Clinical trials: Sequence Optimization
Healthy Volunteers
Optimization of Thoracic Aortic MRI Acquisition Sequences for the Quantification of Diagnostic-assisting Biomarkers
The main objective is to optimize MRI acquisition and image post-processing protocols in order to define the best compromise between short scan time and image quality (contrast between different tissues, spatial and temporal…
- Trial name
- SEQUOIA (NCT05545410)
- Testing
- MRI calibration
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dementia Frontal, Dementia Alzheimers
Optimization and Harmonization of Advanced MRI Sequences
Development of a shared multimodal MRI protocol for the definition and quantification of imaging biomarkers in AD, DLB, FDT dementias, especially white matter alterations.
- Conditions
- Dementia Frontal, Dementia Alzheimers, Lewy Body Variant of Alzheimer Disease, Neuro-Degenerative Disease
- Trial name
- NCT06217237
- Testing
- AD FDT DBL GROUP
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Multiple Sclerosis
Improved Detection of Multiple Sclerosis Plaques in Inversion Recovery by Optimization of Sequence Parameters
This study evaluates different optimized MRI sequences for the detection of brain lesions in patients with multiple sclerosis in comparison with the recommended FLAIR sequence
- Trial name
- FLAIR-SEP (NCT03108573)
- Volunteers
- 27 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Diffuse and Focal Abnormalities of the Liver and Pancreas
Abdominal MR Imaging at 3.0T: Sequence Optimization and Implementation
This project will facilitate the optimization of body MR imaging at 3 Tesla.
- Trial name
- NCT01007357
- Testing
- Body MR imaging
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Spinal Cord Injuries
Evaluation of New MRI Sequences Including 3D-FGAPSIR for the Optimization of Inflammatory Spinal Cord Lesions Research
verification of inclusion and non-inclusion criteria information and collection of consent standard imaging protocol prescribed as part of the usual treatment: sagittal T1 and T2 slices after injection of contrast product…
- Trial name
- ESPOIR2 (NCT04906928)
- Testing
- MRI
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
MRI
OSV-IRM - Volunteer MRI Sequence Optimization
Optimization of magnetic resonance imaging (MRI) protocols on healthy volunteers and voluntary patients. In MRI, a large number of technical parameters (sequence, parameters in sequence, antenna, reconstruction method, etc.) can…
- Trial name
- OSV-IRM (NCT05107232)
- Testing
- MRI
- Where
- France
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Healthy
A Study in Healthy Men to Find the Best Formulation of BI 894416 and to Test How This is Taken up in the Body
The main objective of this trial is to select a formulation principle (tablet vs. capsule) and to optimize the identified extended release formulation of BI 894416, if needed.
- Trial name
- NCT04232839
- Testing
- BI 894416 Reference Formulation, BI 894416 Formulation A2, BI 894416 Formulation C2
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy Volunteers
Magnetic Resonance Imaging (MRI) Sequences Optimization in Healthy Subjects
Magnetic resonance imaging (MRI) is a noninvasive and non-ionizing (no use of X-rays) imaging modality. Today it is considered an anatomical and functional exploration reference technique.
- Trial name
- OSS-IRM (NCT02900339)
- Testing
- Magnetic Resonance Imaging
- Where
- France
- Volunteers
- 628 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Asthma
ROTAHALER Device Optimization Study
This study will compare the pharmacokinetic (PK) of Fluticasone Propionate/Salmeterol combination (FSC) 100/50 micrograms (mcg) delivered via the capsule-based inhaler (Rdpi) relative to FSC 100/50 mcg delivered via the…
- Trial name
- NCT01890863
- Testing
- Fluticasone Propionate / Salmeterol Xinafoate DISKUS, Fluticasone Propionate / Salmeterol Xinafoate ROTACAP
- Where
- Australia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy Subjects, Patient Performing an MRI Examination
Optimization of the Acquisition Sequence to Improve the Quality and Comfort of Magnetic Resonance Imaging Exam
The purpose of this study is to evaluate the optimization of MRI acquisition sequences.
- Trial name
- AIMANT (NCT04645628)
- Testing
- MRI examination
- Where
- France
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Neurosciences, MRI
OPTIMIZATION of ADVANCED MR SEQUENCES
This monocentric methodological study aims at optimizing advanced MR sequences for image quality (reduced artefacts, signal to noise ratio, acquisition time, stability of quantitative measurements) on a new MR unit dedicated to…
- Conditions
- Neurosciences, MRI, Brain Tumor, Mental Disorders
- Trial name
- OPT-IRM (NCT05618990)
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Helicobacter Pylori Infection
Optimization of Minocycline for Helicobacter Pylori Rescue Treatment
The efficacy of bismuth-containing quadruple therapy with minocycline and metronidazole was not inferior to classical bismuth quadruple therapy for refractory H.
- Trial name
- NCT06561711
- Testing
- Vonoprazan, Bismuth Potassium Citrate, Tetracycline,Metronidazole
- Where
- 4 sites in China
- Volunteers
- 480 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Normal Volunteers
Optimization of Novel DCE-MRI Imaging Sequences for Cancer Therapy Monitoring
This pilot clinical trial studies dynamic contrast enhanced (DCE)-magnetic resonance imaging (MRI) in diagnosing cancer. New diagnostic procedures, such as DCE-MRI may help find and diagnose cancer
- Trial name
- NCT01752231
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Sequence Optimization, Protocol Optimization
Optimization of Cardiac-MR Protocols
The aim of the present study is the optimization of various magnetic resonance (MR) investigation protocols of the heart and the lung without contrast agent application as well as the generation of normal values from cardiac MR…
- Conditions
- Sequence Optimization, Protocol Optimization, Normal Values, Feasibility
- Trial name
- NCT00557869
- Where
- Austria
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Optimized MRI Sequences
Optimization of Sequences to Improve the Quality and Comfort of the Magnetic Resonance Imaging Examination
The people included will carry out an MRI comprising the sequence currently used in routine care and the different variants of the sequence being tested, for the optimization of the parameters.
- Trial name
- OPTIM (NCT05326581)
- Testing
- mri
- Where
- France
- Volunteers
- 750 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Memory Disorders
Optimization of MRI Sequences Used in the Study of Neurodegenerative Diseases
The Inserm NeuroPresage team has been using MRI for more than 20 years in the study of normal ageing and memory pathologies to further the understanding and the characterization of early diagnosis and the cerebral substrates of…
- Trial name
- IRMtests (NCT05929144)
- Testing
- MRI sequences testing
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
MRI, Sequence Optimization
Development of MRI Protocols and Associated Neuro-physiological Explorations in Healthy and Pathological Subjects
IRMaGe is a Joint Service Unit (UMS) which provides users of brain exploration equipment (clinical MRI and preclinical, TMS, EEG, NIRS and metabolomics).
- Conditions
- MRI, Sequence Optimization, Physiological Measurement
- Trial name
- MAP-IRMaGE (NCT05036629)
- Testing
- MRI Protocol
- Where
- France
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Magnetic Resonance Imaging Sequences
Test and Optimization of New Specific MRI Sequences on an Imager Dedicated to Research
Magnetic Resonance Imaging (MRI) performance depends on equipment performance, equipment maintenance and relevance of MRI sequence used.
- Trial name
- SEQ-IRM (NCT03674645)
- Testing
- MRI acquisitions
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Healthy
OSS-IRM: Optimization of MRI Sequences in Healthy Volunteers
Using MRI, many technical parameters can be changed to optimize the diagnostic quality of the examination. The study is interventionnal because healthy volunteers are not supposed to have an MRI exam.
- Trial name
- OSS-IRM (NCT03440983)
- Testing
- MRI data acquiring in healthy volunteers
- Where
- France
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital