Clinical trials: Septicemic Shock
Septic Shock, Cerebral Autoregulation
Effects of Targets of Blood Pressure on Cerebral Hemodynamics in Septic Shock
The sudy objective is to evaluate the cerebral haemodynamic status in different ranges of systemic arterial pressure in patients with septic shock by noninvasive tools, transcranial doppler and intracranial compliance by…
- Trial name
- NCT05833607
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- D'Or Institute for Research and Education
Septic Shock
Weaning Approaches for Vasopressin in Sepsis
In this study, we aim to evaluate the incidence of hypotension during vasopressin weaning by comparing two methods - titrated reduction versus abrupt withdrawal - through the conduct of a randomized clinical trial.
- Trial name
- WAVES (NCT07067866)
- Testing
- Titrated weaning of vasopressin., Abrupt weaning of vasopressin.
- Where
- Brazil
- Volunteers
- 82 people
- Sponsor
- Hospital Nossa Senhora da Conceicao
Sepsis, Septic Shock
Mitochondrial Function in Septic Patients
Aim #1 To investigate the prevalence, risk and correlation of the level of sepsis with mitochondrial dysfunction in sepsis patients Aim 1.1 To investigate the prevalence of mitochondria dysfunction among sepsis patients Aim 1.2…
- Trial name
- MtiSS (NCT03748537)
- Testing
- Hydrocortisone
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Chiang Mai University
Septic Shock, Vascular Dysfunction
Shenfu Injection Modulates Carotid Elasticity in Septic Shock
What is this study about? We are studying whether Shenfu Injection (a traditional Chinese herbal medicine) can help improve blood vessel health in patients with septic shock-a severe complication of infections that can damage…
- Conditions
- Septic Shock, Vascular Dysfunction, Arterial Stiffness, Carotid Artery Elasticity Alterations
- Trial name
- NCT06915506
- Testing
- Shenfu Injection
- Where
- China
- Volunteers
- 48 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Sepsis
INFLAmmasomes NLRP3 in Platelets and Leukocytes During SEPSIS in Intensive Care Unit
septic shock is the first cause of mortality in intensive care unit. Innate immunity is the body's first line of defense against pathogens
- Trial name
- INFLA-SEPSIS (NCT04635878)
- Testing
- Blood collection
- Where
- France
- Volunteers
- 11 people
- Sponsor
- University Hospital, Toulouse
Sepsis, Vasoplegia
Occult Vasoplegia in Normotensive Sepsis: Early Prediction With Diastolic Index and Lactate
The goal of this observational study is to learn if the Diastolic Shock Index (DSI) and initial lactate can predict occult vasoplegia in adults with normotensive sepsis.
- Conditions
- Sepsis, Vasoplegia, Septic Shock
- Trial name
- DIAL-SEPSIS (NCT07658014)
- Where
- Mexico
- Volunteers
- 526 people
- Sponsor
- Hospital H+ Queretaro
Shock, Septic, Hemodynamic Instability
Can Shock Indices Be Prognostic Indicators in Sepsis/Septic Shock?
We evaluated the ability of shock indices and hemodynamic parameters to predict 28-day ICU mortality.
- Trial name
- NCT06415006
- Testing
- Measurement of hemodynamic parameters.
- Where
- Turkey (Türkiye)
- Volunteers
- 1,522 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Sepsis, Septic Shock
Treatment of Severe Infection With Antihyperlipidemia Drug
Proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors increase LDL receptors by decreasing its degradation. In sepsis the pathogenic substances, endotoxin, lipoteichoic acid, phospholipomannan are the main cause of the…
- Trial name
- NCT03634293
- Testing
- Alirocumab Injectable Product, Saline Solution
- Where
- Israel
- Volunteers
- 712 people
- Sponsor
- Wolfson Medical Center
Septic Shock
Cerebral Oxygenation in Septic Patients Using Vasopressors - the Conscious Study
The purpose of this study is to reveal if higher doses of vasopressors in septic shock patients correlates with cerebral vasoconstriction and lower cerebral oximetry.
- Trial name
- CONSCIOUS (NCT02237833)
- Where
- Norway
- Volunteers
- 15 people
- Sponsor
- Karl-Andre Wian
Sepsis, Septic Shock
Effects of Electrical Stimulation for Preventing Loss of Muscle Mass in Patients With SIRS, Sepsis and Septic Shock
Background: Electrical stimulation has been used in critical patients as an adjunct strategy of early rehabilitation. In septic or septic shock patients there are reports of only two studies in the literature, with conflicting…
- Conditions
- Sepsis, Septic Shock, SIRS
- Trial name
- NCT03754257
- Testing
- Experimental Electrical Stimulation, Conventional Physiotherapy
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- Hospital Sirio-Libanes
Sepsis
Pharmacokinetic/Pharmacodynamic Evaluation Amikacin in Critically Ill Patients Admitted at the Emergency Department
The aim of the study is the evaluation of PK/PD target attainment of amikacin in ED patients with severe sepsis and septic shock.
- Trial name
- NCT02365272
- Testing
- Amikacin
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Severe Sepsis, Septic Shock
GCIV as an Adjuvant Therapy for Community-Acquired Severe Sepsis or Septic Shock
This study is to determine whether the intravenous application of 'Ⅳ-Globulin S inj. (Human Immunoglobulin G)' can reduce mortality in patients with severe sepsis or septic shock.
- Trial name
- NCT01315496
- Testing
- Immunoglobulin G
- Where
- 17 sites in South Korea
- Volunteers
- 214 people
- Sponsor
- Green Cross Corporation
Sepsis, Septic Shock
Clinical Outcome Study of High-dose Meropenem in Sepsis and Septic Shock Patients
Sepsis and septic shock patients are considered to have a high risk of complications and death. Appropriate antimicrobial therapy plays an important role in determining outcomes in septic patients.
- Conditions
- Sepsis, Septic Shock, Critical Illness, Carbapenem
- Trial name
- NCT03344627
- Testing
- Meropenem standard dose, Meropenem high dose
- Where
- Thailand
- Volunteers
- 76 people
- Sponsor
- Mahidol University
Systemic Inflammatory Response Syndrome, Kidney Failure, Acute
High Cut-Off Continuous Veno-venous Hemodialysis (CVVHD) in Patients Treated for Acute Renal Failure After Systemic Inflammatory Response Syndrome (SIRS)/Septic Shock
This study will assess the influence of the High Cut-Off (HCO) CVVHD treatment on the disease progression in septic patients. The primary aim of the study is to evaluate whether HCO CVVHD leads to a significant improvement of the…
- Trial name
- HICOSS (NCT00875888)
- Testing
- continuous venovenous hemodialysis
- Where
- 4 sites in Austria, Germany
- Volunteers
- 80 people
- Sponsor
- Vantive Health LLC
Septic Shock, Sepsis Bacterial
Quantification of Bacterial DNA in Sepsis
The purpose of this study is to evaluate whether bacterial DNA clearance measured with droplet digital Polymerase Chain Reaction (ddPCR) can be used as a measure of bacterial load in septic intensive care patients.
- Conditions
- Septic Shock, Sepsis Bacterial, Sepsis
- Trial name
- NCT03782454
- Testing
- Blood sampling
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Region Örebro County
Severe Sepsis, Septic Shock
Use of Inflammatory Biomarkers to Guide Antibiotic Therapy in Patients With Severe Infections
In this study the investigators aim to test if C-reactive protein (CRP)or procalcitonin(PCT) - guided strategy allows to reduce the antibiotic use in patients wiht severe sepsis and septic shock.
- Trial name
- NCT00934011
- Testing
- C-reactive protein guided antibiotic therapy, Procalcitonin guided antibiotic therapy
- Where
- Brazil
- Volunteers
- 94 people
- Sponsor
- Federal University of Minas Gerais
Septic Shock
Activated Protein C and Corticosteroids for Human Septic Shock
This study aims at comparing the efficacy and safety of recombinant human activated protein C to that of low dose of corticosteroids and at investigating the interaction between these drugs in the management of septic shock
- Trial name
- APROCCHS (NCT00625209)
- Testing
- recombinant human activated protein C and hydrocortisone and fludrocortisone
- Where
- 4 sites in France
- Volunteers
- 1,241 people
- Sponsor
- University of Versailles
Sepsis, Critical Illness
PF-Organized Corticosteroid-Associated Heterogeneity in Sepsis
This retrospective multicohort observational study evaluates whether the PaO2/FiO2 ratio (P/F ratio) organizes heterogeneity in the association between early systemic corticosteroid exposure and mortality among critically ill…
- Trial name
- NCT07913464
- Testing
- Systemic Corticosteroids
- Where
- China
- Volunteers
- 2,693 people
- Sponsor
- Shanghai Zhongshan Hospital
Severe Sepsis or Septic Shock in Pediatric Intensive Care Unit
Predictive Mini-bolus Fluid Responsiveness in Pediatric Septic Shock
Severe sepsis and septic shock remain of particular gravity in children with a current mortality of about 20 % , despite the international prevention campaigns " survival sepsis campaign ".
- Trial name
- PRECISE (NCT04027699)
- Testing
- Mini-bolus
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Shock
Pilot Study for the SQUEEZE Trial
The purpose of the SQUEEZE Trial is to determine which fluid resuscitation strategy results in the best outcomes for children treated for suspected or confirmed septic shock.
- Trial name
- SQUEEZE (NCT01973907)
- Testing
- Fluid Sparing Resuscitation Strategy
- Where
- Canada
- Volunteers
- 53 people
- Sponsor
- McMaster Children's Hospital
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