Clinical trials: Septic
Sepsis, Severe Sepsis
Prehospital Antibiotics Against Sepsis Trial
Sepsis is one of the most frequent reasons for referral to emergency departments (EDs) worldwide. The incidence of sepsis is likely to rise in the upcoming years.
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- PHANTASi (NCT01988428)
- Testing
- Ceftriaxone 2000 mg
- Where
- 34 sites in Netherlands
- Volunteers
- 2,672 people
- Sponsor
- Amsterdam UMC, location VUmc
Hyperoxia / High FiO₂ Exposure, Uric Acid/Albumin Ratio (UAR)
Association Between Early FiO₂ Exposure and Changes in the Uric Acid/Albumin Ratio in Septic ICU Patients
This prospective, non-interventional study aims to investigate the relationship between early oxygen exposure and oxidative stress in adult intensive care unit (ICU) patients diagnosed with sepsis or septic shock.
- Trial name
- NCT07332637
- Testing
- Oxygen Exposure (Fraction of Inspired Oxygen, FiO₂) - Standard of Care (Observational, No Experimental Intervention)
- Volunteers
- 110 people
- Sponsor
- Istinye University
Sepsis, Critical Illness
PF-Organized Corticosteroid-Associated Heterogeneity in Sepsis
This retrospective multicohort observational study evaluates whether the PaO2/FiO2 ratio (P/F ratio) organizes heterogeneity in the association between early systemic corticosteroid exposure and mortality among critically ill…
- Trial name
- NCT07913464
- Testing
- Systemic Corticosteroids
- Where
- China
- Volunteers
- 2,693 people
- Sponsor
- Shanghai Zhongshan Hospital
Frailty, Septic Shock
Evaluation of the Clinical Frailty Scale (CFS) as a Risk Factor of Mortality in Adult Patients ≤65 Years of Age Admitted to Intensive Care for Septic Shock.
The aim of the study is to demonstrate that "frail" patients, defined as having a CFS score greater than or equal to 5, and "severely" frail patients, defined as having a CFS score between [6-7] as defined by Bagshaw et al (14)…
- Trial name
- Woodstock (NCT05928767)
- Where
- 5 sites in France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier de Lens
Neonatal Sepsis, Shock, Septic
Intravenous Methylene Blue for Treating Refractory Neonatal Septic Shock
Preterm infants (born at less than 37 weeks of pregnancy) sometimes develop a serious blood infection leading to low blood pressure, which does not respond to saline or to the standard medicines for increasing blood pressure…
- Trial name
- NCT06306001
- Testing
- Methylene Blue
- Where
- India
- Volunteers
- 130 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Severe Sepsis, Septic Shock
The Effect of Three Different Fluids(Albumin 5%, Normal Saline, Hydroxyethyl Starch 130 kD) on Microcirculation in Severe Sepsis/Septic Shock Patients
Major microvascular blood flow alterations have been documented in patients with severe sepsis. It was also demonstrated that the microcirculation improved in survivors of septic shock but failed to do so in patients dying from…
- Conditions
- Severe Sepsis, Septic Shock, Microcirculation
- Trial name
- NCT01319630
- Testing
- Sidestream Dark Field (SDF), Near Infrared Spectroscopy (NIRS)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Mercy Research
Sepsis, Sepsis and Coagulopathy
Sepsis-associated Thrombocytopenia and Platelet Transfusion （STAPT）
Currently, there are no multicenter studies on platelet transfusion for SAT patients, and the benefits and risks of platelet transfusion still require further validation based on large-sample data.
- Trial name
- NCT07230067
- Testing
- SAT patients
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Gram Negative Infections, Sepsis and Septic Shock
A Combination Therapy With Ceftazidime and Fosfomycin Will be Compared to Ceftazidime Alone in Hospitalized Adult Patients With Suspected Severe Gram-negative Bacterial Infections
The goal of this clinical trial is to : 1. Test whether the combination of CAZ±AVI and FOS leads to superior clinical outcomes in patients with severe suspected Gram-negative bacterial infection, as demonstrated by a shorter time…
- Trial name
- CAVIFOS (NCT07063095)
- Testing
- Ceftazidime± avibactam with fosfomycin
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Angela HUTTNER
Sepsis, Sepsis Mrsa
Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis
The goal of this quasi-experimental interventional study is to determine the effectiveness of a multifaceted stewardship intervention in reducing overall vancomycin use in five tertiary care Pediatric Intensive Care Units (PICU).
- Conditions
- Sepsis, Sepsis Mrsa, Sepsis Bacteremia, Antimicrobial - Induced Nephropathy
- Trial name
- REVAMP (NCT05975671)
- Testing
- Multifaceted de-implementation strategy to reduce vancomycin overuse
- Where
- 4 sites in United States
- Volunteers
- 52,500 people
- Sponsor
- Children's Hospital of Philadelphia
Arthritis, Septic
Corticosteroid Therapy for Persistent Synovitis in Acute Septic Arthritis on Native Joint
Acute septic arthritis is a rare but life-threatening and functionally serious disease. The improvement or disappearance of pain and functional recovery are sometimes difficult to obtain, with in some cases the persistence of…
- Trial name
- SYNOVITIS (NCT05531227)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Sepsis, Volume Assessment
Evaluation of Fluid Infusion With LifeFlow for Patients With Suspected Septic Shock
The LifeFlow rapid infusion device is a handheld manually-operated device that has been shown in early trials to increase the rate of bolus fluid infusion up to 3 times the rate of delivery attributed to conventional rapid…
- Trial name
- NCT03673891
- Testing
- Life Flow
- Sponsor
- University of Arizona
Sepsis, Ventilator Associated Pneumonia
Intravenous Clarithromycin in Septic Syndrome
The aim of this clinical trial is to clarify the clinical efficacy of clarithromycin as immunotherapy for the management of septic syndrome by ventilator-associated pneumonia.
- Trial name
- NCT00297674
- Testing
- Intravenous Clarithromycin
- Where
- 3 sites in Greece
- Volunteers
- 200 people
- Sponsor
- University of Athens
Septic Shock, Sepsis
Lipid Profile in Patients With Severe Sepsis or Septic Shock Under Strict or Liberal Glycemic Control
Study of the lipid metabolism under glycemic control in septic patients who got an university 14 bed ICU. Hypothesis: establish a relationship between lipid metabolism alterations and glycemic control or infusion of exogenous…
- Trial name
- NCT01013662
- Testing
- glycemic control
- Volunteers
- 69 people
- Sponsor
- University of Sao Paulo
Intra-Abdominal Infections
Abdominal SepsiS Study: Epidemiology of Etiology and Outcome
The aim of the project is to perform a multinational, prospective, observational study on IAIs (IntraAbdominal Infections) in critically ill patients; special emphasis will be given to epidemiology and outcomes.
- Trial name
- AbSeS (NCT02442596)
- Where
- Belgium
- Volunteers
- 2,200 people
- Sponsor
- European Society of Intensive Care Medicine
Sepsis, Septic Shock
Early Goal-directed Therapy and Myocardial Dysfunction
The cardiovascular system plays a central role in the pathophysiology and prognosis of sepsis, yet the correct hemodynamic management of septic patients is still vigorously debated.
- Conditions
- Sepsis, Septic Shock, Myocardial Dysfunction
- Trial name
- SEPT-MD (NCT01312688)
- Testing
- Early Goal Directed Hemodynamic Therapy in Sepsis
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Hadassah Medical Organization
Extracorporeal Membrane Oxygenation, Septic Shock
ExtraCorporeal Membrane Oxygenation in the Therapy for REfractory Septic Shock With Cardiac Function Under Estimated
The ECMO-RESCUE study is a prospective, multicenter, non-randomized, cohort study. In this study, we aimed to assessed whether VA-ECMO treatment can improve the 30-day survival rate of patients with sepsis-induced refractory…
- Conditions
- Extracorporeal Membrane Oxygenation, Septic Shock, Septic Cardiomyopathy, Cardiogenic Shock
- Trial name
- ECMO-RESCUE (NCT05184296)
- Testing
- Extracorporeal Membrane Oxygenation (ECMO)
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Hip Arthroplasty
Differentiation of Aseptic From Septic Loosening by 18F-fluoride PET
In this study, the investigators utilized the 18F-fluoride PET method to evaluate THA cases with a stable, septic or septic loosened implant in order to differentiate these clinical settings using a novel uptake type…
- Trial name
- NCT01017562
- Where
- Japan
- Volunteers
- 61 people
- Sponsor
- Yokohama City University Medical Center
Severe Sepsis With Septic Shock
VTE Incidence in Severe Sepsis and Septic Shock
Prospective studies on the incidence of VTE during severe sepsis and septic shock remain absent, hindering efficacy assessments regarding current VTE prevention strategies in septic patients.
- Trial name
- NCT02353910
- Testing
- Ultrasound
- Volunteers
- 113 people
- Sponsor
- University of Utah
Septic Shock, Compliance
Effects of Nursing Staff on Empiric Antibiotic in Septic Shock
A retrospective, observational study was performed about the patients with septic shock who admitted into intensive care unit (ICU) from January 1, 2015 to February 29, 2016.
- Conditions
- Septic Shock, Compliance, Antibiotic, Nursing Caries
- Trial name
- NCT03085459
- Testing
- work Time
- Volunteers
- 214 people
- Sponsor
- Chun Pan
Sepsis, Septic Shock
Effect of Mesenchymal Stromal Cells on Sepsis and Septic Shock
Methods:Ten patients were enrolled in the study. Adipose derived-MSCs infusions were given (1x 106/ kg, on 1st, 3rd, 5th, 7th and 9th days of therapy) together with Standard therapy.
- Trial name
- NCT05283317
- Testing
- Mesenchymal stem cells
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- TC Erciyes University
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