Clinical trials: Septic
Sepsis
Clinical Research on Shenfu Injection in Septic Patients
Sepsis, characterized by organ dysfunction caused by infection, exhibits increasing incidence and mortality rates, posing a significant challenge to intensive care units.
- Trial name
- NCT06157320
- Testing
- Shen-Fu, Norepinephrine (NE)，antibiotics，fluid resuscitation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Ruijin Hospital
Septic Shock Point Prevalence, Sepsis
İntensive Care Sepsis Prevelance in Turkey (INSEP-TURK)
Sepsis is a life-threatening condition characterized by a dysregulated host response to infection, leading to tissue damage, multiple organ dysfunction (MODS), disseminated intravascular coagulation (DIC), and high mortality.
- Trial name
- INSEP-TURK (NCT07283588)
- Where
- Turkey (Türkiye)
- Volunteers
- 850 people
- Sponsor
- Gulhane Training and Research Hospital
Shock Hypovolemic, Shock, Septic
Management of Shock in Children With SAM or Severe Underweight and Diarrhea
Diarrhea is one of the leading causes of under-five childhood mortality and accounts for 8% of 5.4 million global under-5 deaths.
- Conditions
- Shock Hypovolemic, Shock, Septic, Blood Transfusion, Adrenaline
- Trial name
- NCT04750070
- Testing
- Blood and Dopamine, Blood and adrenaline
- Where
- Bangladesh
- Volunteers
- 135 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Septic Shock
Vasopressin Versus Norepinephrine for the Management of Septic Shock in Cancer Patients
Although arginine vasopressin has been used as an additional drug in refractory shock in worldwide clinical practice, there are no prospective studies using it as a first choice therapy in patients with cancer and septic shock.
- Trial name
- VANCS II (NCT01718613)
- Testing
- Vasopressin, Norepinephrine
- Where
- Brazil
- Volunteers
- 250 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Septic Shock, Cytokine Storm
CLinical Efficacy of Hemoperfusion With a Cytokine Adsorber in Norepinephrine-Resistant SEptic Shock
Sepsis and septic shock are major causes of ICU admission worldwide. Despite recent advances in treatment, including targeted resuscitation and timely use of antimicrobial agents, mortality of ICU patients with septic shock…
- Trial name
- CLEANSE (NCT05136183)
- Testing
- HA-330 Disposable Hemoperfusion Cartridge (Jafron, China)
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Mahidol University
Sepsis
The Degree, Duration and Frequency of Insulin Resistance in Non-operated Patients With Sepsis
Surgery induces insulin resistance lasting for 2-3 weeks. We wanted to elucidate if stress-metabolic, medical conditions carry the same effect.
- Trial name
- NCT04969159
- Testing
- no intervention
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- Jens Rikardt Andersen
Sepsis
ASpirin for Patients With SEPsis and SeptIc Shock
This Randomized, pragmatic, multicentric with blinding of patients and health professionals, intention-to-treat analysis has by primary endpoint to evaluate whether the aspirin use reduces the intensity of organic dysfunction…
- Trial name
- ASP-SEPSIS (NCT01784159)
- Testing
- Aspirin
- Where
- Brazil
- Volunteers
- 167 people
- Sponsor
- Federal University of São Paulo
Sepsis, Septic Shock
Personalized Fluid Resuscitation in the Emergency Department: A Pilot Trial
The goal of this pilot clinical trial is to learn if a fluid assessment using non-invasive cardiac output monitoring (NICOM) is helpful for patients with sepsis who have low blood pressure in the Emergency Department (ED).
- Trial name
- FLUID-ED (NCT07779720)
- Testing
- Non-Invasive Cardiac Output Monitoring (NICOM)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Intermountain Health Care, Inc.
Sepsis
Early Resuscitation in Paediatric Sepsis Using Inotropes
Septic shock in children still carries substantial mortality and morbidity. While resuscitation with 40-60 mL/kg intravenous fluid boluses remains a cornerstone of initial resuscitation, an increasing body of evidence indicates…
- Trial name
- ANDES-CHILD (NCT06478797)
- Testing
- Fluid, Adrenalin
- Where
- 4 sites in Argentina, Bolivia and 1 more
- Volunteers
- 40 people
- Sponsor
- NATALIA LOPERA MUNERA
Sepsis, Severe Sepsis
Septic Encephalopathy and Late Cognitive Dysfunction
Delirium and long-term cognitive dysfunction are important problems in intensive care patients. Patients with sepsis are at a high risk of developing delirium (septic encephalopathy), which may be an important risk factor for the…
- Trial name
- NCT00772096
- Testing
- n-3 fatty acids
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University Hospital, Basel, Switzerland
Respiratory Distress Syndrome, Acute, Respiratory Insufficiency
Bioelectrical Impedance in Monitoring Hyperhydration and Polyneuromyopathy in Critically Ill Patients
This prospective, blinded observational clinical study was aimed to determine the effect of hyperhydration and muscle loss measured by Bioelectrical impedance vector analysis (BIVA) on mortality.
- Conditions
- Respiratory Distress Syndrome, Acute, Respiratory Insufficiency, Lung Ventilator, Hyperhydration
- Trial name
- NCT05991778
- Testing
- Bioelectrical impedance vector analysis (BIVA), Blood and urine analysis, cumulative water balance
- Where
- Czechia
- Volunteers
- 61 people
- Sponsor
- University Hospital Ostrava
Liver Cirrhosis
Impact of Continuous Renal Replacement Therapy on Systemic Hemodynamics and Lactate Clearance in Critically Ill Cirrhotics With Septic Shock.
Consecutive critically ill cirrhotics with septic shock and AKI who give written informed consent will be included in this prospective study.
- Trial name
- NCT04949178
- Testing
- No intervention
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Sepsis and Septic Shock
HOPE-Sepsis: Hemoadsorption Therapy for Sepsis
This is a single-center, prospective, single-arm, open-label study that will enroll 30 adult patients with sepsis at Zhongshan Hospital, Fudan University.
- Trial name
- NCT07865585
- Testing
- Hemoperfusion with CA330 Cytokine Adsorption Column
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Zhongshan Hospital
SIRS, Sepsis
Measurement of Fibrinogen in Patients With Systemic Inflammatory Response Syndrome (SIRS), Sepsis or Chronicle Liver Disease on Intensive Care Units (ICU)
In this study patients with 1. chronicle liver diseases primary biliary cirrhosis primary sclerosing cholangitis alcoholic liver cirrhosis hepatitis b or C Wilson's disease cryptogenic cirrhosis 2.
- Conditions
- SIRS, Sepsis, Liver Disease
- Trial name
- NCT01169168
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Severe Sepsis, Septic Shock
Skeletal Muscle and Platelet Mitochondrial Dysfunction During Sepsis
The primary aim of the study is to demonstrate that mitochondrial dysfunction occurs in both skeletal muscle and circulating platelets of severely septic and septic shock ICU-admitted patients.
- Trial name
- NCT00541827
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Immunology of Septic Shock
Evaluation of Immunosuppression in Septic Shock: Biomarkers and Pharmacological Restoration (IMMUNOSEPSIS)
Septic syndromes (systemic inflammatory response associated with infection) remain a major although largely under-recognized health care problem and represent the first cause of mortality in intensive care units.
- Trial name
- IMMUNOSEPSIS (NCT02803346)
- Testing
- Circulating blood (leukocytes)
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Hospices Civils de Lyon
Sepsis
Diagnostic and Prognostic Value of Serial Procalcitonin (PCT) Measurements in Critically Ill Patients
In 2005, the Food and Drug Administration (FDA) approved procalcitonin in conjunction with other laboratory markers to aid in the risk assessment of critically ill patients with severe infection (sepsis).
- Trial name
- PCT (NCT01362920)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- The Cleveland Clinic
Sepsis, Bloodstream Infection
Microbiology Operations & Time Optimization in Sepsis
The goal of this study is to simulate turn-around times of blood cultures from blood culture collection to final communication of the result.
- Conditions
- Sepsis, Bloodstream Infection, Bacterial Infections, Septic Shock
- Trial name
- MOTION-Sepsis (NCT07817043)
- Testing
- laboratory infrastructure
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- University Medicine Greifswald
Severe Sepsis, Septic Shock
Monitoring Devices in Prediction of Fluid Responsiveness in Severe Sepsis and Septic Shock
Comparison of noninvasive cardiac output monitor (NICOM, Cheetah Medical) with Edwards FloTrac minimally-invasive cardiac output monitor in predicting fluid responsiveness in sepsis and septic shock.
- Trial name
- NCT02972827
- Testing
- NICOM/FloTrac, Crystalloid Fluid Challenge
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Santa Barbara Cottage Hospital
Septic Shock, Fluid Therapy
Fluid Balance in the ICU - Interventions to Minimize Fluids in Patients With Septic Shock
The purpose of the study is to determine if a protocol that assesses patients' daily fluid intake and output can decrease the overall amount of fluid patients receive during the first five days in the ICU.
- Conditions
- Septic Shock, Fluid Therapy, Hypotension
- Trial name
- NCT02473718
- Testing
- Fluid minimization protocol, Ultrasound
- Volunteers
- 82 people
- Sponsor
- Washington University School of Medicine
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