Clinical trials: Septic
Sepsis Septic Shock
Bedside vs. Standard Microbiological Blood Culture Diagnostics - BEMIDIA Study
With a completely bedside blood culture diagnostics system (BACTEC blood culture system in combination with the Accelerate ID/AST System) it is possible to optimize the initial antimicrobial therapy in patients with sepsis and…
- Trial name
- BEMIDIA (NCT03000049)
- Testing
- bedside blood culture
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University Medicine Greifswald
Acute Kidney Injury Due to Sepsis (Disorder)
A Multiple Centre, Cohort Study of New CRRT Membranes oXiris for Patients With Septic Shock
The objectives of this study are to determine whether Continuous Renal Replacement Therapy (CRRT) with oXiris in patients with septic shock would improve clinical outcomes such as the sepsis-related organ failure assessment…
- Trial name
- NCT04073771
- Testing
- Continuous renal replacement therapy with oXiris
- Where
- 2 sites in China
- Volunteers
- 590 people
- Sponsor
- Southeast University, China
Cardiac Output, LIDCO Rapid, Septic Shock
Validation of Uncalibrated Cardiac Output Measurement With LiDCOrapid in the Resuscitation of Critically Ill Patients With Septic Shock: A Prospective Cross-sectional Study.
Transthoracic echocardiography (TTE) has been used as a reference technique for CO measurement and its accuracy has been adequate for many clinical uses. TTE is painless, safe and non-invasive.
- Trial name
- NCT04705493
- Testing
- fluid resuscitation with crystalloid
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Shock, Septic
Efficacy, Safety and Tolerability of Nangibotide in Patients With Septic Shock
This is a randomized, double-blind, placebo-controlled dose-selection study in which two doses of nangibotide are tested versus placebo.
- Trial name
- ASTONISH (NCT04055909)
- Testing
- nangibotide low dose, nangibotide high dose
- Where
- 43 sites in Belgium, Denmark and 4 more
- Volunteers
- 355 people
- Sponsor
- Inotrem
Septic Shock, Fluid Resuscitation
Role of Echocardiography and Ultrasound Indices in Resuscitation of Septic Shock Patients
Fluid replacement is considered the cornerstone of hemodynamic management in critically ill patients especially in patients with septic shock.
- Trial name
- NCT07550400
- Testing
- carotid artery duplex, Left ventricular end diastolic area
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Sepsis, Shock, Septic
Sepsis Assessment in Belgian Emergency Rooms
To validate the use of the Heparin Binding Protein (HBP) concentration to assist in the evaluation of patients admitting to the emergency department with suspected infection.
- Conditions
- Sepsis, Shock, Septic, Severe Sepsis
- Trial name
- SABER (NCT02424721)
- Where
- 4 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- Axis Shield Diagnostics Ltd
Septic Shock, Adverse Event
Early Versus Conventional Cessation of Hydrocortisone in Septic Shock
Septic shock is one of the causes of death in ICU and hospital. Refractory shock is the problem which healthcare providers should recognize though it is difficult to handle with.
- Conditions
- Septic Shock, Adverse Event, Hydrocortisone, Hyperglycemia
- Trial name
- CESSHYDRO (NCT05818826)
- Testing
- normal saline solution, Hydrocortisone and normal saline solution
- Where
- Thailand
- Volunteers
- 160 people
- Sponsor
- Mahidol University
Sepsis, Sepsis and Septic Shock
Hemodynamic Venous Congestion Ultrasound (VExUS) by ICU Nurses in Sepsis Patients.
Sepsis is a serious condition where the body's immune response to infection overreacts, leading to organ damage and death. Venous congestion, a buildup of blood in the veins, can occur in sepsis and contribute to organ injury.
- Conditions
- Sepsis, Sepsis and Septic Shock, Sepsis at Intensive Care Unit, Intensive Care Nurses
- Trial name
- VEXIVAN (NCT07406750)
- Testing
- Education in performing hemodynamic diagnostic ultrasound of venous congestion, Hemodynamic diagnostic ultrasound of venous congestion
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Region Örebro County
Sepsis, Shock, Septic
Comparison of Peripheral Perfusion Indicators and Lactate Levels
In patients with septic shock undergoing intensive care unit monitoring, routine assessment of arterial and/or venous blood gas is conducted.
- Conditions
- Sepsis, Shock, Septic, Hypotensive, Lactate
- Trial name
- NCT06727318
- Where
- Turkey (Türkiye)
- Volunteers
- 192 people
- Sponsor
- Gulhane Training and Research Hospital
To Explore the Influence of CRRT Nursing Team Management Plan on the Prognosis of SAKI Patients
Impact of the CRRT Management Protocol on Prognostic Outcome in Patients With Septic Acute Kidney Injury
The implementation of CRRT nursing team management program in the treatment of SAKI can significantly reduce the incidence of adverse events and complications in CRRT nursing, which has a positive role in improving the success…
- Trial name
- NCT06083285
- Testing
- Implement the CRRT specialist nursing group management program on the basis of routine care
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Xinjiang Medical University
SIRS, Sepsis
Prevalence and Outcome of Hypermetabolism in Initial Prevalence and Outcome of Hypermetabolism in Initial Phase of Intensive Care Unit Patient: a Prospective Observational Study
Patients in critical illness frequently present hypermetabolism， which can extremely increase the rest energy expenditure（REE）. We hypothesize that if we alleviate the extremely increased REE will improve ICU patients' outcome
- Conditions
- SIRS, Sepsis, Septic Shock
- Trial name
- NCT02002676
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Nanjing University School of Medicine
Severe Sepsis, Organ Failure
Comparative Study of the Protein C Pathway in Septic and Non Septic Patients With Organ Failure
This is a comparative study performed in 3 groups of patients/subjects: 30 severe sepsis patients, 30 non-septic patients with organ failure, 30 healthy subjects.
- Trial name
- NCT00361725
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Severe Sepsis, Septic Shock
International Multicentre Prevalence Study on Sepsis
To mark 10 years of the Surviving Sepsis Campaign (SSC), and timed to coincide with World Sepsis Day, on September 13, 2013, the SSC, ESICM and SCCM will be conducting an international point prevalence study of severe sepsis and…
- Trial name
- IMPRESS (NCT01943747)
- Where
- Belgium
- Volunteers
- 1,000 people
- Sponsor
- European Society of Intensive Care Medicine
Sepsis, Septic Shock
Dose-response Study of Arginine Supplementation in Severe Sepsis
Pilot data in patients and data from pig studies indicate that arginine-NO metabolism is impaired in sepsis with changes in splanchnic metabolism and function, and reduced survival at low nitrate levels.
- Trial name
- NCT01775020
- Testing
- L-arginine
- Volunteers
- 8 people
- Sponsor
- Maastricht University Medical Center
Septic Shock, Antibiotic Resistant Infection
Pharmacokinetics of High-dose Tigecycline in Critically Ill Patients
The objective of this study is to describe the pharmacokinetics of tigecycline in critically ill patients receiving continuous venovenous haemodialysis (CVVHD) and to evaluate the frequency of pharmacokinetic/pharmacodynamic…
- Conditions
- Septic Shock, Antibiotic Resistant Infection, Critical Illness
- Trial name
- NCT03034174
- Where
- Poland
- Volunteers
- 37 people
- Sponsor
- Medical University of Lublin
Severe Sepsis, Septic Shock
Neutrophil Gelatinase Associated Lipocalin (NGAL) in Urine: Can This Prove to be a Biomarker for Acute Kidney Injury in Patients With Sepsis?
Patients with severe infection and sepsis are in high risk of hypo perfusion and therefore organ affection. Temporary or permanent kidney failure is a common complication in these patients.
- Conditions
- Severe Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- NCT02034240
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Sygehus Lillebaelt
Osteo Arthritis, Cellulitis
Continuous Regional Anesthesia for Septic Limb Orthopedic Surgery
This study aims to assess the safety of using continuous regional anesthesia for post-operative analgesia during septic limb orthopedic surgery.
- Trial name
- ACOSM (NCT01947660)
- Testing
- Systemic analgesia + Continuous regional anesthesia, Systemic analgesia
- Where
- France
- Volunteers
- 260 people
- Sponsor
- University Hospital, Strasbourg, France
Infections, Critical Illness
Ventilator-Associated Pneumonia in Critically Ill COVID-19 vs. Non-COVID-19 Patients
The COVID-19 pandemic has led to an increased incidence of ventilator-associated pneumonia (VAP) among critically ill patients. However, in a context of high prevalence of multidrug-resistant organisms (MDROs) there is a lack of…
- Conditions
- Infections, Critical Illness, Superinfection, Organ Failure, Multiple
- Trial name
- NCT05972980
- Testing
- COVID-19
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Turin, Italy
Septic Shock
Capillary Refill Time Response to a Rapid Fluid Challenge in Septic Shock Patients
In septic shock patients, the hemodynamic coherence between systemic, regional and microcirculatory blood flow can be tracked by "capillary refill time (CRT) response to an increase in stroke volume induced by a rapid fluid…
- Trial name
- AUSTRALIS (NCT04693923)
- Testing
- Fluid challenge
- Where
- Chile
- Volunteers
- 42 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Sepsis, Septic Shock
Ulinastatin Treatment in Adult Patients With Sepsis and Septic Shock in China
A Prospective, Multi-Centre, Double-Blind, Randomized, Placebo-Controlled, Trial of Ulinastatin Treatment in Adult Patients with Sepsis and Septic Shock in China
- Trial name
- NCT02647554
- Testing
- ulinastatin
- Where
- China
- Volunteers
- 347 people
- Sponsor
- Peking Union Medical College Hospital
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