Clinical trials: Septic
Septic Shock
L-Carnitine Administration in Early Sepsis
Sepsis is a severe and overwhelming response to an infection in the body. Over 750,000 patients in the United States develop sepsis every year.
- Trial name
- NCT01193777
- Testing
- L-Carnitine, Normal Saline
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Wake Forest University Health Sciences
Neonatal Sepsis
Effect of Recombinant Human Granulocyte Colony- Stimulating Factor on CD11b in Septic Neonates
The investigators aimed to evaluate the effect of G-CSF administration in septic neonates on neutrophil production and CD11b expression.
- Trial name
- NCT01479114
- Testing
- rh-GCSF
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Septic Tibial Non-union
Management of Septic Non-union of the Tibia Using the "Induced Membrane" Technique
The aim of the study was to assess clinical and radiological results with the "induces membrane" technique, described by A. C. Masquelet in 1986, in a series of patients with septic non-union of the tibia
- Trial name
- SEPT-LEG (NCT03940638)
- Testing
- Data collection
- Where
- France
- Volunteers
- 18 people
- Sponsor
- CHU de Reims
Septic Shock, Sepsis-associated Hypotension
Hypertonic Saline and Terlipressin for Sepsis-associated Hypotension
In hypotensive septic patients with controlled source, an hemodynamic management protocol including hypertonic saline (HS)and terlipressin improves MOD (Multiple Organ Dysfunction) Score by at least 3 points compared to the use…
- Trial name
- HYSATESS-p (NCT01271114)
- Testing
- Hypertonic Saline and Terlipressin, Normal saline and norepinephrine
- Where
- Spain
- Volunteers
- 21 people
- Sponsor
- Hospital General de Ciudad Real
Septic Shock
Esmolol Effects on Heart and Inflammation in Septic Shock
Beta adrenergic system, over-activated in septic shock patients, is a key modulator of the inflammatory response. Experimental works demonstrated that Esmolol, an highly selective beta-1 blocker, reduces heart rate and regulates…
- Trial name
- ESMOSEPSIS (NCT02068287)
- Testing
- Esmolol
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Central Hospital, Nancy, France
Cardiac Ultrasound Phenotypes, Septic Myocardial Suppression
A Multicenter Cross-sectional Study of Cardiac Ultrasound Phenotypes in Patients With Sepsis
The heart, one of the most important organs for oxygen supply and consumption, is frequently involved in sepsis, i.e. septic cardiomyopathy, also known as septic myocardial suppression.
- Conditions
- Cardiac Ultrasound Phenotypes, Septic Myocardial Suppression, Hyperdynamic State Left Ventricular Function in Sepsis Patients, Outcome
- Trial name
- NCT05161104
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fujian Provincial Hospital
Septic Shock
LANdiolol MIcrocirculatory Effects During Septic chOc (MILANOS)
The objectives of this study are to evaluate the effect of continuous intravenous Landiolol injection (from 0.5 to 10 µg/kg/min during 12 hours ) up to a 15% decrease in Heart Rate (HR) on microcirculatory vascular reactivity vs.
- Trial name
- MILANOS (NCT04931225)
- Testing
- Landiolol
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis Syndrome, Septic Shock
Identification of Markers of Poor Clinical Prognosis in Sepsis by Epigenetic Analysis
Sepsis is a multifactorial syndrome characterized by a dynamic course and a clinical outcome dependent on several factors, and responsible for one in five deaths worldwide.
- Conditions
- Sepsis Syndrome, Septic Shock, Sepsis
- Trial name
- EPISEPSIS (NCT06446947)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Septic Shock
Pilot Phase II Study: Hemodynamic Tolerance and Anti-inflammatory Effects of Esmolol During the Treatment of Septic Shock
The purpose of this study is : to evaluate the hemodynamic tolerance of esmolol titrated to obtain a lowering of heart rate of 10% or 20%.
- Trial name
- THANE (NCT02120404)
- Testing
- Esmolol administration
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis
Arterial Blood Pressure-complexity in Septic Patients
Arterial blood pressure (ABP) is regulated by multiple, interconnected feedback loops resulting in a variable and complex time course.
- Trial name
- NCT00793078
- Where
- Germany
- Volunteers
- 72 people
- Sponsor
- University Hospital, Bonn
Sepsis, Shock, Septic
Sepsis Assessment in Belgian Emergency Rooms
To validate the use of the Heparin Binding Protein (HBP) concentration to assist in the evaluation of patients admitting to the emergency department with suspected infection.
- Conditions
- Sepsis, Shock, Septic, Severe Sepsis
- Trial name
- SABER (NCT02424721)
- Where
- 4 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- Axis Shield Diagnostics Ltd
Hypotension, Shock, Septic
Midodrine During Recovery From Septic Shock
The purpose of this study is to determine whether midodrine administration decreases duration of intravenous vasopressors and intensive care unit length of stay for patients in septic shock.
- Conditions
- Hypotension, Shock, Septic, Sepsis
- Trial name
- NCT02771158
- Testing
- Midodrine
- Sponsor
- Northwell Health
Septic Shock
Fever Control Using External Cooling in Mechanically Ventilated Patients With Septic Shock
The best strategy for managing fever in patients with septic shock remains unknown. In a pilot study, the investigators showed that fever control at normothermia allowed a better control of shock and evolution of organ failures.
- Trial name
- NCT04494074
- Testing
- External Cooling
- Where
- 33 sites in France
- Volunteers
- 820 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Bloodstream Infection, Sepsis
Clinical Performance Study of Microbio InfectID-BSI for Detection of Bacteria and Yeast With Patient Blood Samples
The objective of the study is to determine the efficacy of the Microbio InfectID-BSI qPCR kit in a clinical laboratory environment using patient whole blood for pathogen detection and identification versus standard of care…
- Conditions
- Bloodstream Infection, Sepsis, Septic Shock
- Trial name
- IID-BSIqPCR (NCT06531031)
- Testing
- InfectID-BSI (Bloodstream Infection) qPCR Assay
- Where
- 8 sites in United States, Australia and 1 more
- Volunteers
- 1,500 people
- Sponsor
- Microbio Co Ltd
D012139, D003924
Metformine as a Protective Factor of Mortality in Type 2 Diabetic Patients Admitted to the ICU for Septic Shock.
Septic shock is a major complication of sepsis and is one of the leading causes of admission to intensive care unit (ICU) as well as a major contributor to global mortality, accounting for one in five deaths worldwide and…
- Trial name
- SEPSMET (NCT07591402)
- Where
- France
- Volunteers
- 2,740 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Shock, Sepsis
Effects of Anisodamine on Sublingual Microcirculation and Vascular Waterfall Phenomenon in Patients With Septic Shock
This prospective, multicenter, single-arm, open-label interventional pilot study aims to evaluate the short-term physiological effects of intravenous anisodamine on sublingual microcirculation and vascular-waterfall parameters in…
- Conditions
- Septic Shock, Sepsis, Critical Illness
- Trial name
- ANISO-MICRO (NCT07657702)
- Testing
- Anisodamine intravenous infusion
- Where
- China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Sepsis, Infections
The Role of NLR in the Diagnosis and Prognosis of Sepsis
Neutrophil-lymphocyte ratio (NLR), as an inflammatory index, is cheap and easy to obtain, and could be widely used in hospitals at all levels.
- Trial name
- NCT05636202
- Testing
- No intervention
- Where
- China
- Volunteers
- 606 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Septic Shock
Norepinephrine Exerts an Inotropic Effect at the Early Phase of Human Septic Shock
Norepinephrine (NE) is a potent vasopressor used in septic shock to reverse hypotension. Early infusion of NE was associated with a favorable clinical outcome in a large cohort of patients .
- Trial name
- NCT02750683
- Volunteers
- 38 people
- Sponsor
- Hopital Antoine Beclere
Septic Shock
Septic Shock Management Guided by Ultrasound: SEPTICUS Trial
This clinical study aims to compare the recent septic shock management protocol from American College of Critical Care Medicine (ACCM) to Ultrasound-guided Septic Shock Management (USSM) protocol.
- Trial name
- NCT04728529
- Testing
- USSM protocol, ACCM protocol
- Where
- Indonesia
- Volunteers
- 340 people
- Sponsor
- Saptadi Yuliarto
Sepsis, Septic Shock
Evaluation of Safety and Dosing of a Vitamin C Bundle for Sepsis Treatment in Africa
Open-label phase 2a Randomized Controlled Trial (RCT) assessing the pharmacokinetics of two different doses of intravenous vitamin C given alongside vitamin B1 in adult medical patients with sepsis and hypotension.
- Conditions
- Sepsis, Septic Shock, HIV
- Trial name
- REVISTA-DOSE (NCT04999137)
- Testing
- Vitamin C, Vitamin B1
- Where
- 2 sites in Uganda
- Volunteers
- 60 people
- Sponsor
- Liverpool School of Tropical Medicine
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