Clinical trials: Septicemic Shock
Septic Shock
Blessing or Curse? Combined Vitamin Therapy in Non Viral Septic Shock.
Introduction: Septic shock leads to high morbidity and mortality in critically ill patients. Several lower-case scientific studies have supported the synergistic positive effect of vitamin C, thiamine, and hydrocortisone on…
- Trial name
- NCT06152458
- Testing
- Vitamin C
- Where
- Hungary
- Volunteers
- 43 people
- Sponsor
- University of Pecs
Sepsis, Microcirculation
Myocardial Contrast Echocardiography in Septic Patients
Myocardial microcirculatory alterations may be involved in the pathogenesis of acute cardiac dysfunction or septic cardiomyopathy in septic patients.
- Trial name
- NCT04397640
- Testing
- Sonovue
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitair Ziekenhuis Brussel
Septic Shock
Transpulmonary Thermodilution and Transesophageal Echocardiography in Early Septic Shock
The purpose of this study is to assess the concordance of therapeutic changes proposed after an early hemodynamic evaluation (hemodynamic profile) in septic shock patients using jointly the transpulmonary thermodilution technique…
- Trial name
- HEMOSEPSIS (NCT01188993)
- Testing
- early septic shock
- Where
- 2 sites in France
- Volunteers
- 153 people
- Sponsor
- University Hospital, Limoges
Sepsis, Perfusion Index
Observational Study About the Use of Perfusion Index to Use Vasopressor in Sepsis
In this thesis we will use the current state of knowledge that PI can provide a reliable information about the state of peripheral microcirculation during the state of sepsis and septic shock in ICU patients and that can…
- Conditions
- Sepsis, Perfusion Index, Vasopressor
- Trial name
- NCT06860438
- Testing
- Vasoconstrictor Agents
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Sepsis-induced Cardiomyopathy, the Recovery Phase of Septic Shock
Recombinant Human Brain Natriuretic Peptide for the Recovery Stage of Septic Shock
As infection control improves and circulation stabilizes, treatment de-escalation of septic shock begins, accompanied by fluid redistribution from interstitial spaces to the vasculature, increasing cardiac volume load.
- Trial name
- rh-BNP-RSS (NCT06745206)
- Testing
- Lyophilized Recombinant Human Brain Natriuretic Peptide
- Volunteers
- 30 people
- Sponsor
- Sichuan Provincial People's Hospital
Septic Shock
A Prediction Model of 28-day Mortality in Septic Shock
This clinical study adopts the design of cohort research, selects the sepsis shock patients admitted to our hospital ICU as the research object, takes the 28-day mortality rate as the outcome index, collects the baseline data of…
- Trial name
- NCT04915625
- Where
- China
- Volunteers
- 530 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Sepsis
Endotoxin Adsorber Hemoperfusion and Microcirculation
Despite maintaining adequate mean arterial pressure and central venous oxygen saturation, the mortality is still high in severe sepsis and septic shock.
- Trial name
- NCT01756755
- Testing
- PMX-20R Hemoperfusion
- Where
- 3 sites in Taiwan
- Volunteers
- 29 people
- Sponsor
- National Taiwan University Hospital
Septic Shock
The Construction and Application of Therapeutic System of Intelligent Decision-Oriented Hemodynamic Organized Therapy for Shock Patients
Patients with septic shock with norepinephrine >0.25ug/kg/min were enrolled. Informed consent was obtained for inclusion in the study and random assignment into the combination or norepinephrine group.
- Trial name
- NCT05886192
- Testing
- norepinephrine+vasopressin, Norepinephrine
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Sepsis, Septic Shock
Comparing Blood-Based Ratios for Predicting Outcomes in Sepsis and Septic Shock
Sepsis and septic shock are serious conditions associated with a high risk of organ dysfunction and death. Simple laboratory-based markers may help identify critically ill patients who are at greater risk of poor outcomes.
- Trial name
- NCT07819708
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Benha University
Septic Shock
Adjunctive Methylene Blue in Septic Shock
Adjunctive Methylene BLUe in Septic SHock (BLUSH) is a single centre concealed-allocation parallel-group open-label randomized controlled pilot trial to ascertain the feasibility of a trial evaluating the efficacy and safety of…
- Trial name
- BLUSH (NCT06900140)
- Testing
- Methylene Blue, Usual Care
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Dr. Shannon M. Fernando
Sepsis, Severe Sepsis
Unsupervised Machine Learning for Clustering of Septic Patients to Determine Optimal Treatment
The focus of this study will be to conduct a prospective, randomized controlled trial (RCT) at Cape Regional Medical Center (CRMC), Oroville Hospital (OH), and UCSF Medical Center (UCSF) in which a fluid treatment-specific…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT03752489
- Testing
- Treatment-specific InSight, InSight
- Volunteers
- 51,645 people, healthy volunteers welcome
- Sponsor
- Dascena
Septic Shock
Correlation Salivary Cortisol and Free Serum Cortisol to Total Serum Cortisol in MICU Septic Shock
The purpose of the study is: to correlate salivary cortisol to free serum cortisol (as salivary cortisol is considered to be almost complete free cortisol) and, to correlate free serum cortisol to total serum cortisol levels Both…
- Trial name
- NCT00523198
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The University of Texas Health Science Center, Houston
Septic Shock, Hypertension
Effect of Different Strategies for Titrating a High MAP on Microcirculation
Assess the effect of fluids and norepinephrine for mean arterial pressure titration to patients' usual level on the microcirculation of initial resuscitated hypertensive septic shock patients.
- Trial name
- NCT02085291
- Testing
- Norepinephrine, Crystalloid
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Southeast University, China
Severe Sepsis, Septic Shock
A Study to Assess Safety,and Tolerability of 2 Doses of AZD9773 (CytoFab™) in Japanese With Severe Sepsis/Septic Shock
The two co-primary objectives of this study are to assess in Japanese patients with severe sepsis and/or septic shock: 1) the safety and tolerability of two different doses of intravenous AZD9773 and 2) the PK of AZD9773.
- Trial name
- NCT01144624
- Testing
- AZD9773
- Where
- 7 sites in Japan
- Volunteers
- 20 people
- Sponsor
- AstraZeneca
Septic Shock, Severe Sepsis
GM-CSF to Decrease ICU Acquired Infections
The concept of acquired immunodeficiency after a first severe infection in the ICU is widely described in the literature. There is a dual risk: increased mortality and increased secondary infections.
- Trial name
- GRID (NCT02361528)
- Testing
- Sargramostim: Leukine (Genzyme USA)
- Where
- 18 sites in France
- Volunteers
- 166 people
- Sponsor
- Hospices Civils de Lyon
Infection, Sepsis
Proadrenomedullin and Microcirculation in Monitoring Organ Dysfunction in Patient With Infection
This study evaluates the association between plasmatic levels of Mid Regional Proadrenomedullin (MR-proADM) and the sublingual microcirculation in critical care patients admitted with infection, sepsis or septic shock.
- Conditions
- Infection, Sepsis, Septic Shock
- Trial name
- NCT03931967
- Testing
- MR-proADM
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Università Politecnica delle Marche
Frailty, Septic Shock
Evaluation of the Clinical Frailty Scale (CFS) as a Risk Factor of Mortality in Adult Patients ≤65 Years of Age Admitted to Intensive Care for Septic Shock.
The aim of the study is to demonstrate that "frail" patients, defined as having a CFS score greater than or equal to 5, and "severely" frail patients, defined as having a CFS score between [6-7] as defined by Bagshaw et al (14)…
- Trial name
- Woodstock (NCT05928767)
- Where
- 5 sites in France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier de Lens
Septic Shock, Multi Organ Failure
The Role of Blood Purification by Hemoadsorption as Adjunctive Treatment in Children With Septic Shock
Sepsis is a major healthcare problem and leading cause of death in the pediatric population. Despite advances in supportive care of critically ill patients, sepsis remains an important cause of death worldwide in children.
- Trial name
- NCT05401695
- Testing
- HA330 hemoadsorption technique
- Where
- Thailand
- Volunteers
- 10 people
- Sponsor
- Chulalongkorn University
Septic Shock
Comparison of ECMO Use and Conventional Treatment in Adults With Septic Shock
Although few cases reported successful treatment of septic shock using extracorporeal membrane oxygenation (ECMO) in adults, no studies compared ECMO to conventional treatment (without ECMO) as treatment for adults with septic…
- Trial name
- NCT01685112
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Septic Shock, Cardiomyopathy
Effects of Levosimendan, Milrinone and Norepinephrine on Left and Right Ventricular Function in Septic Shock
The aim of this study is to investigate the effects milrinon and levosimandan on n heart function in septic cardiomyopathy and how norepinephrine affects the left and right ventricular function in patients with septick shock…
- Trial name
- SCLM (NCT02640846)
- Testing
- Norepinephrine, Milrinone, Levosimendan
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Sahlgrenska University Hospital
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