Clinical trials: Septicemic Shock
Septic Shock, Acute Kidney Injury
The Effect of Vasopressor Therapy on Renal Perfusion in Septic Shock
Acute kidney injury (AKI) is a common complication of septic shock and together these conditions carry a high mortality risk. In septic patients who develop severe AKI renal cortical perfusion is deficient despite normal…
- Trial name
- REPERFUSE (NCT06234592)
- Testing
- Angiotensin II, Vasopressin, Norepinephrine
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- King's College Hospital NHS Trust
Bloodstream Infection
Comparison of Bloodstream Infections With Carbapenem Hetero-resistant vs Carbapenem Resistant Klebsiella Pneumoniae
COMBAT trial was contemplated to elucidate unknown clinical relevance of carbapenem heteroresistance among Klebsiella pneumoniae species.
- Trial name
- COMBAT (NCT04229498)
- Testing
- Monotherapy and combination therapy (all antibiotics that are given by attending pysicians and can be active against Klebsiella pneumoniae will be evaluated)
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- SCARE (Study group for carbapenem resistance)
Septic Shock
Selepressin Evaluation Programme for Sepsis-Induced Shock - Adaptive Clinical Trial
This is a double-blind, randomised, placebo-controlled, two-part adaptive clinical trial. The trial is designed to investigate the efficacy and safety of multiple dosing regimens of selepressin and to confirm the efficacy and…
- Trial name
- SEPSIS-ACT (NCT02508649)
- Testing
- selepressin
- Where
- 21 sites in United States, Belgium and 3 more
- Volunteers
- 868 people
- Sponsor
- Ferring Pharmaceuticals
Sepsis, Septic Shock
Nucleosome Monitoring Relevance for Outcome Prediction in Critically Ill Patients
NUROPI is a single-centre, prospective, non-interventional study in the Intensive Care Unit (ICU) of Erasme Hospital (Hôpital Universitaire de Bruxelles, Brussels, Belgium).
- Conditions
- Sepsis, Septic Shock, Cardiac Arrest (CA), Pancreatitis
- Trial name
- NuROPI (NCT07184593)
- Testing
- Plasma H3.1 nucleosome measurement
- Volunteers
- 1,000 people
- Sponsor
- Erasme University Hospital
Healthy Volunteer Safety Study
AB103 Peptide Antagonist in Healthy Volunteers
The primary objective of this study is to establish the safety profile and maximum tolerated dose (MTD) of AB103 given as a single intravenous (IV) infusion in healthy volunteers.
- Trial name
- NCT01166984
- Testing
- AB103
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Atox Bio Ltd
Sepsis, Septic Shock
Assessment of Heparin Binding Protein for the Prediction of Severe Sepsis
The purpose of this prospective, non-interventional, multi-centre clinical study is to assess the clinical validity of the Heparin Binding Protein (HBP) assay for indicating the presence, or outcome, of severe sepsis (including…
- Conditions
- Sepsis, Septic Shock, Sepsis With Acute Organ Dysfunction
- Trial name
- NCT03113721
- Where
- 5 sites in United States
- Volunteers
- 571 people
- Sponsor
- Axis Shield Diagnostics Ltd
Acute Kidney Injury, Septic Shock
RRT With a Cytokine Absorption Filter (oXiris ®) in Patients With Septic Shock
Acute kidney injury (AKI) is a common complication in critically ill patients. Multiple studies have reported evidence that the main cause of ARF is sepsis, as part of the Multiple Organ Dysfunction Syndrome: up to 50% of septic…
- Trial name
- NCT04952714
- Testing
- Oxiris
- Where
- Colombia
- Volunteers
- 93 people
- Sponsor
- Clinica CES
Shock, Septic
Effects of Hydrocortison Treatment on Angiotensin II and Angiotensin II Receptors in Patients With Septic Shock
This study aims to evaluate the role of angiotensin II, AT1, and AT2 on catecholomine responsive and catecholomine resistant septic shock, and the effect of hydrocortisone traetment on catecholomine resistant septic shock and…
- Trial name
- NCT04647552
- Testing
- Drug Steroid
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Inonu University
Sepsis, Severe Sepsis
Control of Fever in Septic Patients
The benefits of fever treatment in critically ill patients remains unclear. The aim of the prospective, randomized clinical trial was to verify the hypothesis that the administration of ibuprofen in order to decrease the fever in…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- COVERSEP (NCT04227652)
- Testing
- Ibuprofen administration
- Where
- Czechia
- Volunteers
- 140 people
- Sponsor
- University Hospital Ostrava
Shock
GapCO2 and Respiratory Rate in Patients Under Volume Mechanical Ventilation
As an approximate of the difference between venous-to-arterial CO2 tension (∆PCO2), ∆PCO2 is proportional to CO2 production and inversely related to cardiac output (Fick equation).
- Trial name
- gapCO2 (NCT02867943)
- Testing
- Effects of respiratory rate on gapCO2
- Volunteers
- 28 people
- Sponsor
- 105 Hospital of Chinese People's Liberation Army
Sodium Disorder
Sodium Status in Septic Patients and Its Relation to Prognosis an Hospital Stay
The aim of the present study is to identify the prevalence and prognostic impact of sodium imbalance on sepsis and septic shock patients
- Trial name
- NCT04564508
- Volunteers
- 50 people
- Sponsor
- Assiut University
Sepsis
Evaluation of Hemodynamic Effects of Cascade Hemofiltration in Septic Shock
Septic shock is a major cause of mortality and morbidity in critically ill patients. Septic Shock is associated with an overwhelming, systemic overflow of pro inflammatory and anti-inflammatory mediators, which leads to…
- Trial name
- Cascade (NCT00922870)
- Testing
- Cascade, Standard treatment
- Where
- 5 sites in France
- Volunteers
- 60 people
- Sponsor
- Vantive Health LLC
Septic Shock, Mechanical Ventilation Complication
Adjunctive Esketamine for Analgesia in Mechanically Ventilated Septic Shock Patients
Sedation and analgesia in patients with sepsis and hemodynamic instability may be challenging in the ICU. Opioids and propofol can further exacerbate tissue infusion in septic shock by reducing cardiac contractility, increasing…
- Trial name
- NCT05839366
- Testing
- Esketamine, Saline, Remifentanil + propofol
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Sepsis and Septic Shock, Acute Respiratory Failure
Eduction in ImmunoSuppressive Regimen Among Kidney Transplant Recipients Patients Admitted to the Intensive Care Unit for Septic Shock and/or Acute Respiratory Failure
Kidney transplantation is the treatment of choice for end-stage chronic kidney disease. Kidney transplantation is at the first rank of solid organ transplantation in France, with 3,376 grafts performed in 2022.
- Conditions
- Sepsis and Septic Shock, Acute Respiratory Failure, Kidney Transplant Recipients, Immunosuppressive Agents
- Trial name
- REDIS (NCT06881927)
- Testing
- Hydrocortisone Hemisuccinate: 200 mg per day., reduction of the level of immunosuppression
- Where
- France
- Volunteers
- 212 people
- Sponsor
- University Hospital, Strasbourg, France
Sepsis, Septic Shock
Ulinastatin Treatment in Adult Patients With Sepsis and Septic Shock in China
A Prospective, Multi-Centre, Double-Blind, Randomized, Placebo-Controlled, Trial of Ulinastatin Treatment in Adult Patients with Sepsis and Septic Shock in China
- Trial name
- NCT02647554
- Testing
- ulinastatin
- Where
- China
- Volunteers
- 347 people
- Sponsor
- Peking Union Medical College Hospital
Shock, Septic
Protocolized Reduction of Non-resuscitation Fluids vs Usual Care in Septic Shock Feasibility Trial
The objectives of this feasibility trial are to assess the efficacy and feasibility of methods and procedures of a protocol purposed to compare a reduction of administration of non-resuscitation fluids to usual care in patients…
- Trial name
- NCT05249088
- Testing
- Protocolised reduction of non-resuscitation fluids, Usual care
- Where
- 8 sites in Sweden
- Volunteers
- 98 people
- Sponsor
- Region Skane
Septic Shock
Study of the Role of Interferon αon the Endothelial Dysfunction During Septic Shock
Septic shock is the most severe form of a bacterial infection, affecting 24 million patients per year worldwide, with a high mortality (> 30%).
- Trial name
- INTERSEP (NCT04204694)
- Testing
- 3-time blood sampling for septic shock patients, Only one blood sampling for controls patients
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Critical Illness, Fluid Over-load
Effect of Dynamic Arterial Elastance and Assisted Fluid Management Software Guided Resuscitation in Septic Shock: Pilot Study
To investigate the benefit of using the AFM and Eadyn-guided fluid and vasopressor therapy in septic shock resuscitation for mechanically ventilated patients compared with the standard of care.
- Conditions
- Critical Illness, Fluid Over-load, Dynamic Arterial Elastance, Septic Shock
- Trial name
- DAFM shock (NCT06937918)
- Testing
- The AFM and Eadyn - guided resuscitation group, The standard care for septic shock
- Where
- 3 sites in Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Septic Shock, Hypoperfusion
Early Methylene Blue in the Microhemodynamics of Septic Patients
The aim of the study is to evaluate the viability and feasibility of its protocol in order to conduct a larger clinical trial to assess whether methylene blue can improve patient-centered clinical outcomes such as mortality or…
- Trial name
- NCT07264543
- Testing
- Methylene blue infusion
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva
Heart Failure, Myocarditis
CharacterisatiON of carDiac funCTion in Intensive Care Unit Survivors of Sepsis.
Cardiac dysfunction is common following hospital admission with sepsis and one of the most frequent causes for readmissions to hospital, however underlying mechanisms by which this might occur are unclear.
- Conditions
- Heart Failure, Myocarditis, Sepsis, Septic Shock
- Trial name
- CONDUCT-ICU (NCT05633290)
- Testing
- CMR, hs-troponin, NT-pro BNP
- Where
- 2 sites in United Kingdom
- Volunteers
- 69 people
- Sponsor
- NHS Greater Glasgow and Clyde
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