Clinical trials: Septic
Sepsis, Septic Shock
Immune Failure in Critical Therapy (INFECT) Study
Patients admitted to intensive care units (ICU) are at high risk of developing secondary infections, and this is in part due to dysfunction or failure of their 'germ killing' functions (the immune system).
- Trial name
- INFECT (NCT02186522)
- Where
- 4 sites in United Kingdom
- Volunteers
- 168 people
- Sponsor
- University of Edinburgh
Sepsis, Septic Shock
Vitamin C & Thiamine to Treat Sepsis and Septic Shock
Investigators propose to investigate the use of IV vitamins B1 and C in a randomized, double-blinded, prospective trial to determine if these medications decrease mortality rates in patients with severe sepsis or septic shock.
- Trial name
- NCT03592277
- Testing
- Vitamin C, Vitamin B1
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Trinity Health Of New England
Septic Shock, Nonchemotherapy Drug-induced Neutropenia
Russian Clinical Trial of Mesenchymal Cells in Patients With Septic Shock and Severe Neutropenia
Septic shock remains a significant clinical problem associated with high rates of mortality among neutropenic patient despite antimicrobial therapy and supportive care.
- Conditions
- Septic Shock, Nonchemotherapy Drug-induced Neutropenia, Neutropenia After Chemotherapy in Oncohematological Patients, Neutropenia in Patients With Aplastic Anemia
- Trial name
- NCT01849237
- Testing
- Mesenchymal stromal cells, Standard therapy of septic shock
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- National Research Center for Hematology, Russia
Septic Shock, Vasoplegia
Evaluating in Cirrhotics With Refractory Vasoplegia the Effect of Methylene Blue
Mortality rates associated septic shock remains unacceptably high, around 20-50%, with refractory hypotension in half of these patients.
- Conditions
- Septic Shock, Vasoplegia, Cirrhosis, Liver, Refractory Shock
- Trial name
- CRuMBS (NCT03120637)
- Testing
- Methylene Blue
- Where
- India
- Volunteers
- 111 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Septic Shock, Sepsis
Vitamin C to Reduce Vasopressor Dose in Septic Shock
Randomized, controlled, double blind clinical trial. Adult patients admitted to the ICU of the Hospital Español de México with a diagnosis of septic shock will be included.
- Trial name
- ViCiS (NCT03835286)
- Testing
- Vitamin C
- Where
- Mexico
- Sponsor
- Hospital Español de Mexico
Septic Shock
A Trial of Adjunctive Fludrocortisone (50mcg, 100mcg or Placebo) in Critically Ill Patients With Septic Shock Receiving Hydrocortisone, Evaluating Survival and Functional Recovery and the Influence of Transcriptomic Response
The FLUDRO-SHOCK trial is a large international randomised controlled double-blinded study aiming to improve treatment for people with septic shock, a life-threatening condition caused by severe infection.
- Trial name
- FLUDRO-SHOCK (NCT07898462)
- Testing
- Fludrocortisone 50 mcg daily, Fludrocortisone 100 mcg daily
- Where
- 8 sites in Australia
- Volunteers
- 2,200 people
- Sponsor
- The George Institute
Anesthesia, Endothelial Dysfunction
Effect of Fluid Challenge on Glycocalyx
Interventional study comparing effect of two regimes of fluid challenge in patients with sepsis and in patients undergoing elective major surgery on glycocalyx by using perfused Boundary Region in sublingual microcirculation.
- Conditions
- Anesthesia, Endothelial Dysfunction, Sepsis, Septic Shock
- Trial name
- NCT03891342
- Testing
- Fluid bolus administration
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- University Hospital Hradec Kralove
Acute Kidney Injury, Septic Shock
Targeting Abdominal Perfusion Pressure in Septic Shock
A randomized control trial among patients with septic shock, studying the incidence, progression and recovery of AKI.
- Conditions
- Acute Kidney Injury, Septic Shock, Resuscitations
- Trial name
- MAP-APP (NCT03582046)
- Testing
- Abdominal Perfusion Pressure (APP), Mean Arterial Pressure (MAP)
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Potrero Medical
Septic Shock
Treatment of Severe Infections With Mesenchymal Stem Cells
The main purpose at the early phase of septic shock on the evolution of organ failure judged by the SOFA (Sepsis Organ Failure Assessment score) score on Day 7 (or the day of death or the day of discharge from the intensive care…
- Trial name
- CHOCMSC (NCT02883803)
- Testing
- Injection of mesenchymal stem cells, Injection of albumin alone
- Where
- 4 sites in France
- Volunteers
- 66 people
- Sponsor
- Central Hospital, Nancy, France
Critically Ill Patients
Clearance of Vasoactive Metabolites With Blood Purification
Extracorporeal blood purification is a supportive therapy in the management of patients with sepsis or vasoplegic shock. The pathophysiology of sepsis is based on an inappropriate host response to infection.
- Trial name
- VITAL (NCT06109142)
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Arthritis, Septic
Two Versus Four Weeks of Antibiotic Treatment in Native Joint Arthritis
The optimal duration of systemic antibiotic administration for native joint septic arthritis is unknown. The investigators perform a randomized study allowing up to 3 surgical lavages and allocating patients into a two-week's and…
- Trial name
- NCT03615781
- Testing
- Two week's arm - surgery, Four week's arm - surgery, Two week's arm - drugs
- Where
- Switzerland
- Volunteers
- 85 people
- Sponsor
- University Hospital, Geneva
Severe Sepsis, Severe Sepsis Without Septic Shock
Sepsis Clinical Decision Support [CDS] Master Enrollment Study Protocol
This protocol will collect real-world data retrospectively from the electronic health record (EHR) as data obtained from the delivery of routine medical care to develop a machine learning (ML)-based Clinical Decision Support…
- Trial name
- NCT05304728
- Where
- 10 sites in United States
- Volunteers
- 40,000 people
- Sponsor
- Beckman Coulter, Inc.
Sepsis, Liver Failure
Lactate Clearance According to the Presence of Hepatic Dysfunction
The purpose of this study is to compare lactate clearance in patients with severe sepsis and septic shock according to the presence of hepatic dysfunction.
- Trial name
- NCT01709565
- Where
- South Korea
- Volunteers
- 245 people
- Sponsor
- Samsung Medical Center
Septic Shock, Acute Kidney Injury
Early Co-Administration of Crystalloid Fluid and Norepinephrine for Preventing Acute Kidney Injury in Septic Shock
Septic shock is a life-threatening condition that can cause severe circulatory failure and damage to vital organs, including the kidneys.
- Trial name
- NCT07418541
- Testing
- Norepinephrine, Crystalloid Fluid Resuscitation
- Volunteers
- 100 people
- Sponsor
- Universitas Sumatera Utara
Diverticular Perforation, Open Abdomen
Damage Control Surgery Over the World in Acute Diverticulitis (DACOSAD)
To analyze the possible benefit of damage control surgery by performing bowel resection, open abdomen, and delayed anastomosis in the treatment of Hinchey III or IV diverticulitis.
- Trial name
- DACOSAD (NCT06428370)
- Testing
- Damage Control Surgery
- Where
- 9 sites in Chile, Italy
- Volunteers
- 300 people
- Sponsor
- Link Campus University
Septic Shock
Ivabradine for Heart Rate Control In Septic Shock
Septic shock is a major health problem, with several million cases annually worldwide and a mortality approaching 45%. Tachycardia is associated with excess mortality during septic shock.
- Trial name
- IRISS (NCT04031573)
- Testing
- Ivabradine
- Where
- France
- Volunteers
- 429 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Shock
Epinephrine to Prevent Postintubation Collapse in Shocked ICU Patients
Endotracheal intubation is a lifesaving procedure that is performed in various settings within the hospital or even in the pre-hospital field.
- Trial name
- NCT06115473
- Testing
- epinephrine, isotonic fluid
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Ain Shams University
Septic Shock
Effects of Levosimendan on Cellular Metabolic Alterations in Patients With Septic Shock
To investigate changes in the concentration of glucose, lactate, pyruvate and glycerol in the extracellular fluid of the skeletal muscle following levosimendan administration in patients with septic shock.
- Trial name
- NCT02963454
- Testing
- Microdialysis Probe (Muscle microdialysis), Dobutamine, Levosimendan
- Where
- Tunisia
- Volunteers
- 50 people
- Sponsor
- Military Hospital of Tunis
Septic Shock, Cirrhosis, Liver
Efficacy and Safety of Vasopressin Versus Terlipressin as a Second Vasopressor in Critically Ill Cirrhotics With Septic Shock- the VITEL-C Trial
Sepsis is a life-threatening organ dysfunction caused by dysregulated host response. A Subset of sepsis is septic shock which has almost 4-6 times the mortality when compared to sepsis.
- Trial name
- NCT05315557
- Testing
- Terlipressin, vasopressin
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Sepsis, Gastrointestinal Dysfunction
Study of Biomarkers in Patients of Sepsis Complicated With Gastrointestinal Dysfunction
1. Title: Study of Biomarkers in Patients of Sepsis Complicated With Gastrointestinal Dysfunction 2. Research center: Single-center study. 3. Design of the research: A prospective and cohort study. 4.
- Trial name
- NCT04647201
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Jianbo Yu
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