Clinical trials: Septic
Septic Shock
Lung Ultrasound-guided Fluid Resuscitation in Neonatal Septic Shock
object name: Lung ultrasound-guided fluid resuscitation in neonatal septic shock. type of study: prospective observational study.
- Trial name
- LUGFRINSS (NCT06144463)
- Testing
- lung ultrasound-guided fluid resuscitation
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Guangdong Second Provincial General Hospital
Septic Shock, Cirrhosis, Liver
Efficacy and Safety of Vasopressin Versus Terlipressin as a Second Vasopressor in Critically Ill Cirrhotics With Septic Shock- the VITEL-C Trial
Sepsis is a life-threatening organ dysfunction caused by dysregulated host response. A Subset of sepsis is septic shock which has almost 4-6 times the mortality when compared to sepsis.
- Trial name
- NCT05315557
- Testing
- Terlipressin, vasopressin
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Joint Effusion
Use of Infrared Spectroscopy in Septic Arthritis Diagnosis
The main objective of this study is to assess the ability of Fiber-optic Evanescent Wave Spectroscopy (FEWS) to discriminate synovial fluids samples of septic arthritis patients from other causes of joint effusion by analyzing ex…
- Trial name
- SynoFAST (NCT02860871)
- Testing
- infrared spectroscopy
- Where
- France
- Volunteers
- 611 people
- Sponsor
- Rennes University Hospital
SIRS, Sepsis
SIRS and Bacterial Sepsis Discrimination by Biomarkers in ICU
Aim of the study : The primary aim of the investigators study is to highlight the presence of biomarkers (biological indicators of the presence of inflammation or infection) of infectious processes during the systemic…
- Conditions
- SIRS, Sepsis, Severe Sepsis, Septic Shock
- Trial name
- Captain (NCT01378169)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Sepsis, Liver Failure
Lactate Clearance According to the Presence of Hepatic Dysfunction
The purpose of this study is to compare lactate clearance in patients with severe sepsis and septic shock according to the presence of hepatic dysfunction.
- Trial name
- NCT01709565
- Where
- South Korea
- Volunteers
- 245 people
- Sponsor
- Samsung Medical Center
Cognitive Impairment, Functional Magnetic Resonance Imaging
Functional Magnetic Resonance Imaging (fMRI) of Brain in ICU Survivors With Cognitive Impairment
Long-term cognitive dysfunction greatly influences patient's quality of life after critical illness. However,its neurophysiological basis remains unknown.This is a 3 year fMRI study conducted at the Jiangyin people's Hospital.
- Conditions
- Cognitive Impairment, Functional Magnetic Resonance Imaging, Septic Shock, Inflammation
- Trial name
- NCT03946839
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Jian-jun Yang
Septic Shock
The Prognostic Role of Tricuspid Annular Plane Systolic Excursion in Critically Ill Patients With Septic Shock
The aim of this study is to evaluate the possible prognostic performance of RV dysfunction, as assessed by TAPSE, in non-cardiac patients with septic shock.
- Trial name
- NCT06008067
- Testing
- tricuspid annular plane systolic excursion (TAPSE)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Alexandria University
Methicillin Resistant Staphylococcus Aureus, Osteomyelitis Acute
Trimethoprim-sulfamethoxazole vs. Clindamycin for the Treatment of Children With Invasive MRSA Infections
The goal of this clinical trial is to learn if trimethoprim-sulfamethoxazole (TMP-SMX) works to treat invasive infections due to methicillin-resistant Staphylococcus aureus (MRSA) in children.
- Conditions
- Methicillin Resistant Staphylococcus Aureus, Osteomyelitis Acute, Septic Arthritis, Orbital Cellulitis
- Trial name
- NCT06982105
- Testing
- Trimethoprim Sulfamethoxazole
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Indiana University
Volume Overload, Tissue Perfusion
Non-Invasive Cardiometry and Ultrasound Guided Inferior Vena Cava Collapsibility Index in Assessing Fluid Responsiveness
43 patients between 18-60 years presenting with criteria of sepsis (life-threatening organ dysfunction caused by a dysregulated host response to infection, suspected or documented infection and an acute increase ≥2 SOFA…
- Trial name
- NCT05104528
- Testing
- OSYPKA Medical ICONTM Noninvasive CardiometerTM Model C3, Fujifilm Sonosite M-Turbo C Ultrasound system
- Where
- Egypt
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute, Egypt
Sepsis
Time Course of Procalcitonin and C Reactive Protein in Septic Patients Under Treatment With Corticosteroids
A systemic treatment with corticosteroids has been advocated for various bacterial infectious diseases. Since the production of CRP is down-regulated by corticosteroids, a smaller increase or a more rapid decrease of this acute…
- Trial name
- NCT00141973
- Where
- Switzerland
- Sponsor
- Ospedale Regionale Bellinzona e Valli
Severe Sepsis or Septic Shock
Effects of Early Exercise Rehabilitation on Long-term Functional Recovery in Patients With Severe Sepsis
We hypothesized that early exercise rehabilitation for patients with severe sepsis or septic shock would decrease their functional disability and cognitive impairment.
- Trial name
- NCT01845766
- Testing
- exercise rehabilitation
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Septic Shock Hyperdynamic
ILOPROST in Septic Shock With Persistent Microperfusion Defects (I-MICRO)
Septic shock remains a major cause of death in critically ill patients. Alterations in microcirculation have long been proposed as a key pathophysiological factor of organ dysfunction and death in septic shock patients.
- Trial name
- I-MICRO (NCT03788837)
- Testing
- ILOPROST, NaCl
- Where
- France
- Volunteers
- 240 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Failure, Respiratory Arrest
Postoperative Respiratory Abnormalities
The study aims to determine how historical cases of respiratory abnormalities are documented by clinicians in the electronic health records (EHR) of Memorial Hermann Healthcare System (MHHS) inpatient facilities.
- Conditions
- Respiratory Failure, Respiratory Arrest, Respiratory Distress Syndrome, Acute Respiratory Failure
- Trial name
- AI-ARF (NCT04079829)
- Testing
- Observational retrospective cohort to describe data validity; and Data reliability; and Completeness of the data
- Where
- United States
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Efficacy Care R&D Ltd
Severe Sepsis With Septic Shock
Evaluating a CytoSorb Score in Septic Shock
Systemic hyperinflammatory states, e.g. triggered by infection/sepsis, represent a major challenge for modern medicine. After an initially localized onset, inflammation can extend to an excessive, uncontrolled inflammatory…
- Trial name
- ECSISS (NCT03977688)
- Testing
- Cytokin Adsorption
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Klinikum Emden
Shock, Septic
Australasian Resuscitation In Sepsis Evaluation: FLUid or Vasopressors In Emergency Department Sepsis
This multicentre, randomised controlled trial will enrol 1000 patients presenting with septic shock to the emergency department (ED) of participating hospitals in Australia and New Zealand.
- Trial name
- ARISE FLUIDS (NCT04569942)
- Testing
- Vasopressor, Fluids
- Where
- 50 sites in Australia, Ireland and 1 more
- Volunteers
- 1,000 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Septic Shock
Infusion of Prostacyclin (Iloprost) vs Placebo for 72-hours in Patients With Septic Shock Suffering From Organ Failure
The purpose of this trial is to investigate the efficacy and safety of continuous intravenous administration of low dose iloprost versus placebo for 72-hours, in up to a total of 380 patients with septic shock suffering from…
- Trial name
- COMBAT-SHINE (NCT04123444)
- Testing
- Iloprost, Isotonic saline
- Where
- 6 sites in Denmark
- Volunteers
- 279 people
- Sponsor
- Jakob Stensballe, MD, PhD
Septicemia
Immunoadsorption of LPS, C5a and IL-6 in Severe Sepsis and Septic Shock (ISASS-1)
The purpose of this study is to determine whether immunoadsorption of LPS, Il-6 and C5a reduces systemic hyperinflammation, improves immune function and improves organ function in patients with severe sepsis and septic shock
- Trial name
- NCT00146432
- Testing
- Immunoadsorption of LPS, IL-6 and C5a
- Where
- Germany
- Sponsor
- Charite University, Berlin, Germany
Septic Shock
Therapeutic Plasma Exchange in Adult Patients With Severe Sepsis
The incidence of sepsis (severe infection) has increased over the last four decades. Severe sepsis and septic shock are among the leading causes of death for patients admitted to critical care units with mortality ranging from…
- Trial name
- NCT04057872
- Testing
- Therapeutic plasma exchange
- Where
- 2 sites in Canada
- Volunteers
- 17 people
- Sponsor
- Alberta Health Services, Calgary
Septic Shock, Endotoxemia
Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study
Prospective, multicenter, randomized, open-label study of standard of care plus the PMX cartridge versus standard of care alone in patients with endotoxemic septic shock
- Trial name
- TIGRIS (NCT03901807)
- Testing
- Toraymyxin PMX 20R Extracorporeal Hemoperfusion Cartridge
- Where
- 20 sites in United States
- Volunteers
- 157 people
- Sponsor
- Spectral Diagnostics (US) Inc.
Septic Shock
Heparin Anticoagulation to Improve Outcomes in Septic Shock: The HALO Pilot
Life-threatening infections account for 10% of all intensive care unit admissions and constitute the second more frequent cause of death in the ICU after heart diseases.
- Trial name
- NCT01648036
- Testing
- Unfractionated heparin, Dalteparin
- Where
- 9 sites in Canada
- Volunteers
- 76 people
- Sponsor
- University of Manitoba
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