Clinical trials: Septic
Musculoskeletal Infection, Acute Hematogenous Osteomyelitis
Next-Generation Sequencing for Pathogen Detection and Quantification in Children With Musculoskeletal Infections
The purpose of this study is to evaluate the use of a blood test: Karius® plasma-based next-generation sequencing test (Karius Test), to see if we can detect and measure the infection causing agent in children with…
- Conditions
- Musculoskeletal Infection, Acute Hematogenous Osteomyelitis, Septic Arthritis, Osteomyelitis
- Trial name
- KDG-002 (NCT03846804)
- Testing
- Karius Test
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Indiana University
Septic Shock
Midodrine Effect on the Mortality Rates in Septic Shock Patients
Assessing the safety and efficacy of the adjunctive use of midodrine as a vasopressor in septic shock patients by measuring the difference in the mortality rates between control and intervention groups.
- Trial name
- NCT05778838
- Testing
- Midodrine Oral Tablet
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Noha Mansour
Sepsis, Severe Sepsis
Control of Fever in Septic Patients
The benefits of fever treatment in critically ill patients remains unclear. The aim of the prospective, randomized clinical trial was to verify the hypothesis that the administration of ibuprofen in order to decrease the fever in…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- COVERSEP (NCT04227652)
- Testing
- Ibuprofen administration
- Where
- Czechia
- Volunteers
- 140 people
- Sponsor
- University Hospital Ostrava
Septic Shock, Multiple Organ Dysfunction Syndrome
Therapeutic Plasma Exchange Adsorption Diafiltration
The purpose of this study is to evaluate the efficacy of coupled therapeutic plasma exchange adsorption diafiltration (PEAF )for treating septic shock with multiple organ dysfunction syndrome patients in ICU.
- Trial name
- PEAF (NCT03589378)
- Testing
- PEAF
- Where
- 12 sites in China
- Volunteers
- 168 people
- Sponsor
- Shenzhen Second People's Hospital
Sepsis, Septic Shock
Serial Vasopressin and Copeptin Levels in Children With Sepsis and Septic Shock
Patients with severe infection can develop very low blood pressure. There are many mechanisms leading to this, and one of them appears to involve a hormone called vasopressin.
- Trial name
- VaCoSS (NCT00698048)
- Where
- Singapore
- Volunteers
- 136 people
- Sponsor
- Jan Hau Lee
Sepsis, Septic Shock
Influence of Cytosorb on Amount of Catecholamine and Mortality in Sepsis
The aim of this retrospective study was to identify if the enrolled patient might have had a profit of Cytosorb therapy. Primarily the decline in catecholamine therapy under Cytosorb therapy will be investigated.
- Conditions
- Sepsis, Septic Shock, Cytokine Storm, Cytokine Release Syndrome
- Trial name
- NCT04567199
- Testing
- Observational, retrospective
- Where
- Austria
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Septic Shock, Calcium Sensing Receptor
Impact of Vascular Calcification and CASR Expression by Monocytes in Septic Shock
In septic shock, bacterial LPS is able to activate the CaSR of cardiomyocytes inducing their apoptosis in vitro. CaSR activation in monocytes is responsible for activation of the NLRP3 inflammasome and macropinocytosis.
- Conditions
- Septic Shock, Calcium Sensing Receptor, Calcium Phosphate Disorders, Inflammation
- Trial name
- CASRCHOC (NCT06853340)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Opioid Use Disorder, Bloodstream Infection
Retention and Re-Engagement in Treatment for Addiction Following Serious Injection Related Infections (RETAIN)
This project is a pilot study of an adapted intervention of an existing Opioid Use Disorder (OUD) treatment retention intervention called Recovery Management Checkups (RMC).
- Conditions
- Opioid Use Disorder, Bloodstream Infection, Osteomyelitis, Endocarditis
- Trial name
- RETAIN (NCT06489535)
- Testing
- RETAIN, Unrelated videos
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston Medical Center
Sepsis, Septic Shock
Safety and Feasibility of Metformin for Sepsis Induced AKI
Acute kidney injury (AKI) is an independent risk factor for death that affects 10-15% of hospitalized patients and more than 50% of patients admitted to the intensive care unit.
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury, Metformin
- Trial name
- NCT05900284
- Testing
- Metformin low dose, Metformin high dose
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Hernando Gomez
Osteomyelitis, Septic Arthritis
Oral-only Antibiotics for Bone and Joint Infections in Children
A nationwide, multicenter, randomized, non-inferiority trial of children with bone and joint infections. The primary objective is to determine if oral-only antibiotics (experimental arm) is non-inferior to initial intravenous…
- Conditions
- Osteomyelitis, Septic Arthritis, Bone Infection, Joint Infection
- Trial name
- CHILD@HOME_BJI (NCT04563325)
- Testing
- Oral co-amoxiclav or oral dicloxacillin only, IV ceftriaxon followed by oral co-amoxiclav or oral dicloxacillin
- Where
- Denmark
- Volunteers
- 180 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Severe Sepsis, Organ Failure
Comparative Study of the Protein C Pathway in Septic and Non Septic Patients With Organ Failure
This is a comparative study performed in 3 groups of patients/subjects: 30 severe sepsis patients, 30 non-septic patients with organ failure, 30 healthy subjects.
- Trial name
- NCT00361725
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Critical Illness
Clinical and Economic Outcome of Simvastatin in Critically Ill Septic Patient
determination of the effectiveness and the cost-effectiveness of simvastatin(Zocor 40 mg) plus standard therapy (SSCG)versus standard therapy alone in critically ill septic patient from the societal perspective over one year.
- Trial name
- NCT02067949
- Testing
- Simvastatin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- sara mostafa amin eladawy
Septic Shock
Assessing the Efficacy of Dapagliflozin as a Vasculoprotective Treatment in Septic Shock Patients With Microcirculatory Dysfunction
Microcirculatory dysfunction is a key driver of organ failure and mortality in septic shock, characterized by endothelial injury and impaired vasoregulation.
- Trial name
- GLIFLOSHOCK (NCT07488689)
- Testing
- Dapaglifozin
- Where
- France
- Volunteers
- 568 people
- Sponsor
- University Hospital, Strasbourg, France
Sepsis, Septic Shock
Renin Levels as Prognostic Indicators of Septic Shock Severity and Outcome
The Surviving Sepsis Campaign (SSC) of 2021 characterizes sepsis as a life-threatening organ dysfunction caused by a dysregulated host response to infection, with a mortality rate of over 30%, which increases to 40% or more in…
- Trial name
- NCT06545838
- Testing
- Analysis of plasma renin concentration
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology
Septic Shock, Sepsis
Stress Doses of Hydrocortisone on Coagulation Dysfunction in Patients With Septic Shock
The purpose of this study is to find out whether stress doses of hydrocortisone attenuate coagulation dysfunction in patients with septic shock.
- Trial name
- NCT02266589
- Testing
- Hydrocortisone
- Volunteers
- 84 people
- Sponsor
- Nanjing PLA General Hospital
Septic Arthritis
The Predictive Role of C-reactive Protein to Albumin Ratio (CAR) in the Treatment of Septic Arthritis in Young Chlidren
Purpose: C-reactive protein to albumin ratio (CAR) has emerged as a novel marker of inflammation. However, almost no research has evaluated the role of CAR in septic arthritis (SA).
- Trial name
- NCT06241365
- Volunteers
- 82 people
- Sponsor
- wangxiaodong
Septic Shock, Vasopressor Resistance
Efficacy of the Alpha 2 Agonist Dexmedetomidine for Sympathetic Deactivation in REfractory Septic Shock
Septic shock is one of the most frequent reasons for admission to intensive care units and remains associated with a high mortality rate of approximatively 40% at 28 days.
- Trial name
- ADRESS (NCT07569536)
- Testing
- Dexmedetomidine 100 µg/mL, intravenous solution, Stardard care
- Where
- 18 sites in France
- Volunteers
- 360 people
- Sponsor
- Hospices Civils de Lyon
Sepsis, Septic Shock
Analysis of Sublingual Glycocalyx Damage at ICU Admission to Predict Risk of Death
The aim of this observative, prospective study is to evaluate if and to what extent glycocalyx damage/microcirculation data at admission in the ICU as well as during ICU stay can be predictive of mortality and clinical course in…
- Conditions
- Sepsis, Septic Shock, Endothelial Dysfunction
- Trial name
- ASGARD (NCT03847493)
- Testing
- Endothelial Glycocalyx
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University Hospital Muenster
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Soft Tissue Infections, Mediastinitis
Delafloxacin Plasma and Tissue Concentration in Patients With Skin, Soft Tissue, and Bone and Joint Infections.
The goal of this observational study is to measure how well the antibiotic delafloxacin penetrates into the blood and various body tissues in adult patients over 18 years old.
- Conditions
- Soft Tissue Infections, Mediastinitis, Osteomyelitis/Septic Arthritis, Prosthetic Joint Infection
- Trial name
- DELA-PLAT (NCT07426471)
- Testing
- delafloxacin
- Volunteers
- 20 people
- Sponsor
- IRCCS San Raffaele
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