Clinical trials: Septic
Arrhythmia, Hemorrhage
Suitability of Unobtrusive Bed Monitoring and Wrist-worn Heart Rate Monitor for Patient Monitoring
Novel technology enables it to monitor noninvasively the vital signs of a patient. Such a monitoring is immediately required to improve patient safety and to reduce hospital readmissions.
- Conditions
- Arrhythmia, Hemorrhage, Septic Shock, Consciousness, Loss of
- Trial name
- BedMon (NCT03572751)
- Testing
- Bed-, wrist- and ECG-sensor monitoring
- Where
- Finland
- Volunteers
- 36 people
- Sponsor
- Tampere University Hospital
Septic Shock
Dexmedetomidine on Microcirculation in Septic Shock
Dexmedetomidine was found might be beneficial to sepsis. Dexmedetomidine were found to improve microcirculation in sepsis animal studies and non-sepsis patients.
- Trial name
- NCT02270281
- Testing
- Dexmedetomidine 0.7 Mcg/kg/h
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Southeast University, China
Thrombocytopenia, Septic Shock
Mortality Due to Septic Shock Associated With Thrombocytopenia
A prospective longitudinal study similar to the one performed by Claushuis and colleagues (2016) will be performed in order to further understand the epidemiology and clinical relationship between platelet levels and mortality…
- Conditions
- Thrombocytopenia, Septic Shock, Sepsis Bacterial
- Trial name
- NCT03617965
- Testing
- Platelet count
- Where
- Mexico
- Volunteers
- 350 people
- Sponsor
- Universidad de Guanajuato
Septic Shock, Sepsis
Decatecholaminisation of Septic Shock With Dexmedetomidine and In-hospital Mortality
The study aims to determine whether the infusion of DEX in septic shock can reduce in-hospital mortality, norepinephrine infusion, need and duration for mechanical ventilation, and acute kidney injury without significant adverse…
- Trial name
- DECATSepsis (NCT05283083)
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Mansoura University
Shock, Septic, Severe Sepsis
Protocol-driven Hemodynamic Support for Patients With Septic Shock
This research is being done to see if a protocol (a set of orders that determine how much and how quickly a drug/fluid is given) for fluid and drugs used to increase blood pressure (vasopressors) will work better then general…
- Conditions
- Shock, Septic, Severe Sepsis, Sepsis
- Trial name
- NCT00335907
- Testing
- Fluid and Vasopressor Protocol
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
Sodium Disorder
Sodium Status in Septic Patients and Its Relation to Prognosis an Hospital Stay
The aim of the present study is to identify the prevalence and prognostic impact of sodium imbalance on sepsis and septic shock patients
- Trial name
- NCT04564508
- Volunteers
- 50 people
- Sponsor
- Assiut University
Septic Shock, Fluid Responsiveness
Timing of Preload Responsiveness in Sepsis
During acute circulatory failure, volume expansion does not always lead to a significant increase in cardiac output (fluid responsiveness).
- Trial name
- TIPRES (NCT05627817)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Bicetre Hospital
Septic Shock
Pilot Study of Bevacizumab (Avastin) in Patients With Septic Shock
The purpose of this study is to perform a pilot study to assess the potential use of Bevacizumab (a vascular endothelial growth factor (VEGF) inhibitor) in sepsis.
- Trial name
- NCT01063010
- Testing
- Bevacizumab
- Where
- 3 sites in United States
- Sponsor
- Beth Israel Deaconess Medical Center
Severe Sepsis, Septic Shock
A Study to Assess Safety,and Tolerability of 2 Doses of AZD9773 (CytoFab™) in Japanese With Severe Sepsis/Septic Shock
The two co-primary objectives of this study are to assess in Japanese patients with severe sepsis and/or septic shock: 1) the safety and tolerability of two different doses of intravenous AZD9773 and 2) the PK of AZD9773.
- Trial name
- NCT01144624
- Testing
- AZD9773
- Where
- 7 sites in Japan
- Volunteers
- 20 people
- Sponsor
- AstraZeneca
Shock, Septic
Strategy of Early Improvement of Tissue Oxygenation Decrease the Mortality of Severe Sepsis and Septic Shock
The impact of lactate guided therapy on septic shock has not been extensively investigated, however the goal directed therapy has been used for years.
- Trial name
- NCT01310790
- Testing
- lactate group:lactate acide clearance directed group; ScvO2 group:ScvO2 directed group;control group
- Where
- China
- Volunteers
- 420 people
- Sponsor
- Chinese Septic Shock Network
Sepsis, Septic Shock
Fluids in Sepsis and Septic Shock
Despite evidence of the physiologic benefits and possible lower mortality associated with low chloride solutions, normal saline remains the most wildly used fluid in the world.
- Trial name
- FISSH (NCT02748382)
- Testing
- higher chloride crystalloid, higher chloride albumin, lower chloride crystalloid
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- McMaster University
Septic Shock, Multi Organ Failure
Extracorporeal Blood Purification Using Oxiris for Septic Shock (EXPLORE Study)
The goal of this clinical trial is to evaluate if a blood purification treatment called "Oxiris" works to help adults with septic shock.
- Trial name
- EXPOLRE (NCT07334327)
- Testing
- Oxiris Filter (Blood Purification Device)
- Volunteers
- 62 people
- Sponsor
- Pusan National University Yangsan Hospital
Severe Sepsis, Septic Shock
Efficacy of Mw Vaccine in Treatment of Severe Sepsis
Study Hypothesis Enhancement of Th-1 response with the help of a poly TLR agonist (Mw) is likely to increase survival in patients with severe sepsis.
- Conditions
- Severe Sepsis, Septic Shock, Immune Modulation
- Trial name
- MISS (NCT02025660)
- Testing
- Mw, 0.3ml x three days sc
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Sepsis, Septic Shock
Prognostic Accuracy of qSOFA, SIRS, and EWSs for In-hospital Mortality in Emergency Department
Early identification of a patient with infection who may develop sepsis is of utmost importance. Unfortunately, this remains elusive because no single clinical measure or test can reflect complex pathophysiological changes in…
- Trial name
- PASSEM (NCT05172479)
- Testing
- Measurement of qSOFA score, Measurement of SIRS criteria, Measurement of NEWS
- Where
- 20 sites in Bahrain, Kuwait and 5 more
- Volunteers
- 3,274 people
- Sponsor
- Aseer Central Hospital
Sepsis and Septic Shock, Trauma
Fibrinolysis Resistance in Infection and Trauma
Blood coagulation disorders are often seen in critically ill patients e.g. with severe infection or following extensive injury, that can lead to life threatening events as a result of excessive blood clot formation leading to…
- Trial name
- FORTITUDE (NCT06680180)
- Testing
- Viscoelastometric assessment of fibrinolysis
- Where
- 4 sites in Australia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Anders Aneman
Acute Respiratory Distress Syndrome, Septic Shock
Assessment of Preload Responsiveness in ARDS Patients During Prone Position
Evaluation of preload responsiveness in ARDS patients during prone position is difficult and only one study showed Trendelenburg manoeuvre can be used in this group of patients.
- Conditions
- Acute Respiratory Distress Syndrome, Septic Shock, Hemodynamic Instability
- Trial name
- PR-ARDS-PP (NCT04457739)
- Testing
- Tidal volume challenge, End-expiratory occlusion test, Trendelenburg maneuver
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Bicetre Hospital
Septic Shock
Comparison of Radial and Femoral Artery Site Invasive Blood Pressure Measurement in Septic Shock Patients
Inaccurate monitoring of mean arterial pressure (MAP) could lead to improper treatment in the form of excessive fluid infusion or unnecessary vasopressor therapy; therefore, accurate hemodynamic monitoring is crucial in treatment…
- Trial name
- NCT03475667
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Septic Shock, Hyperlactatemia
Early Goal Directed Therapy Using a Physiological Holistic View. The ANDROMEDA-SHOCK Study
Septic shock is a highly lethal condition associated with a mortality risk of 30 to 60%. Optimizing tissue perfusion and oxygenation is the aim to decrease mortality and morbidity in septic shock patients.
- Conditions
- Septic Shock, Hyperlactatemia, Peripheral Perfusion
- Trial name
- ANDROMEDA (NCT03078712)
- Testing
- Peripheral Perfusion guided resuscitation, Lactate guided resuscitation
- Where
- Chile
- Volunteers
- 424 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Sepsis, Septic Shock
Can Gdf-15 Level Predict Progression to Multiple Organ Failure in Patients With Septic Shock
The aim of this observational study is to investigate whether GDF-15 levels can predict clinical outcome in patients admitted to the intensive care unit with a diagnosis of septic shock.
- Conditions
- Sepsis, Septic Shock, Multi Organ Failure
- Trial name
- NCT06808100
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Ankara City Hospital Bilkent
Sepsis
HFIP Ex-vivo Study
Sepsis, a multi organ failure caused by infectious diseases, is a major health burden with an average mortality rate of 26%. Cells of the innate immune system of hosts recognize specific patterns of pathogenic bacteria and…
- Trial name
- NCT04059263
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- University of Zurich
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