Clinical trials: Septic
Severe Sepsis, Sepsis
Early Identification and Effective Management of Pediatric Sepsis
In patients diagnosed as sepsis on PICU admission, early and accurate identification of patients who will develop organ dysfunction (severe sepsis) is critical for effective management and positive outcome.
- Conditions
- Severe Sepsis, Sepsis, Septic Shock
- Trial name
- NCT03996720
- Where
- 4 sites in China
- Volunteers
- 175 people
- Sponsor
- Children's Hospital of Fudan University
Septic Shock, Sepsis
Heamodynamic Effects of Paracetamol in Septic Shock Patients
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Septic shock is defined as sepsis that has circulatory, cellular, and metabolic abnormalities that are associated with a greater…
- Trial name
- NCT06076980
- Testing
- Paracetamol, Normal saline
- Where
- Egypt
- Volunteers
- 61 people
- Sponsor
- Ayah Mohammed Khalil
Sepsis Syndrome, Sepsis
Sepsis: From Syndrome to Personalized Care
This is a prospective, observational study designed to examine the performance of biomarkers, molecular biological methods and other analysis in blood from patient with suspected sepsis in the Emergency department, as well as…
- Conditions
- Sepsis Syndrome, Sepsis, Sepsis, Severe, Septic Shock
- Trial name
- NCT04203979
- Where
- Norway
- Volunteers
- 1,950 people
- Sponsor
- Oslo University Hospital
Sepsis, Severe Sepsis
The Effects of Eicosapentaenoic Acid (EPA), Gamma-Linolenic Acid (GLA) and Antioxidants in the Treatment of Sepsis
The scope of this clinical study is to evaluate the possible role of an enteral formulation enriched with EPA, GLA and Antioxidants in patients diagnosed in the early stages of sepsis despite mechanical ventilation requirements…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT00329680
- Testing
- Eicosapentaenoic acid, Gamma-Linolenic Acid and Antioxidant Vitamins, Standard ICU enteral diet, isocaloric to the study diet
- Where
- 12 sites in Brazil
- Volunteers
- 115 people
- Sponsor
- Fernandes Tavora Hospital
Sepsis, Septic Shock
Association of EASIX in Sepsis
This prospective study aims to determine the relationship between the EASIX score and mortality and prognosis in sepsis.
- Conditions
- Sepsis, Septic Shock, Septic Syndrome
- Trial name
- NCT06887439
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Sepsis, Septic Shock
Leukocyte MOrphology and CORticosteroids Response in SEPtic Patients (MOCORSEP)
Non-interventional, prospective, monocentric study on the exploration of leukocyte morphological parameters according to the infectious condition and response to corticosteroid therapy of septic patients.
- Conditions
- Sepsis, Septic Shock, Sepsis Syndrome, Infection
- Trial name
- MOCORSEP (NCT04292431)
- Where
- France
- Volunteers
- 175 people
- Sponsor
- Beckman Coulter, Inc.
Septic, Acute Respiratory Distress Syndrome
Lessening Organ Dysfunction With VITamin C in Septic ARDS
The primary objective of the study aims to compare the effect of high-dose intravenous vitamin C vs. placebo on a composite of death or persistent organ dysfunction - defined as continued dependency on mechanical ventilation, new…
- Trial name
- LOVIT ARDS (NCT04404387)
- Testing
- Administration of vitamin C
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis
TRIM25 in Septic Patients
Sepsis is a life-threatening condition caused by the body's overwhelming response to infection, which can lead to organ damage and failure.
- Trial name
- NCT07320638
- Testing
- Gene and Inflammatory Marker Analysis in Sepsis
- Where
- China
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Stellate Ganglion Block, Radial Artery Cannulation
Effect of Stellate Ganglion Block on Blood Flow in the Cannulated Radial Artery
To evaluate the value of US-guided Stellate ganglion block for improving radial arterial blood flow and peripheral perfusion in Septic shock patients on vasopressor support with an indwelling radial arterial cannula, which can…
- Trial name
- NCT03042663
- Testing
- USG stellate ganglion block
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Eslam Ayman Mohamed Shawki
Septic Shock, Acute Kidney Injury
Use of Oxiris Filter in Septic Shock Patients Requiring Renal Replacement Therapy: A Retrospective Cohort Study
Sepsis and septic shock are major causes of mortality in critically ill patients and are frequently associated with acute kidney injury requiring renal replacement therapy.
- Trial name
- NCT07569406
- Testing
- Oxiris filter, Standard Hemofilter
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Sepsis
Role of PCO2 Gap as Predictor of Clinical Outcome in ICU Septic Patients
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, if not recognized early and managed promptly, it can lead to septic shock, multiple organ failure and death.
- Trial name
- PCO2 (NCT06256198)
- Testing
- measurement of serum lactate and procalcitonin and PCO2 gap
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Sepsis, Severe
Bispectral Index (BIS) for Classification of Procalcitonin (PCT) Sepsis Grades in Critically Ill Patients With Sepsis
To evaluate the discriminative power of BIS monitoring to classify the degree of mental state associated with the PCT graded sepsis cascade, and to assess its utility for monitoring the improvement or deterioration of sepsis.
- Trial name
- BIS6 (NCT03244293)
- Testing
- no intervention
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Suez Canal University
Sepsis
Correlation Between PTP1B Expression and Organ Failure During Sepsis
Despite major advances in the treatment and understanding of the pathophysiological mechanisms, mortality of severe sepsis remains high, ranging from 25 to 50%.
- Trial name
- SEPP1B (NCT02295514)
- Testing
- PTP1B dosage
- Where
- France
- Volunteers
- 54 people
- Sponsor
- University Hospital, Rouen
Sepsis, Critical Illness
Indirect Calorimetry Usage and Effect in Ventilator-free Days and Muscle Thickness in Septic Ventilated Patients
Patients admitted to the ICU with diagnosis of sepsis and requiring mechanical ventilation for at least 24-hours and receiving enteral or parenteral nutrition will be prospectively randomized to one of two arms.
- Conditions
- Sepsis, Critical Illness, Respiratory Failure, Nutrition Disorders
- Trial name
- NCT03440593
- Testing
- Caloric delivery will target results of IC measurement.
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Baylor Research Institute
Sepsis, Septic Cardiomyopathy
Identification of Cardiovascular and Molecular Prognostic Factors for the Mid- and Long-term Outcome of Sepsis
Sepsis is a life-threatening condition which can affect people of any age. An infection triggers a host response resulting in organ failure.
- Conditions
- Sepsis, Septic Cardiomyopathy, Cardiomyopathies
- Trial name
- ICROS (NCT03620409)
- Where
- Germany
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- Jena University Hospital
Sepsis, Septic Shock
DDX17 Orchestrate Septic Vascular Endothelial Pyroptosis by Controlling Gasdermin D Pore Formation
Objective: To investigate the correlation between plasma levels of DDX17 and GSDMD with vascular endothelial dysfunction and prognosis of in sepsis patients. Design: A single center, prospective, observational research.
- Trial name
- NCT06013033
- Volunteers
- 60 people
- Sponsor
- Zhongda Hospital
Osteomyelitis, Septic Arthritis
Cefadroxil and Cephalexin Drug Levels and Dosing in Pediatric Musculoskeletal Infections
The goal of this study is to figure out the best doses for two antibiotics (called cefadroxil and cephalexin) when they are used to treat bone, joint, or muscle infections in children.
- Conditions
- Osteomyelitis, Septic Arthritis, Pyomyositis
- Trial name
- NCT03802552
- Testing
- Cefadroxil, Cephalexin
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Colorado, Denver
Septic Shock, Ventilator Acquired Pneumonia
Intravenous Metoprolol in Septic Shock
A RCT designed to assess the effect of giving intravenous beta-blockers in patients with septic shock after achieving hemodynamic stability.
- Trial name
- NCT06592547
- Testing
- Intravenous metoprolol tartrate, Standard Care (in control arm)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Alexandria University
Severe Sepsis, Septic Shock
Minimally-Invasive Cardiovascular Hemodynamic Optimization (MiCHO) Versus Early Goal-Directed Therapy (EGDT) in the Management of Septic Shock
Early intervention in the treatment of septic shock, including early goal-directed therapy (EGDT) in the first 6 hours of disease presentation, has been shown to significantly decrease mortality.
- Trial name
- MiCHO (NCT00535821)
- Testing
- Esophageal Doppler monitoring - CardioQ, Deltex Inc, Central line with CVP and continuous ScvO2 monitoring
- Where
- 4 sites in United States
- Volunteers
- 5 people
- Sponsor
- Loma Linda University
Septic Shock
Venous to Arterial Carbon Dioxide Difference (P₍ᵥ-ₐ₎CO₂): Predictor of Septic Patient Prognosis Depending on the ScvO₂
the investigators will include 120 patients with a diagnosis of septic shock in accordance with the definition given by the 2001 expert consensus.
- Trial name
- NCT03292120
- Testing
- measure of the SOFA score
- Where
- France
- Volunteers
- 124 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
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