Clinical trials: Septic
Septic Shock
Clinical Trial Comparing Noradrenaline (NA) Plus Placebo Versus Noradrenaline Plus Terlipressin (TP) in Septic Shock
Septic shock is a major health problem. In the clinical practice guidelines of the Surviving Sepsis Campaign is recommended to add vasopressin (VP) or epinephrine in case of not reaching the goal of mean arterial pressure (MAP)…
- Trial name
- NCT05207280
- Testing
- Noradrenaline plus Terlipressin
- Where
- 10 sites in Spain
- Volunteers
- 152 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Sepsis
Role of the Kallikrein-kinin System in Septic Cardiomyopathy
The purpose of this study is to investigate whether there are differential expressions of molecules in the kallikrein-kinin system (KKS) pathway in septic cardiomyopathy, and to analyze their regulatory mechanisms and gene…
- Trial name
- NCT06080282
- Testing
- Ulinastatin
- Where
- China
- Volunteers
- 567 people
- Sponsor
- Qin Zhang
Septic Shock
Impact of Early Goal-Directed Therapy to Perfusion and Metabolism of Brain
Early goal directed therapy (EGDT) is an effective treatment for patients with septic shock, which is widely used in clinic. Fluid resuscitation can significantly reduce the mortality of patients with septic shock and improve the…
- Trial name
- NCT02706379
- Testing
- Local cerebral oxygen saturation
- Volunteers
- 26 people
- Sponsor
- Southeast University, China
Sepsis, Septic Shock
Lactate Kinetics in Septic Shock
Lactate kinetics will be studied in hospitalized septic patients using a bolus injection of stable isotopically labeled lactate.
- Trial name
- LKISS (NCT05349370)
- Testing
- Isotopically labeled lactate
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Karolinska University Hospital
Hyperglycemia, Hypotension
Feasibility of Using the "CGM GUARDIAN 2" Interstitial Fluid Glucose Measurement System in Intensive Care Medicine
Glycemic imbalances are very common in shock patients admitted to intensive care units. A blood glucose control every 2 hours is routinely performed in patients requiring insulin therapy.
- Conditions
- Hyperglycemia, Hypotension, Shock, Septic
- Trial name
- GALI (NCT04910841)
- Testing
- CGM GUARDIAN 2
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Septic Shock, Hemodynamic Instability
Hemodynamic Measurements of Macrocirculatory and Perfusion Parameters in ICU
In septic shock there is growing evidence of a state of hemodynamic "disconnection" with seemingly adequate macrocirculatory values despite actual microcirculation failing to meet cellular demand.
- Conditions
- Septic Shock, Hemodynamic Instability, Vasoconstriction
- Trial name
- NCT05225402
- Testing
- Hemodynamic measurements during reduction in Norepinephrine and fluid boli.
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Septic Shock, Sepsis
Effects of Paroxetine on Cardiovascular Function in Septic Patients
It is known that septic shock is characterized by arterial hypotension, decreased peripheral vascular resistance and hyporeactivity to vasoconstrictor agents, with NO being an important mediator of this organ dysfunction.
- Trial name
- NCT05725837
- Testing
- Paroxetine
- Where
- 2 sites in Brazil
- Volunteers
- 130 people
- Sponsor
- Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude
Septic Shock
The Effect of Early Use of Methylene Blue on Hemodynamics in Septic Shock
This study will include patients requiring high dose of norepinephrine (NA) to maintain blood pressure after fluid resuscitation.
- Trial name
- NCT04970602
- Testing
- Methylene Blue
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Xiangya Hospital of Central South University
Septic Shock, Sepsis
Vitamin C and Septic Shock
This is a randomized, double-blind, placebo-controlled clinical trial to compare Vitamin C versus placebo for patients presenting to the ICU with a diagnosis of septic shock.
- Trial name
- NCT03338569
- Testing
- Vitamin C
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Minnesota
Sepsis and Septic Shock
MIRNA QUANTIFICATION IN PATIENTS WITH SEPTIC SHOCK
Sepsis-induced immunosuppression (SIS) is a common complication in patients with septic shock. Reduced expression of Human leukocyte antigen isotype DR (HLA-DR) on circulating monocytes is a marker for SIS and correlates with…
- Trial name
- MIRSEP (NCT07597122)
- Where
- Switzerland
- Volunteers
- 56 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Sepsis, Heart Failure
Mean Systemic Filling Pressure Continuous Diuretics Critical Care Patients
Within clinical settings observation of hemodynamic changes (e.g. mean systemic filling pressure, cardiac output) in critically ill patients with a clinical indication for deresuscitation with intravenous diuretic therapy.
- Conditions
- Sepsis, Heart Failure, Heart Diseases, Septic Shock
- Trial name
- NCT03395951
- Testing
- Diuretics
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Septic Shock
Vasopressin for Septic Shock Pragmatic Trial
Life-threatening low blood pressure due to a serious infection is called "septic shock." Septic shock is treated with vasopressors, medications that raise blood pressure.
- Trial name
- VASSPR (NCT06217562)
- Testing
- Vasopressin, Recommendation to use a lower initiation threshold for vasopressin, Recommendation to use a higher initiation threshold for vasopressin
- Where
- 13 sites in United States
- Volunteers
- 3,959 people
- Sponsor
- Intermountain Health Care, Inc.
Escalation of Care, Cardiopulmonary Arrest
Early Warning System for Clinical Deterioration on General Hospital Wards
The goal is to develop a two-tiered monitoring system to improve the care of patients at risk for clinical deterioration on general hospital wards (GHWs) at Barnes-Jewish Hospital (BJH).
- Conditions
- Escalation of Care, Cardiopulmonary Arrest, Respiratory Arrest, Severe Sepsis
- Trial name
- NCT01280942
- Testing
- EWS Nursing Alerts, Wireless Remote Sensor
- Where
- United States
- Volunteers
- 20,031 people
- Sponsor
- Washington University School of Medicine
Sepsis, Infections
The Role of NLR in the Diagnosis and Prognosis of Sepsis
Neutrophil-lymphocyte ratio (NLR), as an inflammatory index, is cheap and easy to obtain, and could be widely used in hospitals at all levels.
- Trial name
- NCT05636202
- Testing
- No intervention
- Where
- China
- Volunteers
- 606 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Sepsis, Severe Sepsis
Microcirculatory Oxygen Uptake in Sepsis
Forearm vasoocclusive testing (VOT) will be performed with laser-doppler spectrophotometry system in septic patients on ICU. Microcirculatory oxygen uptake will be checked for prognostic value and for associations with tissue…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT02430142
- Testing
- Vasoocclusive testing
- Where
- Germany
- Volunteers
- 102 people
- Sponsor
- Universitätsmedizin Mannheim
Severe Sepsis, Septic Shock
Scandinavian Starch for Severe Sepsis/Septic Shock Trial
By tradition hydroxyethyl starch (HES) is used to obtain fast circulatory stabilisation in critically ill. High molecular weight HES may, however, cause acute kidney failure in patients with severe sepsis.
- Trial name
- 6S (NCT00962156)
- Testing
- 6% Hydroxyethyl starch 130/0.4, Ringers acetate
- Where
- 26 sites in Denmark, Finland and 2 more
- Volunteers
- 804 people
- Sponsor
- Anders Perner
Sepsis, Septic Shock
IL-40 and IL-41 Levels in Sepsis, Septic Shock, and Healthy Individuals
This study aims to investigate the blood levels of two recently identified immune-related proteins, Interleukin-40 (IL-40) and Interleukin-41 (IL-41), in patients with sepsis and its more severe form, septic shock.
- Conditions
- Sepsis, Septic Shock, Inflammation, Biomarkers
- Trial name
- NCT06963541
- Testing
- No intervention; Observational study
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Melahat Yalcin Solak
Septic Shock
Continuos Terlipressin Infusion in Septic Shock
The purpose of this study is to evaluate the efficacy of terlipressin for treating septic shock.
- Trial name
- NCT01697410
- Testing
- Terlipressin, Norepinephrine
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Shock, Septic
Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis: A Pilot Feasibility Study
The objective of this pilot study is to assess overall feasibility prior to embarking on a larger randomized pragmatic trial comparing the clinical effectiveness of fluid resuscitation with NS versus LR for pediatric patients…
- Trial name
- PRoMPT BOLUS (NCT03340805)
- Testing
- Lactated Ringer, Normal saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Children's Hospital of Philadelphia
Sepsis Syndrome, Sepsis
Sepsis: From Syndrome to Personalized Care
This is a prospective, observational study designed to examine the performance of biomarkers, molecular biological methods and other analysis in blood from patient with suspected sepsis in the Emergency department, as well as…
- Conditions
- Sepsis Syndrome, Sepsis, Sepsis, Severe, Septic Shock
- Trial name
- NCT04203979
- Where
- Norway
- Volunteers
- 1,950 people
- Sponsor
- Oslo University Hospital
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