Clinical trials: Septicemic Shock
Septic Shock, Acute Kidney Injury
The Effect of Vasopressor Therapy on Renal Perfusion in Septic Shock
Acute kidney injury (AKI) is a common complication of septic shock and together these conditions carry a high mortality risk. In septic patients who develop severe AKI renal cortical perfusion is deficient despite normal…
- Trial name
- REPERFUSE (NCT06234592)
- Testing
- Angiotensin II, Vasopressin, Norepinephrine
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- King's College Hospital NHS Trust
Septic Shock
Rapid Administration of Carnitine in sEpsis
Prior work has shown that exogenous L-carnitine administration enhances glucose and lactate oxidation, attenuates fatty acid toxicity, and improves endothelial-smooth muscle coupling and cardiac mechanical efficiency.
- Trial name
- RACE (NCT01665092)
- Testing
- Levo-Carnitine
- Where
- 14 sites in United States
- Volunteers
- 250 people
- Sponsor
- University of Mississippi Medical Center
Septic Shock, Acute Kidney Injury
Comparing Cytokines, Toxins Adsorbing oXiris Filter to ST150 Filter During CRRT in Patients With Septic Shock
The Oxiris® filter is a registered product for CRRT already safely used in routine care. In in vitro experiments, the Oxiris® filter has been demonstrated to adsorb endotoxin and cytokines.
- Trial name
- oXiris (NCT02600312)
- Testing
- oXiris
- Where
- Sweden
- Volunteers
- 16 people
- Sponsor
- Skane University Hospital
Gram Negative Infections, Sepsis and Septic Shock
A Combination Therapy With Ceftazidime and Fosfomycin Will be Compared to Ceftazidime Alone in Hospitalized Adult Patients With Suspected Severe Gram-negative Bacterial Infections
The goal of this clinical trial is to : 1. Test whether the combination of CAZ±AVI and FOS leads to superior clinical outcomes in patients with severe suspected Gram-negative bacterial infection, as demonstrated by a shorter time…
- Trial name
- CAVIFOS (NCT07063095)
- Testing
- Ceftazidime± avibactam with fosfomycin
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Angela HUTTNER
Severe Sepsis, Septic Shock
Prognostic Evaluation Of Severe Sepsis And Septic Shock. Procalcitonin Versus Delta Sofa
The purpose of this study is to compare the tendency of plasma concentration and clearance of procalcitonin in the first 24 and 48 hours of management of patients with severe sepsis and septic shock with another marker of early…
- Trial name
- NCT01841190
- Where
- 2 sites in Brazil
- Volunteers
- 128 people
- Sponsor
- Hospital Sao Domingos
Septic Shock
Effect of Simulation Application in Septic Shock Management
This research will be conducted to determine the effect of the Tag Team Patient Safety Simulation application applied to second-year students of a university's Nursing Department on their knowledge level, patient safety attitudes…
- Trial name
- NCT07032779
- Testing
- simulation
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Amasya University
Sepsis, Septic Shock
Impact of CVVHD With Adsorption Capacity Membranes in Septic Acute Kidney Injury
Septic patients with acute kidney injury (SA-AKI) requiring continuous renal replacement therapies (CRRT) present high mortality due to systemic inflammatory response, cytokine liberation, and finally multiorgan dysfunction.
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- NCT01790620
- Testing
- CVVHD, CVVH
- Where
- 2 sites in Spain
- Volunteers
- 110 people
- Sponsor
- Hospital Universitari de Bellvitge
Sepsis and Septic Shock, Acute Respiratory Failure
Eduction in ImmunoSuppressive Regimen Among Kidney Transplant Recipients Patients Admitted to the Intensive Care Unit for Septic Shock and/or Acute Respiratory Failure
Kidney transplantation is the treatment of choice for end-stage chronic kidney disease. Kidney transplantation is at the first rank of solid organ transplantation in France, with 3,376 grafts performed in 2022.
- Conditions
- Sepsis and Septic Shock, Acute Respiratory Failure, Kidney Transplant Recipients, Immunosuppressive Agents
- Trial name
- REDIS (NCT06881927)
- Testing
- Hydrocortisone Hemisuccinate: 200 mg per day., reduction of the level of immunosuppression
- Where
- France
- Volunteers
- 212 people
- Sponsor
- University Hospital, Strasbourg, France
Sepsis, Septic Shock
Aminoglycoside Administration in Septic Patients
Sepsis is one of the main causes of mortality and morbidity in an ICU setting, while the responsible microorganisms most frequently isolated are multidrug-resistant gram-negative bacteria.
- Conditions
- Sepsis, Septic Shock, Aminoglycoside Toxicity, Renal Replacement Therapy
- Trial name
- AMASEP (NCT06226441)
- Testing
- Continuous Renal Replacement Therapy
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- University of Thessaly
Shock, Septic Shock
LV Diastolic Function vs IVC Diameter Variation as Predictor of Fluid Responsiveness in Shock
Fluid responsive is defined as increasing in Cardiac output or Stroke volume by 10-15% after fluid challenge. Left ventricular diastolic dysfunction is associated with lower left ventricular end-diastolic volume (LVEDV) resulting…
- Trial name
- NCT05066256
- Testing
- Left ventricular diastolic function, Inferior vena cava variation
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Mahidol University
Sepsis, Septic Shock
PCT Guided Stopping of Antibiotic Therapy in Children With Sepsis
The investigators' objective is to compare the risk of treatment failure* in children admitted to the pediatric intensive care unit (PICU) with sepsis and managed by procalcitonin guided therapy for stopping of antibiotics ('PCT…
- Conditions
- Sepsis, Septic Shock, Antibiotic Use, Procalcitonin
- Trial name
- NCT03388944
- Testing
- PCT group
- Where
- 2 sites in India
- Volunteers
- 561 people
- Sponsor
- All India Institute of Medical Sciences
Sepsis, Severe, Septic Shock
Effects of Endotoxin Absorption and Cytokine Removal Hemofilter on Severe Septic Shock
In recent years, many studies have pointed out that bacterial toxin and cytokine storm are the main causes of shock and multiple organ failure in patients with sepsis.
- Trial name
- NCT03974386
- Testing
- oXiris blood purification set
- Where
- Taiwan
- Volunteers
- 12 people
- Sponsor
- National Taiwan University Hospital
Septic Shock
Characterization of Hemostatic Disordres in Septic Shock: Searching for Biological Markers
Sepsis induces hemostatic disorders due to the exessive or inappropriate activation of inflammation, which could lead either to hypercoagulability or hypocoagulability.
- Trial name
- COASEPT (NCT02692053)
- Testing
- blood sampling
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France
Septic Shock
Midodrine Use in Septic Shock
The investigators aim to perform a randomized, double-blind, placebo-controlled trial to investigate the efficacy of midodrine in decreasing time to IV vasopressor liberation in patients with septic shock.
- Trial name
- NCT03706053
- Testing
- Midodrine Hydrochloride
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Interstitial Liquid, Septic Shock
Interstitial Fluid Composition in Patients With Septic Versus Non-septic Shock: an Exploratory Pilot Study
Septic shock is a common reason for admission to intensive care units and severe infections are responsible for 6 million deaths a year worldwide.
- Trial name
- INTERSEP (NCT05039151)
- Testing
- interstitial fluid sampling, blood sampling
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Sepsis, Septic Shock
PRIME Sepsis Trial: Early Sepsis Detection in the Emergency Department Using Presepsin and Immature Granulocytes
Early identification and timely intervention for sepsis in the emergency department (ED) are critical for improving patient outcomes.
- Trial name
- NCT07822412
- Where
- Taiwan
- Volunteers
- 699 people
- Sponsor
- Chang Gung Memorial Hospital
Septic Shock
The Multicentre Prospective Observational Study on the Management of Septic Shock
Although there are published guidelines for the management of shock in general and septic shock in particular, the extent to which these guidelines are adhered to or achievable is unknown.
- Trial name
- OSS (NCT07453901)
- Volunteers
- 5,000 people
- Sponsor
- Bicetre Hospital
Septic Shock, Polymyxin B Hemoperfusion
Safety and Efficacy of Heparin Dosing Score Protocol for Polymyxin-B Hemoperfusion
Polymyxin B hemoperfusion (PMX-HP) is mainly used to remove endotoxins in septic shock patients with intra-abdominal infections.
- Trial name
- NCT03177330
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Sepsis Syndrome, Sepsis
Mitochondrial DNA as a Biomarker of Sepsis Severity
Mitochondria are organelles (a specialized subunit of a cell) responsible for providing cells with energy. For reasons not yet understood, mitochondria will release their DNA into blood in response to cellular injury or cell…
- Conditions
- Sepsis Syndrome, Sepsis, Severe Sepsis, Septic Shock
- Trial name
- MBOSS (NCT03077672)
- Where
- 2 sites in United States
- Volunteers
- 1,304 people
- Sponsor
- Weill Medical College of Cornell University
Neonatal Sepsis, Shock, Septic
Intravenous Methylene Blue for Treating Refractory Neonatal Septic Shock
Preterm infants (born at less than 37 weeks of pregnancy) sometimes develop a serious blood infection leading to low blood pressure, which does not respond to saline or to the standard medicines for increasing blood pressure…
- Trial name
- NCT06306001
- Testing
- Methylene Blue
- Where
- India
- Volunteers
- 130 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
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