Clinical trials: Septic
Sepsis, Infection
Evaluation of the Heparin Binding Protein Levels in Sepsis
Present criteria used to define sepsis are non-specific, making it difficult to both distinguish sepsis from other diseases and to predict which patients are likely to become more severely ill.
- Conditions
- Sepsis, Infection, Septic Shock
- Trial name
- HBP (NCT02533011)
- Testing
- HBP lab test
- Where
- United States
- Volunteers
- 1,055 people
- Sponsor
- Christiana Care Health Services
Infection, Hypervolemia
Observational Study to Evaluate Peripheral IntraVenous Analysis (PIVA) in Euvolemic, Hypovolemic, and Hypervolemic Emergency Department Patients
The overall goal of this multicenter project is to characterize the expected normal range of Peripheral IntraVenous Volume Analysis (PIVA) values during a euvolemic state, and how those ranges may be altered by comorbidities; the…
- Conditions
- Infection, Hypervolemia, Hypovolemia, Septic Shock
- Trial name
- PIVA (NCT03736421)
- Testing
- Peripheral Intravenous Analysis (PIVA), Non-invasive fluid response measure, Passive leg raise (PLR)
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Septic Shock
Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis
Multicenter, prospective, phase 3 randomized non-blinded interventional trial of fluid treatment strategies in the first 24 hours for patients with sepsis-induced hypotension.
- Trial name
- CLOVERS (NCT03434028)
- Testing
- Early Vasopressors, Early Fluids
- Where
- 50 sites in United States
- Volunteers
- 1,563 people
- Sponsor
- Massachusetts General Hospital
Sepsis, Septic Shock
DDX17 Orchestrate Septic Vascular Endothelial Pyroptosis by Controlling Gasdermin D Pore Formation
Objective: To investigate the correlation between plasma levels of DDX17 and GSDMD with vascular endothelial dysfunction and prognosis of in sepsis patients. Design: A single center, prospective, observational research.
- Trial name
- NCT06013033
- Volunteers
- 60 people
- Sponsor
- Zhongda Hospital
Sepsis
Statin for Immunomudulation in Sepsis
The purpose of this study is to determine whether atorvastatin can improve the inflammatory answer in the septic patients
- Trial name
- NCT00452608
- Testing
- amido pill, atorvastatina
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Sepsis, Septic Shock
Intravenously Administered M6229 in Critically Ill Sepsis Patients
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Mortality is high and survivors frequently suffer from long-term sequelae.
- Conditions
- Sepsis, Septic Shock, Critical Illness
- Trial name
- HistoSeps (NCT05208112)
- Testing
- M6229
- Where
- 2 sites in Netherlands
- Volunteers
- 10 people
- Sponsor
- A.P.J. Vlaar
Septic Shock, Acute Kidney Injury
Norepinephrine / Vasopressin Combination for Resuscitation in Septic Shock
Although norepinephrine is commonly used and is the recommended agent for the treatment of hypotension in volume-resuscitated hyperdynamic septic shock, Low doses of vasopressin may be added to norepinephrine to maintain arterial…
- Trial name
- NCT04302584
- Testing
- norepinephrine / Vasopressin
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Sepsis, Septic Shock
Can Gdf-15 Level Predict Progression to Multiple Organ Failure in Patients With Septic Shock
The aim of this observational study is to investigate whether GDF-15 levels can predict clinical outcome in patients admitted to the intensive care unit with a diagnosis of septic shock.
- Conditions
- Sepsis, Septic Shock, Multi Organ Failure
- Trial name
- NCT06808100
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Ankara City Hospital Bilkent
Infection, Sepsis
Proadrenomedullin and Microcirculation in Monitoring Organ Dysfunction in Patient With Infection
This study evaluates the association between plasmatic levels of Mid Regional Proadrenomedullin (MR-proADM) and the sublingual microcirculation in critical care patients admitted with infection, sepsis or septic shock.
- Conditions
- Infection, Sepsis, Septic Shock
- Trial name
- NCT03931967
- Testing
- MR-proADM
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Università Politecnica delle Marche
Septic Shock
Comparison of Radial and Femoral Artery Site Invasive Blood Pressure Measurement in Septic Shock Patients
Inaccurate monitoring of mean arterial pressure (MAP) could lead to improper treatment in the form of excessive fluid infusion or unnecessary vasopressor therapy; therefore, accurate hemodynamic monitoring is crucial in treatment…
- Trial name
- NCT03475667
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Septic Shock
Intravenous AII for the Treatment of Severe Hypotension in High Output Shock: A Pilot Study
The investigators propose a dose finding study to determine the feasibility of Angiotensin II (AII) to increase mean arterial pressure in high-output shock.
- Trial name
- ATHOS (NCT01393782)
- Testing
- Angiotensin II
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- George Washington University
Intracranial Pressure Changes
Impact of Low Dose Ketamine Infusion in Septic Patient on Non-invasive Estimators of ICP
Severe sepsis is a major healthcare problem with a reported incidence of 1-2% in all hospitalizations. It is a major cause of death in the intensive care units worldwide and is the second leading cause of death in noncoronary…
- Trial name
- NCT05149586
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Zagazig University
Septic Shock
ASSET - a Double-Blind, Randomized Placebo-Controlled Clinical Investigation With Alteco® LPS Adsorber
The primary objective of this clinical investigation is to investigate the feasibility and possible benefits of the Alteco® LPS Adsorber in treating patients with septic shock with presumed endotoxemia of abdominal or urogenital…
- Trial name
- ASSET (NCT02335723)
- Testing
- Alteco LPS Adsorber
- Where
- 6 sites in Finland, Norway and 1 more
- Volunteers
- 15 people
- Sponsor
- Alteco Medical AB
Septic Shock, Endotoxemia
Open-label Evaluation of Polymyxin B Hemoperfusion for Septic Shock
Open-label, non-controlled study of standard care plus the TORAYMYXIN PMX-20R (PMX cartridge) in subjects who have endotoxemia and septic shock.
- Trial name
- EUPHORIA (NCT02825329)
- Testing
- TORAYMYXIN PMX-20R
- Sponsor
- Spectral Diagnostics (US) Inc.
Septic Shock
Discontinuation Order of Vasopressors in Septic Shock
The purpose of this study is to evaluate the incidence of hypotension based on the discontinuation order of norepinephrine and vasopressin in patients receiving concomitant norepinephrine and vasopressin infusions for the…
- Trial name
- DOVSS (NCT01493102)
- Testing
- Vasopressin, Norepinephrine
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Samsung Medical Center
Pseudoarthrosis of Bone
Septic Pseudarthrosis Of Long Bone : Experience In A Regional Reference Center
Description of septic pseudarthrosis with chirurgical treatment in two steps (first step : Implementation of cement, second step : bone reconstruction, with or without device)
- Trial name
- NCT03620305
- Testing
- Description of treatment of septic pseudarthrosis
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Septic Shock
Extracorporeal Cytokine Removal in Patients With Septic Shock in an Adult Intensive Care Unit
Goals Primary: compare changes in norepinephrine requirements before and after hemoperfusion (HP) treatment. Secondary: demonstrate the decrease in levels of IL-6 , assess the total and individual change of SEQUENTIAL ORGAN…
- Trial name
- NCT04231695
- Where
- Argentina
- Volunteers
- 20 people
- Sponsor
- Hospital Jose Maria Cullen
Septic Shock
Study the Impact of Statins in Septic Shock
Sepsis is a common, expensive, frequently fatal and highly complex inflammatory syndrome wherein multiple cellular and humoral pathways are involved.
- Trial name
- NCT02681653
- Testing
- Atorvastatin
- Where
- 2 sites in India
- Volunteers
- 40 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Sepsis, Septic Shock
Clearance of Antibacterial Agents During Hemoperfusion in Patients With Sepsis
One of the significants health problems in the world is sepsis, with the number of cases reaching 20-30 million per year, according to the WHO.
- Trial name
- NCT06602245
- Where
- 4 sites in Russia
- Volunteers
- 30 people
- Sponsor
- Efferon JSC
Shock, Septic
Pilot Study: Echocardiographic and Hemodynamic Effects of Esmolol in Septic Shock Patients
After initial hemodynamic stabilization, 36 septic shock patients with heart rate > of 90 bpm and requiring norepinephrine to maintain mean arterial pressure (MAP) more than 65 mmHg will be randomised into two groups, esmolol…
- Trial name
- NCT02842983
- Testing
- Esmolol
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Peking Union Medical College Hospital
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