Clinical trials: Septic
Abdominal Infection
Effect Study of Tigecycline to Treat Severe Sepsis and Septic Shock
Selection of tigecycline in severe sepsis and septic shock patients in empirical antibiotic therapy (Hai Zheng Energy Star ®) combined with piperacillin / tazobactam (tazocin ®) scheme, compared with the classical scheme…
- Trial name
- Tigecycline (NCT02191475)
- Testing
- glycopeptide plus carbapenem, Haizheng Li Xing ® plus tazocin ®
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Severe Sepsis, Septic Shock
The Role of Dysfunctional HDL in Severe Sepsis
Severe sepsis results in over 300,000 Emergency Department (ED) visits and 215,000 deaths annually in the US. Currently there are no effective drug therapies for sepsis.
- Conditions
- Severe Sepsis, Septic Shock, Sepsis
- Trial name
- NCT02370186
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Florida
Shock Hypovolemic, Shock, Septic
Management of Shock in Children With SAM or Severe Underweight and Diarrhea
Diarrhea is one of the leading causes of under-five childhood mortality and accounts for 8% of 5.4 million global under-5 deaths.
- Conditions
- Shock Hypovolemic, Shock, Septic, Blood Transfusion, Adrenaline
- Trial name
- NCT04750070
- Testing
- Blood and Dopamine, Blood and adrenaline
- Where
- Bangladesh
- Volunteers
- 135 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Septic Shock, Microcirculatory Dysfunction
Papaverine and Sublingual Microcirculation in Septic Shock
This is a prospective, multicenter, single-arm, open-label, pilot physiological study designed to evaluate the effects of intravenous papaverine on sublingual microcirculation and the vascular waterfall phenomenon in adult…
- Conditions
- Septic Shock, Microcirculatory Dysfunction, Sublingual Microcirculation, Hemodynamic Instability
- Trial name
- NCT07657741
- Testing
- Papaverine
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Septic Shock, Sepsis
Cellular Immunotherapy for Septic Shock
Septic shock is associated with substantial burden in terms of both mortality and morbidity for survivors of this illness. Pre-clinical sepsis studies suggest that mesenchymal stem (stromal) cells may modulate inflammation…
- Conditions
- Septic Shock, Sepsis, Pathologic Processes, Shock
- Trial name
- CISS2 (NCT03369275)
- Testing
- Allogeneic Bone Marrow-Derived Human Mesenchymal Stem Cells
- Volunteers
- 114 people
- Sponsor
- Ottawa Hospital Research Institute
Sepsis, Septic Shock
The Efficacy of Adjunctive Use of Ondansetron in Patients With Sepsis and Septic Shock
Sepsis is a systemic inflammatory response that has deleterious effects and considered the leading cause of death in critically ill patients 1 .
- Trial name
- NCT05402553
- Testing
- Ondansetron
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Noha Mansour
Severe Sepsis or Septic Shock, Fluid Resuscitation
COrporeal Compression at the ONset of Severe Sepsis and Septic Shock
Early and adequate fluid resuscitation (< 6 hours) in patients with circulatory failure is essential but may exacerbate oedema, which may itself: 1) aggravate pulmonary lesions and prolong mechanical ventilation, 2) aggravate…
- Trial name
- COCOON (NCT02656654)
- Testing
- Whole-body compression
- Where
- 2 sites in France
- Volunteers
- 64 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Sepsis, Septic Shock
Early Goal-directed Therapy and Myocardial Dysfunction
The cardiovascular system plays a central role in the pathophysiology and prognosis of sepsis, yet the correct hemodynamic management of septic patients is still vigorously debated.
- Conditions
- Sepsis, Septic Shock, Myocardial Dysfunction
- Trial name
- SEPT-MD (NCT01312688)
- Testing
- Early Goal Directed Hemodynamic Therapy in Sepsis
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Hadassah Medical Organization
Septic Shock
Barrier Function and Production of Inflammatory Cytokines in the Rectal Mucosa in Patients With Septic Shock
Life-threatening infection impairs bloodflow to the gut, thereby causing less delivery of oxygen. This leads to increased formation of different inflammatory and infectious markers.
- Trial name
- NCT00378586
- Testing
- Rectal biopsy, Measurement of inflammatory markers in the rectal mucosa, Measurement of rectal lactic acid
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Severe Sepsis
Hydrocortisone for Prevention of Septic Shock
Severe sepsis is a disease with a high mortality. Development of shock is a most serious complication and increases the risk of death considerably.
- Trial name
- HYPRESS (NCT00670254)
- Testing
- Hydrocortisone
- Where
- 30 sites in Germany
- Volunteers
- 380 people
- Sponsor
- Charite University, Berlin, Germany
Sepsis, Disease of Diaphragm
Ultrasound Diaphragmatic Thickening to Monitor Its Dysfunction in Patients With Sepsis
Diaphragmatic dysfunction is associated with sepsis severity and pejorative prognosis. Aim of this study is to assess diaphragmatic function with the Diaphragmatic Thickening Fraction (DTF) ultrasound measure in patients with…
- Conditions
- Sepsis, Disease of Diaphragm, Defect of Diaphragm, Intensive Care Neuropathy
- Trial name
- US-Diamonds (NCT02474797)
- Testing
- Diaphragmatic ultrasonography
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Severe Sepsis, Persistent Hypotension
Epidemiology of Septic Shock in Medical or Polyvalent ICU in the North-East Region of France
The epidemiology of this study aims and outcome of patients with septic shock in the intensive care unit (or versatile) of the North-East region in france as well as the modalities of care.
- Trial name
- NCT01903746
- Volunteers
- 1,495 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Sepsis
Incidence of Sepsis After Craniocerebral Operation
To investigate the incidence and outcome of sepsis in critical patients undergoing craniotomy.
- Trial name
- NCT03803813
- Where
- China
- Volunteers
- 907 people
- Sponsor
- Jianfang Zhou
Heart Failure, Myocarditis
CharacterisatiON of carDiac funCTion in Intensive Care Unit Survivors of Sepsis.
Cardiac dysfunction is common following hospital admission with sepsis and one of the most frequent causes for readmissions to hospital, however underlying mechanisms by which this might occur are unclear.
- Conditions
- Heart Failure, Myocarditis, Sepsis, Septic Shock
- Trial name
- CONDUCT-ICU (NCT05633290)
- Testing
- CMR, hs-troponin, NT-pro BNP
- Where
- 2 sites in United Kingdom
- Volunteers
- 69 people
- Sponsor
- NHS Greater Glasgow and Clyde
Sepsis, Sepsis, Severe
EMS Prehospital Blood Culture Collection and Antibiotic Administration: A Two-Phase Pilot Project to Reduce Mortality in Patients With Severe Sepsis and Septic Shock
This study is designed to improve the outcomes for patients suffering from severe sepsis and septic shock (SS/SS) by decreasing the time from first medical contact to antibiotic administration.
- Conditions
- Sepsis, Sepsis, Severe, Septic Shock
- Trial name
- NCT04134624
- Testing
- Sepsis care bundle
- Where
- United States
- Volunteers
- 215 people
- Sponsor
- HealthPartners Institute
Patients With Septic Shock, Surgical Patients
Dobutamine for Management of Surgical Patients With Septic Shock
Septic shock is the last and most severe stage of sepsis and is defined by extremely low blood pressure, despite lots of intravenous fluids. The incidence of septic shock related cardiomyopathy was 10% to 70%.
- Conditions
- Patients With Septic Shock, Surgical Patients, General Anesthesia
- Trial name
- NCT06462313
- Testing
- Dobutamine, Norepinephrine
- Where
- China
- Volunteers
- 584 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Sepsis
The Degree, Duration and Frequency of Insulin Resistance in Non-operated Patients With Sepsis
Surgery induces insulin resistance lasting for 2-3 weeks. We wanted to elucidate if stress-metabolic, medical conditions carry the same effect.
- Trial name
- NCT04969159
- Testing
- no intervention
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- Jens Rikardt Andersen
Septic Shock
Evaluation of the Role of Hydrocortisone Either Alone or Combined With Fludrocortisone in the Outcome of Septic Shock in Adults
During Infection, oflfending microbes interact with the host immune system producing a downstream inflammatory cascade involving cytokines and other mediators, which in turn triggers a systemic response.
- Trial name
- NCT04492280
- Testing
- Hydrocortisone
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Ain Shams University
Acute Kidney Injury, Septic Shock
Does High-dose Vitamin B3 Supplementation Prevent Major Adverse Kidney Events During Septic Shock?
Sepsis is the most common cause of acute kidney injury (AKI) in critically ill patients and is associated with a high mortality rate. Currently there is no available specific treatment to prevent or treat AKI in this setting.
- Conditions
- Acute Kidney Injury, Septic Shock, Nicotinamide, Mortality
- Trial name
- VITAKI (NCT04589546)
- Testing
- Nicotinamide treatment
- Where
- France
- Volunteers
- 310 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Severe Sepsis
Outcome Following Vitamin C Administration in Sepsis
This study is designed to determine if Vitamin C administration to septic patients will result in an improvement in organ dysfunction which occurs during a septic illness. Hypothesis: 1.
- Trial name
- NCT01590303
- Testing
- Vitamin C
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
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