Clinical trials: Septic
Sepsis, Septic Shock
Specific miRNAs in Sepsis and Nephrotoxic Antibiotic Treatment
Critically ill patients are prone to develop acute kidney injury due to sepsis itself and by administration of potentially nephrotoxic antibiotic treatment (vancomycin or gentamicin).
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- NCT04991376
- Testing
- Blood-specific miRNA levels
- Where
- Czechia
- Volunteers
- 53 people
- Sponsor
- University Hospital Ostrava
Sepsis, Volume Assessment
Evaluation of Fluid Infusion With LifeFlow for Patients With Suspected Septic Shock
The LifeFlow rapid infusion device is a handheld manually-operated device that has been shown in early trials to increase the rate of bolus fluid infusion up to 3 times the rate of delivery attributed to conventional rapid…
- Trial name
- NCT03673891
- Testing
- Life Flow
- Sponsor
- University of Arizona
Sepsis, Septic Shock
Fluid Resuscitation in Septic Shock Patients With BMI Elevation
To explore the safety and feasibility of alternative fluid resuscitation strategies in obese patients with septic shock.
- Conditions
- Sepsis, Septic Shock, Obesity
- Trial name
- FRISSBE (NCT04759989)
- Testing
- Actual Body Weight Dosing, Adjusted Body Weight Dosing, Ideal Body Weight Dosing
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Wake Forest University Health Sciences
Sepsis
Can Respiratory Rate Predict the Risk of Deterioration of Septic Patients
The primary objective is to determine if the trend in Respiratory Rate measurements provided by the device under investigation can be used to predict an increase in Sequential/Sepsis-related Organ Failure Assessment (SOFA) score.
- Trial name
- NCT03752047
- Where
- Denmark
- Volunteers
- 132 people
- Sponsor
- PMD Solutions
Septic Shock, Inflammation
Pharmacology of Exenatide in Pediatric Sepsis
Pharmacology of Exenatide in Pediatric Sepsis, PEPS is a phase 1-2 research study that will examine drug safety, drug metabolism, drug action and preliminary drug clinical effects of four does of exenatide injected every 12 hours…
- Conditions
- Septic Shock, Inflammation, Glucose Homeostasis, Organ Dysfunction
- Trial name
- PEPS (NCT01573806)
- Testing
- Exenatide, Exenatide vehicle
- Where
- United States
- Sponsor
- Seattle Children's Hospital
Diabetic Ketoacidosis, Heart Disease, Ischemic
Effectiveness of Music Intervention on Anxiety and Physiological Responses in Critical Ill Patient
Music intervention is a non-pharmacological and effective intervention that can alleviate anxiety and agitation in patients undergoing weaning.
- Conditions
- Diabetic Ketoacidosis, Heart Disease, Ischemic, Stroke, GastroIntestinal Bleeding
- Trial name
- NCT04977011
- Testing
- relaxing music
- Where
- Taiwan
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Min-Sheng General Hospital
Septic Shock, Sepsis
Stress Doses of Hydrocortisone on Coagulation Dysfunction in Patients With Septic Shock
The purpose of this study is to find out whether stress doses of hydrocortisone attenuate coagulation dysfunction in patients with septic shock.
- Trial name
- NCT02266589
- Testing
- Hydrocortisone
- Volunteers
- 84 people
- Sponsor
- Nanjing PLA General Hospital
Septic Shock
Survey of Non-resuscitation Fluids in Septic Shock
The objective of this study is to survey the type and the amount of non-resuscitation fluids that patients with septic shock receives during their first 5 days of ICU admission.
- Trial name
- SURF (NCT03438097)
- Where
- 9 sites in Canada, Sweden
- Volunteers
- 200 people
- Sponsor
- Region Skane
Severe Sepsis, Organ Failure
Comparative Study of the Protein C Pathway in Septic and Non Septic Patients With Organ Failure
This is a comparative study performed in 3 groups of patients/subjects: 30 severe sepsis patients, 30 non-septic patients with organ failure, 30 healthy subjects.
- Trial name
- NCT00361725
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Shock
Vasopressin Versus Norepinephrine for the Management of Septic Shock in Cancer Patients
Although arginine vasopressin has been used as an additional drug in refractory shock in worldwide clinical practice, there are no prospective studies using it as a first choice therapy in patients with cancer and septic shock.
- Trial name
- VANCS II (NCT01718613)
- Testing
- Vasopressin, Norepinephrine
- Where
- Brazil
- Volunteers
- 250 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Septic Shock
Temporal Changes of Lactate in CLASSIC Patients
This study aim to examine if randomization to different treatment strategies had any effect on the time to normalization of lactate in intensive care patients treated for septic shock.
- Trial name
- NCT05629780
- Testing
- Resuscitation fluid
- Where
- Sweden
- Volunteers
- 777 people
- Sponsor
- Karolinska University Hospital
Intensive Care Units, Shock, Septic
Fluid Overload Quantification in Septic Shock
Fluid management in septic shock patients remain a great challenge. Insufficient fluid filling lead to hypovolemia, organ failure and increased death, whereas fluid overload was associated to an increased morbidity and mortality…
- Trial name
- FOTOShock (NCT04114162)
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Septic Shock, Compliance
Effects of Nursing Staff on Empiric Antibiotic in Septic Shock
A retrospective, observational study was performed about the patients with septic shock who admitted into intensive care unit (ICU) from January 1, 2015 to February 29, 2016.
- Conditions
- Septic Shock, Compliance, Antibiotic, Nursing Caries
- Trial name
- NCT03085459
- Testing
- work Time
- Volunteers
- 214 people
- Sponsor
- Chun Pan
Glucose Fluctuations in Sepsis
Usage of Glucose Fluctuations as a Prognostic Marker in Septic Shock Patients
To determine whether glucose fluctuations prior to antibiotic administration are associated with sepsis severity and poor clinical outcomes.
- Trial name
- NCT07234526
- Volunteers
- 105 people
- Sponsor
- Assiut University
Shock, Septic, Community Acquired Pneumonia
Clinical Practice Guidelines and Impact of Audit and Feedback in the Emergency Department
This study will develop and test an intervention given to emergency medicine providers to improve adherence to clinical practice guidelines (CPGs) for pneumonia and sepsis.
- Trial name
- NCT02427048
- Testing
- Feedback with Peer Comparison
- Volunteers
- 24 people
- Sponsor
- Denver Health and Hospital Authority
Sepsis and Septic Shock
Dynamic SvO2 in Predicting Fluid Responsiveness in Septic Shock
This prospective observational diagnostic accuracy study investigates the efficacy of dynamic central venous oxygen saturation in predicting fluid responsiveness in septic shock, compared to measurements obtained using…
- Trial name
- NCT07516236
- Testing
- Measuring dynamic central venous oxygen saturation (ScvO2) at baseline and after fluid challenge. Measuring Cardiac output by echocardiography or cardiometry at baseline and after fluid challenge.
- Where
- Egypt
- Volunteers
- 115 people
- Sponsor
- Menoufia University
Septic Shock
Heparin Anticoagulation to Improve Outcomes in Septic Shock: The HALO Pilot
Life-threatening infections account for 10% of all intensive care unit admissions and constitute the second more frequent cause of death in the ICU after heart diseases.
- Trial name
- NCT01648036
- Testing
- Unfractionated heparin, Dalteparin
- Where
- 9 sites in Canada
- Volunteers
- 76 people
- Sponsor
- University of Manitoba
Sepsis and Septic Shock
The Prognostic Impact of Right Ventricular Systolic Dysfunction on the Survival of Patients With Sepsis and Septic Shock
This study sought to evaluate the association of right ventricular systolic dysfunction and 28-day in-hospital mortality in patients with sepsis and septic shock.
- Trial name
- NCT06193109
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Burapha University
Severe Sepsis and Septic Shock
Statistical Analysis Plan for an Individual Patient Data Meta-analysis of Three, International Trials Comparing Protocolised With Usual Resuscitation in Patients Presenting to the Emergency Department With Severe Sepsis and Septic Shock
This is the statistical analysis plan for an individual patient data meta-analysis (IPDMA) of three EGDT clinical trials.
- Trial name
- NCT02030158
- Volunteers
- 4,210 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Septic Shock
Stress Hydrocortisone In Pediatric Septic Shock
SHIPSS is a multi-institutional, prospective, controlled, randomized, double-blinded interventional trial that will examine the potential benefits and risks of adjunctive hydrocortisone prescribed for children with fluid and…
- Trial name
- SHIPSS (NCT03401398)
- Testing
- Hydrocortisone, sodium succinate, Normal saline
- Where
- 44 sites in United States, Brazil and 8 more
- Volunteers
- 500 people
- Sponsor
- Jerry Zimmerman
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