Clinical trials: Septicemic Shock
Septic Shock
Systematic Adjunction of Vasopressine in Septic Shock
Septic shock is a syndrome associated with severe infection and a mortality rate of approximately 45%. In line with current recommendations, norepinephrine is the first-line vasopressor used in patients with septic shock.
- Trial name
- SAVSepticShock (NCT07052084)
- Testing
- Vasopressin administration, Sodium chloride administration
- Where
- 3 sites in France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Septic Shock
Treatment of Septic Shock by Inhibiting Autodigestion and Preserving Gut Integrity With Enteric LB1148
Septic shock is a potentially life-threatening condition that can result in multi-organ dysfunction syndrome (MODS) and mortality.
- Trial name
- SSAIL (NCT02317549)
- Testing
- LB1148
- Where
- 34 sites in United States, Canada
- Volunteers
- 8 people
- Sponsor
- Leading BioSciences, Inc
Shock, Septic
Personalized Dose Optimization of Amikacin Guided by Pharmacokinetic Modeling Software in Patients With Septic Shock
Amikacin dose optimization is challenging in critically ill patients. The use of BestDose software algorithm-based drug optimization could help to achieve the recommended target concentrations (60-80 mg/L) after administration of…
- Trial name
- AMINO BESTDOSE (NCT04178148)
- Testing
- Amikacin dose optimization
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Sepsis, Septic Shock
Molecular Diagnosis and Risk Stratification of Sepsis in India
Background: Globally, sepsis is common with an estimated population incidence of 437 cases per 100, 000 person-years and acute mortality of 26%, one of the few major medical conditions whose incidence and resulting mortality…
- Conditions
- Sepsis, Septic Shock, Sepsis Syndrome
- Trial name
- MARS-India (NCT03727243)
- Where
- India
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Sepsis, Septic Shock
ICITRU : Randomized Trial of Immunonutrition With L-citrulline in Patients Hospitalized in Intensive Care for Sepsis or Septic Shock
Immunonutrition in intensive care has not yet demonstrated a beneficial effect on organ failure, the acquisition of nosocomial infections, or mortality.
- Trial name
- ICITRU (NCT04513288)
- Testing
- Experimental treatment L-citrulline (Protéocit®)
- Where
- 5 sites in France
- Volunteers
- 130 people
- Sponsor
- Rennes University Hospital
Sepsis, Septic Shock
Effectiveness of Non-invasive Vagus Nerve Stimulation as an Adjuvant Treatment in Patients With Sepsis in Intensive Care.
Sepsis is one of the leading causes of death in intensive care. About 50% of patients with septic shock die after 1 year; and 50% of survivors suffer from cognitive decline.
- Trial name
- SNV-Sepsis (NCT04774705)
- Testing
- SNV activ group (Non-invasive transcutaneous stimulation of the vagus nerve )
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Shock, Fluid Reponsiveness
This Study Compares Two Noninvasive Dynamic Tools: Lung Ultrasound and Transthoracic Echocardiography Using LVOT VTI. It Aims to Measure the Sensitivity and Specificity of LUS in Guiding Fluid Resuscitation and Early Detection of Fluid Responsiveness and to Prevent Volume Overload
Reliability of the LVOT-VTI versus lung ultrasonography for early detection of fluid intolerance during fluid resuscitation of septic patients.
- Trial name
- lvotvti (NCT07797751)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Septic Shock
Ivabradine for Heart Rate Control In Septic Shock
Septic shock is a major health problem, with several million cases annually worldwide and a mortality approaching 45%. Tachycardia is associated with excess mortality during septic shock.
- Trial name
- IRISS (NCT04031573)
- Testing
- Ivabradine
- Where
- France
- Volunteers
- 429 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Shock
Therapeutic Plasmaexchange in Early Septic Shock
Sepsis is defined by the occurrence of critical organ dysfunction in the context of infection. Unfortunately, its incidence appears to be rising, and the mortality of septic shock remains extraordinary high (> 60%).
- Trial name
- EXCHANGE (NCT04231994)
- Testing
- TPE
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Hannover Medical School
Septic Shock
Evaluation of Sepsis-induced Immunosuppression Base on QuantiFERON Monitor® in Septic Shock
QuantiFERON Monitor® is an immunological test evaluating the nonspecific cellular response by measuring interferon gamma (IFNγ) secretions after T-cell and natural killer lymphocyte stimulation.
- Trial name
- MONITOR SEPSIS (NCT04320394)
- Testing
- QuantiFERON Monitor®
- Sponsor
- Centre Hospitalier Universitaire de Nice
Septic Shock
Effect of Metformin Use on Mortality in Diabetic and Non Diabetic Patients With Sepsis and Septic Shock.
We aimed to determine if metformin use in both diabetic and non diabetic patients with sepsis and septic shock affects 28 day mortality and its effect on inflammatory markers.
- Trial name
- NCT05572060
- Testing
- Metformin, standardized protocol
- Volunteers
- 75 people
- Sponsor
- Assiut University
Shock, Septic
Effect of Albumin Administration on Vasopressor Duration in Resolving Septic Shock
The role of albumin in sepsis has been controversial for decades. Although hypoalbuminemia has been associated with worse outcomes in sepsis, definitive evidence does not exist that replacing albumin in these patients improves…
- Trial name
- NCT02716597
- Testing
- 25% Albumin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Alexander Flannery, 859-323-4011
Sepsis, Septic Shock
Personalized Fluid Resuscitation in the Emergency Department: A Pilot Trial
The goal of this pilot clinical trial is to learn if a fluid assessment using non-invasive cardiac output monitoring (NICOM) is helpful for patients with sepsis who have low blood pressure in the Emergency Department (ED).
- Trial name
- FLUID-ED (NCT07779720)
- Testing
- Non-Invasive Cardiac Output Monitoring (NICOM)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Intermountain Health Care, Inc.
Septic Shock
Clinical Trial Comparing Noradrenaline (NA) Plus Placebo Versus Noradrenaline Plus Terlipressin (TP) in Septic Shock
Septic shock is a major health problem. In the clinical practice guidelines of the Surviving Sepsis Campaign is recommended to add vasopressin (VP) or epinephrine in case of not reaching the goal of mean arterial pressure (MAP)…
- Trial name
- NCT05207280
- Testing
- Noradrenaline plus Terlipressin
- Where
- 10 sites in Spain
- Volunteers
- 152 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Septic Shock
Ketamine Versus Fentanyl for Induction of Anesthesia in Septic Shock
The aim of this work is to compare two protocols (ketamine-midazolam versus fentanyl-midazolam) for induction of anesthesia in patients with septic shock aiming to find the most safe protocol with regards to hemodynamic status of…
- Trial name
- NCT03251170
- Testing
- Ketamine, Fentanyl, Midazolam
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Cairo University
Sepsis
Diagnostic and Prognostic Value of Serial Procalcitonin (PCT) Measurements in Critically Ill Patients
In 2005, the Food and Drug Administration (FDA) approved procalcitonin in conjunction with other laboratory markers to aid in the risk assessment of critically ill patients with severe infection (sepsis).
- Trial name
- PCT (NCT01362920)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- The Cleveland Clinic
Septic Shock, Microcirculatory Dysfunction
Papaverine and Sublingual Microcirculation in Septic Shock
This is a prospective, multicenter, single-arm, open-label, pilot physiological study designed to evaluate the effects of intravenous papaverine on sublingual microcirculation and the vascular waterfall phenomenon in adult…
- Conditions
- Septic Shock, Microcirculatory Dysfunction, Sublingual Microcirculation, Hemodynamic Instability
- Trial name
- NCT07657741
- Testing
- Papaverine
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Shock, Septic
Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis: A Pilot Feasibility Study
The objective of this pilot study is to assess overall feasibility prior to embarking on a larger randomized pragmatic trial comparing the clinical effectiveness of fluid resuscitation with NS versus LR for pediatric patients…
- Trial name
- PRoMPT BOLUS (NCT03340805)
- Testing
- Lactated Ringer, Normal saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Children's Hospital of Philadelphia
Septic Shock
Relation Between Mean Arterial Pressure and Renal Resistive Index in the Early Phase of Septic Shock
This study evaluates if improvement of renal resistive index when mean arterial pressure increase (at 65 mmHg to 85 mmHg) in early phase of septic shock is predictive of better renal survival.
- Trial name
- SEPSIR (NCT04281277)
- Testing
- increase of mean arterial pressure at 80-85 mmHg., increase of mean arterial pressure at 65-70 mmHg.
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Angers
Sepsis
Comparison of Microcirculation Indexes and Hemodynamic Indexes to Guide Resuscitation in Patients With Septic Shock
Comparison of Microcirculation Indexes and Hemodynamic Indexes to Guide Resuscitation in Patients With Septic Shock
- Trial name
- NCT05118646
- Testing
- sublingual microcirculation,, hemodynamic monitoring
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Xiangya Hospital of Central South University
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