Clinical trials: Septicemic Shock
Shock, Septic
COMPACT 2 - COMbining Plasma-filtration and Adsorption Clinical Trial 2
The study objective is to clarify whether the application of high doses CPFA (coupled plasma-filtration adsorption) in addition to the current clinical practice is able to reduce hospital mortality in septic shock patients in…
- Trial name
- COMPACT-2 (NCT01639664)
- Testing
- High doses CPFA
- Where
- 13 sites in Italy
- Volunteers
- 115 people
- Sponsor
- Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva
Septic Shock, Sepsis
Ascorbic Acid and Thiamine Effect in Septic Shock
The aim of this study is to evaluate the efficacy of early metabolic resuscitation with combination therapy using vitamin C and thiamine in improving organ function and survival in patients with septic shock.
- Trial name
- ATESS (NCT03756220)
- Testing
- Combination therapy of vitamin C and thiamine, Normal saline solution
- Where
- 6 sites in South Korea
- Volunteers
- 116 people
- Sponsor
- Tae Gun Shin
Encephalopathy, Organ Dysfunction Syndrome
Prospective Analysis of Septic Associated Encephalopathy Using the Non-invasive Acoustocerebrography-ACG
The patients of the group "sepsis" are measured several times with the non-invasive multi-spectral sonography (Sonovum "ACG-Diagnosesystem") (days 1, 3, 7 and 14).
- Trial name
- SAEACG (NCT03173196)
- Testing
- Non-invasive Multispectral Sonography
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Rostock
Septic Shock
PK/PD of Extended-infusion Meropenem, Piperacillin-tazobactam and Cefepime in the Early Phase of Septic Shock
This study evaluates PK/PD of an extended-infusion protocol of meropenem, piperacillin-tazobactam and cefepime, in the early phase of septic shock.
- Trial name
- PAACS (NCT02820987)
- Testing
- MEROPENEM, PIPERACILLIN-TAZOBACTAM, CEFEPIME
- Where
- France
- Volunteers
- 119 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Critically Ill, Acute Kidney Injury
Effects of AN69 ST Hemofilter on Coagulation During Continuous Renal Replacement Therapy in Critically Ill
Compared with AN69 hemofilter, AN69 ST hemofilter may prolong the time of hemofilter and decrease the quantity of heparin during continuous renal replacement therapy in critically ill.
- Conditions
- Critically Ill, Acute Kidney Injury, Septic Shock
- Trial name
- NCT01823484
- Testing
- AN 69 ST hemofilter, AN 69 hemofilter
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhongda Hospital
Septic Shock
Comparison of ECMO Use and Conventional Treatment in Adults With Septic Shock
Although few cases reported successful treatment of septic shock using extracorporeal membrane oxygenation (ECMO) in adults, no studies compared ECMO to conventional treatment (without ECMO) as treatment for adults with septic…
- Trial name
- NCT01685112
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Septic Shock
Velocity Time Integral vs PICCO for Evaluation of Passive Leg Raising in Septic Shock
The objective of the present study is to investigate accuracy of changes in cardiac output following passive leg raising as estimated by transthoracic ultrasound as method to predict fluid responsiveness and compare that to…
- Trial name
- VIPS (NCT03621449)
- Where
- 2 sites in Sweden
- Sponsor
- Region Skane
Septic Shock, Critically Ill
Resuscitation Strategies in Septic Shock
The purpose of this study, in mechanically ventilated septic shock patients, is to determine whether a fluid loading strategy based on parameters derived from the transpulmonary thermodilution technique may lead to more…
- Trial name
- ReSSeS (NCT02150512)
- Testing
- Transpulmonary Thermodilution, Surviving Sepsis Guidelines (SSG)
- Where
- Netherlands
- Volunteers
- 170 people
- Sponsor
- Medisch Spectrum Twente
Intensive Care Unit Acquired Weakness, Sepsis, Severe
Is NMES Treatment in Sepsis/ Septic Shock Patients Protective in Development of ICU-AW?
Background: Sarcopenia (muscle weakness) characterized by a decrease in muscle mass, strength and performance is a condition that increases with old age.
- Trial name
- NCT04833621
- Testing
- NMES GROUP
- Where
- Turkey (Türkiye)
- Volunteers
- 148 people
- Sponsor
- Ondokuz Mayıs University
Septic Shock, Sepsis
Observed Pharmacokinetic of Piperacillin/Tazobactam Compared to Amikacin in ICU
The pharmacokinetics of antimicrobials is profoundly modified in Intensive care unit (ICU) patients. To adapt the treatment, it is recommended to measure blood levels of antibiotics.
- Conditions
- Septic Shock, Sepsis, Sepsis Syndrome
- Trial name
- OPTIMA (NCT03990467)
- Testing
- Plasma dosage of amikacin, piperacillin and tazobactam
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Sepsis, Severe, Septic Shock
High-dose Intravenous Vitamin C in Patients With Septic Shock
Despite promising observational and phase 1 data, the therapeutic potential of vitamin C for the management of septic shock has not borne out in recent large multi-centre randomized controlled trials.
- Trial name
- HIGH-VIS (NCT04796636)
- Testing
- Sodium Ascorbate
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Melbourne Health
Sepsis
Electroencephalographic Patterns of Septic Patients and Its Correlation With Cognitive Outcomes
The investigators evaluated the electroencephalographic pattern by the Sinek and Young scales during ICU stay and its correlation with cognitive impairment determined by the Montreal Cognitive Assessment (MOCA) in septic patients…
- Trial name
- NCT05448534
- Testing
- Eletroencephalography
- Where
- Brazil
- Volunteers
- 160 people
- Sponsor
- Hospital Sao Domingos
Shock, Septic
Sevoflurane Sedation in Patients With Septic Shock
Recent in vivo studies from others as well as the investigators group demonstrated that volatile anesthetics immunomodulate sepsis and improve outcome.
- Trial name
- SSiS (NCT03643367)
- Testing
- Sevoflurane, Control Group
- Where
- 4 sites in Switzerland
- Volunteers
- 153 people
- Sponsor
- University of Zurich
Septic Shock, Delirium
Septic Shock and Delirium Because of rSO2 Abnormalities in Intensive Care Unit Patients (The SAD BRAIN Study)
Delirium in the ICU is a prevalent problem occurring in up to 80% of ICU patients. A potential cause of delirium in ICU patients could be cerebral hypoxia. Septic shock is associated with high rates of delirium.
- Conditions
- Septic Shock, Delirium, Renal Failure
- Trial name
- NCT01836302
- Testing
- Observation
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University of Manitoba
Sepsis
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Sepsis and Septic Shock
In this prospective clinical study, the investigators compare the outcome and clinical course of consecutive septic participants treated with intravenous vitamin C, hydrocortisone, and thiamine (treatment group) with a control…
- Trial name
- HYVCTTSSS (NCT03258684)
- Testing
- Hydrocortisone, Vitamin C, and Thiamine, Normal saline
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhujiang Hospital
Sepsis
Safety of Heparin in Patients With Septic Shock
Sepsis is a syndrome comprised of a systemic inflammatory response, signs of tissue hypoperfusion, and organ in the setting of presumed infection.
- Trial name
- NCT01234285
- Testing
- heparin
- Where
- United States
- Sponsor
- University of Colorado, Denver
Sepsis, Septic Shock
Vitamin C, Thiamine, Cyanocobalamine, Pyridoxine and Hydrocortisone in Sepsis
Prospective, experimental, longitudinal cohort study in septic patients treated at ER and ICU at General Hospital Zone 11 IMSS Piedras Negras Coahuila.
- Trial name
- NCT04197115
- Testing
- Vitamin C, Hydrocortisone, Complex B
- Where
- Mexico
- Volunteers
- 19 people
- Sponsor
- IMSS Hospital General de Zona 11, Piedras Negras
Sepsis, Septic Shock
Evaluation of Safety and Dosing of a Vitamin C Bundle for Sepsis Treatment in Africa
Open-label phase 2a Randomized Controlled Trial (RCT) assessing the pharmacokinetics of two different doses of intravenous vitamin C given alongside vitamin B1 in adult medical patients with sepsis and hypotension.
- Conditions
- Sepsis, Septic Shock, HIV
- Trial name
- REVISTA-DOSE (NCT04999137)
- Testing
- Vitamin C, Vitamin B1
- Where
- 2 sites in Uganda
- Volunteers
- 60 people
- Sponsor
- Liverpool School of Tropical Medicine
Septic Shock
Natriuresis as a Predictor of the Haemodynamic Response to Steroid Replacement Therapy in Patients in Septic Shock
Septic shock is responsible in 20% of cases of acute adrenal insufficiency and in 50% of cases of chronic 'slow' adrenal insufficiency.
- Trial name
- NARCOSE (NCT03258619)
- Testing
- Aldosterone / renin dosage, Natriuresis
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Septic Shock
Early Haemodynamic Optimization Using Preload Dependence During Septic Shock = EHOSS-1
Haemodynamic optimization is of paramount importance in septic shock, but is really consensual and standardized during the first 6 hours of treatment.
- Trial name
- EHOSS-1 (NCT01972828)
- Testing
- FLUID MANAGEMENT GUIDED WITH PRELOAD-DEPENDENCE PARAMETERS (VOLUVEN ®), STANDARD-GUIDED FLUID MANAGEMENT (VOLUVEN ®)
- Volunteers
- 61 people
- Sponsor
- Hospices Civils de Lyon
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