Clinical trials: Septic
Septic Shock
Evaluation of the Prognostic Value of Immature Platelet Fraction
Sepsis is a public health issue responsible for six million deaths worldwide each year. It is one of the leading causes of admission and morbidity and mortality in critical care.
- Trial name
- IPSIS (NCT07039227)
- Where
- France
- Volunteers
- 196 people
- Sponsor
- University Hospital, Rouen
Complication of Surgical Procedure
Cardiovascular Risk Factors of Medical and Septic Complications After Laparoscopic Bariatric Surgery
A prospective, observational study of all morbidly obese patients undergoing laparoscopic Roux-en-Y gastric bypass (LRYGB) or laparoscopic sleeve gastrectomy (LSG) was performed.
- Trial name
- NCT04683666
- Testing
- Bariatric surgery
- Volunteers
- 177 people
- Sponsor
- Hospital General Universitario Elche
Sepsis, Septic Shock
Sodium Bicarbonate Ringer's Solution Versus Normal Saline for Early Fluid Resuscitation in Patients With Sepsis
At present, people still have different opinions on choosing which kind of crystalloid solution for patients with sepsis, and there is no unified standard yet.
- Trial name
- NCT04621981
- Testing
- Sodium Bicarbonate Ringer's Solution, Normal Saline
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Xiangya Hospital of Central South University
Sepsis Syndrome
Blood Gases Versus Lactate Clearance as an Indicator of Initial Resuscitation in Septic Patients: Comparative Study
This perspective blind randomized single center study was designed to assess central venous and arterial gases level including P(v-a)CO2/C(a-v)O2 ratio and P(v-a)CO2 difference against lactate clearance as an indicator of initial…
- Trial name
- NCT05049941
- Testing
- lactat and blood gases
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Minia University
Septic Shock, Platelet Signal Processing Defect
PLatelets Acetyl-CoA Carboxylase Phosphorylation State in SEPtic Shock
Knowing the dramatic increase in thrombin generation during sepsis, our research hypothesis is that AMPK-induced ACC phosphorylation in platelets is increased and that this might modulate platelets metabolism and more…
- Conditions
- Septic Shock, Platelet Signal Processing Defect, Inflammatory Response, Disseminated Intravascular Coagulation
- Trial name
- PLACCSEPS (NCT04107402)
- Testing
- Assessment of coagulopathy, Platelets activation and Platelets-Neutrophils interplay
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Sepsis, Septic Shock
IL-40 and IL-41 Levels in Sepsis, Septic Shock, and Healthy Individuals
This study aims to investigate the blood levels of two recently identified immune-related proteins, Interleukin-40 (IL-40) and Interleukin-41 (IL-41), in patients with sepsis and its more severe form, septic shock.
- Conditions
- Sepsis, Septic Shock, Inflammation, Biomarkers
- Trial name
- NCT06963541
- Testing
- No intervention; Observational study
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Melahat Yalcin Solak
Severe Sepsis With Septic Shock
Immune Reconstitution of Immunosuppressed Sepsis Patients
A multicenter, randomized, double-blinded, placebo-controlled study of two dosing frequencies of recombinant Interleukin-7 (CYT107) treatment to restore absolute lymphocyte counts in sepsis patients; IRIS-7A (Immune…
- Trial name
- IRIS-7a (NCT02797431)
- Testing
- Interleukin-7
- Where
- 3 sites in France
- Volunteers
- 16 people
- Sponsor
- University Hospital, Limoges
Heading
Can Nephrocheck™ Predict the Reversibility of Early, Acute Kidney Injury During Septic Shock?
Patients with septic shock in the intensive care unit have an elevated risk of developing acute kidney injury (AKI).
- Trial name
- AKI-CHECK (NCT02812784)
- Testing
- Nephrocheck TM
- Where
- 11 sites in France
- Volunteers
- 184 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Septic Shock
Venoarterial PCO2 Difference /Arteriovenous O2 Content Difference Ratio as Goal of Early Septic Shock Therapy
Reducing tissue hypoxia is the ultimate goal of severe sepsis and septic shock therapy.Venoarterial PCO2 difference /arteriovenous O2 content difference ratio (△PCO2/Ca-vO2) is considered to be a good indicator of global…
- Trial name
- NCT01877798
- Testing
- volume resuscitation, vasoactive drug
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Peking Union Medical College Hospital
Septic Shock
HCT+F vs. HCT Alone in Critically Ill Medical Septic Shock Patients
This study will be conducted as a single-center, prospective, open-label, randomized trial that will evaluate adult patients admitted with septic shock to the medical critical care unit (MCC).
- Trial name
- NCT03710187
- Testing
- Hydrocortisone
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of Tennessee Medical Center
Septic Shock
Focused Ultrasound in Septic Shock Patients
The investigators hypothesize that lung ultrasound and echocardiography will benefit the septic shock patients by making the treatment more precisely and rapidly.
- Trial name
- NCT01920776
- Testing
- ultrasound examination, Ultrasound group
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
Sepsis, Severe, Septic Shock
High-dose Intravenous Vitamin C in Patients With Septic Shock
Despite promising observational and phase 1 data, the therapeutic potential of vitamin C for the management of septic shock has not borne out in recent large multi-centre randomized controlled trials.
- Trial name
- HIGH-VIS (NCT04796636)
- Testing
- Sodium Ascorbate
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Melbourne Health
Cirrhosis With Septic Shock
To Assess the Efficacy of Early Introduction of a Combination of Low Dose Vasopressin Analogue in Addition to Noradrenaline as a Vasopressor in Patients of Cirrhosis With Septic Shock
The consecutive patients admitted to Intensive care unit of Hepatology department of ILBS and full filling all the eligibility criteria will be enrolled in 1:1 ration by the process of randomization.- The study is an open level…
- Trial name
- NCT02468063
- Testing
- Low dose terlipressin, Noradrenaline
- Where
- India
- Volunteers
- 184 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Sepsis, Septic Shock
Early Norepinephrine Administration and Rapid Dose Adjustment
The goal of this clinical trial is to determine whether early initiation of norepinephrine with rapid dose adjustment improves clinical outcomes in adult patients with septic shock.
- Trial name
- CENSER2 (NCT07343206)
- Testing
- Early norepinephrine administration and rapid dose adjustment, Control
- Where
- 6 sites in Thailand
- Volunteers
- 600 people
- Sponsor
- Siriraj Hospital
Sepsis, Septic Shock
Evaluation of Parameters Collected From Routine Data for the Diagnosis of Sepsis and Septic Shock and Their Influence on Time to Diagnosis and Patient Outcome
Retrospective observational study to develop a Machine Learning Algorithm to evaluate parameters collected from routine data for the diagnosis of sepsis and septic shock and their influence on time to diagnosis and patient…
- Trial name
- NCT05383963
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- Charite University, Berlin, Germany
Sepsis
The Effect of CUGP Fluid Management in Patients With Sepsis or Septic Shock
This study aims to assess whether procedural critical ultrasonography guided precise fluid management (CUGP) can affect the clinical fluid management strategy and improve the outcomes of patients with sepsis or septic shock.
- Trial name
- NCT06879249
- Testing
- critical ultrasonography
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Shusheng Li
Critical Illness, Septic Shock
Evaluation of Intestinal Brush Border Enzyme Function in Critically Ill Patients
The purpose of this study is to evaluate the role of several enzymes of the gut mucosa in preventing invasion of gastrointestinal bacteria.
- Conditions
- Critical Illness, Septic Shock, SIRS
- Trial name
- NCT01585909
- Testing
- Gastroscopy
- Where
- Austria
- Volunteers
- 39 people
- Sponsor
- Medical University of Vienna
New Onset Atrial Fibrillation, Severe Sepsis
Use of Amiodarone in Atrial Fibrillation Associated With Severe Sepsis or Septic Shock
Purpose/Objectives: Severe sepsis and septic shock are a common cause of new onset atrial fibrillation (NOAF) in the intensive care unit. Development of NOAF in this setting can prolong length of stay and increase mortality.
- Conditions
- New Onset Atrial Fibrillation, Severe Sepsis, Septic Shock
- Trial name
- NCT02668432
- Testing
- Amiodarone
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Gap co2, Cardiac Output, Low
Gap CO2 in Septic Patient to Predict Cardiomyopathy Septic
the investigators included 98 patients admitted for sepsis and septic shock (68.4% men, 31.6% women) with an average age of 60.42 years ± 15.13, ranging from 21 to 96 years. The average length of hospital stay was 7.53 days.
- Conditions
- Gap co2, Cardiac Output, Low, Cardiac Defect
- Trial name
- NCT06326762
- Testing
- comparaison
- Where
- Morocco
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Mohammed VI University Hospital
Sepsis, Diabetes Mellitus
The Prognostic Value of Lactate is Different Among Septic Patients
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Early diagnosis of sepsis and identification of more severe sepsis is important to improve the outcomes .Therefore…
- Trial name
- NCT04155060
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Shanghai Zhongshan Hospital
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