can reduce the percentage of patients without microbiological diagnosis in the…
- Trial name
- LIGHTNING (NCT05952648)
- Testing
- Lower tract respiratory samples, Multiplex PCR assay (Film-array Pneumonia Panel Plus), Lower respiratory tract standard culture
- Where
- 4 sites in Italy
- Volunteers
- 126 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sepsis
The Effect of Semi-quantitative Procalcitonin Assay to The Adequacy of Empirical Antibiotics and Mortality in Septic Patients
Sepsis is a serious clinical condition with a considerable morbidity and mortality. Procalcitonin (PCT) is a good biomarker for early diagnosis and infection monitoring.
- Trial name
- NCT01862185
- Testing
- semi-quantitative procalcitonin
- Where
- Indonesia
- Volunteers
- 205 people
- Sponsor
- Universitas Indonesia
Sepsis
Reconstruction of Monocytic Immunocompetence by Granulocyte-macrophage-colony Stimulating Factor (GM-CSF) in Patients With Severe Sepsis and Septic Shock
There is basic science evidence that GM-CSF reconstructs cellular immunity in septic patients. In this prospective, randomised double-blind, placebo-controlled trial, we investigate whether this can be achieved in patients with…
- Trial name
- NCT00252915
- Testing
- GM-CSF (verum)
- Volunteers
- 38 people
- Sponsor
- Charite University, Berlin, Germany
Septic Shock, Sepsis
Effects of Dexmedetomidine on Sublingual Microcirculation and Vascular Waterfall Phenomenon in Patients With Septic Shock
This prospective, multicenter, single-arm, open-label interventional pilot study aims to evaluate the short-term physiological effects of intravenous dexmedetomidine on sublingual microcirculation and vascular-waterfall…
- Conditions
- Septic Shock, Sepsis, Critical Illness
- Trial name
- DEX-MICRO (NCT07657715)
- Testing
- Dexmedetomidine Intravenous Infusion
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Septic Shock
SQUEEZE Trial: A Trial to Determine Whether Septic Shock Reversal is Quicker in Pediatric Patients Randomized to an Early Goal Directed Fluid Sparing Strategy vs. Usual Care
The purpose of the SQUEEZE Trial is to determine which fluid resuscitation strategy results in the best outcomes for children treated for suspected or confirmed septic shock.
- Trial name
- SQUEEZE (NCT03080038)
- Testing
- Fluid Sparing Resuscitation Strategy
- Where
- 8 sites in Canada
- Volunteers
- 406 people
- Sponsor
- McMaster University
Trauma Injury, Acute Coronary Syndrome
Smart Glasses in Emergency Medicine From the Hangzhou Asian Games
The findings of our study will reveal that using smart glasses in the emergency department(ED) could facilitate patient admission. AR Smart Glasses offer the potential to enhance the effectiveness and speed of treatment within ED.
- Conditions
- Trauma Injury, Acute Coronary Syndrome, Stroke, Acute, Septic Shock
- Trial name
- SGINHZAG (NCT06623825)
- Testing
- teleconsultation by Augmented Reality smart glasses, teleconsultation by two-way radio connection.
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Sir Run Run Shaw Hospital
Sepsis, Septic Shock
Peripheral Perfusion Index-guided Fluid Resuscitation for Preventing Acute Skin Failure in Elderly Critically Ill Patients
This prospective, randomized, controlled trial aimed to evaluate whether fluid resuscitation guided by the Peripheral Perfusion Index (PPI) could reduce the incidence of Acute Skin Failure (ASF) in elderly critically ill…
- Conditions
- Sepsis, Septic Shock, Acute Skin Failure
- Trial name
- PPI-PROTECT (NCT07367113)
- Testing
- Peripheral Perfusion Index-guided Fluid Resuscitation Protocol, Conventional Goal-Directed Fluid Resuscitation
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Ying Wang
Sepsis, Septic Shock
Implementation of Timely Management of Sepsis and Septic Shock Protocol in the Emergency Department and Intensive Care Unit: A Quality Improvement Project at AFHJ
Study Title: Implementation of a Sepsis Management Protocol at Armed Forces Hospital Jazan (AFHJ). Purpose: The purpose of this quality improvement project is to determine if implementing a standardized, evidence-based "sepsis…
- Conditions
- Sepsis, Septic Shock, Systemic Inflammatory Response Syndrome (SIRS), Critical Illness
- Trial name
- NCT07460024
- Testing
- Adapted Surviving Sepsis Campaign (SSC) Protocol, Standard Clinical Care
- Where
- Saudi Arabia
- Volunteers
- 120 people
- Sponsor
- Al-Azhar University
Septic Shock, Calcium Sensing Receptor
Impact of Vascular Calcification and CASR Expression by Monocytes in Septic Shock
In septic shock, bacterial LPS is able to activate the CaSR of cardiomyocytes inducing their apoptosis in vitro. CaSR activation in monocytes is responsible for activation of the NLRP3 inflammasome and macropinocytosis.
- Conditions
- Septic Shock, Calcium Sensing Receptor, Calcium Phosphate Disorders, Inflammation
- Trial name
- CASRCHOC (NCT06853340)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Heart Failure, Myocarditis
CharacterisatiON of carDiac funCTion in Intensive Care Unit Survivors of Sepsis.
Cardiac dysfunction is common following hospital admission with sepsis and one of the most frequent causes for readmissions to hospital, however underlying mechanisms by which this might occur are unclear.
- Conditions
- Heart Failure, Myocarditis, Sepsis, Septic Shock
- Trial name
- CONDUCT-ICU (NCT05633290)
- Testing
- CMR, hs-troponin, NT-pro BNP
- Where
- 2 sites in United Kingdom
- Volunteers
- 69 people
- Sponsor
- NHS Greater Glasgow and Clyde
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