Clinical trials: Septic
Neonatal Disease
Analysis of Differential Proteins and Maternal Influencing Factors of Septic Shock in Neonates
1. Explore 32 weeks of premature infants or maternal pregnancy infection of newborn septic shock maternal influence factors. 2. Through maternal blood samples before delivery and labor cord blood sample screening and septic shock…
- Trial name
- NCT06206590
- Testing
- Whole-proteomic assay
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Guangdong Women and Children Hospital
Septic Shock, Sepsis
The Effect of Early Norepinephrine on Stroke Volume Index, Cardiac Index, Lactate, and Arterial Elastance in Pediatric Septic Shock
The complexity of pediatric septic shock arise from its varied pathophysiology, which includes systemic inflammation, cardiovascular collapse, and multiple organ dysfunction.
- Trial name
- NCT06461390
- Testing
- Norepinephrine, Ringer's Lactate
- Where
- Indonesia
- Volunteers
- 42 people
- Sponsor
- Universitas Indonesia
Blood Pressure
Caretaker vs. Blood Pressure Monitoring With Invasive Arterial Pressure Monitoring in Patients With Septic Shock
Caretaker vs. Blood Pressure Monitoring With Invasive Arterial Pressure Monitoring in Patients With Septic Shock
- Trial name
- NCT03933722
- Testing
- Caretaker
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The Cooper Health System
Septic Shock, Sepsis
Terlipressin in Septic Shock: Effects on Microcirculation
The present study was conducted as a prospective, randomized study to investigate the effects of vasopressin receptor agonists terlipressin and vasopressin on systemic hemodynamics and microcirculation in patients with…
- Trial name
- NCT00995839
- Testing
- continuous infusion of terlipressin, Arginine vasopressin, terlipressin bolus administration
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Roma La Sapienza
Septic Shock
Discontinuation Order of Vasopressors in Septic Shock
The purpose of this study is to evaluate the incidence of hypotension based on the discontinuation order of norepinephrine and vasopressin in patients receiving concomitant norepinephrine and vasopressin infusions for the…
- Trial name
- DOVSS (NCT01493102)
- Testing
- Vasopressin, Norepinephrine
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Samsung Medical Center
Severe Sepsis, Septic Shock
Safety, Pharmacokinetics and Pharmacodynamics of BMS-936559 in Severe Sepsis
The purpose of this study is to determine whether BMS-936559 is safe and has the desired pharmacologic activity in patients who have severe sepsis.
- Trial name
- NCT02576457
- Testing
- BMS-936559
- Where
- 13 sites in United States
- Volunteers
- 35 people
- Sponsor
- Bristol-Myers Squibb
Septic Arthritis
The Predictive Role of C-reactive Protein to Albumin Ratio (CAR) in the Treatment of Septic Arthritis in Young Chlidren
Purpose: C-reactive protein to albumin ratio (CAR) has emerged as a novel marker of inflammation. However, almost no research has evaluated the role of CAR in septic arthritis (SA).
- Trial name
- NCT06241365
- Volunteers
- 82 people
- Sponsor
- wangxiaodong
Septic Shock
Protocolised Early De-Resuscitation in Septic Shock (REDUCE)
Background: Recent studies have questioned the safety of current fluid resuscitation strategies in patients with septic shock as prospective and observational data suggesting that the resulting fluid overload is associated with…
- Trial name
- REDUCE (NCT04931485)
- Testing
- Fluid management according to the REDUCE Fluid Protocol, Standard of care
- Where
- 4 sites in Switzerland
- Volunteers
- 170 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Septic Shock
Vitamin C, Steroids, and Thiamine, and Cerebral Autoregulation and Functional Outcome in Septic Shock
This study has been approved as a nested substudy of a multicenter trial (CORVICTES, Clinicaltrials.gov Identifier: NCT03592693).
- Trial name
- CORVICTES-ΥΜ (NCT03649633)
- Testing
- Stress-dose Hydrocortisone plus Vitamin C
- Where
- Greece
- Volunteers
- 26 people
- Sponsor
- University of Athens
Sepsis, Septic Shock
Impact of Early Sepsis Care Guided by the National Early Warning Score 2 in the Emergency Department
The goal of this pilot clinical trial is to determine the feasibility of conducting a fully powered type 1 hybrid effectiveness-implementation trial on early sepsis care that is guided by early warning score in adult emergency…
- Trial name
- NEWS-1-TRIPS (NCT05731349)
- Testing
- 2018 Surviving Sepsis Campaign Hour-1 Bundle
- Where
- 4 sites in Hong Kong
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
Sepsis
Hypoxia Inducible Factor 1 Alpha as a Novel Biomarker in Septic Shock
The purpose of this research study is to determine if a chemical marker in the blood, hypoxia-inducible factor (HIF-1 alpha), can be used to predict subject's hospital outcomes when the subject is diagnosed with sepsis.
- Trial name
- NCT02163473
- Testing
- Septic patients, Healthy Control
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Florida
Pseudoarthrosis of Bone
Septic Pseudarthrosis Of Long Bone : Experience In A Regional Reference Center
Description of septic pseudarthrosis with chirurgical treatment in two steps (first step : Implementation of cement, second step : bone reconstruction, with or without device)
- Trial name
- NCT03620305
- Testing
- Description of treatment of septic pseudarthrosis
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Septic Shock
Metabolic Cluster Analysis in Septic Shock Patients
Observational study including septic shock patients within 24 hours of ICU admission, monitored with a cardiac output estimation system, with ongoing resuscitation.
- Trial name
- ACMEcat (NCT06500156)
- Testing
- Fluid challenge
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Corporacion Parc Tauli
Sepsis, Septic Shock
Renal Arterial Resistive Index Versus Novel Biomarkers for Early Prediction of Sepsis Associated-acute Kidney Injury
Populations at high risk of Sepsis-Associated Acute Kidney Injury (SA-AKI) have been identified. Sources of sepsis, in particular, bloodstream infection, abdominal and genitourinary sepsis, and infective endocarditis, are…
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- RRIBIOSAKI (NCT03799159)
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Islam Elsayed Mohamed Ahmed
Septic Cardiomyopathy
Diagnosis, Treatment, and Outcome Assessment of Septic Cardiomyopathy Using an Integrated Mathematical Model
The goal of this observational study is to evaluate whether a new integrated mathematical model can improve the accuracy of diagnosing septic cardiomyopathy and predicting clinical outcomes in adult patients with suspected septic…
- Trial name
- NCT06793020
- Where
- 2 sites in Lithuania, Poland
- Volunteers
- 100 people
- Sponsor
- Vilnius University
Shock, Septic, Hemodynamic Instability
Impact of an Echographic Algorithm on Hemodynamic Optimization in the First 4 Days of Septic Shock Management
Fluid management is one of the key issues in the initial management of septic shock (SS). Fluid overload and hypovolemia have been associated with increased mortality in several trials.
- Trial name
- STOPFLUID (NCT06043505)
- Testing
- Echographic hemodynamic algorithm guiding fluid resuscitation
- Where
- France
- Volunteers
- 136 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Acute Kidney Injury, Sepsis
Predictive Value of Doppler RSI for Prediction of AKI in Septic Patients in ICU
Acute kidney injury (AKI) Diagnosis is based on rising creatinine. Intrarenal vasoconstriction occurs earlier and measuring flow resistance in the renal circulation (Renal Resistive Index (RRI)) could become part of vital organ…
- Trial name
- NCT04426032
- Testing
- Renal Doppler Ultrasound
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Ain Shams University
Sepsis, Shock, Septic
Medical Education for Sepsis Source Control and Antibiotics
Patients with severe sepsis or septic shock suffer from life-threatening infections. Fast and adequate therapy with antibiotics is crucial for survival.
- Trial name
- MEDUSA (NCT01187134)
- Testing
- Change Management
- Where
- 42 sites in Germany
- Volunteers
- 4,138 people
- Sponsor
- Center for Sepsis Control and Care, Germany
Severe Sepsis, Septic Shock
Activated Protein C and Microcirculation
Objective: to test the hypothesis that recombinant activated protein C (aPC) therapy improves the microcirculation of severe septic patients. Design: Prospective, open study. Setting: University 12-beds intensive care unit.
- Trial name
- NCT01806428
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- Università Politecnica delle Marche
Septic Shock
Assessment of Fluid Responsiveness by Elevation of PEEP in Patients With Septic Shock
The aim of the study is to evaluate whether fluid responsiveness of the critically ill patient can be assessed by analysing the PEEP-induced hemodynamic effects to systolic blood pressure, pulse pressure, aortic blood flow…
- Trial name
- NCT01827007
- Testing
- Volume expansion with gelofusine
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Helsinki University Central Hospital