Clinical trials: Septic
Adult, Intensive Care Unit
Low-Dose Dexmedetomidine for Delirium Prevention in Mechanically Ventilated Septic Patients
Delirium is common in septic patients, especially those receiving mechanical ventilation in the intensive care unit (ICU). Dexmedetomidine is a highly selective α2 adrenoreceptor agonist with anxiolytic, sedative, analgesic, and…
- Conditions
- Adult, Intensive Care Unit, Sepsis, Mechanical Ventilation
- Trial name
- NCT04876937
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Peking University First Hospital
Severe Sepsis, Septic Shock
Outcomes of Severe Sepsis Patients in Surgical Intensive Care Units
Retrospective review of the outcomes of severe sepsis patients in Surgical Intensive Care Unit of National Taiwan University Hospital from January 1, 2009 to December 31, 2011.
- Trial name
- NCT01919138
- Where
- Taiwan
- Volunteers
- 762 people
- Sponsor
- National Taiwan University Hospital
Septic Shock, Sepsis
Effects of Dexmedetomidine on Sublingual Microcirculation and Vascular Waterfall Phenomenon in Patients With Septic Shock
This prospective, multicenter, single-arm, open-label interventional pilot study aims to evaluate the short-term physiological effects of intravenous dexmedetomidine on sublingual microcirculation and vascular-waterfall…
- Conditions
- Septic Shock, Sepsis, Critical Illness
- Trial name
- DEX-MICRO (NCT07657715)
- Testing
- Dexmedetomidine Intravenous Infusion
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Severe Sepsis and Septic Shock
Comparison of Sensitivity Between Presepsine and Lactate for the Diagnosis of Severe Sepsis.
Severe sepsis and sepsis shock are common in emergency department, with a high mortality rate. The potential severity of this disease impose a diagnosis as early as possible to start antibiotic therapy and hemodynamic support.
- Trial name
- PREDI (NCT02300415)
- Testing
- blood sample
- Sponsor
- Centre Hospitalier Universitaire de Nice
Acute on Chronic Liver Failure
Safety and Efficacy of Continuous Infusion of Terlipressin With Norepinephrine Versus Norepinephrine Alone in Improving Outcomes of Acute Kidney Injury in Acute on Chronic Liver Failure With Septic Shock
ACLF is defined differently in APASL,EASL and AASLD.APASL talks of reversibility in ACLF as per its definition and constitution of Homogenous population with ACLF.The definition of ACLF as per APASL is an acute hepatic insult…
- Trial name
- NCT06556472
- Testing
- Terlipressin, Norephrine
- Where
- India
- Volunteers
- 126 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Severe Sepsis, Septic Shock
Efficacy of Melatonin in Patients With Severe Sepsis or Septic Shock
OBJECTIVES. To establish the therapeutic efficiency of melatonin in adult patients with severe sepsis and septic shock. Specifically: 1.
- Trial name
- NCT01858909
- Testing
- Melatonin
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Aragon Institute of Health Sciences
Septic Shock
The Multicentre Prospective Observational Study on the Management of Septic Shock
Although there are published guidelines for the management of shock in general and septic shock in particular, the extent to which these guidelines are adhered to or achievable is unknown.
- Trial name
- OSS (NCT07453901)
- Volunteers
- 5,000 people
- Sponsor
- Bicetre Hospital
Septic Shock
External Cooling in Septic Shock Patients
The rapidity of the resolution of cardiovascular failure has a strong impact on septic shock patients' outcome. The aim of this multicenter randomized controlled trial is to determine whether external cooling might accelerate…
- Trial name
- sepsis-cool (NCT00527007)
- Testing
- External cooling
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Shock, Cytokine Storm
Cytokine Adsorption in Severe, Refractory Septic Shock
Septic shock and the underlying dysregulated inflammatory host-response remain a major contributor to mortality in critically ill patients. Cytokine adsorption represents an attractive approach to the treatment of septic shock.
- Trial name
- NCT04910893
- Testing
- Cytokine Adsorption, Standard of Care
- Volunteers
- 48 people
- Sponsor
- University of Zurich
Sepsis, Emergency
SEPSIS 3 Critera for Risk Stratification in Emergency Patients
Investigators aim to evaluate the SEPSIS 3 criterion for "sepsis" and "septic shock" in a prospective manner. Investigators will evaluate qSOFA performances and other SEPSIS 3 criterion in a population of emergency patients with…
- Trial name
- SCREEN (NCT02738164)
- Where
- 27 sites in Belgium, France and 2 more
- Volunteers
- 879 people
- Sponsor
- Societe Française de Medecine d'urgence
Critical Illness, Septic Shock
Musculoskeletal Ultrasound Study in Critical Care: Longitudinal Evaluation
Each year, 110,000 English/Welsh patients are admitted to Intensive Care Units (ICU). Many face prolonged disability as a result.
- Conditions
- Critical Illness, Septic Shock, Trauma, Organ Failure
- Trial name
- MUSCLE (NCT01106300)
- Where
- 3 sites in United Kingdom
- Volunteers
- 63 people
- Sponsor
- University College, London
HAP - Hospital Acquired Pneumonia, VAP - Ventilator Associated Pneumonia
HAP/VAP Diagnosis in Critically Ill Septic Patients Using a Multiplex PCR Array
Multicenter, randomized, controlled, open-label trial to assess if semiquantitative multiplex PCR assay, as compared to conventional microbiology, can reduce the percentage of patients without microbiological diagnosis in the…
- Trial name
- LIGHTNING (NCT05952648)
- Testing
- Lower tract respiratory samples, Multiplex PCR assay (Film-array Pneumonia Panel Plus), Lower respiratory tract standard culture
- Where
- 4 sites in Italy
- Volunteers
- 126 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Severe Sepsis, Septic Shock
Pharmacogenomic Biomarker Study for Recombinant Human Activated Protein C Treatment in Severe Sepsis
The overall purpose of the study is to determine whether either of the Improved Response Polymorphisms (IRPs) individually predicts a differential DrotAA treatment effect in patients with severe sepsis and high risk of death.
- Trial name
- NCT01486524
- Where
- 8 sites in United States, Canada and 2 more
- Volunteers
- 3,000 people
- Sponsor
- Sirius Genomics Inc.
Sepsis, Septic Shock
Empirical Meropenem Versus Piperacillin/Tazobactam for Adult Patients With Sepsis
The EMPRESS trial aims to test the two most commonly used antibiotics (meropenem and piperacillin/tazobactam) among intensive care patients with sepsis (blood poisoning), as the safety of these two drugs is unclear in this group…
- Trial name
- EMPRESS (NCT06184659)
- Testing
- Meropenem, Piperacillin/Tazobactam
- Where
- 2 sites in Denmark
- Volunteers
- 5,800 people
- Sponsor
- Scandinavian Critical Care Trials Group
DISSEMINATED INTRAVASCULAR COAGULATION ASSOCIATED WITH SEPTIC SHOCK
EVALUATION OF NEUTROPHIL FLUORESCENCE IN PATIENTS WITH DISSEMINATED INTRAVASCULAR COAGULATION ASSOCIATED WITH SEPTIC SHOCK
Neutrophil fluorescence could be a reliable and early diagnostic marker of disseminated intravascular coagulation septic DIC, which can be used routinely.
- Trial name
- HEMATOCLOT (NCT07039487)
- Testing
- Blood sampling collection
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Sepsis Syndrome, Emergency Department
Can we Improve Mortality Prediction in Patients With Sepsis in the Emergency Department
This study aims to identify the prognostic role of procalcitonin (PCT), soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1), the soluble form of the urokinase plasminogen activator receptor (suPAR), highly…
- Conditions
- Sepsis Syndrome, Emergency Department, Biomarker
- Trial name
- NCT06338111
- Testing
- ELISA Sepsis Biomarkers dosage
- Where
- Romania
- Volunteers
- 67 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Sepsis, Septic Shock
Dexmedetomidine and Vasopressin in Septic Shock
Rudiger and Singer suggested strategies for refining adrenergic stress (decatecholaminization). They proposed the use of dexmedetomidine and vasopressin to reduce the catecholamine load during sepsis.
- Trial name
- DecatSepsis-2 (NCT06302998)
- Testing
- DEX-PRESSIN, Standard of Care
- Volunteers
- 260 people
- Sponsor
- Mansoura University
Shock, Septic
Personalized Dose Optimization of Amikacin Guided by Pharmacokinetic Modeling Software in Patients With Septic Shock
Amikacin dose optimization is challenging in critically ill patients. The use of BestDose software algorithm-based drug optimization could help to achieve the recommended target concentrations (60-80 mg/L) after administration of…
- Trial name
- AMINO BESTDOSE (NCT04178148)
- Testing
- Amikacin dose optimization
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Septic Shock and Use of Vasopressin
Effect of Adding Vasopressin on Cardiac Output, Blood Pressure, Diuresis, and Tissue Perfusion Indices in Patients With Septic Shock
In patients with septic shock, vasopressin is increasingly used in combination with norepinephrine, but its timing of initiation remains heterogeneous and its clinical hemodynamic effects are still insufficiently characterized.
- Trial name
- VASO-PHENO (NCT07697144)
- Where
- 8 sites in France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Shock
Effects of Glucocorticoid Combined With Vitamin C and Vitamin B1 on Microcirculation in Severe Septic Shock
This study aimed to investigate the effect of Glucocorticoid combined with vitamin C and vitamin B1 versus hydrocortisone alone on microcirculation in septic shock patients.
- Trial name
- NCT03821714
- Testing
- Glucocorticoid combination therapy, Glucocorticoid
- Where
- China
- Volunteers
- 22 people
- Sponsor
- Southeast University, China
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