Clinical trials: Septicemic Shock
Septic Shock
Pilot Study of Bevacizumab (Avastin) in Patients With Septic Shock
The purpose of this study is to perform a pilot study to assess the potential use of Bevacizumab (a vascular endothelial growth factor (VEGF) inhibitor) in sepsis.
- Trial name
- NCT01063010
- Testing
- Bevacizumab
- Where
- 3 sites in United States
- Sponsor
- Beth Israel Deaconess Medical Center
Septic Shock
Innate Lymphoid Cells in Septic Shock
Less than ten years after their intial description, the comprehension of Innate Lymphoid Cells (ILCs) biology is rapidly improving.
- Trial name
- CriSIs (NCT03297203)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Septic Shock
Effect of Norepinephrine Administration on Ventricular Systolic Function in Septic Shock
This observational, pharmacological, prospective study aims to assess the improvement of ventricular systolic function mediated by norepinephrine (NE) administration in preload non-responders septic shock patients.
- Trial name
- NCT05355961
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sepsis, Shock, Septic
Comparison of Peripheral Perfusion Indicators and Lactate Levels
In patients with septic shock undergoing intensive care unit monitoring, routine assessment of arterial and/or venous blood gas is conducted.
- Conditions
- Sepsis, Shock, Septic, Hypotensive, Lactate
- Trial name
- NCT06727318
- Where
- Turkey (Türkiye)
- Volunteers
- 192 people
- Sponsor
- Gulhane Training and Research Hospital
Septic Shock, Acute Renal Failure (as Defined by the "Failure" Stage of the RIFLE Classification)
I.D.E.A.L.-I.C.U. (Initiation of Dialysis EArly Versus deLayed in Intensive Care Unit)
The purpose of this multicentric, randomized controlled trial is to assess whether the timing of renal replacement therapy initiation (early vs delayed) has an impact on mortality at 90 days in patients with severe acute kidney…
- Trial name
- IDEAL-ICU (NCT01682590)
- Testing
- Renal Remplacement Therapy
- Where
- 27 sites in France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Septic Shock
Hemodynamic Resuscitation and Monitoring in Early Sepsis
"Hemodynamic Resuscitation and Monitoring in Early Sepsis (HERMES Study)" involves recording of patient's medical data related to that has been collected as part of his/her routine medical care in ICU.
- Trial name
- HERMES (NCT04143035)
- Testing
- No Intervention
- Where
- 246 sites in India
- Volunteers
- 500 people
- Sponsor
- Tata Memorial Centre
Septic Shock, Vasopressor Resistance, Multiple Organ Dysfunction
Biological Effects of Hemoadsorption in Septic Shock
Septic shock is the most severe form of sepsis and continues to carry an in-hospital mortality of between 30% and 50% despite advances in compliance with the Surviving Sepsis Campaign care bundles.
- Conditions
- Septic Shock, Vasopressor Resistance, Multiple Organ Dysfunction, Sepsis, Hemoperfusion
- Trial name
- Bio-HA380 (NCT07715110)
- Testing
- Hemoadsorption cartridge
- Where
- 2 sites in Spain
- Volunteers
- 16 people
- Sponsor
- Miguel Sanchez Garcia
Sepsis
POC SPLA2-IIA as a Biomarker for Sepsis and Septic Shock
Septic shock is a major cause of morbidity and mortality. SIRS (systemic inflammatory response syndrome) can progress over hours to days to severe sepsis and septic shock.
- Trial name
- NCT03953404
- Testing
- SPLA2-IIA
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- St. Luke's Hospital, Pennsylvania
Acute Kidney Injury, Septic Shock
Does Urinary TIMP2 and IGFBP7 Can Identify High Risk Patients of Progression From Mild and Moderate to Severe Acute Kidney Injury During Septic Shock?
Septic shock is one of the leading causes of death in patients admitted to the intensive care unit (ICU). Acute kidney injury (AKI) occurs in almost 50% of septic patients and is associated with significant mortality.
- Trial name
- HEMOCHECK (NCT03547414)
- Testing
- Nephrocheck test
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Sepsis, Septic Shock
Sepsis in ICU:Causes and Outcomes of Sepsis in Diabetics Versus Non Diabetics in Assiut University Hospital
Clarify different causes of sepsis in patients admitted to ICU . as well asCompare causes and outcomes of sepsis between diabetics versus non diabetics .
- Trial name
- NCT04015752
- Testing
- culture from infected site
- Volunteers
- 100 people
- Sponsor
- Assiut University
Septic Shock, Disseminated Intravascular Coagulation
Disseminated Intravascular Coagulation (DIC) Score and Organ Dysfunction in Septic Shock Patients
Septic shock is common complication in patients with critical illnesses, with higher incidence in low and medium income countries like ours.
- Trial name
- NCT06363149
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Severe Sepsis, Septic Shock
The Effect of Ketanserin on the Microcirculation in Sepsis
This study is an evaluation of the effect of ketanserine on sublingual microcirculation in intensive care patients with severe sepsis.
- Trial name
- NCT01329887
- Testing
- ketanserin
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Frisius Medisch Centrum
Fluid Responsivness, Right Ventricle
Evaluation of the Association Between Right Atrial Reservoir Strain Variation and Fluid Responsiveness in Patients With Septic Shock
Evaluating preload dependence is crucial for managing fluid administration in septic shock patients. To avoid unnecessary fluid administration, it's recommended to use dynamic tests like the passive leg raising (PLR) maneuver or…
- Trial name
- RAS-FR (NCT06492044)
- Testing
- Transthoracic echocardiography (TTE)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Septic Shock
Mortality Reduction in Septic Shock by Plasma Adsorption
The study objective is to clarify whether the application of high doses CPFA (Coupled Plasma-Filtration Adsorption) in addition to the current clinical practice is able to reduce hospital mortality in septic shock patients in…
- Trial name
- ROMPA (NCT02357433)
- Testing
- High Doses CPFA
- Where
- 10 sites in Spain
- Volunteers
- 55 people
- Sponsor
- Francisco Colomina Climent
Septic Shock, Arterial Pressure
Assessment of Two Levels of Arterial Pressure on Survival in Patients With Septic Shock
The ideal mean arterial pressure in patients with septic shock is unknown. The expert's recommandations have stated a target between 65 and 70 mm Hg. However the scientific basis are weak.
- Conditions
- Septic Shock, Arterial Pressure, Hemodynamics, Mortality
- Trial name
- SEPSISPAM (NCT01149278)
- Testing
- maintain mean arterial pressure between 80-85 mm Hg, maintain mean arterial pressure between 65-70 mm Hg
- Where
- France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Angers
Sepsis, Infection
Biomarkers in Infection
The purpose of this investigation is to evaluate how early biomarkers of infection and inflammation perform in identifying patients at risk for poor outcome in sepsis and septic shock.
- Conditions
- Sepsis, Infection, Inflammation
- Trial name
- NCT02545478
- Where
- 2 sites in United States
- Volunteers
- 4,200 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Acute Respiratory Distress Syndrome
Immune Alveolar Alterations During Pneumonia-Associated Acute Respiratory Distress Syndrome
Sepsis is a dysregulated host response to severe life-threatening infections, leading to organ failure and death in up to 40% of patients with septic shock.
- Trial name
- PICARD2 (NCT03971006)
- Volunteers
- 110 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Shock
Mechanistic Assessment of Norepinephrine Therapy vs. Angiotensin-II in Septic Shock
Despite best therapy efforts, sepsis and septic shock are associated with mortality rates of up to 40%. This clinical trial will determine the benefit of exogenous Angiotensin II versus norepinephrine (conventional care)…
- Trial name
- MANTRA (NCT06746753)
- Testing
- Angiotensin II, Norepinephrine
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- Wake Forest University Health Sciences
Septic Shock, Sepsis
A Phase III, Open Label, Randomized, Controlled Study of VBI-S in the Treatment of Hypovolemia in Patients With Septic Shock (VBI-S-02)
This study is being conducted to evaluate the safety and effectiveness of VBI-S in elevating the blood pressure of septic shock patients with absolute or relative hypovolemia.
- Conditions
- Septic Shock, Sepsis, Hypovolemia
- Trial name
- VBI-S-02 (NCT06072430)
- Testing
- VBI-S
- Where
- 5 sites in United States
- Volunteers
- 39 people
- Sponsor
- Vivacelle Bio
Septic Shock
Thiamine, Vitamin C and Hydrocortisone in the Treatment of Septic Shock
The purpose of this research study is to determine whether patients who receive thiamine (vitamin B1), vitamin C and hydrocortisone while in septic shock have improved outcomes compared to hydrocortisone alone.
- Trial name
- NCT03540628
- Testing
- Thiamine and Vitamin C
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Corewell Health South
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