Clinical trials: Septic
Sepsis, Septic Shock
Serum GDF-15 and LGALS3BP as Prognostic Biomarkers in Sepsis
The purpose of this study is to find out whether blood levels of two proteins, GDF-15 and LGALS3BP, measured at intensive care unit admission and at 72 hours, can help predict survival and organ dysfunction in adult patients with…
- Trial name
- NCT07906561
- Testing
- Serum GDF-15 and LGALS3BP Measurement
- Volunteers
- 150 people
- Sponsor
- Inonu University
Septic Acute Kidney Injury
KDIGO Bundle to Prevent AKI in Sepsis
Summary: Controlled, prospective, randomized and randomized clinical trial of two intervention groups (standard care vs. preventive recommendations the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines for AKI) of…
- Trial name
- NCT04222361
- Testing
- Preventive recommendations for kidney disease: guidelines for improving overall outcomes (KDIGO) for AKI
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital General Universitario Elche
Sepsis, Septic Shock
Evaluation of Plasma Angiotensin II and Angiotensin II Receptor Levels in Patients With Sepsis and Septic Shock: a Prospective Observational Study.
Evaluation of plasma angiotensin II and angiotensin II receptor levels in patients with sepsis and septic shock: a prospective observational study.
- Trial name
- NCT04716842
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Inonu University
Septic Shock, Vasodilatory Shock
Vasopressin Use in Septic Shock From Türkiye
The goal of this observational study is to examine the early hemodynamic effects and clinical outcomes of vasopressin use in patients with septic shock.
- Conditions
- Septic Shock, Vasodilatory Shock, Critical Illness Sepsis, Severe, Critical Illness
- Trial name
- (VASCO-TURK) (NCT06953297)
- Where
- Turkey (Türkiye)
- Volunteers
- 146 people
- Sponsor
- Karadeniz Technical University
Septic Shock
Assessment of Cardiac Output and Stroke Volume in Septic Shock Patients
The aim of this research is to compare the accuracy and reliability of electrical cardiometry versus transthoracic echocardiography in measuring cardiac output and stroke volume in patients with septic shock, to evaluate the…
- Trial name
- NCT07321405
- Testing
- echocardiogram, Electrical cardiometry
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Sepsis, Critical Care
Insufficient Oxygenation in Septic Patients
This study will describe the change of mitochondrial oxygen tension (mitoPO2) compared to traditional parameters of oxygenation and oxygen balance in the first 24 hours of septic patients admitted to the intensive care unit of an…
- Conditions
- Sepsis, Critical Care, Mitochondria, Oxygen
- Trial name
- INOX-SEPSIS (NCT03842722)
- Testing
- Protoporphyrin IX - Triplet State Lifetime Technique
- Where
- Netherlands
- Volunteers
- 81 people
- Sponsor
- Sanquin-LUMC J.J van Rood Center for Clinical Transfusion Research
Septic Shock
Effects of Dobutamine on Microcirculation, Regional and Peripheral Perfusion in Septic Shock Patients
The investigators hypothesize that dobutamine is able to revert negative redistribution of flow by inducing a selective vasodilatory effect on hypoperfused territories, particularly at the sublingual and gastric mucosa, and at…
- Trial name
- NCT01271153
- Testing
- Dobutamine
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Septic Shock
Vitamin C Deficiency in Septic Shock
Objectives: investigators aim to study the effect of addition of vitamin C as a part of treatment in septic shock patients on: Hemodynamics, Inflammation status and ICU outcome.
- Trial name
- NCT06224881
- Testing
- Ascorbic acid
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Cairo University
Severe Sepsis
The Effect of Dexmedetomidine on Microcirculation in Severe Sepsis
Despite early goal-directed maintenance of normal macrocirculation, the reduction of 60-day mortality of patients with severe sepsis and septic shock remained unsatisfied (56.9% to 44.3%).
- Trial name
- NCT02109965
- Testing
- Dexmedetomidine, Midazolam, Propofol
- Where
- Taiwan
- Volunteers
- 12 people
- Sponsor
- National Taiwan University Hospital
Sepsis, Septic Shock
Ultrasound-guided Blood Sampling Drawing for Microbiological Analysis in the Critically Ill
This study will test the feasibility of ultrasound-guided sterile blood sampling for critically ill patients with suspected sepsis requiring blood culture.
- Conditions
- Sepsis, Septic Shock, Infections, Diagnosis
- Trial name
- ECOVEN (NCT06156072)
- Testing
- Ultrasound-guided venipuncture
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Septic Shock
Carotid Doppler and EEOT for Fluid Responsiveness Prediction
Fluid responsiveness prediction prior to fluid challenge administration is a topic of interest, which has been extensively investigated, but remains challenging.
- Trial name
- NCT04470856
- Testing
- End-expiratory occlusion test (EEOT)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Severe Sepsis, Septic Shock
Role of Ulinastatin in Preventing Severe Sepsis and Consequent Morbidities and Mortality
The study will enhance the theory in the frame of reference on the efficacy of Ulinastatin while managing sepsis and subsequent morbidity and mortality.
- Conditions
- Severe Sepsis, Septic Shock, MODS
- Trial name
- MUNI-SEP (NCT05895240)
- Testing
- Ulinastatin
- Where
- Pakistan
- Volunteers
- 175 people
- Sponsor
- Jinnah Postgraduate Medical Centre
Septic Shock, Endotoxemia
Evaluating the Use of Polymyxin B Cartridge Hemoperfusion for Patients With Septic Shock and COVID 19
Prospective, observational, clinical investigation of PMX cartridge use in COVID 19 patients with septic shock
- Conditions
- Septic Shock, Endotoxemia, COVID, Corona Virus Infection
- Trial name
- NCT04352985
- Testing
- Toraymyxin PMX-20R (PMX Cartridge)
- Where
- 3 sites in United States
- Sponsor
- Spectral Diagnostics (US) Inc.
Critical Illness
Clinical and Economic Outcome of Simvastatin in Critically Ill Septic Patient
determination of the effectiveness and the cost-effectiveness of simvastatin(Zocor 40 mg) plus standard therapy (SSCG)versus standard therapy alone in critically ill septic patient from the societal perspective over one year.
- Trial name
- NCT02067949
- Testing
- Simvastatin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- sara mostafa amin eladawy
Septic Shock
Effect of Dexmedetomidine on Perfusion Index and Microcirculation in Severe Sepsis and Septic Shock Patients
Septic shock is one of the major causes of death worldwide with in-hospital mortality rates varying between (11.9% to 47.2 %). Alterations in microcirculatory blood flow were associated with high risk of organ dysfunction and…
- Trial name
- NCT03151668
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Septic Shock
Vasculopathic Injury and Plasma as Endothelial Rescue in Septic Shock (SHOCK) Trial
Efficacy and safety of OctaplasLG® administration vs. crystalloids (standard) in patients with septic shock - a randomized, controlled, open-label investigator-initiated pilot trial
- Trial name
- VIPER-SHOCK (NCT03092245)
- Testing
- OctaplasLG, Ringer-Acetate
- Where
- Denmark
- Volunteers
- 44 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Septic Shock, Volume Status
Thermodilution - Controlled Management of Volume Therapy in Septic Shock
Septic shock and multi-organ failure are among the most frequent causes of death in the ICU. Patients with septic shock require early implementation of hemodynamic therapy to keep the duration of shock state and with it…
- Trial name
- THEMIS (NCT01263977)
- Testing
- Picco- thermodilution catheter
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Claudia Spies
Sepsis, Severe Sepsis
Machine Learning Sepsis Alert Notification Using Clinical Data
Machine learning is a powerful method to create clinical decision support (CDS) tools, when training labels reflect the desired alert behavior.
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- HindSight P2 (NCT04005001)
- Testing
- HindSight, InSight
- Where
- 3 sites in United States
- Volunteers
- 37,986 people, healthy volunteers welcome
- Sponsor
- Dascena
Septic Shock
Vitamin C, Thiamine and Hydrocortisone for the Treatment of Septic Shock
The purpose of this study is to determine whether the combination therapy (vitamin C,thiamine and hydrocortisone) is effective in the treatment of septic shock.
- Trial name
- NCT03872011
- Testing
- Vitamin C,thiamine,hydrocortisone
- Where
- China
- Volunteers
- 408 people
- Sponsor
- Northern Jiangsu People's Hospital
Soft Tissue Infections, Mediastinitis
Delafloxacin Plasma and Tissue Concentration in Patients With Skin, Soft Tissue, and Bone and Joint Infections.
The goal of this observational study is to measure how well the antibiotic delafloxacin penetrates into the blood and various body tissues in adult patients over 18 years old.
- Conditions
- Soft Tissue Infections, Mediastinitis, Osteomyelitis/Septic Arthritis, Prosthetic Joint Infection
- Trial name
- DELA-PLAT (NCT07426471)
- Testing
- delafloxacin
- Volunteers
- 20 people
- Sponsor
- IRCCS San Raffaele
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