Clinical trials: Septic
Sepsis, Septic Shock
Predictive Model for Multidrug Resistance in Patients Admitted to the Emergency Department With Sepsis
Introduction: Timely and accurate antibiotic administration in emergency department (ED) patients with sepsis or septic shock is vital, given mortality rates of 20% and over 40%, respectively.
- Trial name
- NCT07167173
- Volunteers
- 10,000 people
- Sponsor
- Hospital Italiano de Buenos Aires
Bacteremia, Sepsis
Fast Assay for Pathogen Identification and Characterization
Sepsis is a life-threatening disease caused by a dysregulated host response to infection. This can lead to organ-dysfunction and septic shock, which is a subset of sepsis where underlying abnormalities increase mortality…
- Conditions
- Bacteremia, Sepsis, Septic Shock
- Trial name
- FAPIC (NCT03841162)
- Where
- Belgium
- Volunteers
- 1,957 people
- Sponsor
- Hasselt University
Septic Shock
Dose of Norepinephrine and the Concentration of L-Lactate in the Rectum and Stomach in Patients With Septic Shock.
Norepinephrine is a drug used to increase blood pressure in patients with life-threatening infection. However, norepinephrine may limit the bloodflow to the gut, thereby causing relative lack of oxygen to the cells.
- Trial name
- NCT00197886
- Testing
- Changing dose of norepinephrine and blood pressure
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Herlev Hospital
Cancer, Septic Shock
Evaluation of Fluid Resuscitation in Children With Cancer With Severe Sepsis / Septic Shock
Retrospective study to evaluate the characteristics of patients and of fluid resuscitation during intensive care unit hospitalization of patients under septic chock.
- Conditions
- Cancer, Septic Shock, Other Fluid Overload
- Trial name
- NCT01304680
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Grupo de Apoio ao Adolescente e a Crianca com Cancer
Septic Shock, Acute Kidney Injury
Early Endotoxin Burden Reduction With oXiris in Septic Shock Patients Requiring CRRT
The goal of this clinical trial is to learn whether continuous renal replacement therapy (CRRT) using the oXiris filter can lower the amount of endotoxin in the blood of adults with septic shock who need CRRT.
- Trial name
- NCT07807410
- Testing
- oXiris Hemofilter
- Where
- China
- Volunteers
- 13 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Crohn Disease, Ileocolic Resection
CRP Monitoring After ICR in CD Patients
Aim: The aim of this study was to assess the accuracy of the C-reactive protein as an early predictor of intra-abdominal septic complicationss after ileocolic resection for Crohn disease.
- Trial name
- C-ICR-CD (NCT04643496)
- Testing
- Laparoscopic or open Ileocolic resection
- Where
- France
- Volunteers
- 159 people
- Sponsor
- University Hospital, Montpellier
Necrotizing Soft Tissue Infection, Necrotizing Fascitis
Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study
The investigators will analyze biomarkers related to the prognosis and treatment of necrotizing soft tissue infections (NSTI). The focus will be on whether certain endothelial and immune system biomarkers can function as markers…
- Conditions
- Necrotizing Soft Tissue Infection, Necrotizing Fascitis, Gas Gangrene, Fournier Gangrene
- Trial name
- ProTreat (NCT03147352)
- Testing
- Hyperbaric oxygen therapy
- Where
- Denmark
- Volunteers
- 260 people
- Sponsor
- Ole Hyldegaard
Fever, Sepsis
Paracetamol Toxicity in Septic Patients
The investigators will examine the toxicity of therapeutic doses of paracetamol in patients in severe sepsis. Patients with fever and severe sepsis will be randomized to receive paracetamol or dypirone.
- Trial name
- NCT01182974
- Testing
- paracetamol, dypirone
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Barzilai Medical Center
Infection in ICU, Sepsis
Early Optimization of Ceftazidime Regimen in Critical Care
Hospital-acquired infections, most of which are caused by Gram-negative bacteria, are common in intensive care units and have a major impact on patient prognosis.
- Conditions
- Infection in ICU, Sepsis, Septic Shock, Pseudomonas Aeruginosa Infection
- Trial name
- FORTOPTIM_1 (NCT07085624)
- Testing
- ceftazidime, plasma ceftazidime dosage
- Where
- 8 sites in France
- Volunteers
- 128 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Pregnancy, Postpartum
Organ Dysfunction Score for Obstetric Patients
The goal of this observational study is to develop and evaluate an organ dysfunction score adapted to pregnancy and early puerperium (SOFA-OBS) that also incorporates a non-invasive tool to evaluate respiratory function (pulse…
- Conditions
- Pregnancy, Postpartum, Organ Dysfunction, Critical Care, Intensive Care
- Trial name
- SOFA-OBS (NCT07068022)
- Testing
- Organ dysfunction score adjusted to obstetric patients (SOFA-OBS)
- Where
- 18 sites in Argentina, Ecuador and 2 more
- Volunteers
- 130 people
- Sponsor
- Daniela Vasquez
Septic Shock
Hydrocortisone and Fludrocortisone for the Treatment of Septic Shock
The purpose of this study is to evaluate the efficacy and safety of the combination therapy of hydrocortisone and fludrocortisone among adult patients with septic shock.
- Trial name
- NCT07383103
- Testing
- Hydrocortisone plus Fludrocortisone, Standard care
- Where
- China
- Volunteers
- 336 people
- Sponsor
- Northern Jiangsu People's Hospital
Sepsis, Severe, Septic Shock
Effects of Endotoxin Absorption and Cytokine Removal Hemofilter on Severe Septic Shock
In recent years, many studies have pointed out that bacterial toxin and cytokine storm are the main causes of shock and multiple organ failure in patients with sepsis.
- Trial name
- NCT03974386
- Testing
- oXiris blood purification set
- Where
- Taiwan
- Volunteers
- 12 people
- Sponsor
- National Taiwan University Hospital
Septic Shock
Correlation of VEGF-A and Fluid Balance in Septic Shock
VEGF is a key molecule in the control of vascular permeability via interactions with the VEGF-receptor on the endothelial cell. Several authors reported plasma VEGF levels are elevated in sepsis shock and associated with…
- Trial name
- VEGFluid (NCT04474431)
- Testing
- Evaluation of VEGF-A levels in patients with septic shock is positively correlated with a positive fluid balance.
- Where
- France
- Volunteers
- 103 people
- Sponsor
- University Hospital, Rouen
Severe Sepsis, Septic Shock
Mannheim Register of Sepsis and Septic Shock
The study aims to investigate clinically and prognostically relevant parameters in patients with sepsis and septic shock within a monocentric observational clinical register.
- Trial name
- MARSS (NCT05231720)
- Where
- 2 sites in Germany
- Volunteers
- 500 people
- Sponsor
- Universitätsmedizin Mannheim
Pancreatitis
Evaluation of Pancreatic Tissue Penetration of Meronem® in the Prophylaxis of Septic Complications in Severe Pancreatitis
To measure meropenem pancreatic tissue penetration in subjects with severe pancreatitis requiring surgery between 30 to 60 minutes after a bolus of 1 g IV meropenem given during the induction period of anesthesia.
- Trial name
- NCT00318994
- Testing
- Meropenem
- Where
- Colombia
- Volunteers
- 6 people
- Sponsor
- Pfizer
COVID-19, Organ Dysfunction Syndrome Sepsis
Mechanisms for Organ Dysfunction in Covid-19
The study aims to investigate organ dysfunction and biomarkers in patients with suspected or verified COVID-19 during intensive care at Uppsala University Hospital.
- Conditions
- COVID-19, Organ Dysfunction Syndrome Sepsis, Organ Dysfunction Syndrome, Multiple, Septic Shock
- Trial name
- UMODCOVID19 (NCT04316884)
- Where
- Sweden
- Volunteers
- 380 people
- Sponsor
- Uppsala University
Atrial Fibrillation
Magnesium Sulphate for Treatment of New Onset Atrial Fibrillation in Medical Intensive Care Unit Patient
The purpose of this study is to determine the efficacy of Magnesium sulphate for the rate and rhythm control of the new onset (within 48 hours) atrial fibrillation in the hemodynamically unstable patients, admitted in the medical…
- Trial name
- EMSAF (NCT01049464)
- Testing
- Magnesium sulphate
- Where
- Thailand
- Volunteers
- 128 people
- Sponsor
- Mahidol University
SEPSIS, Septic Patients
Peripheral Perfusion and Outcomes in ICU Patients With Sepsis
People with sepsis who are treated in the intensive care unit (ICU) often have impaired blood flow to the skin and other tissues.
- Trial name
- PERFUSE-ICU (NCT07391098)
- Testing
- PERIPHERAL PERFUSION EVALUATION
- Where
- Romania
- Volunteers
- 80 people
- Sponsor
- Alexandra Elena Lazăr
Sepsis, Immunologic Paralysis
Immune Homeostasis in Sepsis and Septic Shock
Detailed description of immune response and its dynamics in sepsis and septic shock patiens by means of transcriptomics, flow-cytometry and cytokine analysis.
- Conditions
- Sepsis, Immunologic Paralysis, Immunologic Suppression, Immune Deficiency
- Trial name
- IMHOTEP (NCT04448951)
- Testing
- transcriptomics, flow-cytometry, cytokines
- Where
- Czechia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Septic Shock
Study the Impact of Statins in Septic Shock
Sepsis is a common, expensive, frequently fatal and highly complex inflammatory syndrome wherein multiple cellular and humoral pathways are involved.
- Trial name
- NCT02681653
- Testing
- Atorvastatin
- Where
- 2 sites in India
- Volunteers
- 40 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
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